Epithelial–mesenchymal transitions in tumour progression (original) (raw)
Lillie, F. R. The Development of the Chick (Henry Holt and Co, New York, 1908). Google Scholar
Trelstad, R. L., Hay, E. D. & Revel, J. D. Cell contact during early morphogenesis in the chick embryo. Dev. Biol.16, 78–106 (1967). ArticleCASPubMed Google Scholar
Hay, E. D. in Epithelial–Mesenchymal Interactions (eds Fleischmajer, R. & Billingham, R. E.) 31–35 (Williams & Wilkins, Baltimore, 1968). Google Scholar
Greenburg, G. & Hay, E. D. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J. Cell Biol.95, 333–339 (1982).The first approach to describe the analysis of EMT in epithelial tissues. ArticleCASPubMed Google Scholar
Stoker, M. & Perryman, M. An epithelial scatter factor released by embryo fibroblasts. J. Cell Sci.77, 209–223 (1985).The firstin vitrostudy that revealed a scatter-factor activity in epithelial cells. ArticleCASPubMed Google Scholar
Stoker, M., Gherardi, E., Perryman, M. & Gray, J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature327, 239–242 (1987). ArticleCASPubMed Google Scholar
Nakamura, T. et al. Molecular cloning and expression of human hepatocyte growth factor. Nature342, 440–443 (1989). ArticleCASPubMed Google Scholar
Naldini, L. et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J.10, 2867–2878 (1991). ArticleCASPubMedPubMed Central Google Scholar
Weidner, K. M. et al. Molecular characteristics of HGF-SF and its role in cell motility and invasion. Exs.65, 311–328 (1993). CASPubMed Google Scholar
Wick, M. R. & Swanson, P. E. Carcinosarcomas: current perspectives and an historical review of nosological concepts. Semin. Diagn. Pathol.10, 118–127 (1993). CASPubMed Google Scholar
Thompson, L., Chang, B. & Barsky, S. H. Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis. Am. J. Surg. Pathol.20, 277–285 (1996). ArticleCASPubMed Google Scholar
Torenbeek, R., Hermsen, M. A., Meijer, G. A., Baak, J. P. & Meijer, C. J. Analysis by comparative genomic hybridization of epithelial and spindle cell components in sarcomatoid carcinoma and carcinosarcoma: histogenetic aspects. J. Pathol.189, 338–343 (1999). ArticleCASPubMed Google Scholar
Mayall, F., Rutty, K., Campbell, F. & Goddard, H. p53 immunostaining suggests that uterine carcinosarcomas are monoclonal. Histopathology24, 211–214 (1994). ArticleCASPubMed Google Scholar
Iascone, C. & Barreca, M. Carcinosarcoma and pseudosarcoma of the esophagus: two names, one disease: comprehensive review of the literature. World J. Surg.23, 153–157 (1999). ArticleCASPubMed Google Scholar
Gilbert, S. F. Developmental Biology (Sinauer Associates Inc., Sunderland, Massachusetts, 1997). Google Scholar
Stern, C. & Ingham, P. Gastrulation (The Company of Biologists Limited, Cambridge, UK, 1992). Google Scholar
Takeichi, M. Morphogenetic roles of classic cadherins. Curr. Opin. Cell Biol.7, 619–627 (1995). ArticleCASPubMed Google Scholar
Kemler, R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet.9, 317–321 (1993). ArticleCASPubMed Google Scholar
Tepass, U., Truong, K., Godt, D., Ikura, M. & Peifer, M. Cadherins in embryonic and neural morphogenesis. Nature Rev. Mol. Cell Biol.1, 91–100 (2000). ArticleCAS Google Scholar
Adams, C. L. & Nelson W. J. Cytomechanics of cadherin-mediated cell-cell adhesion. Curr. Opin. Cell Biol.10, 572–577 (1998). ArticleCASPubMed Google Scholar
Kowalczyk, A. P., Bornslaeger, E. A., Norvell, S. M., Palka, H. L. & Green, K. J. Desmosomes: intercellular adhesive junctions specialized for attachment of intermediate filaments. Int. Rev. Cytol.185, 237–302 (1999). ArticleCASPubMed Google Scholar
Garrod, D., Chidgey, M. & North, A. Desmosomes: differentiation, development, dynamics and disease. Curr. Opin. Cell Biol.8, 670–678 (1996). ArticleCASPubMed Google Scholar
Imhof, B. A., Vollmers, H. P., Goodman, S. L. & Birchmeier, W. Cell–cell interaction and polarity of epithelial cells: specific perturbation using a monoclonal antibody. Cell35, 667–675 (1983). ArticleCASPubMed Google Scholar
