Laforest, S., Labrecque, J., Michaud, A., Cianflone, K. & Tchernof, A. Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction. Crit. Rev. Clin. Lab. Sci.52, 301–313 (2015). ArticleCASPubMed Google Scholar
Denis, G. V. & Obin, M. S. ‘Metabolically healthy obesity’: origins and implications. Mol. Aspects Med.34, 59–70 (2013). ArticleCASPubMed Google Scholar
Michaud, A. et al. Relevance of omental pericellular adipose tissue collagen in the pathophysiology of human abdominal obesity and related cardiometabolic risk. Int. J. Obes. (Lond)40, 1823–1831 (2016). ArticleCAS Google Scholar
Schipper, H. S., Prakken, B., Kalkhoven, E. & Boes, M. Adipose tissue-resident immune cells: key players in immunometabolism. Trends Endocrinol. Metab.23, 407–415 (2012). ArticleCASPubMed Google Scholar
Nawaz, A. et al. CD206(+) M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat. Commun.8, 286 (2017). ArticlePubMedPubMed CentralCAS Google Scholar
Olsen, T. K. & Baryawno, N. Introduction to Single-Cell RNA Sequencing. Curr. Protoc. Mol. Biol. 122, e57 (2018). ArticlePubMedCAS Google Scholar
Schwalie, P. C. et al. A stromal cell population that inhibits adipogenesis in mammalian fat depots. Nature559, 103–108 (2018). ArticleCASPubMed Google Scholar
Helper, C. et al. Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. eLife7, e39636 (2018). Article Google Scholar
Ehrlund, A. et al. The cell-type specific transcriptome in human adipose tissue and influence of obesity on adipocyte progenitors. Sci. Data4, 170164 (2017). ArticleCASPubMedPubMed Central Google Scholar
Briot, A. et al. Senescence alters PPARγ (peroxisome proliferator-activated receptor gamma)-dependent fatty acid handling in human adipose tissue microvascular endothelial cells and favors inflammation. Arterioscler. Thromb. Vasc. Biol.38, 1134–1146 (2018). ArticleCASPubMed Google Scholar
Banerji, S. et al. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J. Cell Biol.144, 789–801 (1999). ArticleCASPubMedPubMed Central Google Scholar
Schluns, K. S., Kieper, W. C., Jameson, S. C. & Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol.1, 426–432 (2000). ArticleCASPubMed Google Scholar
Michelet, X. et al. Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nat. Immunol.19, 1330–1340 (2018). ArticleCASPubMed Google Scholar
Schall, T. J. et al. A human T cell-specific molecule is a member of a new gene family. J. Immunol.141, 1018–1025 (1988). CASPubMed Google Scholar
Small, K. S. et al. Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat. Genet.43, 561–564 (2011). ArticleCASPubMedPubMed Central Google Scholar
Kratz, M. et al. Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab.20, 614–625 (2014). ArticleCASPubMedPubMed Central Google Scholar
Jager, N. A. et al. Folate receptor-β imaging using 99mTc-folate to explore distribution of polarized macrophage populations in human atherosclerotic plaque. J. Nucl. Med.55, 1945–1951 (2014). ArticleCASPubMed Google Scholar
Villani, A. C. et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science356, eaah4573 (2017). ArticlePubMedPubMed CentralCAS Google Scholar
Acosta, J. R. et al. Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes. Diabetologia59, 560–570 (2016). ArticleCASPubMed Google Scholar
Ribeiro, R. et al. Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma. Exp. Biol. Med. (Maywood)237, 1155–1162 (2012). ArticleCAS Google Scholar
Yang, R. Z. et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am. J. Physiol. Endocrinol. Metab.290, E1253–E1261 (2006). ArticleCASPubMed Google Scholar
de Souza Batista, C. M. et al. Omentin plasma levels and gene expression are decreased in obesity. Diabetes56, 1655–1661 (2007). ArticlePubMedCAS Google Scholar
Watanabe, T., Watanabe-Kominato, K., Takahashi, Y., Kojima, M. & Watanabe, R. Adipose tissue-derived omentin-1 function and regulation. Compr. Physiol.7, 765–781 (2017). ArticlePubMed Google Scholar
Chau, Y. Y. et al. Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source. Nat. Cell Biol.16, 367–375 (2014). ArticleCASPubMedPubMed Central Google Scholar
Winnier, D. A. et al. Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES). PLoS One10, e0119941 (2015). ArticlePubMedPubMed CentralCAS Google Scholar
