Goodman CS (1994) The likeness of being: phylogenetically conserved molecular mechanisms of growth cone guidance. Cell78: 353–356 ArticleCASPubMed Google Scholar
Hinck L (2004) The versatile roles of ‘axon guidance’ cues in tissue morphogenesis. Dev. Cell7: 783–793 ArticleCASPubMed Google Scholar
Surawska H, Ma PC and Salgia R (2004) The role of ephrins and Eph receptors in cancer. Cytokine Growth Factor Rev.15: 419–433 ArticleCASPubMed Google Scholar
Kolodkin AL, Matthes DJ and Goodman CS (1993) The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell75: 1389–1399 ArticleCASPubMed Google Scholar
Luo Y, Shepherd I, Li J, Renzi MJ, Chang S and Raper JA (1995) A family of molecules related to collapsin in the embryonic chick nervous system. Neuron14: 1131–1140 ArticleCASPubMed Google Scholar
Fiore R and Puschel AW (2003) The function of semaphorins during nervous system development. Front. Biosci.8: s484–s499 ArticleCASPubMed Google Scholar
Semaphorin Nomenclature Committee (1999) Unified nomenclature for the semaphorins/collapsins. Cell97: 551–552
Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M and Goodman CS (1998) Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell95: 903–916 ArticleCASPubMed Google Scholar
Gherardi E, Love CA, Esnouf RM and Jones EY (2004) The sema domain. Curr. Opin. Struct. Biol.14: 669–678 ArticleCASPubMed Google Scholar
de Castro F, Hu L, Drabkin H, Sotelo C and Chedotal A (1999) Chemoattraction and chemorepulsion of olfactory bulb axons by different secreted semaphorins. J. Neurosci.19: 4428–4436 ArticleCASPubMedPubMed Central Google Scholar
Bagnard D, Lohrum M, Uziel D, Puschel AW and Bolz J (1998) Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections. Development125: 5043–5053 CASPubMed Google Scholar
Polleux F, Morrow T and Ghosh A (2000) Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature404: 567–573 ArticleCASPubMed Google Scholar
He Z and Tessier-Lavigne M (1997) Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell90: 739–751 ArticleCASPubMed Google Scholar
Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ and Ginty DD (1997) Neuropilin is a semaphorin III receptor. Cell90: 753–762 ArticleCASPubMed Google Scholar
Chen H, Chedotal A, He Z, Goodman CS and Tessier-Lavigne M (1997) Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron.19: 547–559 ArticleCASPubMed Google Scholar
Feiner L, Koppel AM, Kobayashi H and Raper JA (1997) Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ. Neuron19: 539–545 ArticleCASPubMed Google Scholar
Cai H and Reed RR (1999) Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. J. Neurosci.19: 6519–6527 ArticleCASPubMedPubMed Central Google Scholar
Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M and Comoglio PM (1999) Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell99: 71–80 ArticleCASPubMed Google Scholar
Castellani V, Chedotal A, Schachner M, Faivre-Sarrailh C and Rougon G (2000) Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance. Neuron27: 237–249 ArticleCASPubMed Google Scholar
Castellani V, Falk J and Rougon G (2004) Semaphorin3A-induced receptor endocytosis during axon guidance responses is mediated by L1 CAM. Mol. Cell Neurosci.26: 89–100 ArticleCASPubMed Google Scholar
Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL and Ginty DD (2004) Semaphorin 3E and Plexin-D1 control vascular pattern independently of neuropilins. Science307: 265–268 ArticleCASPubMed Google Scholar
Takahashi T, Nakamura F, Jin Z, Kalb RG and Strittmatter SM (1998) Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. Nat. Neurosci.1: 487–493 ArticleCASPubMed Google Scholar
Toyofuku T, Zhang H, Kumanogoh A, Takegahara N, Suto F, Kamei J, Aoki K, Yabuki M, Hori M, Fujisawa H and Kikutani H (2004) Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Genes Dev.18: 435–447 ArticleCASPubMedPubMed Central Google Scholar
Yamada T, Endo R, Gotoh M and Hirohashi S (1997) Identification of semaphorin E as a non-MDR drug resistance gene of human cancers. Proc. Natl. Acad. Sci. USA94: 14713–14718 ArticleCASPubMedPubMed Central Google Scholar
