Many stimuli pull the necrotic trigger, an overview (original) (raw)

• Laster SM, Wood JG, Gooding LR . Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J Immunol 1988; 141: 2629–2634.
  CAS PubMed Google Scholar
• Vercammen D, Beyaert R, Denecker G, Goossens V, Van Loo G, Declercq W et al. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 1998; 187: 1477–1485.
  Article CAS PubMed PubMed Central Google Scholar
• Cookson BT, Brennan MA . Pro-inflammatory programmed cell death. Trends Microbiol 2001; 9: 113–114.
  Article CAS PubMed Google Scholar
• Fink SL, Cookson BT . Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 2005; 73: 1907–1916.
  Article CAS PubMed PubMed Central Google Scholar
• Feldmeyer L, Keller M, Niklaus G, Hohl D, Werner S, Beer HD . The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr biol 2007; 17: 1140–1145.
  Article CAS PubMed Google Scholar
• Ariizumi K, Kitajima T, Bergstresser OR, Takashima A . Interleukin-1 beta converting enzyme in murine Langerhans cells and epidermal-derived dendritic cell lines. Eur J Immunol 1995; 25: 2137–2141.
  Article CAS PubMed Google Scholar
• Ayala JM, Yamin TT, Egger LA, Chin J, Kostura MJ, Miller DK . IL-1 beta-converting enzyme is present in monocytic cells as an inactive 45-kDa precursor. J Immunol 1994; 153: 2592–2599.
  CAS PubMed Google Scholar
• Bergsbaken T, Fink SL, Cookson BT . Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 2009; 7: 99–109.
  Article CAS PubMed PubMed Central Google Scholar
• Walsh JG, Logue SE, Luthi AU, Martin SJ . Caspase-1 promiscuity is counterbalanced by rapid inactivation of processed enzyme. J Biol Chem 2011; 286: 32513–32524.
  Article CAS PubMed PubMed Central Google Scholar
• Fink SL, Cookson BT . Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol 2006; 8: 1812–1825.
  Article CAS PubMed Google Scholar
• Festjens N, Vanden Berghe T, Vandenabeele P . Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochimica et biophysica acta 2006; 1757: 1371–1387.
  Article CAS PubMed Google Scholar
• Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G . Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 2010; 11: 700–714.
  Article CAS PubMed Google Scholar
• Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 2000; 1: 489–495.
  Article CAS PubMed Google Scholar
• Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005; 1: 112–119.
  Article CAS PubMed Google Scholar
• Degterev A, Hitomi J, Germscheid M, Ch’en IL, Korkina O, Teng X et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 2008; 4: 313–321.
  Article CAS PubMed PubMed Central Google Scholar
• Cho Y, Challa S, Moquin D, Genga R, Ray TD, Guildford M et al. Phosphorylation-driven assembly of RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009; 137: 1112–1123.
  Article CAS PubMed PubMed Central Google Scholar
• He S, Wang L, Miao L, Wang T, Du F, Zhao L et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009; 137: 1100–1111.
  Article CAS PubMed Google Scholar
• Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009; 325: 332–336.
  Article CAS PubMed Google Scholar
• Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2011; e-pub ahead of print 15 July 2011; doi:10.1038/cdd.2011.96.
  Article CAS Google Scholar
• Goossens V, Grooten J, Fiers W . The oxidative metabolism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells. J Biol Chem 1996; 271: 192–196.
  Article CAS PubMed Google Scholar
• Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T . The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal 2010; 3: re4.
  Article PubMed CAS Google Scholar
• Vanden Berghe T, Vanlangenakker N, Parthoens E, Deckers W, Devos M, Festjens N et al. Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ 2010; 17: 922–930.
  Article CAS PubMed Google Scholar
• Galluzzi L, Vanden Berghe T, Vanlangenakker N, Buettner S, Eisenberg T, Vandenabeele P et al. Programmed necrosis from molecules to health and disease. Int Rev Cell Mol Biol 2011; 289: 1–35.
