Shook, D. & Keller, R. Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development. Mech. Dev.120, 1351–1383 (2003). ArticleCASPubMed Google Scholar
Tarin, D., Thompson, E. W. & Newgreen, D. F. The fallacy of epithelial–mesenchymal transition in neoplasia. Cancer Res.65, 5996–6000 (2005). ArticleCASPubMed Google Scholar
Huber, M. A., Kraut, N. & Beug, H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol.17, 548–558 (2005). ArticleCASPubMed Google Scholar
Thiery, J. P. Epithelial–mesenchymal transitions in tumour progression. Nature Rev. Cancer2, 442–454 (2002). ArticleCAS Google Scholar
Thompson, E. W., Newgreen, D. F. & Tarin, D. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res.65, 5991–5995 (2005). ArticleCASPubMed Google Scholar
Trusolino, L. & Comoglio, P. M. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nature Rev. Cancer4, 289–300 (2002). ArticleCAS Google Scholar
Nakamura, T., Teramoto, H. & Ichihara, A. Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. Proc. Natl Acad. Sci. USA83, 6489–6493 (1986). ArticleCASPubMedPubMed Central Google Scholar
Stoker, M., Gherardi, E., Perryman, M. & Gray, J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature327, 239–242 (1987). ArticleCASPubMed Google Scholar
Savagner, P., Yamada, K. M. & Thiery, J. P. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J. Cell Biol.137, 1403–1419 (1997). ArticleCASPubMedPubMed Central Google Scholar
Montesano, R., Matsumoto, K., Nakamura, T. & Orci, L. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell67, 901–908 (1991). ArticleCASPubMed Google Scholar
Brinkmann, V., Foroutan, H., Sachs, M., Weidner, K. M. & Birchmeier, W. Hepatocyte growth factor/scatter factor induces a variety of tissue- specific morphogenic programs in epithelial cells. J. Cell Biol.131, 1573–1586 (1995). ArticleCASPubMed Google Scholar
Stern, C. D. et al. Epithelial scatter factor and development of the chick embryonic axis. Development110, 1271–1284 (1990). ArticleCASPubMed Google Scholar
Streit, A. et al. A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation. Development121, 813–824 (1995). ArticleCASPubMed Google Scholar
Andermarcher, E., Surani, M. A. & Gherardi, E. Co-expression of the HGF/SF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis. Dev. Genet.18, 254–266 (1996). ArticleCASPubMed Google Scholar
Sonnenberg, E., Meyer, D., Weidner, K. M. & Birchmeier, C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J. Cell Biol.123, 223–235 (1993). ArticleCASPubMed Google Scholar
Yang, Y. et al. Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J. Cell Biol.131, 215–226 (1995). ArticleCASPubMed Google Scholar
Birchmeier, C. & Gherardi, E. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. Trends Cell Biol.8, 404–410 (1998). ArticleCASPubMed Google Scholar
Maina, F. & Klein, R. Hepatocyte growth factor, a versatile signal for developing neurons. Nature Neurosci.2, 213–217 (1999). ArticleCASPubMed Google Scholar
Tamagnone, L. et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell99, 71–80 (1999). ArticleCASPubMed Google Scholar
Giordano, S. et al. The semaphorin 4D receptor controls invasive growth by coupling with Met. Nature Cell Biol.4, 720–724 (2002). ArticleCASPubMed Google Scholar
Bottaro, D. P. et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science251, 802–804 (1991). ArticleCASPubMed Google Scholar
Naldini, L. et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J.10, 2867–2878 (1991). ArticleCASPubMedPubMed Central Google Scholar
Iwama, A., Okano, K., Sudo, T., Matsuda, Y. & Suda, T. Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells. Blood83, 3160–3169 (1994). ArticleCASPubMed Google Scholar
Wang, M. H. et al. Identification of the ron gene product as the receptor for the human macrophage stimulating protein. Science266, 117–119 (1994). ArticleCASPubMed Google Scholar
Ponzetto, C. et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell77, 261–271 (1994). ArticleCASPubMed Google Scholar
Iwama, A., Yamaguchi, N. & Suda, T. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. EMBO J.15, 5866–5875 (1996). ArticleCASPubMedPubMed Central Google Scholar
