IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses (original) (raw)
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
Kai-michael Toellner
Journal of Experimental Medicine, 2010
View PDFchevron_right
IL-21 is the primary common chain-binding cytokine required for human B-cell differentiation in vivo
Joanne Smart
Blood, 2011
View PDFchevron_right
Follicular Helper Cells T + of IL21 Produced by CXCR5 Ig-Secreting Cells: Predominant Role Human B Cell Differentiation into Cytokine-Mediated Regulation of
Lynn Corcoran
2000
View PDFchevron_right
IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
Shane Crotty
PLoS ONE, 2011
View PDFchevron_right
IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
Giorgio Stassi
PLoS ONE, 2012
View PDFchevron_right
IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells
Rosanne Spolski
The Journal of Immunology, 2005
View PDFchevron_right
into Antibody-Secreting Plasma Cells Human Naive and Memory B Cells IL21 Induces Differentiation of
Rachel Fairhurst
View PDFchevron_right
Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6
Daniel Shaffer
The Journal of Immunology, 2004
View PDFchevron_right
The role of IL-21 in regulating B-cell function in health and disease
Stefan Kuchen
Immunological Reviews, 2008
View PDFchevron_right
Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration
Stefan Kuchen
The Journal of …, 2007
View PDFchevron_right
IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo
Morton Cowan
Blood, 2011
View PDFchevron_right
a Novel Inducer of Blimp1 and Bcl6 and Plasma Cell Generation by IL21, Regulation of B Cell Differentiation
Rosanne Spolski
View PDFchevron_right
B Cells Pathways Induced by IL21 in Human Intermediates and Molecular Identification of Cellular
danijela konforte
View PDFchevron_right
A Critical Role for IL-21 in Regulating Immunoglobulin Production
Rosanne Spolski
Science, 2002
View PDFchevron_right
Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells
Sandrine Lécart
The Journal of …, 2004
View PDFchevron_right
IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts
Stephen Adelstein
Blood, 2013
View PDFchevron_right
Cutting Edge: IL-21 Derived from Human Follicular Helper T Cells Acts as a Survival Factor for Secondary Lymphoid Organ, but Not for Bone Marrow, Plasma Cells
Beatriz Rodríguez Bayona
The Journal of Immunology, 2012
View PDFchevron_right
IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from human marginal zone B cells as well as from circulating peripheral blood B cells from autoimmune patients
A. Grammer
Arthritis Research & Therapy, 2007
View PDFchevron_right
IL22, in contrast to IL10, does not induce Ig production, due to absence of a functional IL22 receptor on activated human B cells
Martin Garcia
International Immunology, 2002
View PDFchevron_right
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
D. Fulcher, Pravin Hissaria
Journal of Experimental Medicine, 2010
View PDFchevron_right
IL-21 and T Cell Differentiation: Consider the Context
Allan Zajac
Trends in immunology, 2016
View PDFchevron_right
B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
Louis Tsai
Journal of Experimental Medicine, 2011
View PDFchevron_right
Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells
Santi Suryani
Blood, 2010
View PDFchevron_right
Analysis of murine CD22 during B cell development: CD22 is expressed on B cell progenitors prior to IgM
Angela Stoddart
International Immunology, 1997
View PDFchevron_right
IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice
Quintus Medley, Heath Guay
The Journal of Immunology, 2012
View PDFchevron_right
Follicular helper T cells as cognate regulators of B cell immunity
nadege pelletier
Current Opinion in Immunology, 2009
View PDFchevron_right
Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages
Anton Jetten
Immunity, 2008
View PDFchevron_right
IL-21 induces death of marginal zone B cells during chronic inflammation
Christoph Mueller
Blood, 2010
View PDFchevron_right
CD22 is required for formation of memory B cell precursors within germinal centers
Edward A Clark
PloS one, 2017
View PDFchevron_right
CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice
Dragan Marinkovic
European Journal of Immunology, 2002
View PDFchevron_right
Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help
David Gonzalez
eLife, 2017
View PDFchevron_right
T Follicular Helper Cells Mediate Expansion of Regulatory B Cells via IL-21 in Lupus-Prone MRL/lpr Mice
Yiwei Chu
PLoS ONE, 2013
View PDFchevron_right
Germinal Center B Cell Depletion Diminishes CD4+ Follicular T Helper Cells in Autoimmune Mice
Thomas Tedder
PLoS ONE, 2014
View PDFchevron_right
Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival
Shengli Xu
Proceedings of the National Academy of Sciences, 2012
View PDFchevron_right