Laboratory Mice Research Papers - Academia.edu (original) (raw)

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- Psychopharmacology, Sequence Analysis, Behavioural Analysis Tools, Dendrograms
- by Paul F Brain
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- Castration, Predation, Social Conflict, Males
- by Paul F Brain
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- Animal reproduction, Ambient Temperature, Laboratory Mice, Nest Building
- by Paul F Brain
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- Aggressive Behavior, ACTH, Low Doses, Laboratory Mice

Introduction: There is not much data on parasitic infections of laboratory animals that are kept in conventional conditions in Iran. The present study was designed to investigate intestinal helminths infections in laboratory colonies of rats and mice. Methods: Droppings from 110 mice and 110 rats (each animal one dropping) belonging to experimental and breeding groups in four animal houses were collected. Experimental groups were being used in biomedical researches and breeding groups were not under any experiment. The droppings were preserved in formaldehyde 10% individually and examined by microscopy with 10x magnification. Results: Out of 220 droppings examined, 96 (43.6%) harbored helminths eggs; 53 (48.1%) belonged to mice and 43 (39.09%) to rats. Four helminthes species including, Syphacia obvelata, Syphasia muris, Hymenolepis nana, and Hetrakis spumosa were identified in the both animals, while Aspicularis tetraptera was merely seen in mice. H. nana was the most frequent helminth infection in mice and rats and infection with H. spumosa and A. tetraptera, showed the lowest rates in droppings of mice and rats, respectively. Mixed infections with ≥ two species was observed in 21 (9.5%) of 220 droppings, 14 (12.7%) belonged to mice and 7 (6.3%) to rats. Conclusion: The present results emphasizes more careful monitoring in laboratory animal houses, such as improving the cleaning and ventilating systems as well as adopting therapeutic measures, when required.

- by JoMMID Journal
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- Iran, Helminth, Rat, Laboratory Mice
- by Paul F Brain and +1
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- Aggression (Psychology), Diazepam, Laboratory Mice, Neonatal treatment
- by Paul F Brain
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- Aggression (Psychology), Social Defeat, Males, Winning

Bite targets on opponents used by individually housed male, reproductively experienced male and lacta-ting female subjects from outbred TO and Swiss Webster and inbred NZW/Ola, BALB/c, C57BL/10, DBA/2, CBA/Ca and C3H/He lines of mice were assessed. Ten-minute videotaped encounters with anos-mic male TO or " congenic " opponents were used for this purpose. In general, the attacks shown by males appeared 'ritualised' with the head and ventral surface of the opponent being avoided. The lactating females showed no such inhibition. The intensity and incidence (and damaging nature of the attacks) was clearly influenced by strain of the resident, its sex, its reproductive experience and (in some cases) the nature of the opponent. This data may be helpful in controlling social stress in mouse studies.

- by Paul F Brain
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- Aggression (Psychology), Defense, Inbred Strains, Offence
- by Paul F Brain
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- Group housing, Males, Elevated Plus Maze, Clozapine
- by Dietmar Weinert
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- Thermoregulation, Methodology, Circadian Rhythms, Biological Sciences
- by Dietmar Weinert
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- Chronobiology, Aging, Treatment, Biological Sciences
- by Paul F Brain
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- Aggressive Behavior, Females, Males, ACTH
- by Paul F Brain
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- Alcohol, Ethanol, Group housing, Males
- by Paul F Brain
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- Sex Differences, Laboratory Mice, Motor activity, Dopamine antagonists
- by Paul F Brain
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- Female, Agonistic, Laboratory Mice, Anxiolytic effects
- by Larraitz Garmendia and +2
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- Clozapine, Laboratory Mice, Motor activity, Antiaggressive effect
- by Paul F Brain
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- Social behavior in animals, Laboratory Mice, Chlordiazepoxide, Genetic lines
- by Hans Haltmeier and +1
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- Aggressive Behavior, Testosterone, Females, Oestradiol
- by Paul F Brain
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- Aggressive Behavior, Group housing, Social Dominance, Laboratory Mice
- by Paul F Brain
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- Risk Aversion, Open Field, Emotionality, Hole in the Wall
- by Paul F Brain
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- Aggression (Psychology), Females, Males, Laboratory Mice