Damjanov, I., Damjanov, A. & Damsky, C. H. Developmentally regulated expression of the cell–cell adhesion glycoprotein cell-CAM 120/80 in peri-implantation mouse embryos and extraembryonic membranes. Dev. Biol.116, 194–202 (1986). ArticleCASPubMed Google Scholar
Veltmaat, J. M. et al. Snail is an immediate early target gene of parathyroid hormone related peptide signaling in parietal endoderm formation. Int. J. Dev. Biol.44, 297–307 (2000). CASPubMed Google Scholar
Tepass, U. et al. Shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia. Genes Dev.10, 672–685 (1996). ArticleCASPubMed Google Scholar
Edelman, G. M., Gallin, W. J., Delouvee, A., Cunningham, B. A. & Thiery, J. P. Early epochal maps of two different cell adhesion molecules. Proc. Natl Acad. Sci. USA80, 4384–4388 (1983).The first demonstration of the downregulation of E-cadherin in EMT during gastrulation in the chick. ArticleCASPubMedPubMed Central Google Scholar
Burdsal, C. A., Damsky, C. H. & Pedersen, R. A. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive steak. Development118, 829–844 (1993). ArticleCASPubMed Google Scholar
Kuure, S., Vuolteenaho, R. & Vainio, S. Kidney morpho-genesis: cellular and molecular regulation. Mech. Dev.92, 31–45 (2000). ArticleCASPubMed Google Scholar
Hatta, K., Takagi, S., Fujisawa, H. & Takeichi, M. Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos. Dev. Biol.120, 215–227 (1987). ArticleCASPubMed Google Scholar
Duband, J. L. et al. Adhesion molecules during somitogenesis in the avian embryo. J. Cell Biol.104, 1361–1374 (1987). ArticleCASPubMed Google Scholar
Frixen, U. H. et al. E-cadherin-mediated cell–cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol.113, 173–185 (1991).One of the first extensive reports to correlate the loss of E-cadherin expression and dedifferentiation and invasive properties of carcinoma cells. ArticleCASPubMed Google Scholar
Behrens, J., Mareel, M. M., van Roy, F. M. & Birchmeier, W. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell–cell adhesion. J. Cell Biol.108, 2435–2447 (1989). ArticleCASPubMed Google Scholar
Chen, W. C. & Obrink, B. Cell–cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells. J. Cell Biol.114, 319–327 (1991). ArticleCASPubMed Google Scholar
Kim, J. B. et al. N-cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility. J. Cell Biol.151, 1193–1206 (2000). ArticleCASPubMedPubMed Central Google Scholar
Navarro, P. et al. A role for the E-cadherin cell–cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J. Cell Biol.115, 517–533 (1991). ArticleCASPubMed Google Scholar
Vleminckx, K., Vakaet, L. Jr, Mareel, M., Fiers, W. & van Roy, F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell66, 107–119 (1991). ArticleCASPubMed Google Scholar
Birchmeier, W. & Behrens, J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta1198, 11–26 (1994). CASPubMed Google Scholar
Berx, G. et al. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J.14, 6107–6115 (1995).The first evidence for somatic mutations in the E-cadherin gene in a significant proportion of lobular breast cancer, and the first demonstration that E-cadherin is a tumour suppressor. This finding has allowed the re-interpretation of the classification of lobular cancers. ArticleCASPubMedPubMed Central Google Scholar
Risinger, J. I., Berchuck, A., Kohler, M. F. & Boyd, J. Mutations of the E-cadherin gene in human gynecologic cancers. Nature Genet.7, 98–102 (1994). ArticleCASPubMed Google Scholar
Yoshiura, K. et al. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc. Natl Acad. Sci. USA92, 7416–7419 (1995). ArticleCASPubMedPubMed Central Google Scholar
Hennig, G. et al. Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene11, 475–484 (1995). CASPubMed Google Scholar
Hennig, G., Lowrick, O., Birchmeier, W. & Behrens, J. Mechanisms identified in the transcriptional control of epithelial gene expression. J. Biol. Chem.271, 595–602 (1996). ArticleCASPubMed Google Scholar
