Genome-wide association study identifies five new schizophrenia loci (original) (raw)
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Acknowledgements
We thank the study participants and the research staff at the many study sites. Over 40 US National Institutes of Health grants and similar numbers of government grants from other countries, along with substantial private and foundation support, enabled this work. We greatly appreciate the sustained efforts of T. Lehner (National Institute of Mental Health) on behalf of the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC). Detailed acknowledgments, including grant support, are listed in the Supplementary Note.
Author information
Author notes
- Maurice Jay, Virginia K Lasseter and Leena Peltonen: Deceased.
Authors and Affiliations
- Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
Stephan Ripke, Pamela Sklar, Lizzy Rossin, Douglas M Ruderfer, Sarah E Bergen & Mark J Daly - Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, Evanston, Illinois, USA
Alan R Sanders, Jubao Duan & Pablo V Gejman - Department of Psychiatry and Behavioral Sciences, University of Chicago, Chicago, Illinois, USA
Alan R Sanders, Jubao Duan & Pablo V Gejman - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
Kenneth S Kendler, Brion S Maher, Robert Ribble, Brien P Riley & Brandon Wormley - Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
Kenneth S Kendler, Ayman Fanous, Brion S Maher, Robert Ribble, Brien P Riley & Brandon Wormley - Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
Kenneth S Kendler, Brion S Maher, Robert Ribble, Brien P Riley & Brandon Wormley - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
Douglas F Levinson & Madeline Alexander - Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
Pamela Sklar & Jeremy M Silverman - Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK
Peter A Holmans, Nicholas Craddock, Sarah Dwyer, Lyudmila Georgieva, Marian Hamshere, George K Kirov, Valentina Moskvina, Ivan Nikolov, Nadine Norton, Michael J Owen, Hywel J Williams, Nigel M Williams, Stan Zammit & Michael C O'Donovan - Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Peter A Holmans, Nicholas Craddock, Sarah Dwyer, Lyudmila Georgieva, Marian Hamshere, George K Kirov, Valentina Moskvina, Ivan Nikolov, Nadine Norton, Michael J Owen, Hywel J Williams, Nigel M Williams, Stan Zammit & Michael C O'Donovan - Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA
Dan-Yu Lin - Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
Roel A Ophoff & Eric Strengman - Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Roel A Ophoff & Eric Strengman - University of California at Los Angeles (UCLA) Center for Neurobehavioral Genetics, University of California at Los Angeles, Los Angeles, California, USA
Roel A Ophoff, Rita M Cantor & Nelson B Freimer - Department of Human Genetics, University of California at Los Angeles, Los Angeles, California, USA
Roel A Ophoff & Rita M Cantor - Psychiatry Section, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Ole A Andreassen, Ingrid Agartz, Srdjan Djurovic, Morten Mattingsdal & Ingrid Melle - Department of Psychiatry, Oslo University Hospital, Oslo, Norway
Ole A Andreassen & Ingrid Melle - Broad Institute, Cambridge, Massachusetts, USA
Edward Scolnick, Shaun Purcell & Benjamin M Neale - Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Sven Cichon, Manuel Mattheisen & Markus M Nöthen - Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany
Sven Cichon - Institute of Human Genetics, University of Bonn, Bonn, Germany
Sven Cichon, Manuel Mattheisen & Markus M Nöthen - Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
David St. Clair - Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
Aiden Corvin, Paul Cormican, Gary Donohoe, Michael Gill, Elaine Kenny, Derek W Morris, Colm T O'Dushlaine & Emma M Quinn - Research Department of Mental Health Sciences, Molecular Psychiatry Laboratory, University College London Medical School, Windeyer Institute of Medical Sciences, London, UK
Hugh Gurling, Nicholas Bass, Khalid Choudhury, Susmita Datta, Robert Krasucki, Jacob Lawrence, Andrew McQuillin, Jonathan Pimm & Vinay Puri - Institute of Biological Psychiatry, Mental Health Center (MHC) Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark
Thomas Werge, Linh Duong, Thomas Hansen, Andrés Ingason, Klaus D Jakobsen, Line Olsen, Henrik B Rasmussen & Johan H Thygesen - Department of Psychiatry, Molecular and Clinical Neurobiology, Ludwig-Maximilians-University, Munich, Germany