Medico, E. et al. The tyrosine kinase receptors Ron and Sea control “scattering” and morphogenesis of liver progenitor cells in vitro. Mol. Biol. Cell7, 495–504 (1996). ArticleCASPubMedPubMed Central Google Scholar
Conrotto, P., Corso, S., Gamberini, S., Comoglio, P. M. & Giordano, S. Interplay between scatter factor receptors and B plexins controls invasive growth. Oncogene23, 5131–5137 (2004). ArticleCASPubMed Google Scholar
Trusolino, L., Bertotti, A. & Comoglio, P. M. A signaling adapter function for α6β4 integrin in the control of HGF-dependent invasive growth. Cell107, 643–654 (2001). ArticleCASPubMed Google Scholar
Santoro, M. M., Gaudino, G. & Marchisio, P. C. The MSP receptor regulates α6β4 and α3β1 integrins via 14-3–3 proteins in keratinocyte migration. Dev. Cell5, 257–271 (2003). ArticleCASPubMed Google Scholar
Bertotti, A. & Comoglio, P. M. Tyrosine kinase signal specificity: lessons from the HGF receptor. Trends Biochem. Sci.28, 527–533 (2003). ArticleCASPubMed Google Scholar
Rosario, M. & Birchmeier, W. How to make tubes: signaling by the Met receptor tyrosine kinase. Trends Cell Biol.13, 328–335 (2003). ArticleCASPubMed Google Scholar
Schmidt, L. et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nature Genet.16, 68–73 (1997). ArticleCASPubMed Google Scholar
Danilkovitch-Miagkova, A. & Zbar, B. Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. J. Clin. Invest109, 863–867 (2002). ArticleCASPubMedPubMed Central Google Scholar
Park, W. S. et al. Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res.59, 307–310 (1999). CASPubMed Google Scholar
Lorenzato, A. et al. Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion. Cancer Res.62, 7025–7030 (2002). CASPubMed Google Scholar
Di Renzo, M. F. et al. Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene19, 1547–1555 (2000). ArticleCASPubMed Google Scholar
Ferracini, R. et al. The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene10, 739–749 (1995). CASPubMed Google Scholar
Ferracini, R. et al. Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas. Oncogene12, 1697–1705 (1996). CASPubMed Google Scholar
Scotlandi, K. et al. Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. Am. J. Pathol.149, 1209–1219 (1996). CASPubMedPubMed Central Google Scholar
Koochekpour, S. et al. Met and hepatocyte growth factor/scatter factor expression in human gliomas. Cancer Res.57, 5391–5398 (1997). CASPubMed Google Scholar
Tuck, A. B., Park, M., Sterns, E. E., Boag, A. & Elliott, B. E. Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma. Am. J. Pathol.148, 225–232 (1996). CASPubMedPubMed Central Google Scholar
Yao, Y. et al. Scatter factor protein levels in human breast cancers: clinicopathological and biological correlations. Am. J. Pathol.149, 1707–1717 (1996). CASPubMedPubMed Central Google Scholar
Rong, S., Segal, S., Anver, M., Resau, J. H. & Vande, W. G. Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. Proc. Natl Acad. Sci. USA91, 4731–4735 (1994). ArticleCASPubMedPubMed Central Google Scholar
Meiners, S., Brinkmann, V., Naundorf, H. & Birchmeier, W. Role of morphogenetic factors in metastasis of mammary carcinoma cells. Oncogene16, 9–20 (1998). ArticleCASPubMed Google Scholar
Takayama, H. et al. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc. Natl Acad. Sci. USA94, 701–706 (1997). ArticleCASPubMedPubMed Central Google Scholar
Otsuka, T. et al. c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Cancer Res.58, 5157–5167 (1998). CASPubMed Google Scholar
Gallego, M. I., Bierie, B. & Hennighausen, L. Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways. Oncogene22, 8498–8508 (2003). ArticleCASPubMed Google Scholar
Birchmeier, C., Birchmeier, W., Gherardi, E. & Vande Woude, G. F. Met, metastasis, motility and more. Nature Rev. Mol. Cell Biol.4, 915–925 (2003). ArticleCAS Google Scholar
Di Renzo, M. F. et al. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin. Cancer Res.1, 147–154 (1995). CASPubMed Google Scholar
Takeuchi, H. et al. c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases. Clin. Cancer Res.9, 1480–1488 (2003). CASPubMed Google Scholar