Hajra, K. M., Ji, X. & Fearon, E. R. Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements. Oncogene18, 7274–7279 (1999). ArticleCASPubMed Google Scholar
Rodrigo, I., Cato, A. C. & Cano, A. Regulation of E-cadherin gene expression during tumor progression: the role of a new Ets-binding site and the E-pal element. Exp. Cell Res.248, 358–371 (1999). ArticleCASPubMed Google Scholar
Tamura, G. et al. E-cadherin gene promoter hypermethylation in primary human gastric carcinomas. J. Natl Cancer Inst.92, 569–573 (2000). ArticleCASPubMed Google Scholar
Batlle, E. et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nature Cell Biol.2, 84–89 (2000).Shows that Snail acts as a transcriptional repressor by binding to the E-boxes of the E-cadherin promoter. Snail might become a valuable target for the restoration of the differentiated phenotype in carcinoma. ArticleCASPubMed Google Scholar
Cano, A. et al. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biol.2, 76–83 (2000).An important contribution to the molecular analysis of mechanisms that govern EMT in embryos and in carcinoma. Snail can be considered a 'master gene' in the conversion from the epithelial to fibroblastic state. ArticleCASPubMed Google Scholar
Leptin, M. Twist and Snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev.5, 1568–1576 (1991). ArticleCASPubMed Google Scholar
Oda, H., Tsukita, S. & Takeichi, M. Dynamic behavior of the cadherin-based cell–cell adhesion system during Drosophila gastrulation. Dev. Biol.203, 435–450 (1998). ArticleCASPubMed Google Scholar
Hemavathy, K., Ashraf, S. I. & Ip, Y. T. Snail/Slug family of repressors: slowly going into the fast lane of development and cancer. Gene257, 1–12 (2000). ArticleCASPubMed Google Scholar
Nieto, M. A., Sargent, M. G., Wilkinson, D. G. & Cooke, J. Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Science264, 835–839 (1994).The first evidence that embryonic EMT is controlled by a zinc-finger transcriptional repressor that belongs to the Snail family. ArticleCASPubMed Google Scholar
Linker, C., Bronner-Fraser, M. & Mayor, R. Relationship between gene expression domains of Xsnail, Xslug, and Xtwist and cell movement in the prospective neural crest of Xenopus. Dev. Biol.224, 215–225 (2000). ArticleCASPubMed Google Scholar
Manzanares, M., Locascio, A. & Nieto, M. A. The increasing complexity of the Snail gene superfamily in metazoan evolution. Trends Genet.17, 178–181 (2001). ArticleCASPubMed Google Scholar
Carl, T. F., Dufton, C., Hanken, J. & Klymkowsky, M. W. Inhibition of neural crest migration in Xenopus using antisense slug RNA. Dev. Biol.213, 101–115 (1999). ArticleCASPubMed Google Scholar
LaBonne, C. & Bronner-Fraser, M. Snail-related transcriptional repressors are required in Xenopus for both the induction of the neural crest and its subsequent migration. Dev. Biol.221, 195–205 (2000). ArticleCASPubMed Google Scholar
del Barrio, M. G. & Nieto, M. A. Overexpression of Snail family members highlights their ability to promote chick neural crest formation. Development129, 1583–1593 (2002). ArticleCASPubMed Google Scholar
Carver, E. A., Jiang, R., Lan, Y., Oram, K. F. & Gridley, T. The mouse Snail gene encodes a key regulator of the epithelial–mesenchymal transition. Mol. Cell Biol.21, 8184–8188 (2001). ArticleCASPubMedPubMed Central Google Scholar
Comijn, J. et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell7, 1267–1278 (2001).A detailed analysis of Sip1, which acts as a strong transcriptional repressor of E-cadherin. Sip1 is controlled both by Tgf-β and tyrosine kinase receptor signalling. ArticleCASPubMed Google Scholar
Perez-Moreno, M. A. et al. A new role for E12/E47 in the repression of E-cadherin expression and epithelial–mesenchymal transitions. J Biol Chem276, 27424–27431 (2001). ArticleCASPubMed Google Scholar
Blanco, M. J. et al. Correlation of Snail expression with histological grade and lymph node in breast carcinomas. Oncogene (in the press).