  Article CAS PubMed Google Scholar
• Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ et al. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 2008; 135: 1311–1323.
  Article CAS PubMed PubMed Central Google Scholar
• Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernandez-Majada V, Ermolaeva M et al. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 2011; 477: 330–334.
  Article CAS PubMed Google Scholar
• Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008; 30: 689–700.
  Article CAS PubMed Google Scholar
• Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K et al. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J Biol Chem 2008; 283: 24295–24299.
  Article CAS PubMed PubMed Central Google Scholar
• Mahoney DJ, Cheung HH, Mrad RL, Plenchette S, Simard C, Enwere E et al. Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc Natl Acad Sci USA 2008; 105: 11778–11783.
  Article CAS PubMed PubMed Central Google Scholar
• Tokunaga F, Iwai K . Involvement of LUBAC-mediated linear polyubiquitination of NEMO in NF-kappaB activation]. Tanpakushitsu Kakusan Koso 2009; 54: 635–642.
  CAS PubMed Google Scholar
• Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E et al. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell 2009; 36: 831–844.
  Article CAS PubMed Google Scholar
• Ikeda F, Deribe YL, Skanland SS, Stieglitz B, Grabbe C, Franz-Wachtel M et al. SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Nature 2011; 471: 637–641.
  Article CAS PubMed PubMed Central Google Scholar
• Emmerich CH, Schmukle AC, Haas TL, Gerlach B, Cordier SM, Rieser E et al. The linear ubiquitin chain assembly complex (LUBAC) forms part of the TNF-R1 signalling complex and is required for effective TNF-induced gene induction and prevents TNF-induced apoptosis. Adv Exp Med Biol 2011; 691: 115–126.
  Article CAS PubMed Google Scholar
• Vanlangenakker N, Bertrand MJM, Bogaert P, Vandenabeele P, Vanden Berghe T . TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis 2011; in press.
• Vanlangenakker N, Vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K et al. cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ 2011; 18: 656–665.
  Article CAS PubMed Google Scholar
• Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011; 471: 368–372.
  Article CAS PubMed PubMed Central Google Scholar
• Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C et al. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011; 471: 363–367.
  Article CAS PubMed PubMed Central Google Scholar
• Zhang H, Zhou X, McQuade T, Li J, Chan FK, Zhang J . Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 2011; 471: 373–376.
  Article CAS PubMed PubMed Central Google Scholar
• Ch’en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM . Mechanisms of necroptosis in T cells. J Exp Med 2011; 208: 633–641.
  Article PubMed PubMed Central CAS Google Scholar
• Gunther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H et al. Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis. Nature 2011; 477: 335–339.
  Article PubMed PubMed Central CAS Google Scholar
• Bonnet MC, Welz PS, Van Loo G, Ermolaeva M, Bloch W, Haase I et al. FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 2011; 35: 572–582.
  Article CAS PubMed Google Scholar
• Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O et al. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med 2009; 206: 2161–2177.
  Article CAS PubMed PubMed Central Google Scholar
• Liedtke C, Bangen JM, Freimuth J, Beraza N, Lambertz D, Cubero FJ et al. Absence of caspase-8 protects from inflammation-related hepatocarcinogenesis in mice but triggers nonapoptotic liver injury. Gastroenterology 2011; e-pub ahead of print 28 August 2011.
• Trichonas G, Manola A, Morizane Y, Thanos A, Koufomichali X, Papakostas TD et al. A novel nonradioactive method to evaluate vascular barrier breakdown and leakage. Invest Ophthalmol Vis Sci 2010; 51: 1677–1682.
  Article PubMed Google Scholar
• Upton JW, Kaiser WJ, Mocarski ES . Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 2010; 7: 302–313.
  Article CAS PubMed PubMed Central Google Scholar
• Northington FJ, Chavez-Valdez R, Graham EM, Razdan S, Gauda EB, Martin LJ . Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. J Cereb Blood Flow Metab 2010; 31: 178–189.
