original ) (raw )Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro
Peter Roughley
Biochemical Journal, 1999
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Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation
Robert Newton
Annals of the New York Academy of Sciences, 1999
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Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments1
André Struglics
Osteoarthritis and Cartilage, 2006
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Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage
Peter Roughley
Osteoarthritis and Cartilage, 2008
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The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism
John Mort
Biochemical Journal, 2002
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Recombinant Human Aggrecan G1-G2 Exhibits Native Binding Properties and Substrate Specificity for Matrix Metalloproteinases and Aggrecanase
Karena Last
Journal of Biological Chemistry, 1999
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A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs
Peter Mitchell
Osteoarthritis and Cartilage, 2010
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The cleavage of biglycan by aggrecanases
Peter Roughley
Osteoarthritis and Cartilage, 2006
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Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants
Karena Last
2000
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The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis
John Sandy
Arthritis & Rheumatism, 1993
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Cleavage of the Carboxyl Tail from the G3 Domain of Aggrecan but Not Versican and Identification of the Amino Acids Involved in the Degradation
Burton Yang
Journal of Biological Chemistry, 2002
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Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay
David Buttle
Molecular Pathology, 1997
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The Interglobular Domain of Cartilage Aggrecan Is Cleaved by Hemorrhagic Metalloproteinase HT-d (Atrolysin C) at the Matrix Metalloproteinase and Aggrecanase Sites
Jay Fox
Journal of Biological Chemistry, 1998
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Aggrecan Turnover in Human Articular Cartilage: Use of Aspartic Acid Racemization as a Marker of Molecular Age
Nathali Kaushansky
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Soluble Recombinant Neprilysin Induces Aggrecanase-Mediated Cleavage of Aggrecan in Cartilage Explant Cultures
Caroline Hoemann
Archives of Biochemistry and Biophysics, 2001
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Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity
André Struglics
Arthritis research & therapy, 2017
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The role of aggrecan in normal and osteoarthritic cartilage
John Mort
Journal of Experimental Orthopaedics, 2014
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Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage
Peter Roughley
European cells & materials
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Coincubation of Bovine Synovial or Capsular Tissue with Cartilage Generates a Soluble “Aggrecanase” Activity
David Buttle
Biochemical and Biophysical Research Communications, 1999
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Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
Karena Last
FEBS Letters, 1996
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Variations in aggrecan structure modulate its susceptibility to aggrecanases
John Mort , Peter Roughley
Biochemical Journal, 2003
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Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
Demitrios Vynios
The Biochemical journal, 1996
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A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid
André Struglics
Matrix Biology, 2010
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TIMP-3 Inhibition of ADAMTS-4 (Aggrecanase-1) Is Modulated by Interactions between Aggrecan and the C-terminal Domain of ADAMTS-4
Augustin Amour
Journal of Biological Chemistry, 2007
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Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy
Laurel Ng , John Sandy
Journal of Structural Biology, 2003
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Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown
Corinne Gendron
Arthritis Research Therapy, 2005
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Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage
Karena Last
Nature Protocols, 2011
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Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study
André Struglics
Arthritis Research & Therapy, 2009
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MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
Peter Roughley
Matrix Biology, 2011
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Western blot quantification of aggrecan fragments in human synovial fluid indicates differences in fragment patterns between joint diseases
André Struglics
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 2009
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The Folded Modules of Aggrecan G3 Domain Exert Two Separable Functions in Glycosaminoglycan Modification and Product Secretion
Burton Yang
Journal of Biological Chemistry, 2001
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ELISA for the core protein of the cartilage large aggregating proteoglycan, aggrecan: Comparison with the concentrations of immunogenic keratan sulphate in synovial fluid, serum and urine
Jens-christian Poulsen
Clinica Chimica Acta, 1994
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Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site
Peter Roughley
Arthritis research & therapy, 2006
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Metalloproteinase digestion of cartilage proteoglycan. Pattern of cleavage by stromelysin and susceptibility to collagenase
Tim Hardingham
1991
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