Yokoyama, K. et al. Reverse correlation of E-cadherin and Snail expression in oral squamous cell carcinoma cells in vitro. Oral Oncol.37, 65–71 (2001). ArticleCASPubMed Google Scholar
De Medina, S. G. et al. Relationship between E-cadherin and fibroblast growth factor receptor-2β expression in bladder carcinomas. Oncogene18, 5722–5726 (1999). ArticleCASPubMed Google Scholar
Berx, G., Becker, K. F., Hofler, H. & van Roy, F. Mutations of the human E-cadherin (CDH1) gene. Hum. Mutat.12, 226–237 (1998). ArticleCASPubMed Google Scholar
Becker, K. F. et al. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res.54, 3845–3852 (1994).The first study that shows that somatic mutations in the E-cadherin gene contribute to the progression of diffuse gastric carcinomas. CASPubMed Google Scholar
Guilford, P. et al. E-cadherin germline mutations in familial gastric cancer. Nature392, 402–405 (1998).The first report to describe E-cadherin germ-line mutations in a large kindred from New Zealand, which was found to be responsible for the early onset of high-grade diffuse gastric tumours. ArticleCASPubMed Google Scholar
Guilford, P. J. et al. E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Hum. Mutat.14, 249–255 (1999). ArticleCASPubMed Google Scholar
Richards, F. M. et al. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum. Mol. Genet.8, 607–610 (1999). ArticleCASPubMed Google Scholar
Keller, G. et al. Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation. Am. J. Pathol.155, 337–342 (1999). ArticleCASPubMedPubMed Central Google Scholar
Perl, A. K., Wilgenbus, P., Dahl, U., Semb, H. & Christofori, G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature392, 190–193 (1998). ArticleCASPubMed Google Scholar
Reichmann, E. et al. Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. Cell71, 1103–1116 (1992). ArticleCASPubMed Google Scholar
Eger, A., Stockinger, A., Schaffhauser, B., Beug, H. & Foisner, R. Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of β-catenin and upregulation of β-catenin/lymphoid enhancer binding factor-1 transcriptional activity. J. Cell Biol.148, 173–188 (2000). ArticleCASPubMedPubMed Central Google Scholar
Gottardi, C. J., Wong, E. & Gumbiner, B. M. E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner. J. Cell Biol.153, 1049–1060 (2001). ArticleCASPubMedPubMed Central Google Scholar
Stockinger, A., Eger, A., Wolf, J., Beug, H. & Foisner, R. E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity. J. Cell Biol.154, 1185–1196 (2001). ArticleCASPubMedPubMed Central Google Scholar
Logan, C. Y., Miller, J. R., Ferkowicz, M. J. & McClay, D. R. Nuclear β-catenin is required to specify vegetal cell fates in the sea urchin embryo. Development126, 345–357 (1999). ArticleCASPubMed Google Scholar
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G. & Birchmeier, W. β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell105, 533–545 (2001). ArticleCASPubMed Google Scholar
Novak, A. et al. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways. Proc. Natl Acad. Sci. USA95, 4374–4379 (1998). ArticleCASPubMedPubMed Central Google Scholar
Morali, O. G. et al. IGF-II induces rapid β-catenin relocation to the nucleus during epithelium to mesenchyme transition. Oncogene20, 4942–4950 (2001). ArticleCASPubMed Google Scholar