Rieger J, Wick W and Weller M (2003) Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins. Glia42: 379–389 ArticlePubMed Google Scholar
Moreno-Flores MT, Martin-Aparicio E, Martin-Bermejo MJ, Agudo M, McMahon S, Avila J, Diaz-Nido J and Wandosell F (2003) Semaphorin 3C preserves survival and induces neuritogenesis of cerebellar granule neurons in culture. J. Neurochem.87: 879–890 ArticleCASPubMed Google Scholar
Christensen CR, Klingelhofer J, Tarabykina S, Hulgaard EF, Kramerov D and Lukanidin E (1998) Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer Res.58: 1238–1244 CASPubMed Google Scholar
Martin-Satue M and Blanco J (1999) Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display. J. Surg. Oncol.72: 18–23 ArticleCASPubMed Google Scholar
Miyazaki N, Furuyama T, Amasaki M, Sugimoto H, Sakai T, Takeda N, Kubo T and Inagaki S (1999) Mouse semaphorin H inhibits neurite outgrowth from sensory neurons. Neurosci. Res.33: 269–274 ArticleCASPubMed Google Scholar
Sakai T, Furuyama T, Ohoka Y, Miyazaki N, Fujioka S, Sugimoto H, Amasaki M, Hattori S, Matsuya T and Inagaki S (1999) Mouse semaphorin H induces PC12 cell neurite outgrowth activating Ras-mitogen-activated protein kinase signaling pathway via Ca(2+) influx. J. Biol. Chem.274: 29666–29671 ArticleCASPubMed Google Scholar
Gitler AD, Lu MM and Epstein JA (2004) PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev. Cell7: 107–116 ArticleCASPubMed Google Scholar
Torres-Vazquez J, Gitler AD, Fraser SD, Berk JD, Van NP, Fishman MC, Childs S, Epstein JA and Weinstein BM (2004) Semaphorin–plexin signaling guides patterning of the developing vasculature. Dev. Cell7: 117–123 ArticleCASPubMed Google Scholar
Roche J, Drabkin H and Brambilla E (2002) Neuropilin and its ligands in normal lung and cancer. Adv. Exp. Med. Biol.515: 103–114 ArticleCASPubMed Google Scholar
Tomizawa Y, Sekido Y, Kondo M, Gao B, Yokota J, Roche J, Drabkin H, Lerman MI, Gazdar AF and Minna JD (2001) Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. Proc. Natl. Acad. Sci. USA98: 13954–13959 ArticleCASPubMedPubMed Central Google Scholar
de Lange R, Dimoudis N and Weidle UH (2003) Identification of genes associated with enhanced metastasis of a large cell lung carcinoma cell line. Anticancer Res.23: 187–194 CASPubMed Google Scholar
Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Williams NN, Kaiser LR and Croce CM (2003) Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer. Cancer Res.63: 3352–3355 CASPubMed Google Scholar
Castro-Rivera E, Ran S, Thorpe P and Minna JD (2004) Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect. Proc. Natl. Acad. Sci. USA101: 11432–11437 ArticleCASPubMedPubMed Central Google Scholar
Tse C, Xiang RH, Bracht T and Naylor SL (2002) Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. Cancer Res.62: 542–546 CASPubMed Google Scholar
Lantuejoul S, Constantin B, Drabkin H, Brambilla C, Roche J and Brambilla E (2003) Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines. J. Pathol.200: 336–347 ArticleCASPubMed Google Scholar
Nasarre P, Constantin B, Rouhaud L, Harnois T, Raymond G, Drabkin HA, Bourmeyster N and Roche J (2003) Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading. Neoplasia5: 83–92 ArticleCASPubMedPubMed Central Google Scholar
Bielenberg DR, Hida Y, Shimizu A, Kaipainen A, Kreuter M, Kim CC and Klagsbrun M (2004) Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. J. Clin. Invest.114: 1260–1271 ArticleCASPubMedPubMed Central Google Scholar
Kessler O, Shraga-Heled N, Lange T, Gutmann-Raviv N, Sabo E, Baruch L, Machluf M and Neufeld G (2004) Semaphorin-3F is an inhibitor of tumor angiogenesis. Cancer Res.64: 1008–1015 ArticleCASPubMed Google Scholar
Xiang R, Davalos AR, Hensel CH, Zhou XJ, Tse C and Naylor SL (2002) Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice. Cancer Res.62: 2637–2643 CASPubMed Google Scholar