Dan Rujescu, Marion Friedl, Ina Giegling, Annette M Hartmann, Heike Konnerth & Bettina Konte - Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Douglas H R Blackwood, Alan W Maclean, Pat Malloy, Kevin A McGhee & Andrew McIntosh - Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Carlos N Pato & Michele T Pato - Department of Psychiatry, Division of Research, The Zucker Hillside Hospital Division of the North Shore-Long Island Jewish Health System, Glen Oaks, New York, USA
Anil K Malhotra & Todd Lencz - Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Anil K Malhotra & Todd Lencz - Department of Psychiatry and Behavioral Science, Albert Einstein College of Medicine of Yeshiva University, New York, New York, USA
Anil K Malhotra & Todd Lencz - Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
Frank Dudbridge - Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Peter M Visscher - Department of Functional Genomics, Vrije Universiteit (VU), Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam, The Netherlands
Danielle Posthuma - Department of Medical Genomics, VU Medical Centre, Amsterdam, The Netherlands
Danielle Posthuma - Washington Veteran's Affairs Medical Center, Washington, DC, USA
Ayman Fanous & Richard L Amdur - Department of Psychiatry, Georgetown University School of Medicine, Washington, DC, USA
Ayman Fanous & Richard L Amdur - deCODE Genetics, Reykjavik, Iceland
Hreinn Stefansson, Stacy Steinberg & Kari Stefansson - Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia
Bryan J Mowry, John J McGrath & Deborah A Nertney - Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland, Australia
Bryan J Mowry, John J McGrath & Deborah A Nertney - Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia
Vera Golimbet - University Psychiatric Centre, Catholic University Leuven, Kortenberg, Belgium
Marc De Hert & Ruud van Winkel - Department of Clinical Neuroscience, Human Brain Informatics (HUBIN) Project, Karolinska Institutet and Hospital, Stockholm, Sweden
Erik G Jönsson & Lars Terenius - Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
István Bitter & János M Réthelyi - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Olli P H Pietiläinen & Leena Peltonen - Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Olli P H Pietiläinen & Leena Peltonen - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK
David A Collier - Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
Sarah Tosato & Mirella Ruggeri - Department of Research, Diakonhjemmet Hospital, Oslo, Norway
Ingrid Agartz - State Mental Hospital, Haar, Germany
Margot Albus - Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA
Farooq Amin - Department of Psychiatry and Behavioral Sciences, Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA
Farooq Amin - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Donald W Black - Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
Anders D Børglum & Ditte Demontis - Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark
Anders D Børglum & Ole Mors - University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia
Matthew A Brown & Patrick A Danoy - Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Richard Bruggeman & Durk Wiersma - School of Nursing, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Nancy G Buccola - Department of Psychiatry, University of California at San Francisco, San Francisco, California, USA
William F Byerley - NCIRE (Northern California Institute for Research and Education), San Francisco, California, USA
William F Byerley - Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Wiepke Cahn & René S Kahn - School of Psychiatry, University of New South Wales and Schizophrenia Research Institute, Sydney, New South Wales, Australia
Vaughan J Carr - Department of Psychiatry, University of Queensland, Royal Brisbane Hospital, Brisbane, Australia
Stanley V Catts - Department of Psychiatry, Washington University, St. Louis, Missouri, USA
C Robert Cloninger - Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Lieuwe de Haan & Don H Linszen - Department of Psychiatry, University of Athens Medical School, Athens, Greece
Dimitris Dikeos & George Papadimitriou - Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
Srdjan Djurovic - Wellcome Trust Centre for Human Genetics, Oxford, UK
Peter Donnelly, Chris C A Spencer & Amy Strange - Department of Statistics, University of Oxford, Oxford, UK
Peter Donnelly - Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
Anders Fink-Jensen - Department of Psychiatry, University of Colorado Denver, Aurora, Colorado, USA
Robert Freedman & Ann Olincy - Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Copenhagen University Hospital, Glostrup, Denmark
Birte Glenthøj - INSERM, Institut de Myologie, Hôpital de la Pitié-Salpêtrière, Paris, France
Stephanie Godard - Illumina, Inc., La Jolla, California, USA
Mark Hansen - School of Electrical Engineering and Computing Science, University of Newcastle, Newcastle, New South Wales, Australia