  Article PubMed PubMed Central CAS Google Scholar
• Smith CC, Davidson SM, Lim SY, Simpkin JC, Hothersall JS, Yellon DM . Necrostatin: a potentially novel cardioprotective agent? Cardiovas Drugs Ther 2007; 21: 227–233.
  Article CAS Google Scholar
• Wang L, Du F, Wang X . TNF-alpha induces two distinct caspase-8 activation pathways. Cell 2008; 133: 693–703.
  Article CAS PubMed Google Scholar
• Biton S, Ashkenazi A . NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-alpha feedforward signaling. Cell 2011; 145: 92–103.
  Article CAS PubMed Google Scholar
• Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M et al. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 2011; 43: 449–463.
  Article CAS PubMed PubMed Central Google Scholar
• Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F et al. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 2011; 43: 432–448.
  Article CAS PubMed Google Scholar
• Chen GY, Nunez G . Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 2010; 10: 826–837.
  Article CAS PubMed PubMed Central Google Scholar
• Scaffidi P, Misteli T, Bianchi ME . Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418: 191–195.
  Article CAS PubMed Google Scholar
• Christofferson DE, Yuan J . Cyclophilin a release as a biomarker of necrotic cell death. Cell Death Differ 2010; 17: 1942–1943.
  Article CAS PubMed Google Scholar
• Kazama H, Ricci JE, Herndon JM, Hoppe G, Green DR, Ferguson TA . Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 2008; 29: 21–32.
  Article CAS PubMed PubMed Central Google Scholar
• Lamkanfi M, Sarkar A, Vande Walle L, Vitari AC, Amer AO, Wewers MD et al. Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol 2010; 185: 4385–4392.
  Article CAS PubMed Google Scholar
• Vande Walle L, Kanneganti TD, Lamkanfi M . HMGB1 release by inflammasomes. Virulence 2011; 2: 162–165.
  Article PubMed PubMed Central Google Scholar
• Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M et al. HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep 2004; 5: 825–830.
  Article CAS PubMed PubMed Central Google Scholar
• Kramer G, Erdal H, Mertens HJ, Nap M, Mauermann J, Steiner G et al. Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Can Res 2004; 64: 1751–1756.
  Article CAS Google Scholar
• Linder S, Olofsson MH, Herrmann R, Ulukaya E . Utilization of cytokeratin-based biomarkers for pharmacodynamic studies. Expert Rev Mol Diagn 2010; 10: 353–359.
  Article CAS PubMed Google Scholar
• Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ 2009; 16: 1093–1107.
  Article CAS PubMed Google Scholar
• Krysko DV, Vanden Berghe T, Parthoens E, D’Herde K, Vandenabeele P . Methods for distinguishing apoptotic from necrotic cells and measuring their clearance. Methods Enzymol 2008; 442: 307–341.
  Article PubMed Google Scholar
• Kepp O, Galluzzi L, Lipinski M, Yuan J, Kroemer G . Cell death assays for drug discovery. Nat Rev Drug Discov 2011; 10: 221–237.
  Article CAS PubMed Google Scholar
• Vercammen D, Vandenabeele P, Beyaert R, Declercq W, Fiers W . Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells. Cytokine 1997; 9: 801–808.
  Article CAS PubMed Google Scholar
• Vercammen D, Brouckaert G, Denecker G, Van de Craen M, Declercq W, Fiers W et al. Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J Exp Med 1998; 188: 919–930.
  Article CAS PubMed PubMed Central Google Scholar
• Matsumura H, Shimizu Y, Ohsawa Y, Kawahara A, Uchiyama Y, Nagata S . Necrotic death pathway in Fas receptor signaling. J Cell Biol 2000; 151: 1247–1256.
  Article CAS PubMed PubMed Central Google Scholar
• Kemp TJ, Kim JS, Crist SA, Griffith TS . Induction of necrotic tumor cell death by TRAIL/Apo-2L. Apoptosis 2003; 8: 587–599.
  Article CAS PubMed Google Scholar
• Meurette O, Rebillard A, Huc L, Le Moigne G, Merino D, Micheau O et al. TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions. Cancer Res 2007; 67: 218–226.