Soker S, Takashima S, Miao HQ, Neufeld G and Klagsbrun M (1998) Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell92: 735–745 ArticleCASPubMed Google Scholar
Soker S, Miao HQ, Nomi M, Takashima S and Klagsbrun M (2002) VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding. J. Cell. Biochem.85: 357–368 ArticleCASPubMed Google Scholar
Miao HQ, Soker S, Feiner L, Alonso JL, Raper JA and Klagsbrun M (1999) Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J. Cell. Biol.146: 233–242 CASPubMedPubMed Central Google Scholar
Serini G, Valdembri D, Zanivan S, Morterra G, Burkhardt C, Caccavari F, Zammataro L, Primo L, Tamagnone L, Logan M, Tessier-Lavigne M, Taniguchi M, Puschel AW and Bussolino F (2003) Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature424: 391–397 ArticleCASPubMed Google Scholar
Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL and Ginty DD (2003) Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev. Cell5: 45–57 ArticleCASPubMedPubMed Central Google Scholar
Gagnon ML, Bielenberg DR, Gechtman Z, Miao HQ, Takashima S, Soker S and Klagsbrun M (2000) Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity. Proc. Natl. Acad. Sci. USA97: 2573–2578 ArticleCASPubMedPubMed Central Google Scholar
Cackowski FC, Xu L, Hu B and Cheng SY (2004) Identification of two novel alternatively spliced Neuropilin-1 isoforms. Genomics84: 82–94 ArticleCASPubMed Google Scholar
Gluzman-Poltorak Z, Cohen T, Herzog Y and Neufeld G (2000) Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165. J. Biol. Chem.275: 29922 CAS Google Scholar
Broholm H and Laursen H (2004) Vascular endothelial growth factor (VEGF) receptor neuropilin-1's distribution in astrocytic tumors. Apmis112: 257–263 ArticleCASPubMed Google Scholar
Bachelder RE, Lipscomb EA, Lin X, Wendt MA, Chadborn NH, Eickholt BJ and Mercurio AM (2003) Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res.63: 5230–5233 CASPubMed Google Scholar
Catalano A, Caprari P, Rodilossi S, Betta P, Castellucci M, Casazza A, Tamagnone L and Procopio A (2004) Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferation. FASEB J.18: 358–360 ArticleCASPubMed Google Scholar
Shirvan A, Shina R, Ziv I, Melamed E and Barzilai A (2000) Induction of neuronal apoptosis by Semaphorin3A-derived peptide. Brain Res. Mol. Brain Res.83: 81–93 ArticleCASPubMed Google Scholar
Vikis HG, Li W, He Z and Guan KL (2000) The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proc. Natl. Acad. Sci. USA97: 12457–12462 ArticleCASPubMedPubMed Central Google Scholar
Swiercz JM, Kuner R, Behrens J and Offermanns S (2002) Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron35: 51–63 ArticleCASPubMed Google Scholar
Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L and Comoglio PM (2002) The semaphorin 4D receptor controls invasive growth by coupling with Met. Nat. Cell Biol.4: 720–724 ArticleCASPubMed Google Scholar
Conrotto P, Corso S, Gamberini S, Comoglio PM and Giordano S (2004) Interplay between scatter factor receptors and B plexins controls invasive growth. Oncogene23: 5131–5137 ArticleCASPubMed Google Scholar
Worzfeld T, Puschel AW, Offermanns S and Kuner R (2004) Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development. Eur. J. Neurosci.19: 2622–2632 ArticlePubMed Google Scholar
Kumanogoh A and Kikutani H (2003) Immune semaphorins: a new area of semaphorin research. J. Cell Sci.116: 3463–3470 ArticleCASPubMed Google Scholar
Granziero L, Circosta P, Scielzo C, Frisaldi E, Stella S, Geuna M, Giordano S, Ghia P and Caligaris-Cappio F (2003) CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes. Blood101: 1962–1969 ArticleCASPubMed Google Scholar
Dorfman DM, Shahsafaei A, Nadler LM and Freeman GJ (1998) The leukocyte semaphorin CD100 is expressed in most T-cell, but few B-cell, non-Hodgkin's lymphomas. Am. J. Pathol.153: 255–262 ArticleCASPubMedPubMed Central Google Scholar
Basile JR, Barac A, Zhu T, Guan KL and Gutkind JS (2004) Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res.64: 5212–5224 ArticleCASPubMed Google Scholar
