Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis (original) (raw)

• Ackermann J, Frutschi M, Kaloulis K, McKee T, Trumpp A, Beermann F . (2005). Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res 65: 4005–4011.
  Article CAS PubMed Google Scholar
• Arboleda MJ, Lyons JF, Kabbinavar FF, Bray MR, Snow BE, Ayala R et al. (2003). Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 63: 196–206.
  CAS PubMed Google Scholar
• Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA, Chin L . (2001). Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol 21: 2144–2153.
  Article CAS PubMed PubMed Central Google Scholar
• Bardeesy N, Kim M, Xu J, Kim RS, Shen Q, Bosenberg MW et al. (2005). Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol 25: 4176–4188.
  Article CAS PubMed PubMed Central Google Scholar
• Birck A, Ahrenkiel V, Zeuthen J, Hou-Jensen K, Guldberg P . (2000). Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies. J Invest Dermatol 114: 277–280.
  Article CAS PubMed Google Scholar
• Blanco-Aparicio C, Renner O, Leal JF, Carnero A . (2007). PTEN, more than the AKT pathway. Carcinogenesis 28: 1379–1386.
  Article CAS PubMed Google Scholar
• Brummelkamp TR, Bernards R, Agami R . (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550–553.
  CAS PubMed Google Scholar
• Chin L, Garraway LA, Fisher DE . (2006). Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev 20: 2149–2182.
  Article CAS PubMed Google Scholar
• Chin L, Pomerantz J, Polsky D, Jacobson M, Cohen C, Cordon-Cardo C et al. (1997). Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev 11: 2822–2834.
  Article CAS PubMed PubMed Central Google Scholar
• Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N et al. (1999). Essential role for oncogenic Ras in tumour maintenance. Nature 400: 468–472.
  Article CAS PubMed Google Scholar
• Chudnovsky Y, Adams AE, Robbins PB, Lin Q, Khavari PA . (2005). Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Nat Genet 37: 745–749.
  Article CAS PubMed PubMed Central Google Scholar
• Cully M, You H, Levine AJ, Mak TW . (2006). Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6: 184–192.
  Article CAS PubMed Google Scholar
• Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky Jr WE et al. (2009). Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet 41: 544–552.
  Article CAS PubMed PubMed Central Google Scholar
• Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S et al. (2002). Mutations of the BRAF gene in human cancer. Nature 417: 949–954.
  Article CAS PubMed Google Scholar
• Davies MA, Stemke-Hale K, Tellez C, Calderone TL, Deng W, Prieto VG et al. (2008). A novel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer 99: 1265–1268.
  Article CAS PubMed PubMed Central Google Scholar
• Dhawan P, Singh AB, Ellis DL, Richmond A . (2002). Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res 62: 7335–7342.
  CAS PubMed Google Scholar
• Dhomen N, Reis-Filho JS, da Rocha Dias S, Hayward R, Savage K, Delmas V et al. (2009). Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell 15: 294–303.
  Article CAS PubMed Google Scholar
• Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP . (1998). Pten is essential for embryonic development and tumour suppression. Nat Genet 19: 348–355.
  CAS PubMed Google Scholar
• Dinulescu DM, Ince TA, Quade BJ, Shafer SA, Crowley D, Jacks T . (2005). Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med 11: 63–70.
  Article CAS PubMed Google Scholar
• Forbes SA, Bhamra G, Bamford S, Dawson E, Kok C, Clements J et al. (2008). The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr Protoc Hum Genet 57: 10.11.1–10.11.26.
  Google Scholar
• Goel VK, Ibrahim N, Jiang G, Singhal M, Fee S, Flotte T et al. (2009). Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene 28: 2289–2298.
  Article CAS PubMed PubMed Central Google Scholar
• Gonzalez E, McGraw TE . (2009). The Akt kinases: isoform specificity in metabolism and cancer. Cell Cycle 8: 2502–2508.
  Article CAS PubMed Google Scholar
• Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J . (1997). Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 57: 3660–3663.
  CAS PubMed Google Scholar
• Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B et al. (2007). Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 129: 957–968.
  Article CAS PubMed Google Scholar
• Ikeda T, Yoshinaga K, Suzuki A, Sakurada A, Ohmori H, Horii A . (2000). Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer. Oncol Rep 7: 567–570.
  CAS PubMed Google Scholar
• Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K et al. (2009). MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal 2: ra62.
  Article PubMed PubMed Central Google Scholar
• Jafari M, Papp T, Kirchner S, Diener U, Henschler D, Burg G et al. (1995). Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma. J Cancer Res Clin Oncol 121: 23–30.
  Article CAS PubMed Google Scholar
• Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B et al. (2006). Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell 125: 1269–1281.
  Article CAS PubMed Google Scholar
• Kotelevets L, van Hengel J, Bruyneel E, Mareel M, van Roy F, Chastre E . (2005). Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness. FASEB J 19: 115–117.