  Article CAS PubMed Google Scholar
• Chan FK, Shisler J, Bixby JG, Felices M, Zheng L, Appel M et al. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J Biol Chem 2003; 278: 51613–51621.
  Article CAS PubMed Google Scholar
• Lin Y, Choksi S, Shen HM, Yang QF, Hur GM, Kim YS et al. Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem 2004; 279: 10822–10828.
  Article CAS PubMed Google Scholar
• Kumar A, Eby MT, Sinha S, Jasmin A, Chaudhary PM . The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. J Biol Chem 2001; 276: 2668–2677.
  Article CAS PubMed Google Scholar
• Yan M, Zhang Z, Brady JR, Schilbach S, Fairbrother WJ, Dixit VM . Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice. Curr Biol 2002; 12: 409–413.
  Article CAS PubMed Google Scholar
• Chen MC, Hwang MJ, Chou YC, Chen WH, Cheng G, Nakano H et al. The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death. J Biol Chem 2003; 278: 16073–16081.
  Article CAS PubMed Google Scholar
• May MJ, Madge LA . Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species. J Biol Chem 2007; 282: 16105–16116.
  Article CAS PubMed Google Scholar
• Zhang H, Lin Y, Li J, Pober JS, Min W . RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. J Biol Chem 2007; 282: 14788–14796.
  Article CAS PubMed Google Scholar
• Fotin-Mleczek M, Henkler F, Samel D, Reichwein M, Hausser A, Parmryd I et al. Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. J Cell Sci 2002; 115 (Part 13): 2757–2770.
  Article CAS PubMed Google Scholar
• Grell M, Zimmermann G, Gottfried E, Chen CM, Grunwald U, Huang DC et al. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J 1999; 18 (11): 3034–3043.
  Article CAS PubMed PubMed Central Google Scholar
• Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007; 131: 669–681.
  Article CAS PubMed Google Scholar
• Vince JE, Chau D, Callus B, Wong WW, Hawkins CJ, Schneider P et al. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol 2008; 182: 171–184.
  Article CAS PubMed PubMed Central Google Scholar
• Ikner A, Ashkenazi A . TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD) and caspase-8. J Biol Chem 2011; 286: 21546–21554.
  Article CAS PubMed PubMed Central Google Scholar
• Wilson CA, Browning JL . Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis. Cell Death Differ 2002; 9: 1321–1333.
  Article CAS PubMed Google Scholar
• Eliopoulos AG, Davies C, Knox PG, Gallagher NJ, Afford SC, Adams DH et al. CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Mol Cell Biol 2000; 20: 5503–5515.
  Article CAS PubMed PubMed Central Google Scholar
• Knox PG, Davies CC, Ioannou M, Eliopoulos AG . The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. J Cell Biol 2011; 192: 391–399.
  Article CAS PubMed PubMed Central Google Scholar
• Lenardo MJ, Angleman SB, Bounkeua V, Dimas J, Duvall MG, Graubard MB et al. Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env. J Virol 2002; 76: 5082–5093.
  Article CAS PubMed PubMed Central Google Scholar
• Petit F, Arnoult D, Lelievre JD, Moutouh-de Parseval L, Hance AJ, Schneider P et al. Productive HIV-1 infection of primary CD4+ T cells induces mitochondrial membrane permeabilization leading to a caspase-independent cell death. J Biol Chem 2002; 277: 1477–1487.
  Article CAS PubMed Google Scholar
• Peri P, Nuutila K, Vuorinen T, Saukko P, Hukkanen V . Cathepsins are involved in virus-induced cell death in ICP4 and Us3 deletion mutant herpes simplex virus type 1-infected monocytic cells. J Gen Virol 2011; 92 (Part 1): 173–180.
  Article CAS PubMed Google Scholar
• Chu JJ, Ng ML . The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose. J Gen Virol 2003; 84 (Part 12): 3305–3314.
