Tritium Research Papers - Academia.edu (original) (raw)

The active ingredient of marijuana is(−)-Δ 9 -tetrahydrocannabinol(Δ 9 -THC).Δ 9 -THC and other natural and synthetic cannabinoids such as CP-55, 940 inhibit spontaneous activity and produce catalepsy in animals in a receptor-mediated... more

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- Cognitive Science, Chemistry, Kinetics, Medicine

Troxacitabine (Troxatyl; BCH-4556; (-)-2'-deoxy-3'-oxacytidine), a deoxycytidine analogue with an unusual dioxolane structure and nonnatural L-configuration, has potent antitumor activity in animal models and is in clinical... more

- by John Mackey
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- Clinical Trial, Cancer, Membrane Proteins, Prostate Cancer
- by Matthew Meselson
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- Multidisciplinary, Nature, Cellulose, Magnesium
- by Marcel Bergeron
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- Water Supply, Ground Water, Drinking Water, Conceptual Model
- by Conway Chang
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- Biochemistry, Plants, Oxygen Isotopes, Enzyme
- by Peter Duesberg
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- Virology, Biological Sciences, Carbon Isotopes, Animals
- by Gustavo Aguirre
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- Biological Sciences, Dogs, Female, Animals
- by Zaida Diaz-cabiale and +1
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- Cognitive Science, Oxytocin, Brain, Blood Pressure

The ability of stationary-phase cells of Escherichia coli W7 to incorporate radioactive precursorsinto macromolecular murein has been studied. During the initial 6 h of the stationary phase, resting cells incorporated... more

- by Antonio Pisabarro
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- Chemistry, Bacteriology, Kinetics, Biology

The aim of this study was to investigate the possible involvement of the glutamatergic system in the toxicity of organochalcogens, since this is an important neurotransmitter system for signal transduction and neural function. The results... more

- by João Batista
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- Cognitive Science, Signal Transduction, Glutamate, Brain
- by Apostolos Armaganidis
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- Adolescent, Pulmonary Hypertension, Humans, Capillaries
- by David Comings
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- RNA, Transmission Electron Microscopy, DNA, Mice
- by Michael Marletta
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- Chemistry, Organic Chemistry, Medicine, Nitric oxide
- by Beatriz Schaan
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- Enzyme Inhibitors, Autonomic Nervous System, Insulin Resistance, Diabetes mellitus
- by Juan Lopez-Gimenez
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- Psychology, Neuropharmacology, In Situ Hybridization, Brain
- by Wenlin Sun
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- Life Sciences, Brain, Female, Animals
- by Willem G.e.j. Schoonen
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- Physiology, Zoology, STEROIDS, Testosterone
- by P. Toivanen
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- Cornea, Animals, Infection, Clinical Sciences
- by Gloria Muday
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- Botany, Genetics, Gene expression, Arabidopsis thaliana
- by Richard Kouzes
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- Physics, Well Logging, Helium, Neutron Detection
- by Ursula Bechert
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- Physiology, Zoology, Carnivora, Mammals
- by Dean Martin
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- Chemical Engineering, Kinetics, Biological Sciences, Animals
- by M. Cheatham
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- Hearing, Animals, Nicotinic Acetylcholine Receptors, Acetylcholine
- by Tahir Husain
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- Manganese, Dopamine, Brain, Animals

In the last decade, the physiology of cerebellar neurons and synapses has been extended to a considerable extent. We have found that the mossy fiber-granule cell relay can generate a complex form of long-term potentiation (mf-GrC LTP) following high-frequency mf discharge. Induction. Mf-GrC LTP depends on NMDA and mGlu receptor activation, intracellular Ca(2+) increase, PKC activation, and NO production. The preventative action of intracellular agents (BAPTA, PKC-inhibitors) and of membrane hyperpolarization, and the correlated increase in intracellular Ca(2+) observed using fluorescent dyes, indicate that induction occurs postsynaptically. Expression. Expression includes three components: (a) an increase of synaptic currents, (b) an increase of intrinsic excitability in GrC, and (c) an increase of intrinsic excitability in mf terminals. Based on quantal analysis, the EPSC increase is mostly explained by enhanced neurotransmitter release. NO is a candidate retrograde neurotransmitte...

- by Arianna Maffei
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- Psychology, Cognitive Science, Long Term Potentiation, Calcium
- by Eric Herlenius and +1
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- Endocrinology, Genetics, Cardiology, Hematology
- by Anton Hartmann and +1
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- Escherichia coli, Iron, European, Anti-Bacterial Agents
- by Miriam Melis and +2
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- Neurobiology Of Disease, Prefrontal Cortex, Glutamate receptors, Female
- by Paul Licht
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- Evolutionary Biology, Genetics, Zoology, Kinetics

... Robert J. Beller, Bernard D. Davis,* and Michael Gottlieb ... Since the overall equilibrium is sensitive to Mg2+, while the equilibrium between DF and derived 30s subunits is not (Zitomer and Flaks, 1972), the effect of Mgz'... more

- by Robert Beller
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- Biochemistry, Chemistry, Kinetics, Medicine
- by Agilan Veerasingam
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- Chemistry, Protein Purification, Chromatography, Polysaccharides

This paper describe the viability of nuclear battery for powering micro electromechanical system(MEMS) devices.The potential of a nuclear battery for longer shelf-life and higher energy density when compared with other modes of energy storage make them an attractive alternative to investigate. The public is familiar with nuclear energy in nuclear power plants but not in nuclear batteries. Nuclear batteries are in fact closer to nuclear power plants than traditional batteries in that they use radioactivity to generate power instead of storing an amount of charge. When compared to chemical batteries, nuclear batteries are characterized by higher volumetric energy density and stronger endurance in harsh conditions. This report will explore the present state of nuclear battery technology and its importance.