  Article CAS PubMed Google Scholar
• Lahtz C, Stranzenbach R, Fiedler E, Helmbold P, Dammann RH . (2010). Methylation of PTEN as a prognostic factor in malignant melanoma of the skin. J Invest Dermatol 130: 620–622.
  Article CAS PubMed Google Scholar
• Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI et al. (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943–1947.
  Article CAS PubMed Google Scholar
• Lin WM, Baker AC, Beroukhim R, Winckler W, Feng W, Marmion JM et al. (2008). Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res 68: 664–673.
  Article CAS PubMed Google Scholar
• Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA et al. (2006). Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci USA 103: 4134–4139.
  Article CAS PubMed PubMed Central Google Scholar
• Ma X, Ziel-van der Made AC, Autar B, van der Korput HA, Vermeij M, van Duijn P et al. (2005). Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res 65: 5730–5739.
  Article CAS PubMed Google Scholar
• Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q et al. (2003). Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci USA 100: 7841–7846.
  Article CAS PubMed PubMed Central Google Scholar
• Maroulakou IG, Oemler W, Naber SP, Tsichlis PN . (2007). Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 67: 167–177.
  Article CAS PubMed Google Scholar
• Mirmohammadsadegh A, Marini A, Nambiar S, Hassan M, Tannapfel A, Ruzicka T et al. (2006). Epigenetic silencing of the PTEN gene in melanoma. Cancer Res 66: 6546–6552.
  Article CAS PubMed Google Scholar
• Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM et al. (1999). Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci USA 96: 1563–1568.
  Article CAS PubMed PubMed Central Google Scholar
• Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM et al. (2003). High frequency of BRAF mutations in nevi. Nat Genet 33: 19–20.
  Article CAS PubMed Google Scholar
• Salmena L, Carracedo A, Pandolfi PP . (2008). Tenets of PTEN tumor suppression. Cell 133: 403–414.
  Article CAS PubMed Google Scholar
• Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA . (1996). Role of the INK4a locus in tumor suppression and cell mortality. Cell 85: 27–37.
  Article CAS PubMed Google Scholar
• Sharpless NE, Kannan K, Xu J, Bosenberg MW, Chin L . (2003). Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. Oncogene 22: 5055–5059.
  Article CAS PubMed Google Scholar
• Stahl JM, Cheung M, Sharma A, Trivedi NR, Shanmugam S, Robertson GP . (2003). Loss of PTEN promotes tumor development in malignant melanoma. Cancer Res 63: 2881–2890.
  CAS PubMed Google Scholar
• Stahl JM, Sharma A, Cheung M, Zimmerman M, Cheng JQ, Bosenberg MW et al. (2004). Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res 64: 7002–7010.
  Article CAS PubMed Google Scholar
• Stambolic V, Tsao MS, Macpherson D, Suzuki A, Chapman WB, Mak TW . (2000). High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/− mice. Cancer Res 60: 3605–3611.
  CAS PubMed Google Scholar
• Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH et al. (1997). Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356–362.
  Article CAS PubMed Google Scholar
• Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I et al. (1998). High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8: 1169–1178.
  Article CAS PubMed Google Scholar
• Sviderskaya EV, Bennett DC, Ho L, Bailin T, Lee ST, Spritz RA . (1997). Complementation of hypopigmentation in p-mutant (pink-eyed dilution) mouse melanocytes by normal human P cDNA, and defective complementation by OCA2 mutant sequences. J Invest Dermatol 108: 30–34.
  Article CAS PubMed Google Scholar
• Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM . (1999). PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 274: 20693–20703.
  Article CAS PubMed Google Scholar
• Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, Xiao A et al. (2003). Pten dose dictates cancer progression in the prostate. PLoS Biol 1: E59.
  Article PubMed PubMed Central Google Scholar
• Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H et al. (2007). Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128: 141–156.
  Article CAS PubMed PubMed Central Google Scholar
• Tsao H, Goel V, Wu H, Yang G, Haluska FG . (2004). Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol 122: 337–341.
  Article CAS PubMed PubMed Central Google Scholar
• Tsao H, Zhang X, Benoit E, Haluska FG . (1998). Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. Oncogene 16: 3397–3402.
  Article CAS PubMed Google Scholar
• Tsao H, Zhang X, Fowlkes K, Haluska FG . (2000). Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res 60: 1800–1804.
  CAS PubMed Google Scholar
• Vogelmann R, Nguyen-Tat MD, Giehl K, Adler G, Wedlich D, Menke A . (2005). TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. J Cell Sci 118: 4901–4912.
  Article CAS PubMed Google Scholar
• Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J et al. (2003). Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 4: 209–221.
  Article CAS PubMed Google Scholar
• You MJ, Castrillon DH, Bastian BC, O'Hagan RC, Bosenberg MW, Parsons R et al. (2002). Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci USA 99: 1455–1460.
  Article CAS PubMed PubMed Central Google Scholar
• Yuan ZQ, Feldman RI, Sussman GE, Coppola D, Nicosia SV, Cheng JQ . (2003). AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem 278: 23432–23440.
  Article CAS PubMed Google Scholar