Basement Membrane Research Papers - Academia.edu (original) (raw)

Background: Skin laxity, rhytides, and photoaging are generally treated by ablative procedures that injure or destroy the epidermis and its basement membrane, at least in the beginning, and subsequently lead to fibrosis of the papillary dermis. The ideal treatment would be to preserve the epidermis and promote normal collagen and elastin formation in the dermis. Percutaneous collagen induction takes us

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- Adolescent, Plastic and Reconstructive Surgery, South Africa, Humans
- by Xi Xu
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- Humans, Basement Membrane, Mice, Female
- by Sushma Srivastava
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- Electron Microscopy, Antioxidants, Basement Membrane, Curcumin
- by Alexandra Brito
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- Cognitive Science, ABC, Microcirculation, Intelligent Transport System
- by Roxana Carare
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- Immune response, Multiple sclerosis, Cerebrospinal Fluid, Brain
- by Valeria Aoki
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- Biopsy, Humans, Basement Membrane, Vasculitis
- by Sushma Srivastava
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- Inflammation, Transmission Electron Microscopy, Antioxidants, Basement Membrane
- by Graham Burton
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- Cognitive Science, Biology, Tobacco, Anatomy
- by Leopoldo Raij
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- Electron Microscopy, Fluorescence Microscopy, Kidney transplantation, Biopsy
- by Jan Talts
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- Biological Sciences, Humans, Nomenclature, Basement Membrane
- by Robert Ritch
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- Extracellular Matrix, Humans, Basement Membrane, Glaucoma
- by Jung-Keug Park and +1
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- Engineering, Technology, Wine, Bioscience
- by Freddy Haesebrouck
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- Microbiology, Extracellular Matrix, Virulence, Disease Outbreaks
- by Bryony Bonning
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- Basement Membrane, Animals, Insects, Cuticle
- by Ruben Ramirez
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- Wound Healing, Enzyme Inhibitors, Extracellular Matrix, Humans
- by Peter Baluk
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- Genetics, Humans, Basement Membrane, Endothelial Cells
- by Daniel Rukstalis
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- Prostate Cancer, Cell Division, Cell line, Humans

Loss of cell-cell adhesion in carcinoma cells may be an important step in the acquisition of an invasive, metastatic phenotype. We have examined the expression of the epithelial-specific cell adhesion molecule uvomorulin (E-cadherin, cell-CAM 120/80, L-CAM) in human breast cancer cell lines. We find that fibroblastoid, highly invasive, vimentin-expressing breast cancer cell lines do not express uvomorulin. Of the more epithelial-appearing, less invasive, keratin-expressing breast cancer cell lines, some express uvomorulin, and some do not. We examined the morphologies of the cell lines in the reconstituted basement membrane matrix Matrigel and measured the ability of the cells to traverse a Matrigel-coated filter as in vitro models for detachment of carcinoma cells from neighboring cells and invasion through basement membrane into surrounding tissue. Colonies of uvomorulin-positive cells have a characteristic fused appearance in Matrigel, whereas uvomorulin-negative cells appear det...

- by Edward Gelmann
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- Fluorescence Microscopy, Cell Adhesion, Gene expression, Extracellular Matrix
- by Edward Gelmann
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- Breast Cancer, Cell line, Cell Differentiation, Humans

Alport syndrome (AS) is an hereditary disease characterised by the association of progressive hematuria nephritis. The diagnosis is based on clinical genetic and ultrastructural findings. Nowadays, immunohistochemical technique is of great interest. It enables us to analyze the distribution of the different chains of the type IV collagen in renal basement membrane (RBM) and epidermal basement membrane (EBM) which appeared

- by Krichen Makni
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- Genetics, Immunohistochemistry, Adolescent, Biopsy
- by Adèle Arcangelis
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- Physiology, Morphogenesis, Extracellular Matrix, Protein Structure and Function
- by Esther Middelkoop
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- Nonparametric Statistics, Wound Healing, Humans, Basement Membrane
- by Lynn Perlmutter
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- Multidisciplinary, Humans, Basement Membrane, Female
- by Marina Glukhova
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- Transgenic Mice, Basement Membrane, Mammary gland, Transgene Expression
- by Robert Mittra
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- Vitreoretinal Surgery, Humans, Basement Membrane, Diabetic Retinopathy

Patients struggling with diabetes are at elevated risks for several sight-threatening diseases, including proliferative diabetic retinopathy (DR). DR manifests in two stages: first, the retinal microvasculature is compromised and capillary degeneration occurs; subsequently, an over-compensatory angiogenic response is initiated. Early changes in the retinal microcirculation include disruptions in blood flow, thickening of basement membrane, eventual loss of mural cells, and the genesis of acellular capillaries. Endothelial apoptosis and capillary dropout lead to a hypoxic inner retina, alterations in growth factors, and upregulation of inflammatory mediators. With disease progression, pathologic angiogenesis generates abnormal preretinal microvessels. Current therapies, which include panretinal photocoagulation and vitrectomy, have remained unaltered for several decades. With several exciting preclinical advances, emergent technologies and innovative cellular targets may offer newfou...