Suzuki, K. et al. Expression of the c-met protooncogene in human hepatocellular carcinoma. Hepatology20, 1231–1236 (1994). ArticleCASPubMed Google Scholar
Ueki, T., Fujimoto, J., Suzuki, T., Yamamoto, H. & Okamoto, E. Expression of hepatocyte growth factor and its receptor, the c- c--met proto-oncogene, in hepatocellular carcinoma. Hepatology25, 619–623 (1997). ArticleCASPubMed Google Scholar
Peghini, P. L. et al. Overexpression of epidermal growth factor and hepatocyte growth factor receptors in a proportion of gastrinomas correlates with aggressive growth and lower curability. Clin. Cancer Res.8, 2273–2285 (2002). CASPubMed Google Scholar
Di Renzo, M. F., Poulsom, R., Olivero, M., Comoglio, P. M. & Lemoine, N. R. Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res.55, 1129–1138 (1995). CASPubMed Google Scholar
Amemiya, H. et al. c--Met expression in gastric cancer with liver metastasis. Oncology63, 286–296 (2002). ArticleCASPubMed Google Scholar
Humphrey, P. A. et al. Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. Am. J. Pathol.147, 386–396 (1995). CASPubMedPubMed Central Google Scholar
Di Renzo, M. F. et al. Overexpression of the Met/HGF receptor in ovarian cancer. Int. J. Cancer58, 658–662 (1994). ArticleCASPubMed Google Scholar
Huntsman, D., Resau, J. H., Klineberg, E. & Auersperg, N. Comparison of c-met expression in ovarian epithelial tumors and normal epithelia of the female reproductive tract by quantitative laser scan microscopy. Am. J. Pathol.155, 343–348 (1999). ArticleCASPubMedPubMed Central Google Scholar
Beviglia, L., Matsumoto, K., Lin, C. S., Ziober, B. L. & Kramer, R. H. Expression of the c-Met/HGF receptor in human breast carcinoma: correlation with tumor progression. Int. J. Cancer74, 301–309 (1997). ArticleCASPubMed Google Scholar
Ghoussoub, R. A. et al. Expression of c-met is a strong independent prognostic factor in breast carcinoma. Cancer82, 1513–1520 (1998). ArticleCASPubMed Google Scholar
Lee, W. Y. et al. Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients. Clin. Cancer Res.11, 2222–2228 (2005). ArticleCASPubMed Google Scholar
Wang, R., Ferrell, L. D., Faouzi, S., Maher, J. J. & Bishop, J. M. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J. Cell Biol.153, 1023–1034 (2001). ArticleCASPubMedPubMed Central Google Scholar
Michieli, P. et al. Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists. Oncogene18, 5221–5231 (1999). ArticleCASPubMed Google Scholar
Kankuri, E., Cholujova, D., Comajova, M., Vaheri, A. & Bizik, J. Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness. Cancer Res.65, 9914–9922 (2005). ArticleCASPubMed Google Scholar
Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature414, 105–111 (2001). ArticleCASPubMed Google Scholar
Huntly, B. J. & Gilliland, D. G. Leukaemia stem cells and the evolution of cancer-stem-cell research. Nature Rev. Cancer5, 311–321 (2005). ArticleCAS Google Scholar
Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature367, 645–648 (1994). ArticleCASPubMed Google Scholar
Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med.3, 730–737 (1997). ArticleCASPubMed Google Scholar
Al Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA100, 3983–3988 (2003). ArticleCASPubMedPubMed Central Google Scholar
Kim, C. F. et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell121, 823–835 (2005). ArticleCASPubMed Google Scholar
Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature432, 396–401 (2004). ArticleCASPubMed Google Scholar
Tu, S. M., Lin, S. H. & Logothetis, C. J. Stem-cell origin of metastasis and heterogeneity in solid tumours. Lancet Oncol.3, 508–513 (2002). ArticleCASPubMed Google Scholar
Brabletz, T., Jung, A., Spaderna, S., Hlubek, F. & Kirchner, T. Opinion: migrating cancer stem cells- an integrated concept of malignant tumour progression. Nature Rev. Cancer5, 744–749 (2005). ArticleCAS Google Scholar
Kucia, M. et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells23, 879–894 (2005). ArticleCASPubMed Google Scholar