Kim, K., Pang, K. M., Evans, M. & Hay, E. D. Overexpression of β-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol. Biol. Cell.11, 3509–3523 (2000). ArticleCASPubMedPubMed Central Google Scholar
Trusolino, L. & Comoglio, P. M. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nature Rev. Cancer2, 289–300 (2002). ArticleCAS Google Scholar
Schmidt, C. et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature373, 699–702 (1995).The first demonstration of the function of Hgfin vivoduring embryogenesis in liver and placental development. ArticleCASPubMed Google Scholar
Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A. & Birchmeier, C. Essential role for the c-Met receptor in the migration of myogenic precursor cells into the limb bud. Nature376, 768–771 (1995) ArticleCASPubMed Google Scholar
Bottaro, D. P. et al. Identification of the hepatocyte growth factor receptor as the c-Met proto-oncogene product. Science251, 802–804 (1991). ArticleCASPubMed Google Scholar
Weidner, K. M., Sachs, M. & Birchmeier, W. The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J. Cell Biol.121, 145–154 (1993). ArticleCASPubMed Google Scholar
Ponzetto, C. et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell77, 261–271 (1994).The first description of the multifunctional docking site for the Met receptor that recognizes SH2-containing adaptor and effector proteins that are involved in diverse functions. ArticleCASPubMed Google Scholar
Comoglio, P. M. Pathway specificity for Met signalling. Nature Cell Biol.3, E161–E162 (2001). ArticleCASPubMed Google Scholar
Furge, K. A., Zhang, Y. W. & Van de Woude, G. F. Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene19, 5582–5589 (2000). ArticleCASPubMed Google Scholar
Itoh, M. et al. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol. Cell. Biol.20, 3695–3704 (2000). ArticleCASPubMedPubMed Central Google Scholar
Gual, P. et al. Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene19, 1509–1518 (2000). ArticleCASPubMed Google Scholar
Schaeper, U. et al. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J. Cell Biol.149, 1419–1432 (2000).A detailed study of the multifunctional adaptor Gab1 and the finding that the tyrosine phosphatase Shp2 is crucial in branching morphogenesis. ArticleCASPubMedPubMed Central Google Scholar
Petrelli, A. et al. The endophilin–CIN85–CBL complex mediates ligand-dependent downregulation of c-MET. Nature416, 187–190 (2002). ArticleCASPubMed Google Scholar
Fournier, T. M. et al. Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion. Mol. Biol. Cell11, 3397–3410 (2000). ArticleCASPubMedPubMed Central Google Scholar
Peschard, P. et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol. Cell8, 995–1004 (2001). ArticleCASPubMed Google Scholar
Maina, F. et al. Coupling Met to specific pathways results in distinct developmental outcomes. Mol. Cell.7, 1293–1306 (2001).Addresses the multiple functions of Met in development, focusing on the two most important docking sites for the adaptor and effector proteins. ArticleCASPubMed Google Scholar
Tulasne, D., Paumelle, R., Weidner, K. M., Vandenbunder, B. & Fafeur, V. The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering. Mol. Biol. Cell10, 551–565 (1999). ArticleCASPubMedPubMed Central Google Scholar
