Chromatin structure and the inheritance of epigenetic information (original) (raw)

• Wigler, M., Levy, D. & Perucho, M. The somatic replication of DNA methylation. Cell 24, 33–40 (1981).
  CAS PubMed Google Scholar
• Berger, S. L., Kouzarides, T., Shiekhattar, R. & Shilatifard, A. An operational definition of epigenetics. Genes Dev. 23, 781–783 (2009).
  CAS PubMed PubMed Central Google Scholar
• Trojer, P. & Reinberg, D. Histone lysine demethylases and their impact on epigenetics. Cell 125, 213–217 (2006).
  CAS PubMed Google Scholar
• Luger, K., Mader, A. W., Richmond, R. K., Sargent, D. F. & Richmond, T. J. Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 389, 251–260 (1997).
  CAS PubMed Google Scholar
• Kouzarides, T. Chromatin modifications and their function. Cell 128, 693–705 (2007).
  CAS PubMed Google Scholar
• Vaquero, A., Loyola, A. & Reinberg, D. The constantly changing face of chromatin. Sci. Aging Knowledge Environ. 2003, re4 (2003).
  PubMed Google Scholar
• Ruthenburg, A. J., Li, H., Patel, D. J. & Allis, C. D. Multivalent engagement of chromatin modifications by linked binding modules. Nature Rev. Mol. Cell Biol. 8, 983–994 (2007).
  CAS Google Scholar
• Campos, E. I. & Reinberg, D. Histones: annotating chromatin. Annu. Rev. Genet. 43, 559–599 (2009).
  CAS PubMed Google Scholar
• Shahbazian, M. D. & Grunstein, M. Functions of site-specific histone acetylation and deacetylation. Annu. Rev. Biochem. 76, 75–100 (2007).
  CAS PubMed Google Scholar
• Ekwall, K., Olsson, T., Turner, B. M., Cranston, G. & Allshire, R. C. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres. Cell 91, 1021–1032 (1997).
  CAS PubMed Google Scholar
• Brickner, D. G. et al. H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state. PLoS Biol. 5, e81 (2007).
  PubMed PubMed Central Google Scholar
• Kundu, S., Horn, P. J. & Peterson, C. L. SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster. Genes Dev. 21, 997–1004 (2007).
  CAS PubMed PubMed Central Google Scholar
• Zacharioudakis, I., Gligoris, T. & Tzamarias, D. A yeast catabolic enzyme controls transcriptional memory. Curr. Biol. 17, 2041–2046 (2007).
  CAS PubMed Google Scholar
• Ng, H. H., Robert, F., Young, R. A. & Struhl, K. Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol. Cell 11, 709–719 (2003).
  CAS PubMed Google Scholar
• Lemieux, K., Larochelle, M. & Gaudreau, L. Variant histone H2A.Z, but not the HMG proteins Nhp6a/b, is essential for the recruitment of Swi/Snf, Mediator, and SAGA to the yeast GAL1 UASG . Biochem. Biophys. Res. Commun. 369, 1103–1107 (2008).
  CAS PubMed Google Scholar
• Ansari, A. & Hampsey, M. A role for the CPF 3′-end processing machinery in RNAP II-dependent gene looping. Genes Dev. 19, 2969–2978 (2005).
  CAS PubMed PubMed Central Google Scholar
• Laine, J. P., Singh, B. N., Krishnamurthy, S. & Hampsey, M. A physiological role for gene loops in yeast. Genes Dev. 23, 2604–2609 (2009).
  CAS PubMed PubMed Central Google Scholar
• Tan-Wong, S. M., Wijayatilake, H. D. & Proudfoot, N. J. Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex. Genes Dev. 23, 2610–2624 (2009).
  CAS PubMed PubMed Central Google Scholar
• Girton, J. R. & Johansen, K. M. Chromatin structure and the regulation of gene expression: the lessons of PEV in Drosophila. Adv. Genet. 61, 1–43 (2008).