Thery, C., Sharpe, M. J., Batley, S. J., Stern, C. D. & Gherardi, E. Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick development. Dev. Genet.17, 90–101 (1995). ArticleCASPubMed Google Scholar
Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A. & Birchmeier, C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature376, 768–771 (1995). ArticleCASPubMed Google Scholar
Dietrich, S. et al. The role of SF/HGF and c-Met in the development of skeletal muscle. Development126, 1621–1629 (1999). ArticleCASPubMed Google Scholar
Takayama, H., La Rochelle, W. J., Anver, M., Bockman, D. E. & Merlino, G. Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc. Natl Acad. Sci. USA93, 5866–5871 (1996). ArticleCASPubMedPubMed Central Google Scholar
Kollet, O. et al. HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. J. Clin. Invest112, 160–169 (2003). ArticleCASPubMedPubMed Central Google Scholar
Rosu-Myles, M. et al. A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis. J. Cell Sci.118, 4343–4352 (2005). ArticleCASPubMed Google Scholar
Kucia, M. et al. Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction. Circ. Res.95, 1191–1199 (2004). ArticleCASPubMedPubMed Central Google Scholar
Kucia, M. et al. Cells enriched in markers of neural tissue-committed stem cells reside in the bone marrow and are mobilized into the peripheral blood following stroke. Leukemia20, 18–28 (2006). ArticleCASPubMed Google Scholar
Neuss, S., Becher, E., Woltje, M., Tietze, L. & Jahnen-Dechent, W. Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem Cells22, 405–414 (2004). ArticleCASPubMed Google Scholar
Forte, G. et al. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells24, 23–33 (2006). ArticleCASPubMed Google Scholar
Galimi, F. et al. Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors. J. Cell Biol.127, 1743–1754 (1994). ArticleCASPubMed Google Scholar
Weimar, I. S. et al. Hepatocyte growth factor/scatter factor (HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells (CD34+). Exp. Hematol.26, 885–894 (1998). CASPubMed Google Scholar
Cornelison, D. D. & Wold, B. J. Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells. Dev. Biol.191, 270–283 (1997). ArticleCASPubMed Google Scholar
Urbanek, K. et al. Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ. Res.97, 663–673 (2005). ArticleCASPubMed Google Scholar
Di Renzo, M. F. et al. Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene6, 1997–2003 (1991). CASPubMed Google Scholar
Prat, M. et al. The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Int. J. Cancer49, 323–328 (1991). ArticleCASPubMed Google Scholar
Pardal, R., Clarke, M. F. & Morrison, S. J. Applying the principles of stem-cell biology to cancer. Nature Rev. Cancer3, 895–902 (2003). ArticleCAS Google Scholar
Mueller, M. M. & Fusenig, N. E. Friends or foes — bipolar effects of the tumour stroma in cancer. Nature Rev. Cancer4, 839–849 (2004). ArticleCAS Google Scholar
Ivan, M., Bond, J. A., Prat, M., Comoglio, P. M. & Wynford-Thomas, D. Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells. Oncogene14, 2417–2423 (1997). ArticleCASPubMed Google Scholar
Gambarotta, G. et al. Ets up-regulates MET transcription. Oncogene13, 1911–1917 (1996). CASPubMed Google Scholar
Boccaccio, C., Gaudino, G., Gambarotta, G., Galimi, F. & Comoglio, P. M. Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF. J. Biol. Chem.269, 12846–12851 (1994). ArticleCASPubMed Google Scholar
Anastasi, S. et al. A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiation. J. Cell Biol.137, 1057–1068 (1997). ArticleCASPubMedPubMed Central Google Scholar
Sharp, R. et al. Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis. Nature Med.8, 1276–1280 (2002). ArticleCASPubMed Google Scholar
Jankowski, K. et al. Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer Res.63, 7926–7935 (2003). CASPubMed Google Scholar
Vasyutina, E. et al. CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev.19, 2187–2198 (2005). ArticleCASPubMedPubMed Central Google Scholar
Natali, P. G. et al. Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression. Br. J. Cancer68, 746–750 (1993). ArticleCASPubMedPubMed Central Google Scholar