- by Ira M Herman
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- Humans, Basement Membrane, Endothelial Cells, Diabetic Retinopathy
- by Danladi C Husaini
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- Nigeria, Basement Membrane, Reproductive toxicology, Animals
- by Michael Dictor
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- Lymphangiogenesis, Humans, Basement Membrane, Endothelial Cells
- by Maxime Battistella
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- Dermatology, Humans, Autoimmune diseases, Basement Membrane
- by Luis Díaz
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- Electron Microscopy, Cell separation, Cytoskeleton, Basement Membrane
- by Cassandra Kelleher
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- Extracellular Matrix, Humans, Basement Membrane, Collagen
- by Carol Box
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- Extracellular Matrix, Molecular Mechanics, Tumor microenvironment, Humans
- by Jeffrey L Winters
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- Kidney diseases, Kidney transplantation, Metabolic Bone Disease, Humans
- by Valerie Weaver
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- Genetics, Cell Adhesion, Apoptosis, Extracellular Matrix

Epidermolysis bullosa (EB) is classified into major types - EB simplex (EBS), junctional EB (JEB) and dystrophic EB (DEB) - on the basis of the level of tissue separation within the cutaneous basement membrane zone. Recent advances in research on EB have led to the identification of 10 genes responsible for EB. The Japanese Ministry of Health, Labor and Welfare has designated JEB and DEB, but not EBS, as specified diseases. However, EBS has a lethal variant and should also be registered as a specified disease. In the Third Consensus Meeting on the Diagnosis and Classification of EB held in Vienna in 2007, it was recommended that Kindler syndrome should be classified as a subtype of EB. Corrective gene therapy is the most ideal therapy for EB, but much more research is required before it can be developed and used in clinical practice. Cell-based therapies using fibroblasts and bone marrow cells have recently attracted considerable attention.

- by Hajime Nakano
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- Membrane Proteins, Humans, Basement Membrane, Epidermolysis Bullosa
- by Jan Shearer
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- Veterinary Medicine, Basement Membrane, Animals, Connective tissue
- by Jones Fox
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- Electron Microscopy, Pregnancy, Humans, Basement Membrane
- by Abdullah Refeidi
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- Basement Membrane, Fine Structure Constant, Alcian blue, Electron Microscope
- by Francisco Gude
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- Electron Microscopy, Immunohistochemistry, Cryopreservation, Humans

Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes. Podocyte foot processes form a characteristic interdigitating pattern with foot processes of neighboring podocytes, leaving in between the filtration slits that are bridged by the glomerular slit diaphragm. The highly dynamic foot processes contain an actin-based contractile apparatus comparable to that of smooth muscle cells or pericytes. Mutations affecting several podocyte proteins lead to rearrangement of the actin cytoskeleton, disruption of the filtration barrier and subsequent renal disease. The fact that the dynamic regulation of the podocyte cytoskeleton is vital to kidney function has led to podocytes emerging as an excellent model system for studying actin cytoskeleton dynamics in a physiological context.

- by Christian Faul
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- Calcium, Membrane Proteins, Cytoskeleton, Signal Transduction
- by david fernandez
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- Natural History, Pulmonary Hypertension, Humans, Interstitial Lung Disease
- by Arnold Caplan
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- Tissue Engineering, Extracellular Matrix, Biological Sciences, Humans
- by Nerida Cole and +1
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- Contact Lenses, Humans, Basement Membrane, Contact Lens

Neutrophil extravasation at post-capillary venules, consisting of EC, PC, and the shared ECM, increases following fibrotic remodeling in the lung, liver, and skin. The role of fibrotic pericyte-derived ECM in regulating EC activation and neutrophil recruitment remains unexplored. To elucidate the role of human pericyte-derived ECM in EC activation, we characterized PC-derived ECM following transforming growth factor-β1, IL-1β, CCL2, or bleomycin activation, and examined surface adhesion molecule expression and neutrophil recruitment by EC cultured on PC-ECM. Pro-inflammatory activation of PC-induced deposition of compositionally distinct ECM compared with non-activated control. Bleomycin activation induced fibronectin-rich and collagen-poor ECM remodeling by PC, facilitating increased neutrophil transendothelial migration when compared with non-activated pericyte ECM (49.9 ± 3.4% versus 29.7 ± 1.4%). Increases in fibronectin compared to collagen I, are largely responsible for ECM-re...

- by Parid Sava
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- Microcirculation, Extracellular Matrix, Humans, Basement Membrane

The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.

- by Valerie Weaver
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- Extracellular Matrix, Biological Sciences, Humans, Basement Membrane
- by Judy Boughey
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- Radiation, Research Design, Clinical Trial, Breast Cancer
- by Sungjin Park
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- Pathology, Adolescent, Humans, Basement Membrane
- by Kurt Zatloukal and +2
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- Gastroenterology, Immunohistochemistry, Liver diseases, Basement Membrane
- by Carine Munaut
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- Mechanical Engineering, Physiology, Dentistry, Neurosurgery