Paumelle, R. et al. Sequential activation of ERK and repression of JNK by scatter factor/hepatocyte growth factor in madin-darby canine kidney epithelial cells. Mol. Biol. Cell11, 3751–3763 (2000). ArticleCASPubMedPubMed Central Google Scholar
Boccaccio, C. et al. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature391, 285–288 (1998). ArticleCASPubMed Google Scholar
Di Renzo, M. F. et al. Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas. Oncogene7, 2549–2553 (1992). CASPubMed Google Scholar
Di Renzo, M. F., Poulsom, R., Olivero, M., Comoglio, P. M. & Lemoine, N. R. Expression of the MET/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res.55, 1129–1138 (1995). CASPubMed Google Scholar
Di Renzo, M. F. et al. Overexpression and amplification of the MET/HGF receptor gene during the progression of colorectal cancer. Clin. Cancer Res.1, 147–154 (1995). CASPubMed Google Scholar
Di Renzo, M. F. et al. Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene19, 1547–1555 (2000). ArticleCASPubMed Google Scholar
Schmidt, L. et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nature Genet.16, 68–73 (1997).This recently recognized form of renal carcinoma results from a constitutive activation of the Met receptors by missense mutations in the tyrosine kinase domain. ArticleCASPubMed Google Scholar
Lee, J. H. et al. A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene19, 4947–4953 (2000). ArticleCASPubMed Google Scholar
Giordano, S. et al. Different point mutations in the Met oncogene elicit distinct biological properties. FASEB J.14, 399–406 (2000). ArticleCASPubMed Google Scholar
Valles, A. M. et al. Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line. Proc. Natl Acad. Sci. USA87, 1124–1128 (1990). ArticleCASPubMedPubMed Central Google Scholar
Morali, O. G., Jouneau, A., McLaughlin, K. J., Thiery, J. P. & Larue, L. IGF-II promotes mesoderm formation. Dev. Biol.227, 133–145 (2000). ArticleCASPubMed Google Scholar
Khoury, H. et al. Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB2/Neu receptor. Oncogene20, 788–799 (2001). ArticleCASPubMed Google Scholar
Meiners, S., Brinkmann, V., Naundorf, H. & Birchmeier, W. Role of morphogenetic factors in metastasis of mammary carcinoma cells. Oncogene16, 9–20 (1998). ArticleCASPubMed Google Scholar
Ciruna, B. & Rossant, J. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev. Cell.1, 37–49 (2001).Links, for the first time, the signal-transduction pathways of EMT and the determination of the mesodermal lineage in mouse gastrula. ArticleCASPubMed Google Scholar
Thiery, J. P. & Chopin, D. Epithelial cell plasticity in development and tumor progression. Cancer Metastasis Rev.18, 31–42 (1999). ArticleCASPubMed Google Scholar
Boyer, B., Roche, S., Denoyelle, M. & Thiery, J. P. Src and Ras are involved in separate pathways in epithelial cell scattering. EMBO J.16, 5904–5913 (1997).The first evidence forSlugas a crucial gene in EMT of carcinoma cells. ArticleCASPubMedPubMed Central Google Scholar
Savagner, P., Yamada, K. M. & Thiery, J. P. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J. Cell Biol.137, 1403–1419 (1997). ArticleCASPubMedPubMed Central Google Scholar
Edme, N., Downward, J., Thiery, J. P. & Boyer, B. Involvement of MAPK and Rac in epithelial cell scatterring. J. Cell Sci. (in the press).
