Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites (original) (raw)

• Elsasser, S. & Finley, D. Delivery of ubiquitinated substrates to protein-unfolding machines. Nat. Cell Biol. 7, 742–749 (2005).
  Article CAS PubMed Google Scholar
• Pickart, C.M. & Cohen, R.E. Proteasomes and their kin: proteases in the machine age. Nat. Rev. Mol. Cell Biol. 5, 177–187 (2004).
  Article CAS PubMed Google Scholar
• Maupin-Furlow, J.A. et al. Proteasomes from structure to function: perspectives from Archaea. Curr. Top. Dev. Biol. 75, 125–169 (2006).
  Article CAS PubMed Google Scholar
• Smith, D.M. et al. Docking of proteasomal ATPases' carboxyl termini in the 20S proteasomal alpha ring opens the gate for substrate entry. Mol. Cell 27, 731–744 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Groll, M. et al. A gated channel into the proteasome core particle. Nat. Struct. Biol. 7, 1062–1067 (2000).
  Article CAS PubMed Google Scholar
• Glickman, M.H. et al. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell 94, 615–623 (1998).
  Article CAS PubMed Google Scholar
• Verma, R. et al. Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science 298, 611–615 (2002).
  Article CAS PubMed Google Scholar
• Yao, T. & Cohen, R.E. A cryptic protease couples deubiquitination and degradation by the proteasome. Nature 419, 403–407 (2002).
  Article CAS PubMed Google Scholar
• Hartmann-Petersen, R., Tanaka, K. & Hendil, K.B. Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking. Arch. Biochem. Biophys. 386, 89–94 (2001).
  Article CAS PubMed Google Scholar
• Nandi, D., Tahiliani, P., Kumar, A. & Chandu, D. The ubiquitin-proteasome system. J. Biosci. 31, 137–155 (2006).
  Article CAS PubMed Google Scholar
• Liu, C.W. et al. ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol. Cell 24, 39–50 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Hoffman, L., Pratt, G. & Rechsteiner, M. Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate. J. Biol. Chem. 267, 22362–22368 (1992).
  CAS PubMed Google Scholar
• Armon, T., Ganoth, D. & Hershko, A. Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity. J. Biol. Chem. 265, 20723–20726 (1990).
  CAS PubMed Google Scholar
• Eytan, E., Ganoth, D., Armon, T. & Hershko, A. ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. Proc. Natl. Acad. Sci. USA 86, 7751–7755 (1989).
  Article CAS PubMed PubMed Central Google Scholar
• Smith, D.M. et al. ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol. Cell 20, 687–698 (2005).
  Article CAS PubMed Google Scholar
• Satoh, K., Sasajima, H., Nyoumura, K.I., Yokosawa, H. & Sawada, H. Assembly of the 26S proteasome is regulated by phosphorylation of the p45/Rpt6 ATPase subunit. Biochemistry 40, 314–319 (2001).
  Article CAS PubMed Google Scholar
• Leggett, D.S. et al. Multiple associated proteins regulate proteasome structure and function. Mol. Cell 10, 495–507 (2002).
  Article CAS PubMed Google Scholar
• Stanhill, A. et al. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Mol. Cell 23, 875–885 (2006).
  Article CAS PubMed Google Scholar
• Imai, J., Maruya, M., Yashiroda, H., Yahara, I. & Tanaka, K. The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome. EMBO J. 22, 3557–3567 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Schmidt, M. et al. The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat. Struct. Mol. Biol. 12, 294–303 (2005).
  Article CAS PubMed Google Scholar
• Park, Y. et al. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. Mol. Cell. Biol. 25, 3842–3853 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Leggett, D.S., Glickman, M.H. & Finley, D. Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast. Methods Mol. Biol. 301, 57–70 (2005).
  CAS PubMed Google Scholar
• Bajorek, M., Finley, D. & Glickman, M.H. Proteasome disassembly and downregulation is correlated with viability during stationary phase. Curr. Biol. 13, 1140–1144 (2003).