- by JASKARAN SINGH
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- Tritium, Nuclear Battery, Atomic Battery

Recent increased interest from regulators and the public has led more organizations to consider the environmental impact and safety considerations of tritium handling. Examples include the significance of the tritium isotope separation system on ITER licensing, remediation of ground water from power utilities and government facilities and concerns of high tritium concentrations within operational CANDU reactors.
GE Healthcare, formerly Amersham plc, has been producing tritium-labelled chemicals since the late 1940s. GE’s manufacturing site located near Cardiff, UK has installed a tritium waste treatment and enrichment facility to radically reduce tritium discharges to the environment. This facility employs a continuous processing plant that recovers tritium from a complex mixture of tritiated organic and aqueous waste compounds. Two isotope separation techniques are used to achieve a final pure tritium product, which is used in the manufacturing of labelled compounds.
Building upon this experience, together with Special Separations Applications Inc. (SSAI), GE has developed a large-scale diffusion-based isotope separation process as an alternative to conventional cryogenic distillation. Having a tritium inventory an order of magnitude lower than conventional cryogenic distillation, this process is attractive for heavy water detritiation, applicable to single and multi-unit CANDU reactors and research reactors as well as fusion applications. Additionally, the new process has advantages of being cryogen-free, less complex, simple to operate and having improved conventional and radiological safety.

- by Ian Bonnett and +1
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- Tritium

Integrating heavy water upgrading with detritiation in CANDU® stations has the potential to provide cost savings and simplicity in comparison to stations with separate heavy water upgrading and detritiation systems. This paper presents results of a concept study into alternative processes for managing heat transport and moderator system water quality, including a new non-cryogenic isotope separation process being developed by Special Separations Applications, Inc. (SSAI) and General Electric (GE) for tritium removal. Overview descriptions are presented for the process design and process characteristics are described.

- by Ian Bonnett and +1
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- Tritium
- by Steve Waldman
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- Organic Chemistry, Medicinal Chemistry, Animal Behavior, Hippocampus

We have recently determined that human multidrug resistance protein (MRP) 3, which confers resistance to certain natural product agents and methotrexate (MTX), is competent in the MgATP-energized transport of MTX and the monoanionic bile constituent glycocholate as well as several glutathione and glucuronate conjugates. Of these capabilities, the facility of MRP3 in conferring resistance to and mediating the transport of MTX is of particular interest because it raises the possibility that this pump is a component of the previously described cellular efflux system for this antimetabolite. However, if this is to be the case, a critical property of cellular MTX efflux that must be addressed is its ability to mediate the export of MTX but not that of its intracellular polyglutamylated derivatives. Here we examine the role of MRP3 in these and related processes by determining the selectivity of this transporter for MTX, MTX polyglutamates, and physiological folates. In so doing, we show ...

- by Philip Rea and +1
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- Cancer, Folic acid, Humans, Mice
- by Nissar Ahmad Wani
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- Kinetics, Immunohistochemistry, Transmission Electron Microscopy, Folic acid
- by Rainer Kuhn and +1
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- Endocrinology, Psychology, Cognitive Science, Kinetics
- by Patrick Cassidy
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- Kinetics, Multidisciplinary, Escherichia coli, Salmonella Typhimurium
- by Pierre Le Goff and +2
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- Water, Food Analysis, Biological Sciences, Environmental Sciences

The heavy water inventory of a typical PHWR constitutes about 12% of the capital cost of the PHWR. The typical tritium production in a single unit PHWR is about 2x106 Ci/y. Heavy water and tritium control are important aspects of PHWR operation, and this involves people, procedures, equipment and heavy water and tritium separation systems. Station personnel are trained to understand the importance of heavy water management and the economics and environmental impact of tritiated heavy water losses. The tritium and heavy water losses from a PHWR are both airborne and waterborne in nature.

- by Ian Bonnett and +1
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- Tritium
- by george ricaurte
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- Psychology, Cognitive Science, Psychopharmacology, Neuroimaging
- by Imara Perera and +1
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- Genetics, Plant Biology, Tobacco, Calcium
- by Anupam Bishayee
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- DNA damage, Animals, Lung, Electrons

The high affinity binding sites for the antidepressant desmethlyimipramine (DMI) have been localized in rat brain by quantitative autoradiography. There are high concentrations of binding sites in the locus ceruleus, the anterior ventral thalamus, the ventral portion of the bed nucleus of the stria terminalis, the paraventricular and the dorsomedial nuclei of the hypothalamus. The distribution of DMI binding sites is in striking accord with the distribution of norepinephrine terminals. Pretreatment of rats with the neurotoxin 6-hydroxydopamine, which causes a selective degeneration of catecholamine terminals, results in 60 to 90% decrease in DMI binding. These data support the idea that high affinity binding sites for DMI are located on presynaptic noradrenergic terminals.

- by Anat Biegon
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- Kinetics, Brain, Animals, Male
- by Marion Murray
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- Psychology, Optic Nerve, Animals, Fishes