  Article CAS PubMed Google Scholar
• Bolton DL, Hahn BI, Park EA, Lehnhoff LL, Hornung F, Lenardo MJ . Death of CD4(+) T-cell lines caused by human immunodeficiency virus type 1 does not depend on caspases or apoptosis. J Virol 2002; 76: 5094–5107.
  Article CAS PubMed PubMed Central Google Scholar
• Arjona A, Ledizet M, Anthony K, Bonafe N, Modis Y, Town T et al. West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. J Immunol 2007; 179: 8403–8409.
  Article CAS PubMed Google Scholar
• Li M, Beg AA . Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells. J Virol 2000; 74: 7470–7477.
  Article CAS PubMed PubMed Central Google Scholar
• Mack C, Sickmann A, Lembo D, Brune W . Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein. Proc Natl Acad Sci USA 2008; 105: 3094–3099.
  Article CAS PubMed PubMed Central Google Scholar
• Upton JW, Kaiser WJ, Mocarski ES . Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1. J Biol Chem 2008; 283: 16966–16970.
  Article CAS PubMed PubMed Central Google Scholar
• Lamkanfi M, Dixit VM . Manipulation of host cell death pathways during microbial infections. Cell Host Microbe 2010; 8: 44–54.
  Article CAS PubMed Google Scholar
• Willingham SB, Bergstralh DT, O’Connor W, Morrison AC, Taxman DJ, Duncan JA et al. Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe 2007; 2 (3): 147–159.
  Article CAS PubMed PubMed Central Google Scholar
• Duncan JA, Gao X, Huang MT, O’Connor BP, Thomas CE, Willingham SB et al. Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J Immunol 2009; 182: 6460–6469.
  Article CAS PubMed Google Scholar
• Huang MT, Taxman DJ, Holley-Guthrie EA, Moore CB, Willingham SB, Madden V et al. Critical role of apoptotic speck protein containing a caspase recruitment domain (ASC) and NLRP3 in causing necrosis and ASC speck formation induced by Porphyromonas gingivalis in human cells. J Immunol 2009; 182: 2395–2404.
  Article CAS PubMed Google Scholar
• Willingham SB, Allen IC, Bergstralh DT, Brickey WJ, Huang MT, Taxman DJ et al. NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. J Immunol 2009; 183: 2008–2015.
  Article CAS PubMed Google Scholar
• Motani K, Kushiyama H, Imamura R, Kinoshita T, Nishiuchi T, Suda T . Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity. J Biol Chem 2011; 286: 33963–33972.
  Article CAS PubMed PubMed Central Google Scholar
• Lee J, Remold HG, Ieong MH, Kornfeld H . Macrophage apoptosis in response to high intracellular burden of _Mycobacterium tuberculosis_is mediated by a novel caspase-independent pathway. J Immunol 2006; 176: 4267–4274.
  Article CAS PubMed Google Scholar
• Chen M, Gan H, Remold HG . A mechanism of virulence: virulent _Mycobacterium tuberculosis_strain H37Rv, but not attenuated H37Ra, causes significant mitochondrial inner membrane disruption in macrophages leading to necrosis. J Immunol 2006; 176: 3707–3716.
  Article CAS PubMed Google Scholar
• Wong KW, Jacobs Jr WR . Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis. Cell Microbiol 2011; 13: 1371–1384.
  Article CAS PubMed PubMed Central Google Scholar
• Welin A, Eklund D, Stendahl O, Lerm M . Human macrophages infected with a high burden of ESAT-6-expressing M. tuberculosis undergo caspase-1- and cathepsin B-independent necrosis. PLoS One 2011; 6: e20302.
  Article CAS PubMed PubMed Central Google Scholar
• Carneiro LA, Travassos LH, Soares F, Tattoli I, Magalhaes JG, Bozza MT et al. Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe 2009; 5: 123–136.
  Article CAS PubMed Google Scholar
• Zhao YO, Khaminets A, Hunn JP, Howard JC . Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathog 2009; 5: e1000288.