Woodhouse EC, Fisher A, Bandle RW, Bryant-Greenwood B, Charboneau L, Petricoin III EF and Liotta LA (2003) Drosophila screening model for metastasis: semaphorin 5c is required for l(2)gl cancer phenotype. Proc. Natl. Acad. Sci. USA100: 11463–11468 ArticleCASPubMedPubMed Central Google Scholar
Goldberg JL, Vargas ME, Wang JT, Mandemakers W, Oster SF, Sretavan DW and Barres BA (2004) An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells. J. Neurosci.24: 4989–4999 ArticleCASPubMedPubMed Central Google Scholar
Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan DW, Giger RJ and Kolodkin AL (2004) Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron44: 961–975 ArticleCASPubMed Google Scholar
Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM and Tamagnone L (2004) Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep.5: 710–714 ArticleCASPubMedPubMed Central Google Scholar
Tsibris JC, Segars J, Coppola D, Mane S, Wilbanks GD, O'Brien WF and Spellacy WN (2002) Insights from gene arrays on the development and growth regulation of uterine leiomyomata. Fertil. Steril.78: 114–121 ArticlePubMedPubMed Central Google Scholar
Stassar MJ, Devitt G, Brosius M, Rinnab L, Prang J, Schradin T, Simon J, Petersen S, Kopp-Schneider A and Zoller M (2001) Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization. Br. J. Cancer85: 1372–1382 ArticleCASPubMedPubMed Central Google Scholar
Toyofuku T, Zhang H, Kumanogoh A, Takegahara N, Yabuki M, Harada K, Hori M and Kikutani H (2004) Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling. Nat. Cell Biol.6: 1204–1211 ArticleCASPubMed Google Scholar
Elhabazi A, Lang V, Herold C, Freeman GJ, Bensussan A, Boumsell L and Bismuth G (1997) The human semaphorin-like leukocyte cell surface molecule CD100 associates with a serine kinase activity. J. Biol. Chem.272: 23515–23520 ArticleCASPubMed Google Scholar
Godenschwege TA, Hu H, Shan-Crofts X, Goodman CS and Murphey RK (2002) Bi-directional signaling by Semaphorin 1a during central synapse formation in Drosophila. Nat. Neurosci.5: 1294–1301 ArticleCASPubMed Google Scholar
Kikuchi K, Chedotal A, Hanafusa H, Ujimasa Y, de Castro F, Goodman CS and Kimura T (1999) Cloning and characterization of a novel class VI semaphorin, semaphorin Y. Mol. Cell. Neurosci.13: 9–23 ArticleCASPubMed Google Scholar
Xu XM, Fisher DA, Zhou L, White FA, Ng S, Snider WD and Luo Y (2000) The transmembrane protein semaphorin 6A repels embryonic sympathetic axons. J. Neurosci.20: 2638–2648 ArticleCASPubMedPubMed Central Google Scholar
Qu X, Wei H, Zhai Y, Que H, Chen Q, Tang F, Wu Y, Xing G, Zhu Y, Liu S, Fan M and He F (2002) Identification, characterization, and functional study of the two novel human members of the semaphorin gene family. J. Biol. Chem.277: 35574–35585 ArticleCASPubMed Google Scholar
Correa RG, Sasahara RM, Bengtson MH, Katayama ML, Salim AC, Brentani MM, Sogayar MC, de Souza SJ and Simpson AJ (2001) Human semaphorin 6B [(HSA)SEMA6B], a novel human class 6 semaphorin gene: alternative splicing and all-trans-retinoic acid-dependent downregulation in glioblastoma cell lines. Genomics73: 343–348 ArticleCASPubMed Google Scholar
Collet P, Domenjoud L, Devignes MD, Murad H, Schohn H and Dauca M (2004) The human semaphorin 6B gene is down regulated by PPARs. Genomics83: 1141–1150 ArticleCASPubMed Google Scholar
Klostermann A, Lutz B, Gertler F and Behl C (2000) The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. J. Biol. Chem.275: 39647–39653 ArticleCASPubMed Google Scholar
Xu X, Ng S, Wu ZL, Nguyen D, Homburger S, Seidel-Dugan C, Ebens A and Luo Y (1998) Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. J. Biol. Chem.273: 22428–22434 ArticleCASPubMed Google Scholar
Comeau MR, Johnson R, DuBose RF, Petersen M, Gearing P, VandenBos T, Park L, Farrah T, Buller RM, Cohen JI, Strockbine LD, Rauch C and Spriggs MK (1998) A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. Immunity8: 473–482 ArticleCASPubMed Google Scholar
Pasterkamp RJ and Kolodkin AL (2003) Semaphorin junction: making tracks toward neural connectivity. Curr. Opin. Neurobiol.13: 79–89 ArticleCASPubMed Google Scholar