  CAS PubMed Google Scholar
• Eissenberg, J. C. & Reuter, G. Cellular mechanism for targeting heterochromatin formation in Drosophila. Int. Rev. Cell Mol. Biol. 273, 1–47 (2009).
  CAS PubMed Google Scholar
• Schotta, G. et al. Central role of Drosophila SU(VAR)3–9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J. 21, 1121–1131 (2002).
  CAS PubMed PubMed Central Google Scholar
• Ebert, A., Lein, S., Schotta, G. & Reuter, G. Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Res. 14, 377–392 (2006).
  CAS PubMed Google Scholar
• Karachentsev, D., Sarma, K., Reinberg, D. & Steward, R. PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev. 19, 431–435 (2005).
  CAS PubMed PubMed Central Google Scholar
• Brower-Toland, B., Riddle, N. C., Jiang, H., Huisinga, K. L. & Elgin, S. C. Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster. Genetics 181, 1303–1319 (2009).
  CAS PubMed PubMed Central Google Scholar
• Bao, X., Deng, H., Johansen, J., Girton, J. & Johansen, K. M. Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin. Genetics 176, 1355–1358 (2007).
  CAS PubMed PubMed Central Google Scholar
• Sclafani, R. A. & Holzen, T. M. Cell cycle regulation of DNA replication. Annu. Rev. Genet. 41, 237–280 (2007).
  CAS PubMed PubMed Central Google Scholar
• Machida, Y. J., Hamlin, J. L. & Dutta, A. Right place, right time, and only once: replication initiation in metazoans. Cell 123, 13–24 (2005).
  CAS PubMed Google Scholar
• Blow, J. J. & Dutta, A. Preventing re-replication of chromosomal DNA. Nature Rev. Mol. Cell Biol. 6, 476–486 (2005).
  CAS Google Scholar
• Moldovan, G. L., Pfander, B. & Jentsch, S. PCNA, the maestro of the replication fork. Cell 129, 665–679 (2007).
  CAS PubMed Google Scholar
• Tagami, H., Ray-Gallet, D., Almouzni, G. & Nakatani, Y. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell 116, 51–61 (2004).
  CAS PubMed Google Scholar
• English, C. M., Adkins, M. W., Carson, J. J., Churchill, M. E. & Tyler, J. K. Structural basis for the histone chaperone activity of Asf1. Cell 127, 495–508 (2006).
  CAS PubMed PubMed Central Google Scholar
• Natsume, R. et al. Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4. Nature 446, 338–341 (2007).
  CAS PubMed Google Scholar
• Sobel, R. E., Cook, R. G., Perry, C. A., Annunziato, A. T. & Allis, C. D. Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4. Proc. Natl Acad. Sci. USA 92, 1237–1241 (1995).
  CAS PubMed PubMed Central Google Scholar
• Loyola, A., Bonaldi, T., Roche, D., Imhof, A. & Almouzni, G. PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state. Mol. Cell 24, 309–316 (2006).
  CAS PubMed Google Scholar
• Li, Q. et al. Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly. Cell 134, 244–255 (2008).
  CAS PubMed PubMed Central Google Scholar
• Xie, W. et al. Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol. Cell 33, 417–427 (2009).
  CAS PubMed PubMed Central Google Scholar
• Das, C., Lucia, M. S., Hansen, K. C. & Tyler, J. K. CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 459, 113–117 (2009).
  CAS PubMed PubMed Central Google Scholar
• Tjeertes, J. V., Miller, K. M. & Jackson, S. P. Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J. 28, 1878–1889 (2009).
  CAS PubMed PubMed Central Google Scholar
• Ransom, M., Dennehey, B. K. & Tyler, J. K. Chaperoning histones during DNA replication and repair. Cell 140, 183–195 (2010).
  CAS PubMed PubMed Central Google Scholar
• Groth, A. et al. Regulation of replication fork progression through histone supply and demand. Science 318, 1928–1931 (2007).
  CAS PubMed Google Scholar
• Dodd, I. B., Micheelsen, M. A., Sneppen, K. & Thon, G. Theoretical analysis of epigenetic cell memory by nucleosome modification. Cell 129, 813–822 (2007).