  Article PubMed PubMed Central CAS Google Scholar
• Kuwae A, Matsuzawa T, Ishikawa N, Abe H, Nonaka T, Fukuda H et al. BopC is a novel type III effector secreted by Bordetella bronchiseptica and has a critical role in type III-dependent necrotic cell death. J Biol Chem 2006; 281: 6589–6600.
  Article CAS PubMed Google Scholar
• Stockbauer KE, Foreman-Wykert AK, Miller JF . Bordetella type III secretion induces caspase 1-independent necrosis. Cell Microbiol 2003; 5: 123–132.
  Article CAS PubMed Google Scholar
• Hentze H, Lin XY, Choi MS, Porter AG . Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. Cell Death Differ 2003; 10: 956–968.
  Article CAS PubMed Google Scholar
• Takeuchi O, Akira S . Pattern recognition receptors and inflammation. Cell 2010; 140: 805–820.
  Article CAS PubMed Google Scholar
• Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K et al. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol 2002; 169: 6668–6672.
  Article CAS PubMed Google Scholar
• Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T . TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 2003; 4: 161–167.
  Article CAS PubMed Google Scholar
• Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 2004; 5: 503–507.
  Article CAS PubMed Google Scholar
• Kalai M, Van Loo G, Vanden Berghe T, Meeus A, Burm W, Saelens X et al. Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA. Cell Death Differ 2002; 9: 981–994.
  Article CAS PubMed Google Scholar
• Csak T, Dolganiuc A, Kodys K, Nath B, Petrasek J, Bala S et al. Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. Hepatology 2011; 53: 1917–1931.
  Article CAS PubMed Google Scholar
• Ma Y, Temkin V, Liu H, Pope RM . NF-kappaB protects macrophages from lipopolysaccharide-induced cell death: the role of caspase 8 and receptor-interacting protein. J Biol Chem 2005; 280: 41827–41834.
  Article CAS PubMed Google Scholar
• Lalanne AI, Moraga I, Hao Y, Pereira JP, Alves NL, Huntington ND et al. CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism. J Immunol 2010; 184: 5678–5685.
  Article CAS PubMed Google Scholar
• Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004; 5: 730–737.
  Article CAS PubMed Google Scholar
• Gitlin L, Barchet W, Gilfillan S, Cella M, Beutler B, Flavell RA et al. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci USA 2006; 103: 8459–8464.
  Article CAS PubMed PubMed Central Google Scholar
• Balachandran S, Thomas E, Barber GN . A FADD-dependent innate immune mechanism in mammalian cells. Nature 2004; 432: 401–405.
  Article CAS PubMed Google Scholar
• Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J et al. TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 2008; 28: 651–661.
  Article CAS PubMed Google Scholar
• Rajput A, Kovalenko A, Bogdanov K, Yang SH, Kang TB, Kim JC et al. RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity 2011; 34: 340–351.
  Article CAS PubMed Google Scholar
• Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007; 448: 501–505.
  Article CAS PubMed Google Scholar
• Kaiser WJ, Upton JW, Mocarski ES . Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors. J Immunol 2008; 181: 6427–6434.
  Article CAS PubMed Google Scholar
• Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K et al. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep 2009; 10: 916–922.
  Article CAS PubMed PubMed Central Google Scholar
• Kono H, Chen CJ, Ontiveros F, Rock KL . Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest 2010; 120: 1939–1949.
  Article CAS PubMed PubMed Central Google Scholar
• Cavassani KA, Ishii M, Wen H, Schaller MA, Lincoln PM, Lukacs NW et al. TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med 2008; 205: 2609–2621.
  Article CAS PubMed PubMed Central Google Scholar
• Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest 2009; 119: 305–314.
  CAS PubMed PubMed Central Google Scholar
• Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci USA 2009; 106: 20388–20393.
  Article CAS PubMed PubMed Central Google Scholar
• Yu M, Wang H, Ding A, Golenbock DT, Latz E, Czura CJ et al. HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 2006; 26: 174–179.