  Article CAS PubMed Google Scholar
• Vernace, V.A., Arnaud, L., Schmidt-Glenewinkel, T. & Figueiredo-Pereira, M.E. Aging perturbs 26S proteasome assembly in Drosophila melanogaster. FASEB J. 21, 2672–2682 (2007).
  Article CAS PubMed Google Scholar
• Babbitt, S.E. et al. ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle. Cell 121, 553–565 (2005).
  Article CAS PubMed Google Scholar
• Hendil, K.B., Hartmann-Petersen, R. & Tanaka, K. 26 S proteasomes function as stable entities. J. Mol. Biol. 315, 627–636 (2002).
  Article CAS PubMed Google Scholar
• Rubin, D.M., Glickman, M.H., Larsen, C.N., Dhruvakumar, S. & Finley, D. Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J. 17, 4909–4919 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Kohler, A. et al. The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. Mol. Cell 7, 1143–1152 (2001).
  Article CAS PubMed Google Scholar
• Forster, A., Masters, E.I., Whitby, F.G., Robinson, H. & Hill, C.P. The 1.9 Å structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. Mol. Cell 18, 589–599 (2005).
  Article PubMed Google Scholar
• Smith, D.M., Benaroudj, N. & Goldberg, A. Proteasomes and their associated ATPases: a destructive combination. J. Struct. Biol. 156, 72–83 (2006).
  Article CAS PubMed Google Scholar
• Saeki, Y., Toh-e, A. & Yokosawa, H. Rapid isolation and characterization of the yeast proteasome regulatory complex. Biochem. Biophys. Res. Commun. 273, 509–515 (2000).
  Article CAS PubMed Google Scholar
• Kleijnen, M.F. et al. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol. Cell 6, 409–419 (2000).
  Article CAS PubMed Google Scholar
• Groll, M., Kim, K.B., Kairies, N., Huber, R. & Crews, C.M. Crystal structure of epoxomicin: 20S proteasome reveals a molecular basis for selectivity of α′,β′-epoxyketone proteasome inhibitors. J. Am. Chem. Soc. 122, 1237–1238 (2000).
  Article CAS Google Scholar
• Groll, M., Berkers, C.R., Ploegh, H.L. & Ovaa, H. Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure 14, 451–456 (2006).
  Article CAS PubMed Google Scholar
• Meng, L. et al. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc. Natl. Acad. Sci. USA 96, 10403–10408 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Berkers, C.R. et al. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat. Methods 2, 357–362 (2005).
  Article CAS PubMed Google Scholar
• Arendt, C.S. & Hochstrasser, M. Eukaryotic 20S proteasome catalytic subunit propeptides prevent active site inactivation by N-terminal acetylation and promote particle assembly. EMBO J. 18, 3575–3585 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Joshi, S.A., Hersch, G.L., Baker, T.A. & Sauer, R.T. Communication between ClpX and ClpP during substrate processing and degradation. Nat. Struct. Mol. Biol. 11, 404–411 (2004).
  Article CAS PubMed Google Scholar
• Singh, S.K., Guo, F. & Maurizi, M.R. ClpA and ClpP remain associated during multiple rounds of ATP-dependent protein degradation by ClpAP protease. Biochemistry 38, 14906–14915 (1999).
  Article CAS PubMed Google Scholar
• Chu-Ping, M., Vu, J.H., Proske, R.J., Slaughter, C.A. & DeMartino, G.N. Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome. J. Biol. Chem. 269, 3539–3547 (1994).
  CAS PubMed Google Scholar
• Elsasser, S., Schmidt, M. & Finley, D. Characterization of the proteasome using native gel electrophoresis. Methods Enzymol. 398, 353–363 (2005).
  Article CAS PubMed Google Scholar
• Yang, P. et al. Purification of the Arabidopsis 26 S proteasome: biochemical and molecular analyses revealed the presence of multiple isoforms. J. Biol. Chem. 279, 6401–6413 (2004).
  Article CAS PubMed Google Scholar
• Arendt, C.S. & Hochstrasser, M. Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation. Proc. Natl. Acad. Sci. USA 94, 7156–7161 (1997).
  Article CAS PubMed PubMed Central Google Scholar