Cruz, J., Reis-Filho, J. S., Silva, P. & Lopes, J. M. Expression of c-met tyrosine kinase receptor is biologically and prognostically relevant for primary cutaneous malignant melanomas. Oncology65, 72–82 (2003). ArticleCASPubMed Google Scholar
Hecht, M., Papoutsi, M., Tran, H. D., Wilting, J. & Schweigerer, L. Hepatocyte growth factor/c-Met signaling promotes the progression of experimental human neuroblastomas. Cancer Res.64, 6109–6118 (2004). ArticleCASPubMed Google Scholar
Schmidt, C. et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature373, 699–702 (1995). ArticleCASPubMed Google Scholar
Zheng, Y. W. & Taniguchi, H. Diversity of hepatic stem cells in the fetal and adult liver. Semin. Liver Dis.23, 337–348 (2003). ArticleCASPubMed Google Scholar
Suzuki, A. et al. Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver. J. Cell Biol.156, 173–184 (2002). ArticleCASPubMedPubMed Central Google Scholar
Suzuki, A., Nakauchi, H. & Taniguchi, H. Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting. Diabetes53, 2143–2152 (2004). ArticleCASPubMed Google Scholar
Xian, C. J., Couper, R., Howarth, G. S., Read, L. C. & Kallincos, N. C. Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis. Br. J. Cancer82, 945–952 (2000). ArticleCASPubMedPubMed Central Google Scholar
Boccaccio, C. et al. The MET oncogene drives a genetic programme linking cancer to haemostasis. Nature434, 396–400 (2005). ArticleCASPubMed Google Scholar
Boon, E. M., van der Neut, R., van de Wetering, M., Clevers, H. & Pals, S. T. Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. Cancer Res.62, 5126–5128 (2002). CASPubMed Google Scholar
van de Wetering, M. et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell111, 241–250 (2002). ArticleCASPubMed Google Scholar
Brembeck, F. H. et al. Essential role of BCL9–2 in the switch between β-catenin's adhesive and transcriptional functions. Genes Dev.18, 2225–2230 (2004). ArticleCASPubMedPubMed Central Google Scholar
Zhou, B. P. et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition. Nature Cell Biol.6, 931–940 (2004). ArticleCASPubMed Google Scholar
Stella, M. C., Trusolino, L., Pennacchietti, S. & Comoglio, P. M. Negative feedback regulation of Met-dependent invasive growth by Notch. Mol. Cell Biol.25, 3982–3996 (2005). ArticleCASPubMedPubMed Central Google Scholar
Pear, W. S. & Simon, M. C. Lasting longer without oxygen: The influence of hypoxia on Notch signaling. Cancer Cell8, 435–437 (2005). ArticleCASPubMed Google Scholar
Gustafsson, M. V. et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev. Cell9, 617–628 (2005). ArticleCASPubMed Google Scholar
Ceradini, D. J. et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nature Med.10, 858–864 (2004). ArticleCASPubMed Google Scholar
Ceradini, D. J. & Gurtner, G. C. Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc. Med.15, 57–63 (2005). ArticleCASPubMed Google Scholar
Tepper, O. M. et al. Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells. Blood105, 1068–1077 (2005). ArticleCASPubMed Google Scholar
Staller, P. et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature425, 307–311 (2003). ArticleCASPubMed Google Scholar
Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature410, 50–56 (2001). ArticleCASPubMed Google Scholar
Kang, Y. et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell3, 537–549 (2003). ArticleCASPubMed Google Scholar
Pennacchietti, S. et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell3, 347–361 (2003). ArticlePubMed Google Scholar
Semenza, G. L. Targeting HIF-1 for cancer therapy. Nature Rev. Cancer3, 721–732 (2003). ArticleCAS Google Scholar
Scarpino, S. et al. Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-1 (HIF-1) in tumour cells in papillary carcinoma of the thyroid. J. Pathol.202, 352–358 (2004). ArticleCASPubMed Google Scholar
Oh, R. R. et al. Expression of HGF/SF and Met protein is associated with genetic alterations of VHL gene in primary renal cell carcinomas. APMIS110, 229–238 (2002). ArticleCASPubMed Google Scholar
Ohh, M. et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein. Nature Cell Biol.2, 423–427 (2000). ArticleCASPubMed Google Scholar