  Article CAS PubMed Google Scholar
• Kariko K, Ni H, Capodici J, Lamphier M, Weissman D . mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 2004; 279: 12542–12550.
  Article CAS PubMed Google Scholar
• Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464: 104–107.
  Article CAS PubMed PubMed Central Google Scholar
• Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, Jahn H et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 2009; 10: 266–272.
  Article PubMed CAS Google Scholar
• Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES . AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009; 458: 509–513.
  Article CAS PubMed PubMed Central Google Scholar
• Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009; 458: 514–518.
  Article CAS PubMed PubMed Central Google Scholar
• Mariathasan S, Weiss DS, Newton K, McBride J, O’Rourke K, Roose-Girma M et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006; 440: 228–232.
  Article CAS PubMed Google Scholar
• Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J . Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006; 440: 237–241.
  Article CAS PubMed Google Scholar
• Muruve DA, Petrilli V, Zaiss AK, White LR, Clark SA, Ross PJ et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008; 452: 103–107.
  Article CAS PubMed Google Scholar
• Schroder K, Tschopp J . The inflammasomes. Cell 2010; 140: 821–832.
  Article CAS PubMed Google Scholar
• Lamkanfi M . Emerging inflammasome effector mechanisms. Nat Rev Immunol 2011; 11: 213–220.
  Article CAS PubMed Google Scholar
• Tezel G, Yang X . Caspase-independent component of retinal ganglion cell death, in vitro. Invest Ophthalmol Vis Sci 2004; 45: 4049–4059.
  Article PubMed Google Scholar
• Vanlangenakker N, Berghe TV, Krysko DV, Festjens N, Vandenabeele P . Molecular mechanisms and pathophysiology of necrotic cell death. Curr Mol Med 2008; 8: 207–220.
  Article CAS PubMed Google Scholar
• Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002; 297: 259–263.
  Article CAS PubMed Google Scholar
• Fiorillo C, Ponziani V, Giannini L, Cecchi C, Celli A, Nassi N et al. Protective effects of the PARP-1 inhibitor PJ34 in hypoxic-reoxygenated cardiomyoblasts. Cell Mol Life Sci 2006; 63: 3061–3071.
  Article CAS PubMed Google Scholar
• Xu X, Chua KW, Chua CC, Liu CF, Hamdy RC, Chua BH . Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury. Brain Res 2010; 1355: 189–194.
  Article CAS PubMed PubMed Central Google Scholar
• Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC et al. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res 2010; 88: 1569–1576.
  CAS PubMed PubMed Central Google Scholar
• Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L et al. Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol 2004; 24: 5914–5922.
  Article CAS PubMed PubMed Central Google Scholar
• Kim S, Dayani L, Rosenberg PA, Li J . RIP1 kinase mediates arachidonic acid-induced oxidative death of oligodendrocyte precursors. Int J Physiol Pathophysiol Pharmacol 2010; 2: 137–147.
  CAS PubMed PubMed Central Google Scholar
• Xu X, Chua CC, Kong J, Kostrzewa RM, Kumaraguru U, Hamdy RC et al. Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem 2007; 103: 2004–2014.
  Article CAS PubMed Google Scholar
• Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005; 434: 658–662.
  Article CAS PubMed Google Scholar
• Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H et al. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 2005; 434: 652–658.
  Article CAS PubMed Google Scholar
• Lim SY, Davidson SM, Mocanu MM, Yellon DM, Smith CC . The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore. Cardiovas Drug Ther 2007; 21: 467–469.
  Article CAS Google Scholar
• Loukili N, Rosenblatt-Velin N, Li J, Clerc S, Pacher P, Feihl F et al. Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo. Cardiovasc Res 2011; 89: 586–594.
  Article CAS PubMed Google Scholar
• Xu X, Chua CC, Zhang M, Geng D, Liu CF, Hamdy RC et al. The role of PARP activation in glutamate-induced necroptosis in HT-22 cells. Brain Res 2010; 1343: 206–212.
