HSP Research Papers - Academia.edu (original) (raw)

Sensory-Processing Sensitivity (SPS), as the main component of the Highly Sensitive Person Scale, is regarded as a biological predispositon for a strategy of pausing before acting. There seem to be two components moderating this strategy... more

Sensory-Processing Sensitivity (SPS), as the main component of the Highly Sensitive Person Scale, is regarded as a biological predispositon for a strategy of pausing before acting. There seem to be two components moderating this strategy in humans: a stronger bond between impressions and emotions, and a deeper cognitive processing connected with extraction of meaning. While the effect of higher emotionality has been studied extensively over the years, the implications of the extraction of meaning have been neglected. In order to get a more complete picture of SPS, it is important to understand the implications of an inclination towards a more frequent and deeper extraction of meaning. A trait which is conceptually very close to this aspect of SPS is self-transcendence, which has been described as an innate desire of search for meaning. This thesis aims to contribute to the research in three ways: First, the concepts of SPS and self-transcendence are reviewed. Second, a theoretical framework for a junction of both concepts is proposed. Third, an outlook on the further study of the meaning extraction aspect of SPS is given.

Chicken has been selected for higher production performance over the years and are highly sensitive to changes in their environment. The average global temperature has increased over the century and is further expected to rise. In open... more

Chicken has been selected for higher production performance over the years and are highly sensitive to changes in their environment. The average global temperature has increased over the century and is further expected to rise. In open house rearing system chicken is vulnerable to this increasing environmental temperature and may experience thermal stress. Heat shock proteins (HSP) are highly conserved family of proteins playing important role in normal cellular physiology and cytoprotection against different stressors including heat stress. In chicken levels of different members of HSP family are increased in almost all the tissues in response to heat stress. This increased HSP level protects cellular proteins from heat stress induced damage. Efforts to overcome the heat stress conditions in chicken have lead to development of thermal manipulation protocols whereby epigenetic modifications are introduced. Through epigenetic adaptation the birds acquire protection against the adverse effects of heat stress. This chapter discusses the findings on cellular HSP responses to heat stress and the thermal manipulation strategy to overcome heat stress in chicken.

Abstract. Background: Heat shock proteins (Hsps) assist other proteins in their folding and drive the degradation of defective proteins. During evolution, these proteins have also acquired other roles. Hsp10 is involved in... more

Abstract. Background: Heat shock proteins (Hsps) assist other
proteins in their folding and drive the degradation of defective
proteins. During evolution, these proteins have also acquired
other roles. Hsp10 is involved in immunomodulation and tumor
progression. Hsp90 stabilizes a range of “client” proteins
involved in cell signaling. The present study evaluated the
expression levels of Hsp10 and Hsp90 in normal mucosa and
adenocarcinoma samples of human large bowel. Materials and
Methods: Samples of normal mucosa and adenocarcinoma were
collected and Reverse transcriptase-polymerase chain reaction
RT-PCR, western blotting (WB) analyses, as well as
immunohistochemistry were performed to evaluate the expression
levels of Hsp10 and Hsp90. Results: RT-PCR showed a higher
gene expression of Hsp10 and Hsp90 in adenocarcinoma samples
compared to healthy mucosa. WB results confirmed these
findings. Immunohistochemistry revealed higher levels of Hsp10
in adenocarcinoma in both the epithelium and the lamina
propria, while Hsp90 expression was higher in the adenocarcinoma
samples only in the lamina propria. Conclusion:
Hsp10 and Hsp90 may be involved in large bowel carcinogenesis

Ususret obilježavanju 119. obljetnice smrti dr. Ante Starčevića, u organizaciji Hrvatske stranke prava dr. Ante Starčević (HSP AS) otvorena je, u suradnji sa Narodnim m u z e j o m Z a d a r i Z n a n s t v e n o m knjižnicom Zadar, u... more