Sanders, L. C., Matsumura, F., Bokoch, G. M. & de Lanerolle, P. Inhibition of myosin light chain kinase by p21-activated kinase. Science283, 2083–2085 (1999).Reveals an important regulatory mechanism that controls cell shape in the stationary and motile states. Rho and Rac have an antagonistic function to control actin microfilament dynamics by the phosphorylation of the myosin light chain. ArticleCASPubMed Google Scholar
Hordijk, P. L. et al. Inhibition of invasion of epithelial cells by Tiam1–Rac signaling. Science278, 1464–1466 (1997). ArticleCASPubMed Google Scholar
Rottner, K., Hall, A. & Small, J. V. Interplay between Rac and Rho in the control of substrate contact dynamics. Curr. Biol.9, 640–648 (1999). ArticleCASPubMed Google Scholar
Price, L. S. & Collard, J. G. Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion. Semin. Cancer Biol.11, 167–173 (2001). ArticleCASPubMed Google Scholar
Anastasiadis, P. Z. & Reynolds, A. B. Regulation of Rho GTPases by p120-catenin. Curr. Opin. Cell Biol.13, 604–610 (2001). ArticleCASPubMed Google Scholar
Fujita, Y. et al. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nature Cell Biol.4, 222–231 (2002). ArticleCASPubMed Google Scholar
Muller, T., Choidas, A., Reichmann, E. & Ullrich, A. Phosphorylation and free pool of β-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration. J. Biol. Chem.274, 10173–10183 (1999). ArticleCASPubMed Google Scholar
Jouanneau, J., Moens, G. & Thiery, J. P. The community effect in FGF-1 mediated tumor progression of a rat bladder carcinoma does not involve a direct paracrine signaling. Oncogene18, 327–333 (1999). ArticleCASPubMed Google Scholar
Grassi, M., Moens, G., Rousselle, P., Thiery, J. P. & Jouanneau, J. The SFL activity secreted by metastatic carcinoma cells is related to laminin 5 and mediates cell scattering in an integrin-independent manner. J. Cell Sci.112, 2511–2520 (1999). ArticleCASPubMed Google Scholar
Kaartinen, V. et al. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nature Genet.11, 415–421 (1995). ArticleCASPubMed Google Scholar
Romano, L. A. & Runyan, R. B. Slug is an essential target of TGF-β2 signaling in the developing chicken heart. Dev. Biol.223, 91–102 (2000). ArticleCASPubMed Google Scholar
Lehmann, K. et al. Raf induces TGF-β production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev.14, 2610–2622 (2000).The discovery of a new mechanism in which the apoptotic function of Tgf-β is abrogated in cells in which the Ras/Raf pathway has been activated. ArticleCASPubMedPubMed Central Google Scholar
Oft, M. et al. TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev.10, 2462–2477 (1996). ArticleCASPubMed Google Scholar
Janda, E. et al. Ras and TGF-β cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J. Cell Biol.156, 299–313 (2002). ArticleCASPubMedPubMed Central Google Scholar
Bhowmick, N. A., Zent, R., Ghiassi, M., McDonnell, M. & Moses, H. L. Integrin-β1 signaling is necessary for transforming growth factor-β activation of p38MAPK and epithelial plasticity. J. Biol. Chem.276, 46707–46713 (2001). ArticleCASPubMed Google Scholar
Bhowmick, N. A. et al. Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol. Biol. Cell12, 27–36 (2001). ArticleCASPubMedPubMed Central Google Scholar
Cui, W. et al. TGF-β1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell86, 531–542 (1996). ArticleCASPubMed Google Scholar
Watanabe, T. et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N. Engl. J. Med.344, 1196–1206 (2001). ArticleCASPubMedPubMed Central Google Scholar
Braun, S. & Pantel, K. Biological characteristics of micrometastatic cancer cells in bone marrow. Cancer Metastasis Rev.18, 75–90 (1999). ArticleCASPubMed Google Scholar
Braun, S. et al. Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients. J. Clin. Oncol.18, 80–86 (2000). ArticleCASPubMed Google Scholar
Braun, S. et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N. Engl. J. Med.342, 525–533 (2000). ArticleCASPubMed Google Scholar