  Article CAS PubMed Google Scholar
• Martin LJ . An approach to experimental synaptic pathology using green fluorescent protein-transgenic mice and gene knockout mice to show mitochondrial permeability transition pore-driven excitotoxicity in interneurons and motoneurons. Toxicol Pathol 2011; 39: 220–233.
  Article CAS PubMed Google Scholar
• Li Y, Yang X, Ma C, Qiao J, Zhang C . Necroptosis contributes to the NMDA-induced excitotoxicity in rat's cultured cortical neurons. Neurosci Lett 2008; 447: 120–123.
  Article CAS PubMed Google Scholar
• Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB . Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 2004; 18: 1272–1282.
  Article CAS PubMed PubMed Central Google Scholar
• Los M, Mozoluk M, Ferrari D, Stepczynska A, Stroh C, Renz A et al. Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell 2002; 13: 978–988.
  Article CAS PubMed PubMed Central Google Scholar
• Jurewicz A, Matysiak M, Tybor K, Kilianek L, Raine CS, Selmaj K . Tumour necrosis factor-induced death of adult human oligodendrocytes is mediated by apoptosis inducing factor. Brain 2005; 128 (Part 11): 2675–2688.
  Article PubMed Google Scholar
• Ha HC, Snyder SH . Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci USA 1999; 96: 13978–13982.
  Article CAS PubMed PubMed Central Google Scholar
• Xu Y, Huang S, Liu ZG, Han J . Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem 2006; 281: 8788–8795.
  Article CAS PubMed Google Scholar
• Bertrand MJ, Vandenabeele P . The Ripoptosome: death decision in the cytosol. Mol Cell 2011; 43: 323–325.
  Article CAS PubMed Google Scholar
• Vantieghem A, Assefa Z, Vandenabeele P, Declercq W, Courtois S, Vandenheede JR et al. Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis. FEBS Lett 1998; 440: 19–24.
  Article CAS PubMed Google Scholar
• Buytaert E, Dewaele M, Agostinis P . Molecular effectors of multiple cell death pathways initiated by photodynamic therapy. Biochim Biophys Acta 2007; 1776: 86–107.
  CAS PubMed Google Scholar
• Mikes J, Kleban J, Sackova V, Horvath V, Jamborova E, Vaculova A et al. Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. Photochem Photobiol Sci 2007; 6: 758–766.
  Article CAS PubMed Google Scholar
• Davids LM, Kleemann B, Kacerovska D, Pizinger K, Kidson SH . Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. J Photochem Photobiol B 2008; 91: 67–76.
  Article CAS PubMed Google Scholar
• Coupienne I, Fettweis G, Piette J . RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. Lasers Surg Med 2011; 43: 557–564.
  Article PubMed Google Scholar
• Schildkopf P, Frey B, Mantel F, Ott OJ, Weiss EM, Sieber R et al. Application of hyperthermia in addition to ionizing irradiation fosters necrotic cell death and HMGB1 release of colorectal tumor cells. Biochem Biophys Res Commun 2010; 391: 1014–1020.
  Article CAS PubMed Google Scholar
• Mantel F, Frey B, Haslinger S, Schildkopf P, Sieber R, Ott OJ et al. Combination of ionising irradiation and hyperthermia activates programmed apoptotic and necrotic cell death pathways in human colorectal carcinoma cells. Strahlenther Onkol 2010; 186: 587–599.
  Article PubMed Google Scholar
• Newton K, Sun X, Dixit VM . Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol 2004; 24: 1464–1469.
  Article CAS PubMed PubMed Central Google Scholar
• Cho Y, McQuade T, Zhang H, Zhang J, Chan FK . RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS ONE 2011; 6: e23209.
  Article CAS PubMed PubMed Central Google Scholar
• Zhu S, Zhang Y, Bai G, Li H . Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease. Cell Death Dis 2011; 2: e115.
  Article CAS PubMed PubMed Central Google Scholar
• Micheau O, Tschopp J . Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003; 114: 181–190.
  Article CAS PubMed Google Scholar