Koochekpour, S. et al. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Mol. Cell Biol.19, 5902–5912 (1999). ArticleCASPubMedPubMed Central Google Scholar
Harris, A. L. Hypoxia-a-key regulatory factor in tumour growth. Nature Rev. Cancer2, 38–47 (2002). ArticleCAS Google Scholar
Steeg, P. S. Angiogenesis inhibitors: motivators of metastasis? Nature Med.9, 822–823 (2003). ArticleCASPubMed Google Scholar
Beachy, P. A., Karhadkar, S. S. & Berman, D. M. Tissue repair and stem cell renewal in carcinogenesis. Nature432, 324–331 (2004). ArticleCASPubMed Google Scholar
Rickles, F. R. & Levine, M. N. Epidemiology of thrombosis in cancer. Acta haematol.106, 6–12 (2001). ArticleCASPubMed Google Scholar
Rickles, F. R., Shoji, M. & Abe, K. The role of the hemostatic system in tumor growth, metastasis, and angiogenesis: tissue factor is a bifunctional molecule capable of inducing both fibrin deposition and angiogenesis in cancer. Int. J. Hematol.73, 145–150 (2001). ArticleCASPubMed Google Scholar
Petralia, G. A., Lemoine, N. R. & Kakkar, A. K. Mechanisms of disease: the impact of antithrombotic therapy in cancer patients. Nature Clin. Pract. Oncol.2, 356–363 (2005). ArticleCAS Google Scholar
Palumbo, J. S. et al. Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice. Cancer Res.62, 6966–6972 (2002). CASPubMed Google Scholar
Rong, Y. et al. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res.65, 1406–1413 (2005). ArticleCASPubMed Google Scholar
Yu, J. L. et al. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood105, 1734–1741 (2005). ArticleCASPubMed Google Scholar
Dean, M., Fojo, T. & Bates, S. Tumour stem cells and drug resistance. Nature Rev. Cancer5, 275–284 (2005). ArticleCAS Google Scholar
Corso, S., Comoglio, P. M. & Giordano, S. Cancer therapy: can the challenge be MET? Trends Mol. Med.11, 284–292 (2005). ArticleCASPubMed Google Scholar
Smolen, G. A. et al. Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc. Natl Acad. Sci. USA103, 2316–2321 (2006). ArticleCASPubMedPubMed Central Google Scholar
Michieli, P. et al. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. Cancer Cell6, 61–73 (2004). ArticleCASPubMed Google Scholar
Mazzone, M. et al. An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice. J. Clin. Invest.114, 1418–1432 (2004). ArticleCASPubMedPubMed Central Google Scholar
Bussolino, F. et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol.119, 629–641 (1992). ArticleCASPubMed Google Scholar
Petrelli, A. et al. Ab-induced ectodomain shedding mediates HGF receptor down-regulation and hampers biological activity. Proc. Natl Acad. Sci. USA130, 5090–5095 (2006) ArticleCAS Google Scholar
Ponzetto, C. et al. Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility. J. Biol. Chem.271, 14119–14123 (1996). ArticleCASPubMed Google Scholar
Royal, I., Fournier, T. M. & Park, M. Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis. J. Cell Physiol.173, 196–201 (1997). ArticleCASPubMed Google Scholar
Xiao, G. H. et al. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc. Natl Acad. Sci. USA98, 247–252 (2001). ArticleCASPubMed Google Scholar
Giordano, S. et al. A point mutation in the MET oncogene abrogates metastasis without affecting transformation. Proc. Natl Acad. Sci. USA94, 13868–13872 (1997). ArticleCASPubMedPubMed Central Google Scholar
Boccaccio, C. et al. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature391, 285–288 (1998). ArticleCASPubMed Google Scholar
Gual, P. et al. Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene19, 1509–1518 (2000). ArticleCASPubMed Google Scholar
Maroun, C. R., Naujokas, M. A., Holgado-Madruga, M., Wong, A. J. & Park, M. The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol. Cell Biol.20, 8513–8525 (2000). ArticleCASPubMedPubMed Central Google Scholar
Sakkab, D. et al. Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. J. Biol. Chem.275, 10772–10778 (2000). ArticleCASPubMed Google Scholar
Orian-Rousseau, V., Chen, L., Sleeman, J. P., Herrlich, P. & Ponta, H. CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev.16, 3074–3086 (2002). ArticleCASPubMedPubMed Central Google Scholar