  CAS PubMed Google Scholar
• Probst, A. V., Dunleavy, E. & Almouzni, G. Epigenetic inheritance during the cell cycle. Nature Rev. Mol. Cell Biol. 10, 192–206 (2009).
  CAS Google Scholar
• Shibahara, K. & Stillman, B. Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. Cell 96, 575–585 (1999).
  CAS PubMed Google Scholar
• Goll, M. G. & Bestor, T. H. Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 74, 481–514 (2005).
  CAS PubMed Google Scholar
• Li, E., Bestor, T. H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926 (1992).
  CAS PubMed Google Scholar
• Egger, G. et al. Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc. Natl Acad. Sci. USA 103, 14080–14085 (2006).
  CAS PubMed PubMed Central Google Scholar
• Spada, F. et al. DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J. Cell Biol. 176, 565–571 (2007).
  CAS PubMed PubMed Central Google Scholar
• Chen, T. et al. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nature Genet. 39, 391–396 (2007).
  CAS PubMed Google Scholar
• Jones, P. A. & Liang, G. Rethinking how DNA methylation patterns are maintained. Nature Rev. Genet. 10, 805–811 (2009).
  CAS PubMed Google Scholar
• Leonhardt, H., Page, A. W., Weier, H. U. & Bestor, T. H. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71, 865–873 (1992).
  CAS PubMed Google Scholar
• Chuang, L. S. et al. Human DNA-(cytosine-5) methyltransferase–PCNA complex as a target for p21WAF1. Science 277, 1996–2000 (1997).
  CAS PubMed Google Scholar
• Schermelleh, L. et al. Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation. Nucleic Acids Res. 35, 4301–4312 (2007).
  CAS PubMed PubMed Central Google Scholar
• Sharif, J. et al. The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature 450, 908–912 (2007).
  CAS PubMed Google Scholar
• Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760–1764 (2007).
  CAS PubMed Google Scholar
• Unoki, M., Nishidate, T. & Nakamura, Y. ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene 23, 7601–7610 (2004).
  CAS PubMed Google Scholar
• Meissner, A. et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766–770 (2008).
  CAS PubMed PubMed Central Google Scholar
• Zilberman, D., Coleman-Derr, D., Ballinger, T. & Henikoff, S. Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. Nature 456, 125–129 (2008).
  CAS PubMed PubMed Central Google Scholar
• Bernatavichute, Y. V., Zhang, X., Cokus, S., Pellegrini, M. & Jacobsen, S. E. Genome-wide association of histone H3 lysine nine methylation with CHG DNA methylation in Arabidopsis thaliana. PLoS ONE 3, e3156 (2008).
  PubMed PubMed Central Google Scholar
• Espada, J. et al. Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern. J. Biol. Chem. 279, 37175–37184 (2004).
  CAS PubMed Google Scholar
• Tamaru, H. & Selker, E. U. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414, 277–283 (2001).
  CAS PubMed Google Scholar
• Tamaru, H. et al. Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nature Genet. 34, 75–79 (2003).
  CAS PubMed Google Scholar
• Lehnertz, B. et al. Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol. 13, 1192–1200 (2003).
  CAS PubMed Google Scholar
• Dong, K. B. et al. DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J. 27, 2691–2701 (2008).
  CAS PubMed PubMed Central Google Scholar
• Tardat, M., Murr, R., Herceg, Z., Sardet, C. & Julien, E. PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J. Cell Biol. 179, 1413–1426 (2007).
  CAS PubMed PubMed Central Google Scholar
• Jorgensen, S. et al. The histone methyltransferase SET8 is required for S-phase progression. J. Cell Biol. 179, 1337–1345 (2007).
  PubMed PubMed Central Google Scholar
• Huen, M. S., Sy, S. M., van Deursen, J. M. & Chen, J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J. Biol. Chem. 283, 11073–11077 (2008).