Vaittinen, M. et al. MFAP5 is related to obesity-associated adipose tissue and extracellular matrix remodeling and inflammation. Obesity (Silver Spring)23, 1371–1378 (2015). ArticleCAS Google Scholar
Hou, S. et al. S100A4 protects mice from high-fat diet-induced obesity and inflammation. Lab. Invest.98, 1025–1038 (2018). ArticleCASPubMed Google Scholar
Kuefner, M. S. et al. Secretory phospholipase A2 group IIA modulates insulin sensitivity and metabolism. J. Lipid. Res.58, 1822–1833 (2017). ArticleCASPubMedPubMed Central Google Scholar
Perdikari, A. et al. BATLAS: deconvoluting brown adipose tissue. Cell Rep.25, 784–797 e784 (2018). ArticleCASPubMed Google Scholar
Zou, Y. et al. IRX3 promotes the browning of white adipocytes and its rare variants are associated with human obesity risk. EBioMedicine24, 64–75 (2017). ArticlePubMedPubMed Central Google Scholar
Roberts, A. C. & Porter, K. E. Cellular and molecular mechanisms of endothelial dysfunction in diabetes. Diab. Vasc. Dis. Res.10, 472–482 (2013). ArticlePubMedCAS Google Scholar
Nishimura, S. et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med.15, 914–920 (2009). ArticleCASPubMed Google Scholar
Wu, H. et al. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation115, 1029–1038 (2007). ArticleCASPubMed Google Scholar
Singer, M. et al. A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells. Cell166, 1500–1511 e1509 (2016). ArticleCASPubMedPubMed Central Google Scholar
Coats, B. R. et al. Metabolically activated adipose tissue macrophages perform detrimental and beneficial functions during diet-induced obesity. Cell Rep. 20, 3149–3161 (2017). ArticleCASPubMedPubMed Central Google Scholar
Song, N. J. et al. Small molecule-induced complement factor D (Adipsin) promotes lipid accumulation and adipocyte differentiation. PLoS One11, e0162228 (2016). ArticlePubMedPubMed CentralCAS Google Scholar
Li, C. Y. et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res. Ther.6, 55 (2015). ArticlePubMedPubMed CentralCAS Google Scholar
Acosta, J. R. et al. Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population. Stem Cell Res. Ther.8, 250 (2017). ArticlePubMedPubMed CentralCAS Google Scholar
Chung, S. S. et al. Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor γ in human skeletal muscle cells. Mol. Cell Biol.29, 20–30 (2009). ArticleCASPubMed Google Scholar
Hammarstedt, A. et al. WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4. Proc. Natl Acad. Sci. USA110, 2563–2568 (2013). ArticleCASPubMedPubMed Central Google Scholar
Jang, M. K. & Jung, M. H. ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells. Biochem. Biophys. Res. Commun.456, 80–85 (2015). ArticleCASPubMed Google Scholar
Kim, J. Y. et al. Activating transcription factor 3 is a target molecule linking hepatic steatosis to impaired glucose homeostasis. J. Hepatol.67, 349–359 (2017). ArticlePubMed Google Scholar
Tchernof, A. et al. Regional differences in adipose tissue metabolism in women: minor effect of obesity and body fat distribution. Diabetes55, 1353–1360 (2006). ArticleCASPubMed Google Scholar
Laitinen, A. et al. A robust and reproducible animal serum-free culture method for clinical-grade bone marrow-derived mesenchymal stromal cells. Cytotechnology68, 891–906 (2016). ArticleCASPubMed Google Scholar
Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol.36, 411–420 (2018). ArticleCASPubMedPubMed Central Google Scholar
Aran, D. et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat. Immunol.20, 163–172 (2019). ArticleCASPubMedPubMed Central Google Scholar
Huang da, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc.4, 44–57 (2009). ArticlePubMedCAS Google Scholar
Huang da, W., Sherman, B. T. & Lempicki, R. A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1–13 (2009). ArticlePubMedCAS Google Scholar
Anders, S., Pyl, P. T. & Huber, W. HTSeq–a Python framework to work with high-throughput sequencing data. Bioinformatics31, 166–169 (2015). ArticleCASPubMed Google Scholar
Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014). ArticlePubMedPubMed CentralCAS Google Scholar