Ususret obilježavanju 119. obljetnice smrti dr. Ante Starčevića, u organizaciji Hrvatske stranke prava dr. Ante Starčević (HSP AS)
otvorena je, u suradnji sa Narodnim m u z e j o m Z a d a r i Z n a n s t v e n o m knjižnicom Zadar, u prostorijama Gradske lože u Zadru 20. veljače 2015. izložba slika, postera, knjiga, arhivskog, filatelističkog, numizmatičkog i ostalog kolekcionarskog materijala pod nazivom Dr. Ante Starčević –
Otac domovine. Među nizom zanimljivih se izložaka posebno isticala vojna oznaka za rukav pod eponimnim imenom Brigada dr. Ante Starčević – Gornji Vakuf.

In this paper, we propose a hetero-spacer- dielectric (HSP) double-gate junctionless transistor (DGJLT with high-k spacer towards source side and low-k spacer towards drain side to enhance analog performance at high... more

In this paper, we propose a hetero-spacer- dielectric (HSP) double-gate junctionless transistor (DGJLT with high-k spacer towards source side and low-k spacer towards drain side to enhance analog performance at high drain voltages. The characteristics are revealed through extensive device simulations and compared with other DGJLTs, formed by taking all possible combinations of low-k and high-k spacer dielectrics on both sides of gate. The proposed HSP DGJLT gives superior values of drain current (ID), transconductance (Gm), early voltage (VEA) and intrinsic gain (GmRo) compared to other DGJLTs at high drain voltages. Simulations reveal an improvement of early voltage and intrinsic gain by 45.95% and 14.83% respectively compared to conventional DGJLT having low-k spacer dielectric on both sides of gate. However, unity gain cut-off frequency (fT) of HSP DGJLT decreases by 23.49% due to its high gate capacitance.

The starting point for this model is the resemblance and overlap of many mental problems ranging from ADHD to ASD as well as their frequent comorbidities, such as social anxiety, sensory processing disorder and depression. The objective... more

The starting point for this model is the resemblance and overlap of many mental problems ranging from ADHD to ASD as well as their frequent comorbidities, such as social anxiety, sensory processing disorder and depression. The objective is to unify different models of neurodiversity. Thom Hartmann's hunter-hypothesis for ADHD is widely known. Its core idea is that people with ADHD have a different type of cognition, in particular attention focus. While early farmers had to be able to focus on long routine work, hunter-gatherers were better off with a "radar mind", that hyperfocused when, say, a deer was spotted. The difference is, therefore, bouts of hyperfocus on high-interest objects vs constant focus on boring routine work. This hyperfocus can also be observed in people with ASD when they engage with their special interest, as well as in gifted and highly intelligent people, who tend to reflect much longer on unexplainable phenomena than neurotypicals.

Thermal manipulation during embryogenesis has been shown to improve thermo tolerance in broilers. Heat shock proteins are a family of proteins produced in response to variety of stress and protect cells from damage. The aim of this study... more

Thermal manipulation during embryogenesis has been shown to improve thermo tolerance in broilers. Heat shock proteins are a family of proteins produced in response to variety of stress and protect cells from damage. The aim of this study was to evaluate the effect of thermal manipulation (TM) during embryogenesis on HSP gene and protein expression in the embryos and in chronic heat stressed 42nd day old chicks. On 15th day of incubation, fertile eggs from two breeds-Naked neck (NN) and Punjab Broiler-2 (PB-2) were randomly divided in to two groups, namely Control (C) eggs were incubated under standard incubation conditions and Thermal Conditioning (TC) eggs were exposed to higher incubation temperature (40.5 °C) for 3 h on 15th, 16th and 17th day of incubation. The chicks so obtained from each group were further subdivided and reared from 15th–42nd day as normal (N; 257 1 °C, 70% RH) and heat exposed (HE; 357 1 °C, 50% RH) resulting in four treatment groups (CN, CHE, TCN and TCHE). Embryos of two groups (C and TC) on 17th day and birds from four treatment groups on 42nd day were sacrificed. Liver was collected for analysis of gene expression by real-time PCR and protein expression by Western blot of Heat Shock Proteins (HSP 90 alpha, HSP 90 beta, HSP 70, HSP 60, HSP 27 and ubiquitin). The plasma collected on 42nd day was analyzed for biochemical parameters. Thermal challenging of embryos of both the breeds caused significant (Pr 0.05) increase in all the HSPs gene and protein expression. The TCHE chicks had significantly (Pr 0.05) lower HSPs gene and protein expressions and oxidative stress compared to CHE groups in both NN and PB-2. Based on these findings it can be concluded that TM during incubation provides adaptation to broiler chicks during chronic heat stress.