Brose K and Tessier-Lavigne M (2000) Slit proteins: key regulators of axon guidance, axonal branching, and cell migration. Curr. Opin. Neurobiol.10: 95–102 ArticleCASPubMed Google Scholar
Kidd T, Bland KS and Goodman CS (1999) Slit is the midline repellent for the robo receptor in Drosophila. Cell96: 785–794 ArticleCASPubMed Google Scholar
Rajagopalan S, Nicolas E, Vivancos V, Berger J and Dickson BJ (2000) Crossing the midline: roles and regulation of Robo receptors. Neuron28: 767–777 ArticleCASPubMed Google Scholar
Simpson JH, Kidd T, Bland KS and Goodman CS (2000) Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance. Neuron28: 753–766 ArticleCASPubMed Google Scholar
Rajagopalan S, Vivancos V, Nicolas E and Dickson BJ (2000) Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS. Cell103: 1033–1045 ArticleCASPubMed Google Scholar
Simpson JH, Bland KS, Fetter RD and Goodman CS (2000) Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position. Cell103: 1019–1032 ArticleCASPubMed Google Scholar
Rothberg JM and Artavanis-Tsakonas S (1992) Modularity of the slit protein. Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions. J. Mol. Biol.227: 367–370 ArticleCASPubMed Google Scholar
Rudenko G, Nguyen T, Chelliah Y, Sudhof TC and Deisenhofer J (1999) The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing. Cell99: 93–101 ArticleCASPubMed Google Scholar
Hohenester E, Tisi D, Talts JF and Timpl R (1999) The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin. Mol. Cell4: 783–792 ArticleCASPubMed Google Scholar
Nguyen-Ba-Charvet KT and Chedotal A (2002) Role of Slit proteins in the vertebrate brain. J. Physiol. Paris96: 91–98 ArticleCASPubMed Google Scholar
Yeo SY, Little MH, Yamada T, Miyashita T, Halloran MC, Kuwada JY, Huh TL and Okamoto H (2001) Overexpression of a slit homologue impairs convergent extension of the mesoderm and causes cyclopia in embryonic zebrafish. Dev. Biol. 230: 1–17 ArticleCASPubMed Google Scholar
Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W and Tessier-Lavigne M (1999) Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. Cell96: 771–784 ArticleCASPubMed Google Scholar
Kramer SG, Kidd T, Simpson JH and Goodman CS (2001) Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration. Science292: 737–740 ArticleCASPubMed Google Scholar
Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M and Kidd T (1999) Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell96: 795–806 ArticleCASPubMed Google Scholar
Li HS, Chen JH, Wu W, Fagaly T, Zhou L, Yuan W, Dupuis S, Jiang ZH, Nash W, Gick C, Ornitz DM, Wu JY and Rao Y (1999) Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell96: 807–818 ArticleCASPubMed Google Scholar
Challa AK, Beattie CE and Seeger MA (2001) Identification and characterization of roundabout orthologs in zebrafish. Mech. Dev.101: 249–253 ArticleCASPubMed Google Scholar
Zallen JA, Yi BA and Bargmann CI (1998) The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C.elegans. Cell92: 217–227 ArticleCASPubMed Google Scholar
Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS and Tear G (1998) Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell92: 205–215 ArticleCASPubMed Google Scholar
Kang JS, Mulieri PJ, Miller C, Sassoon DA and Krauss RS (1998) CDO, a robo-related cell surface protein that mediates myogenic differentiation. J. Cell Biol.143: 403–413 ArticleCASPubMedPubMed Central Google Scholar
Huminiecki L, Gorn M, Suchting S, Poulsom R and Bicknell R (2002) Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics79: 547–552 ArticleCASPubMed Google Scholar
Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD and Li DY (2003) Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev. Biol.261: 251–267 ArticleCASPubMed Google Scholar
Suchting S, Heal P, Tahtis K, Stewart LM and Bicknell R (2004) Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration. FASEB J.19: 121–123 ArticleCASPubMed Google Scholar
