Antidiarrhoeal activity Research Papers - Academia.edu (original) (raw)
Based on the traditional folk use, the anti-diarrheal activity of the methanolic extract of Achillea millefolium L. (AM) leaves was evaluated on castor oil-induced diarrhoea and assessment of gastrointestinal propulsion of charcoal meal... more
Based on the traditional folk use, the anti-diarrheal activity of the methanolic extract of Achillea millefolium L.
(AM) leaves was evaluated on castor oil-induced diarrhoea and assessment of gastrointestinal propulsion of
charcoal meal in rats. Achillea millefolium L. commonly known as yarrow belonging to the family Asteraceae, is an
ancient traditional herb native to Europe and is used to treat wounds, hepatic disorders, gastrointestinal disorders,
spasmodic diseases, headaches, pain, inflammation and diarrhoea. The three doeses of Achillea millefolium L.
methanolic extract has been selected (150 mg/kg, 300 mg/kg and 450 mg/kg). Among three dosages of AM leaves,
the two dosages (300 mg/kg-IIIb and 450 mg/kg IIIc) showed a significant reduction in various parameters like
distance travelled (IIIb-25±1.679 cm; IIIc-17±2.534 cm) and % average travelled (IIIb-47.16; IIIc-32.69) travelled
in charcoal meal model when compaired to control group. Phytochemical screening of the plant extract revealed the
presence of flavonoids, tannins, steroids and terpenes. Results showed that the methanolic extract of Achillea
millefolium Leaves possess anti-diarrhoeal activity possibly mediated by inhibiting the intestinal motility,
hydroelectrolyte secretion and by making intestinal mucosa more resistant to chemical alteration and hence reduce
secretions.
Objective: To investigate the Effects of Antidiarrheal and Thrombolytic Activities of methanol extract of Cinnamomum cecidodaphne Meissn. Barks. Castor oil induced diarrhoea test were used to examine the in-vivo antidiarrheal activity in... more
Objective: To investigate the Effects of Antidiarrheal and Thrombolytic Activities of methanol extract of Cinnamomum cecidodaphne Meissn. Barks. Castor oil induced diarrhoea test were used to examine the in-vivo antidiarrheal activity in Swiss albino mice. Results: In vitro clot lysis model was undertaken to investigate the thrombolytic action of the extract. Data were analysed by using statistical software statistical package for social science (SPSS, version 19.0). In this study of antidiarrhel activity Loperamide was used as a standard. For thrombolytic test Streptokinase used as positive control. In case of antidiarrheal study value was found 76.36% 400mg/kg where standard was found 83.33% and the extract shown 35.08% of thrombolysis effect where streptokinase was found 77.06% of clot lysis effect. Conclusion: The extract showed significant activity as compare to standard drugs. Methanol extract of C. cecidodaphne Meissn barks might be triggering the premonition of novel drug discovery in future due to its antidiarrheal effect in animal model.
The present study was undertaken to evaluate the antidiarrheal activity of alcoholic leaf extract of Taxus baccata.The models used in this study were castor oil induced diarrhea in rats, castor oil induced enteropooling, charcoal meal... more
The present study was undertaken to evaluate the antidiarrheal activity of alcoholic leaf extract of Taxus baccata.The models used in this study were castor oil induced diarrhea in rats, castor oil induced enteropooling, charcoal meal test and the effect of Taxus baccata on isolated rat ileum. Each model consisted four groups, control, standard (loperamide), Taxus baccata leaf extract 100 mg/kg and 200 mg/kg