Hypoxia and cell cycle regulation of the von Hippel–Lindau tumor suppressor (original) (raw)
Baker DJ, Dawlaty MM, Galardy P, van Deursen JM . (2007). Mitotic regulation of the anaphase-promoting complex. Cell Mol Life Sci64: 589–600. ArticleCASPubMed Google Scholar
Beroud C, Collod-Beroud G, Boileau C, Soussi T, Junien C . (2000). UMD (universal mutation database): a generic software to build and analyze locus-specific databases. Hum Mutat15: 86–94. ArticleCASPubMed Google Scholar
Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, Salim A et al. (2006). Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med3: e47. ArticlePubMedPubMed Central Google Scholar
de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A et al. (2001). Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci USA98: 1387–1392. CASPubMedPubMed Central Google Scholar
Deshaies RJ, Joazeiro CA . (2009). RING domain E3 ubiquitin ligases. Annu Rev Biochem78: 399–434. ArticleCASPubMed Google Scholar
Fähling M . (2009). Cellular oxygen sensing, signalling and how to survive translational arrest in hypoxia. Acta Physiologica195: 205–230. ArticlePubMed Google Scholar
Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV . (2001). Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem276: 7919–7926. ArticleCASPubMed Google Scholar
Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC . (2007). HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell11: 335–347. ArticleCASPubMedPubMed Central Google Scholar
Hackenbeck T, Knaup KX, Schietke R, Schödel J, Willam C, Wu X et al. (2009). HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia. Cell Cycle8: 1386–1395. ArticleCASPubMed Google Scholar
Harper JV . (2005). Synchronization of cell populations in G1/S and G2/M phases of the cell cycle. Methods Mol Biol296: 157–166. CASPubMed Google Scholar
Hergovich A, Lisztwan J, Barry R, Ballschmieter P, Krek W . (2003). Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat Cell Biol5: 64–70. ArticleCASPubMed Google Scholar
Iliopoulos O, Kibel A, Gray S, Kaelin WG . (1995). Tumor suppression by the human von Hippel-Lindau gene product. Nat Med1: 822–826. ArticleCASPubMed Google Scholar
Iliopoulos O, Ohh M, Kaelin Jr WG . (1998). pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc Natl Acad Sci USA95: 11661–11666. ArticleCASPubMedPubMed Central Google Scholar
Jackson PK . (2004). Linking tumor suppression, DNA damage and the anaphase-promoting complex. Trends Cell Biol14: 331–334. ArticleCASPubMed Google Scholar
Jung CR, Hwang KS, Yoo J, Cho WK, Kim JM, Kim WH et al. (2006). E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis. Nat Med12: 809–816. ArticleCASPubMed Google Scholar
Kaelin Jr WG . (2007b). The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res13: 680s–684s. ArticleCASPubMed Google Scholar
Kaelin Jr WG . (2008). The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer8: 865–873. ArticleCASPubMed Google Scholar
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE . (2004). HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J23: 1949–1956. ArticleCASPubMedPubMed Central Google Scholar
Lendahl U, Lee KL, Yang H, Poellinger L . (2009). Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet10: 821–832. ArticleCASPubMed Google Scholar
Listovsky T, Oren YS, Yudkovsky Y, Mahbubani HM, Weiss AM, Lebendiker M et al. (2004). Mammalian Cdh1/Fzr mediates its own degradation. EMBO J23: 1619–1626. ArticleCASPubMedPubMed Central Google Scholar
Liu L, Simon MC . (2004). Regulation of transcription and translation by hypoxia. Cancer Biol Ther3: 492–497. ArticleCASPubMed Google Scholar
Liu W, Li W, Fujita T, Yang Q, Wan Y . (2008). Proteolysis of CDH1 enhances susceptibility to UV radiation-induced apoptosis. Carcinogenesis29: 263–272. ArticleCASPubMed Google Scholar
Liu W, Wu G, Li W, Lobur D, Wan Y . (2007). Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition. Mol Cell Biol27: 2967–2979. ArticleCASPubMedPubMed Central Google Scholar
Musacchio A, Salmon ED . (2007). The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol8: 379–393. ArticleCASPubMed Google Scholar
Pause A, Lee S, Lonergan KM, Klausner RD . (1998). The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proc Natl Acad Sci USA95: 993–998. ArticleCASPubMedPubMed Central Google Scholar
Pfleger CM, Lee E, Kirschner MW . (2001). Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev15: 2396–2407. ArticleCASPubMedPubMed Central Google Scholar
Schmaltz C, Hardenbergh PH, Wells A, Fisher DE . (1998). Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol Cell Biol18: 2845–2854. ArticleCASPubMedPubMed Central Google Scholar
Schoenfeld A, Davidowitz EJ, Burk RD . (1998). A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc Natl Acad Sci USA95: 8817–8822. ArticleCASPubMedPubMed Central Google Scholar
Semenza GL . (2009). Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis. Blood114: 2015–2019. ArticleCASPubMed Google Scholar
Stebbins CE, Kaelin Jr WG, Pavletich NP . (1999). Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science284: 455–461. ArticleCASPubMed Google Scholar
Stickle NH, Cheng LS, Watson IR, Alon N, Malkin D, Irwin MS et al. (2005). Expression of p53 in renal carcinoma cells is independent of pVHL. Mut Res578: 23–32. ArticleCAS Google Scholar
Sudo T, Ota Y, Kotani S, Nakao M, Takami Y, Takeda S et al. (2001). Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells. EMBO J20: 6499–6508. ArticleCASPubMedPubMed Central Google Scholar
Thoma CR, Frew IJ, Hoerner CR, Montani M, Moch H, Krek W . (2007). pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nat Cell Biol9: 588–595. ArticleCASPubMed Google Scholar
Thoma CR, Toso A, Gutbrodt KL, Reggi SP, Frew IJ, Schraml P et al. (2009). VHL loss causes spindle misorientation and chromosome instability. Nat Cell Biol11: 994–1001. ArticleCASPubMed Google Scholar
van Leuken R, Clijsters L, Wolthuis R . (2008). To cell cycle, swing the APC/C. Biochimica et Biophysica Acta1786: 49–59. CASPubMed Google Scholar
Wan Y, Liu X, Kirschner MW . (2001). The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Mol Cell8: 1027–1039. ArticleCASPubMed Google Scholar
Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup KX et al. (2008). The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp Cell Res314: 2016–2027. ArticleCASPubMed Google Scholar
Wasch R, Robbins JA, Cross FR . (2010). The emerging role of APC/C(Cdh1) in controlling differentiation, genomic stability and tumor suppression. Oncogene29: 1–10. ArticleCASPubMed Google Scholar
Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin Jr WG . (2004). Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature428: 194–198. ArticleCASPubMed Google Scholar
Wykoff CC, Sotiriou C, Cockman ME, Ratcliffe PJ, Maxwell P, Liu E et al. (2004). Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene. Br J Cancer90: 1235–1243. ArticleCASPubMedPubMed Central Google Scholar
Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C et al. (2008). VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat Cell Biol10: 361–369. ArticleCASPubMed Google Scholar