Membrane fatty acid (FA) composition is
correlated with longevity in mammals. The “membrane
pacemaker hypothesis of ageing” proposes that
animals which cellular membranes contain high
amounts of polyunsaturated FAs (PUFAs) have shorter
life spans because their membranes are more susceptible
to peroxidation and further oxidative damage. It
remains to be shown, however, that long-lived phenotypes
such as the Ames dwarf mouse have membranes
containing fewer PUFAs and thus being less prone to
peroxidation, as would be predicted from the membrane
pacemaker hypothesis of ageing. Here, we show
that across four different tissues, i.e., muscle, heart,
liver and brain as well as in liver mitochondria, Ames
dwarf mice possess membrane phospholipids
containing between 30 and 60 % PUFAs (depending
on the tissue), which is similar to PUFA contents of
their normal-sized, short-lived siblings. However, we
found that that Ames dwarf mice membrane phospholipids
were significantly poorer in n-3 PUFAs. While
lack of a difference in PUFA contents is contradicting
the membrane pacemaker hypothesis, the lower n-3
PUFAs content in the long-lived mice provides some
support for the membrane pacemaker hypothesis of
ageing, as n-3 PUFAs comprise those FAs being
blamed most for causing oxidative damage. By comparing
tissue composition between 1-, 2- and 6-monthold
mice in both phenotypes, we found that membranes
differed both in quantity of PUFAs and in the
prevalence of certain PUFAs. In sum, membrane composition
in the Ames dwarf mouse supports the concept
that tissue FA composition is related to longevity.

- by Teresa G . Valencak
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- Lipid peroxidation, Fatty Acid Compositions, Ames Dwarf Mouse, Membrane Phospholipids
- by Paul Brain
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- Stress, Territoriality, Aggressive Behavior, Males
- by Michael McClelland
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- Engineering, Physics, Chemistry, Comparative Genomics
- by Teresa G . Valencak
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- Phospholipids, Oxidative Stress, Biological Sciences, Longevity
- by Paul F Brain
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- Aggressive Behavior, Attachment, Opioid Pharmacology, Laboratory Mice
- by HAUG Marc and +1
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- Aggressive Behavior, Females, Group housing, Males
- by Paul F Brain
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- Prenatal and Perinatal Psychology, Neurochemistry, Social behavior in animals, Laboratory Mice
- by HAUG Marc and +1
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- Aggressive Behavior, Defense, Females, Laboratory Mice
- by Paul F Brain
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- Aggressive Behavior, Females, Diazepam, Laboratory Mice
- by Paul F Brain
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- Prenatal and Perinatal Psychology, Social behavior in animals, Benzodiazepines, Early development
- by Yousif Yacob Yousif and +1
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- Infanticide, Genotype, Laboratory Mice, Intrauterine location
- by HAUG Marc and +1
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- Aggressive Behavior, Psychoactive Drugs, Males, Laboratory Mice
- by Paul F Brain
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- Sequence Analysis, Aggressive Behavior, Endogenous Opioid Peptides, Laboratory Mice
- by HAUG Marc and +1
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- Aggressive Behavior, Castration, Females, Group housing
- by Paul F Brain and +1
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- Aggressive Behavior, Males, Social Dominance, Laboratory Mice
- by Paul F Brain
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- Aggression, Androgens, Group housing, Males
- by Paul F Brain
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- Aggression (Psychology), Adulthood, Neonatal, Males
- by Paul F Brain
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- Digenea, Testosterone, Castration, Disease resistance
- by Paul F Brain
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- Aggression (Psychology), Testosterone, Females, Group housing
- by Paul F Brain
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- Aggressive Behavior, Laboratory Mice, Male Mice, Female Mice