  CAS PubMed PubMed Central Google Scholar
• Rice, J. C. et al. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev. 16, 2225–2230 (2002).
  CAS PubMed PubMed Central Google Scholar
• Yin, Y., Yu, V. C., Zhu, G. & Chang, D. C. SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail. Cell Cycle 7, 1423–1432 (2008).
  CAS PubMed Google Scholar
• Oda, H. et al. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol. Cell. Biol. 29, 2278–2295 (2009).
  CAS PubMed PubMed Central Google Scholar
• Peters, A. H. et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell 12, 1577–1589 (2003).
  CAS PubMed Google Scholar
• Grewal, S. I. & Elgin, S. C. Transcription and RNA interference in the formation of heterochromatin. Nature 447, 399–406 (2007).
  CAS PubMed PubMed Central Google Scholar
• James, T. C. & Elgin, S. C. Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene. Mol. Cell. Biol. 6, 3862–3872 (1986).
  CAS PubMed PubMed Central Google Scholar
• Eissenberg, J. C. et al. Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proc. Natl Acad. Sci. USA 87, 9923–9927 (1990).
  CAS PubMed PubMed Central Google Scholar
• Nakayama, J., Rice, J. C., Strahl, B. D., Allis, C. D. & Grewal, S. I. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292, 110–113 (2001).
  CAS PubMed Google Scholar
• Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116–120 (2001).
  CAS PubMed Google Scholar
• Bannister, A. J. et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120–124 (2001).
  CAS PubMed Google Scholar
• Stewart, M. D., Li, J. & Wong, J. Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol. Cell. Biol. 25, 2525–2538 (2005).
  CAS PubMed PubMed Central Google Scholar
• Sarma, K., Margueron, R., Ivanov, A., Pirrotta, V. & Reinberg, D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol. Cell. Biol. 28, 2718–2731 (2008).
  CAS PubMed PubMed Central Google Scholar
• Hansen, K. H. et al. A model for transmission of the H3K27me3 epigenetic mark. Nature Cell Biol. 10, 1291–1300 (2008).
  CAS PubMed Google Scholar
• Margueron, R. et al. Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 461, 762–767 (2009).
  CAS PubMed PubMed Central Google Scholar
• Vaute, O., Nicolas, E., Vandel, L. & Trouche, D. Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Res. 30, 475–481 (2002).
  CAS PubMed PubMed Central Google Scholar
• Vaquero, A. et al. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450, 440–444 (2007).
  CAS PubMed Google Scholar
• Schotta, G. et al. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev. 22, 2048–2061 (2008).
  CAS PubMed PubMed Central Google Scholar
• Fischle, W. et al. Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature 438, 1116–1122 (2005).
  CAS PubMed Google Scholar
• Bantignies, F., Grimaud, C., Lavrov, S., Gabut, M. & Cavalli, G. Inheritance of Polycomb-dependent chromosomal interactions in Drosophila. Genes Dev. 17, 2406–2420 (2003).
  CAS PubMed PubMed Central Google Scholar
• Hekimoglu, B. & Ringrose, L. Non-coding RNAs in polycomb/trithorax regulation. RNA Biol. 6, 129–137 (2009).
  CAS PubMed Google Scholar
• Grimaud, C. et al. RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124, 957–971 (2006).
  CAS PubMed Google Scholar
• Lanzuolo, C., Roure, V., Dekker, J., Bantignies, F. & Orlando, V. Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex. Nature Cell Biol. 9, 1167–1174 (2007).
  CAS PubMed Google Scholar
• Tiwari, V. K., Cope, L., McGarvey, K. M., Ohm, J. E. & Baylin, S. B. A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations. Genome Res. 18, 1171–1179 (2008).
  CAS PubMed PubMed Central Google Scholar
• Buchenau, P., Hodgson, J., Strutt, H. & Arndt-Jovin, D. J. The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: impact on models for silencing. J. Cell Biol. 141, 469–481 (1998).
  CAS PubMed PubMed Central Google Scholar
• Amaral, P. P. & Mattick, J. S. Noncoding RNA in development. Mamm. Genome 19, 454–492 (2008).