The hereditary spastic paraplegias are a group of genetically heterogeneous neurodegenerative disorders, characterized by progressive spasticity and weakness of the lower limbs. Although conventional brain MR imaging findings are normal... more

The hereditary spastic paraplegias are a group of genetically heterogeneous neurodegenerative disorders, characterized by progressive spasticity and weakness of the lower limbs. Although conventional brain MR imaging findings are normal in patients with pure hereditary spastic paraplegia, microstructural alteration in the cerebral WM can be revealed with DTI. Concomitant investigation of multiple intrinsic diffusivities may shed light on the neurobiologic substrate of the WM degeneration pattern in patients with pure hereditary spastic paraplegia across the whole brain. Tract-based spatial statistics analysis was performed to compare fractional anisotropy and mean, axial, and radial diffusivities of the WM skeleton in a group of 12 patients with pure hereditary spastic paraplegia and 12 healthy volunteers. Data were analyzed counting age and sex as nuisance covariates. The threshold-free cluster-enhancement option was applied, and the family-wise error rate was controlled by using p...

Plasmodium falciparum iron regulatory-like protein (PfIRPa) has homology to both mammalian iron regulatory proteins and aconitases and is capable of binding RNA iron response elements. We examined the subcellular localization of PfIRPa... more

Plasmodium falciparum iron regulatory-like protein (PfIRPa) has homology to both mammalian iron regulatory proteins and aconitases and is capable of binding RNA iron response elements. We examined the subcellular localization of PfIRPa and its enzymatic properties at low oxygen tension. Differential digitonin permeabilization of isolated trophozoites with subsequent Western blot analysis suggests that the localization of PfIRPa is predominantly in the membranous compartments of the parasite, such as the mitochondrion. Immunofluorescence analysis showed that PfIRPa colocalizes with heat shock protein 60 (Hsp60), a mitochondrial marker, and is also present in the parasitic cytosol/food vacuole. Under conditions favoring the formation of an iron-sulfur cluster, recombinant PfIRPa (rPfIRPa) had aconitase activity as detected by a colorimetric NADPH-MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay. As assessed by the hydration of cis-aconitate spectrophotometr...

The 63- kDa antigen of Leishmania donovani is a membrane-anchored matrix metalloprotease that has been shown to be involved in the infection process. We have shown that this antigen alone generates a Th1 type of protective response that... more

The 63- kDa antigen of Leishmania donovani is a membrane-anchored matrix metalloprotease that has been shown to be involved in the infection process. We have shown that this antigen alone generates a Th1 type of protective response that is partial but when the animals are primed with the antigen along with the Hsp70, the level of protection is raised significantly, which is demonstrated by a considerable reduction in parasite load of immunized animals when compared to the infected controls. Delayed-type hypersensitivity responses to leishmanin were measured as an index of cell-mediated immune response and were found to be higher in immunized animals when compared to the infected controls, the maximum being in the animals immunized with cocktail of both the antigens. Maximum IgG2a and minimum IgG1 levels were observed in this group of animals. These animals also generated maximum levels of IFN-γ and IL-2 and minimum levels of IL-4 and IL-10 pointing towards the generation of a protective Th1 response and the suppression of the Th2 type of immune response.