Howitt JA, Clout NJ and Hohenester E (2004) Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit. EMBO J.23: 4406–4412 ArticleCASPubMedPubMed Central Google Scholar
Battye R, Stevens A, Perry RL and Jacobs JR (2001) Repellent signaling by Slit requires the leucine-rich repeats. J. Neurosci.21: 4290–4298 ArticleCASPubMedPubMed Central Google Scholar
Chen JH, Wen L, Dupuis S, Wu JY and Rao Y (2001) The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons. J. Neurosci.21: 1548–1556 ArticleCASPubMedPubMed Central Google Scholar
Nguyen Ba-Charvet KT, Brose K, Ma L, Wang KH, Marillat V, Sotelo C, Tessier-Lavigne M and Chedotal A (2001) Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. J. Neurosci.21: 4281–4289 ArticleCASPubMed Google Scholar
Xian J, Clark KJ, Fordham R, Pannell R, Rabbitts TH and Rabbitts PH (2001) Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Proc. Natl. Acad. Sci. USA98: 15062–15066 ArticleCASPubMedPubMed Central Google Scholar
Xian J, Aitchison A, Bobrow L, Corbett G, Pannell R, Rabbitts T and Rabbitts P (2004) Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. Cancer Res.64: 6432–6437 ArticleCASPubMed Google Scholar
Hivert B, Liu Z, Chuang CY, Doherty P and Sundaresan V (2002) Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. Mol. Cell. Neurosci.21: 534–545 ArticleCASPubMed Google Scholar
Liu Z, Patel K, Schmidt H, Andrews W, Pini A and Sundaresan V (2004) Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol. Cell. Neurosci.26: 232–240 ArticleCASPubMed Google Scholar
Sundaresan V, Chung G, Heppell-Parton A, Xiong J, Grundy C, Roberts I, James L, Cahn A, Bench A, Douglas J, Minna J, Sekido Y, Lerman M, Latif F, Bergh J, Li H, Lowe N, Ogilvie D and Rabbitts P (1998) Homozygous deletions at 3p12 in breast and lung cancer. Oncogene17: 1723–1729 ArticleCASPubMed Google Scholar
Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen Z, Rao Y and Geng JG (2003) Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell4: 19–29 ArticlePubMed Google Scholar
Latil A, Chene L, Cochant-Priollet B, Mangin P, Fournier G, Berthon P and Cussenot O (2003) Quantification of expression of netrins, slits and their receptors in human prostate tumors. Int. J. Cancer103: 306–315 ArticleCASPubMed Google Scholar
Dallol A, Da Silva NF, Viacava P, Minna JD, Bieche I, Maher ER and Latif F (2002) SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. Cancer Res.62: 5874–5880 CASPubMed Google Scholar
Dallol A, Krex D, Hesson L, Eng C, Maher ER and Latif F (2003) Frequent epigenetic inactivation of the SLIT2 gene in gliomas. Oncogene22: 4611–4616 ArticleCASPubMed Google Scholar
Dickinson RE, Dallol A, Bieche I, Krex D, Morton D, Maher ER and Latif F (2004) Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers. Br. J. Cancer91: 2071–2078 ArticleCASPubMedPubMed Central Google Scholar
Plump AS, Erskine L, Sabatier C, Brose K, Epstein CJ, Goodman CS, Mason CA and Tessier-Lavigne M (2002) Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron33: 219–232 ArticleCASPubMed Google Scholar
Wu JY, Feng L, Park HT, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Z, Zhang X and Rao Y (2001) The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature410: 948–952 ArticleCASPubMedPubMed Central Google Scholar
Prasad A, Fernandis AZ, Rao Y and Ganju RK (2004) Slit protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells. J. Biol. Chem.279: 9115–9124 ArticleCASPubMed Google Scholar
Nabeshima K, Shimao Y, Inoue T and Sameshima T (2002) Matrix metalloproteinases (MMP) in lung cancer. Nippon Rinsho.60 (Suppl 5): 103–109 PubMed Google Scholar
Nabeshima K, Inoue T, Shimao Y and Sameshima T (2002) Matrix metalloproteinases in tumor invasion: role for cell migration. Pathol. Int.52: 255–264 ArticleCASPubMed Google Scholar
Cajal Ry (1892) La rétine des vertébrés. La cellule9: 121–133 Google Scholar
Lumsden AG and Davies AM (1986) Chemotropic effect of specific target epithelium in the developing mammalian nervous system. Nature323: 538–539 ArticleCASPubMed Google Scholar