  CAS PubMed Google Scholar
• Willingham, A. T. & Gingeras, T. R. TUF love for 'junk' DNA. Cell 125, 1215–1220 (2006).
  CAS PubMed Google Scholar
• Moazed, D. Small RNAs in transcriptional gene silencing and genome defence. Nature 457, 413–420 (2009).
  CAS PubMed PubMed Central Google Scholar
• Volpe, T. A. et al. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297, 1833–1837 (2002).
  CAS PubMed Google Scholar
• Pal-Bhadra, M. et al. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303, 669–672 (2004).
  CAS PubMed Google Scholar
• Henderson, I. R. & Jacobsen, S. E. Epigenetic inheritance in plants. Nature 447, 418–424 (2007).
  CAS PubMed Google Scholar
• Wallace, J. A. & Orr-Weaver, T. L. Replication of heterochromatin: insights into mechanisms of epigenetic inheritance. Chromosoma 114, 389–402 (2005).
  CAS PubMed Google Scholar
• Kanellopoulou, C. et al. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 19, 489–501 (2005).
  CAS PubMed PubMed Central Google Scholar
• Murchison, E. P., Partridge, J. F., Tam, O. H., Cheloufi, S. & Hannon, G. J. Characterization of Dicer-deficient murine embryonic stem cells. Proc. Natl Acad. Sci. USA 102, 12135–12140 (2005).
  CAS PubMed PubMed Central Google Scholar
• Verdel, A., Vavasseur, A., Le Gorrec, M. & Touat-Todeschini, L. Common themes in siRNA-mediated epigenetic silencing pathways. Int. J. Dev. Biol. 53, 245–257 (2009).
  CAS PubMed Google Scholar
• Buhler, M., Verdel, A. & Moazed, D. Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing. Cell 125, 873–886 (2006).
  CAS PubMed Google Scholar
• Buhler, M., Haas, W., Gygi, S. P. & Moazed, D. RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing. Cell 129, 707–721 (2007).
  CAS PubMed Google Scholar
• Chen, E. S. et al. Cell cycle control of centromeric repeat transcription and heterochromatin assembly. Nature 451, 734–737 (2008).
  CAS PubMed Google Scholar
• Kloc, A., Zaratiegui, M., Nora, E. & Martienssen, R. RNA interference guides histone modification during the S phase of chromosomal replication. Curr. Biol. 18, 490–495 (2008).
  CAS PubMed PubMed Central Google Scholar
• Reuter, G. et al. Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. Nature 344, 219–223 (1990).
  CAS PubMed Google Scholar
• Pandey, R. R. et al. Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol. Cell 32, 232–246 (2008).
  CAS PubMed Google Scholar
• Nagano, T. et al. The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science 322, 1717–1720 (2008).
  CAS PubMed Google Scholar
• Zhao, J., Sun, B. K., Erwin, J. A., Song, J. J. & Lee, J. T. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science 322, 750–756 (2008).
  CAS PubMed PubMed Central Google Scholar
• Ke, X. S. et al. Genome-wide profiling of histone H3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis. PLoS ONE 4, e4687 (2009).
  PubMed PubMed Central Google Scholar
• Cawley, S. et al. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell 116, 499–509 (2004).
  CAS PubMed Google Scholar
• Ptashne, M. On the use of the word 'epigenetic'. Curr. Biol. 17, R233–R236 (2007).
  CAS PubMed Google Scholar
• Wernig, M. et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318–324 (2007).
  CAS PubMed Google Scholar
• Chow, J. & Heard, E. X inactivation and the complexities of silencing a sex chromosome. Curr. Opin. Cell Biol. 21, 359–366 (2009).
  CAS PubMed Google Scholar
• Gelbart, M. E. & Kuroda, M. I. Drosophila dosage compensation: a complex voyage to the X chromosome. Development 136, 1399–1410 (2009).
  CAS PubMed PubMed Central Google Scholar