Slamon, D. J. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med.344, 783–792 (2001).One of the first reports providing evidence that a significant benefit is achieved in metastatic breast cancer patients who overexpressERBB2, by treatment with a monoclonal antibody against this receptor, in combination with chemotherapy. ArticleCASPubMed Google Scholar
Chan, K. C. et al. Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast. Cancer Res.62, 122–128 (2002). CASPubMed Google Scholar
Irby, R. B. & Yeatman, T. J. Role of Src expression and activation in human cancer. Oncogene19, 5636–5642 (2000). ArticleCASPubMed Google Scholar
Boyer, B., Bourgeois, Y. & Poupon, M. F. Src kinase contributes to the metastatic spread of carcinoma cells. Oncogene21, 2347–2356 (2002). ArticleCASPubMed Google Scholar
Lobell, R. B. et al. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Res.61, 8758–8768 (2001). CASPubMed Google Scholar
Milella, M. et al. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J. Clin. Invest.108, 851–859 (2001). ArticleCASPubMedPubMed Central Google Scholar
Tamagnone, L. et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell99, 71–80 (1999). ArticleCASPubMed Google Scholar
Tamagnone, L. & Comoglio, P. M. Signalling by semaphorin receptors: cell guidance and beyond. Trends Cell Biol.10, 377–383 (2000). ArticleCASPubMed Google Scholar
Hlubek, F., Jung, A., Kotzor, N., Kirchner, T. & Brabletz, T. Expression of the invasion factor laminin-γ2 in colorectal carcinomas is regulated by β-catenin. Cancer Res.61, 8089–8093 (2001). CASPubMed Google Scholar
Wu, C. & Dedhar, S. Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J. Cell Biol.155, 505–510 (2001). ArticleCASPubMedPubMed Central Google Scholar
Zhu, X. et al. A large-scale analysis of mRNAs expressed by primary mesenchyme cells of the sea urchin embryo. Development128, 2615–2627 (2001). ArticlePubMed Google Scholar
Kiemer, A. K., Takeuchi, K. & Quinlan, M. P. Identification of genes involved in epithelial–mesenchymal transition and tumor progression. Oncogene20, 6679–6688 (2001). ArticleCASPubMed Google Scholar
Medico, E. et al. Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth. Cancer Res.61, 5861–5868 (2001). CASPubMed Google Scholar
van't Veer, L. J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature415, 530–536 (2002). ArticleCAS Google Scholar
Kreidberg, J. A. et al. WT-1 is required for early kidney development. Cell74, 679–691 (1993). ArticleCASPubMed Google Scholar
Stark, K., Vainio, S., Vassileva, G. & McMahon, A. P. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature372, 679–683 (1994). ArticleCASPubMed Google Scholar
Dudley, A. T., Lyons, K. M. & Robertson, E. J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev.9, 2795–2807 (1995). ArticleCASPubMed Google Scholar
Wynshaw-Boris, A. et al. The role of a single formin isoform in the limb and renal phenotypes of limb deformity. Mol. Med.3, 372–384 (1997). ArticleCASPubMedPubMed Central Google Scholar
Brabletz, T., Herrmann, K., Jung, A., Faller, G. & Kirchner, T. Expression of nuclear β-catenin and c-Myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. Am. J. Pathol.156, 865–870 (2000). ArticleCASPubMedPubMed Central Google Scholar
Brabletz, T. et al. Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc. Natl Acad. Sci. USA98, 10356–10361 (2001). ArticleCASPubMedPubMed Central Google Scholar
Butler, T. P. & Gullino, P. M. Quantification of cell shedding into efferent blood of mammary adenocarcinoma. Cancer Res.35, 512–516 (1975). CASPubMed Google Scholar
Pantel, K., Cote, R. J. & Fodstad, O. Detection and clinical importance of micrometastatic disease. J. Natl Cancer Inst.91, 1113–1124 (1999). ArticleCASPubMed Google Scholar
Naume, B. et al. Detection of isolated tumor cells in bone marrow in early-stage breast carcinoma patients: comparison with preoperative clinical parameters and primary tumor characteristics. Clin. Cancer Res.7, 4122–4129 (2001). CASPubMed Google Scholar
Putz, E. et al. Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: establishment of working models for human micrometastases. Cancer Res.59, 241–248 (1999). CASPubMed Google Scholar
Duval, M. Atlas d'embryologie (Masson, Paris, 1879). Google Scholar