Tessier-Lavigne M, Placzek M, Lumsden AG, Dodd J and Jessell TM (1988) Chemotropic guidance of developing axons in the mammalian central nervous system. Nature336: 775–778 ArticleCASPubMed Google Scholar
Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM and Tessier-Lavigne M (1994) The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell78: 409–424 ArticleCASPubMed Google Scholar
Van Raay TJ, Foskett SM, Connors TD, Klinger KW, Landes GM and Burn TC (1997) The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3. Genomics41: 279–282 ArticleCASPubMed Google Scholar
Wang H, Copeland NG, Gilbert DJ, Jenkins NA and Tessier-Lavigne M (1999) Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. J. Neurosci.19: 4938–4947 ArticleCASPubMedPubMed Central Google Scholar
Yin Y, Sanes JR and Miner JH (2000) Identification and expression of mouse netrin-4. Mech. Dev.96: 115–119 ArticleCASPubMed Google Scholar
Zhang C, Meng F, Wang C, Guo H, Fan M, Liu S, Zhou R and He F (2004) Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. Brain Res. Mol. Brain Res.130: 68–80 ArticleCASPubMed Google Scholar
Colamarino SA and Tessier-Lavigne M (1995) The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell81: 621–629 ArticleCASPubMed Google Scholar
Murase S and Horwitz AF (2002) Deleted in colorectal carcinoma and differentially expressed integrins mediate the directional migration of neural precursors in the rostral migratory stream. J. Neurosci.22: 3568–3579 ArticleCASPubMedPubMed Central Google Scholar
Yebra M, Montgomery AM, Diaferia GR, Kaido T, Silletti S, Perez B, Just ML, Hildbrand S, Hurford R, Florkiewicz E, Tessier-Lavigne M and Cirulli V (2003) Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev. Cell5: 695–707 ArticleCASPubMed Google Scholar
Jiang Y, Liu MT and Gershon MD (2003) Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. Dev. Biol.258: 364–384 ArticleCASPubMed Google Scholar
Spassky N, de Castro F, Le Bras B, Heydon K, Queraud-LeSaux F, Bloch-Gallego E, Chedotal A, Zalc B and Thomas JL (2002) Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1. J. Neurosci.22: 5992–6004 ArticleCASPubMedPubMed Central Google Scholar
Tsai HH, Tessier-Lavigne M and Miller RH (2003) Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal. Development130: 2095–2105 ArticleCASPubMed Google Scholar
Manitt C, Colicos MA, Thompson KM, Rousselle E, Peterson AC and Kennedy TE (2001) Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord. J. Neurosci.21: 3911–3922 ArticleCASPubMedPubMed Central Google Scholar
Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL and Tessier-Lavigne M (1997) Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature386: 833–838 ArticleCASPubMed Google Scholar
Engelkamp D (2002) Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation. Mech. Dev.118: 191–197 ArticleCASPubMed Google Scholar
Corset V, Nguyen-Ba-Charvet KT, Forcet C, Moyse E, Chedotal A and Mehlen P (2000) Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. Nature407: 747–750 ArticleCASPubMed Google Scholar
Shewan D, Dwivedy A, Anderson R and Holt CE (2002) Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway. Nat. Neurosci.5: 955–962 ArticleCASPubMed Google Scholar
Patel BN and Van Vactor DL (2002) Axon guidance: the cytoplasmic tail. Curr. Opin. Cell Biol.14: 221–229 ArticleCASPubMed Google Scholar
Ackerman SL, Kozak LP, Przyborski SA, Rund LA, Boyer BB and Knowles BB (1997) The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature386: 838–842 ArticleCASPubMed Google Scholar
Przyborski SA, Knowles BB and Ackerman SL (1998) Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary. Development125: 41–50 CASPubMed Google Scholar
Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M and Stein E (1999) A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell97: 927–941 ArticleCASPubMed Google Scholar
Keleman K and Dickson BJ (2001) Short- and long-range repulsion by the Drosophila Unc5 netrin receptor. Neuron32: 605–617 ArticleCASPubMed Google Scholar
Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG and Tessier-Lavigne M (1996) Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell87: 175–185 ArticleCASPubMed Google Scholar
Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P and Chedotal A (2004) RGM and its receptor neogenin regulate neuronal survival. Nat. Cell Biol.6: 749–755 ArticleCASPubMed Google Scholar
Rajagopalan S, Deitinghoff L, Davis D, Conrad S, Skutella T, Chedotal A, Mueller BK and Strittmatter SM (2004) Neogenin mediates the action of repulsive guidance molecule. Nat. Cell Biol.6: 756–762 ArticleCASPubMed Google Scholar
Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW and Vogelstein B (1990) Identification of a chromosome 18q gene that is altered in colorectal cancers. Science247: 49–56 ArticleCASPubMed Google Scholar
Liu J, Yao F, Wu R, Morgan M, Thorburn A, Finley Jr RL and Chen YQ (2002) Mediation of the DCC apoptotic signal by DIP13 alpha. J. Biol. Chem.277: 26281–26285 ArticleCASPubMed Google Scholar
Kato HD, Kondoh H, Inoue T, Asanoma K, Matsuda T, Arima T, Kato K, Yoshikawa T and Wake N (2004) Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis. Gynecol. Oncol.95: 281–289 ArticleCASPubMed Google Scholar
Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G and Mehlen P (2003) The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc. Natl. Acad. Sci. USA100: 4173–4178 ArticleCASPubMedPubMed Central Google Scholar
Mehlen P and Thibert C (2004) Dependence receptors: between life and death. Cell. Mol. Life Sci.61: 1854–1866 ArticleCASPubMed Google Scholar
Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, Bredesen DE, Scoazec JY and Mehlen P (2004) Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature431: 80–84 ArticleCASPubMed Google Scholar
Park KW, Crouse D, Lee M, Karnik SK, Sorensen LK, Murphy KJ, Kuo CJ and Li DY (2004) The axonal attractant Netrin-1 is an angiogenic factor. Proc. Natl. Acad. Sci. USA101: 16210–16215 ArticleCASPubMedPubMed Central Google Scholar
Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Breant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M and Eichmann A (2004) The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature432: 179–186 ArticleCASPubMed Google Scholar
Hanahan D and Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell86: 353–364 ArticleCASPubMed Google Scholar
Shirvan A, Kimron M, Holdengreber V, Ziv I, Ben-Shaul Y, Melamed S, Melamed E, Barzilai A and Solomon AS (2002) Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy. J. Biol. Chem.277: 49799–49807 ArticleCASPubMed Google Scholar
Kikuchi K, Kishino A, Konishi O, Kumagai K, Hosotani N, Saji I, Nakayama C and Kimura T (2003) In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin. J. Biol. Chem.278: 42985–42991 ArticleCASPubMed Google Scholar
Song HJ and Poo MM (1999) Signal transduction underlying growth cone guidance by diffusible factors. Curr. Opin. Neurobiol.9: 355–363 ArticleCASPubMed Google Scholar
Tordjman R, Lepelletier Y, Lemarchandel V, Cambot M, Gaulard P, Hermine O and Romeo PH (2002) A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response. Nat. Immunol.3: 477–482 ArticleCASPubMed Google Scholar
Guan H, Zu G, Xie Y, Tang H, Johnson M, Xu X, Kevil C, Xiong WC, Elmets C, Rao Y, Wu JY and Xu H (2003) Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses. J. Immunol.171: 6519–6526 ArticleCASPubMed Google Scholar
Ohta K, Mizutani A, Kawakami A, Murakami Y, Kasuya Y, Takagi S, Tanaka H and Fujisawa H (1995) Plexin: a novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions. Neuron14: 1189–1199 ArticleCASPubMed Google Scholar
Stein E and Tessier-Lavigne M (2001) Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science291: 1928–1938 ArticleCASPubMed Google Scholar
Miyashita T, Yeo SY, Hirate Y, Segawa H, Wada H, Little MH, Yamada T, Takahashi N and Okamoto H (2004) PlexinA4 is necessary as a downstream target of Islet2 to mediate Slit signaling for promotion of sensory axon branching. Development131: 3705–3715 ArticleCASPubMed Google Scholar