Frans A Henskens - Department of Clinical Chemistry and Immunology, Section of Neonatal Screening and Hormones, The State Serum Institute, Copenhagen, Denmark
David M Hougaard - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Christina M Hultman, Paul Lichtenstein & Patrick F Sullivan - Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Perth, Western Australia, Australia
Assen V Jablensky - Department of Child and Adolescent Psychiatry, Pierre and Marie Curie Faculty of Medicine, Paris, France
Maurice Jay & Claudine Laurent - Department of Clinical Pharmacology, Bispebjerg University Hospital, Copenhagen, Denmark
Gesche Jürgens - Department of Psychology, University of Colorado, Boulder, Boulder, Colorado, USA
Matthew C Keller - Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Centre, Maastricht, The Netherlands
Gunter Kenis & Ruud van Winkel - Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Yunjung Kim & Patrick F Sullivan - Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands
Lydia Krabbendam, Inez Myin-Germeys & Jim van Os - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Virginia K Lasseter, Gerald Nestadt & Ann E Pulver - Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
F Bernard Lerer - Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
Kung-Yee Liang - Department of Psychiatry, Columbia University, New York, New York, USA
Jeffrey A Lieberman & T Scott Stroup - Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
Jouko Lönnqvist & Jaana Suvisaari - Schizophrenia Research Institute, Sydney and Centre for Brain and Mental Health Research, University of Newcastle, Newcastle, New South Wales, Australia
Carmel M Loughland - Department of Psychiatry, University of Bonn, Bonn, Germany
Wolfgang Maier & Marcella Rietschel - Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière, Paris, France
Jacques Mallet - Institute of Medical Biometry, Informatics and Epidemiology (IMBIE), University of Bonn, Bonn, Germany
Manuel Mattheisen - Department of Research, Sørlandet Hospital, Kristiansand, Norway
Morten Mattingsdal - Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland, Australia
Duncan E McLean - Functional NeuroImaging Laboratory, School of Psychology, University of Newcastle, Sydney, New South Wales, Australia
Patricia T Michie - Schizophrenia Research Institute, Sydney, New South Wales, Australia
Patricia T Michie & Ulrich Schall - Department of Psychiatry, First Psychiatric Clinic, Alexander University Hospital, Sofia, Bulgaria
Vihra Milanova - National Centre for Register-Based Research, University of Aarhus, Aarhus, Denmark
Preben B Mortensen - Department of Psychiatry, University of Toronto, Toronto, Canada
Pierandrea Muglia - NeuroSearch A/S, Ballerup, Denmark
Pierandrea Muglia - Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg, Denmark
Jimmi Nielsen - Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
Merete Nordentoft - Department of Psychiatry, Queens University, Belfast, Ireland
F Anthony O'Neill - ARoS Applied Biotechnology A/S, Skejby, Denmark
Torben F Ørntoft - Department of Molecular Medicine, Aarhus University Hospital, Skejby, Denmark
Torben F Ørntoft - Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia
Christos Pantelis - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Leena Peltonen - Department of Psychiatry, National University Hospital, Reykjavik, Iceland
Hannes Petursson & Engilbert Sigurdsson - Strathclyde Institute of Pharmacy and Biomedical Sciences, The John Arbuthnott Building, University of Strathclyde, Glasgow, UK
Ben Pickard - Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford, UK
Digby Quested - Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Marcella Rietschel & Thomas G Schulze - Priority Centre for Brain and Mental Health Research, University of Newcastle, Sydney, New South Wales, Australia
Ulrich Schall - Department of Psychiatry and Psychotherapy, Georg-August-University, Göttingen, Germany
Thomas G Schulze - School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia
Sibylle G Schwab & Dieter B Wildenauer - Department of Psychiatry, University of Erlangen-Nuremberg, Erlangen, Germany
Sibylle G Schwab - Centre for Medical Research, Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia
Sibylle G Schwab - Centre for Information Based Medicine, University of Newcastle, Hunter Medical Research Institute, Newcastle and Schizophrenia Research Institute, Sydney, New South Wales, Australia
Rodney J Scott - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Jianxin Shi - Department of Psychiatry, University of Iceland, Reykjavik, Iceland
Engilbert Sigurdsson - Department of Psychiatry, Veterans Affairs Medical Center, New York, New York, USA
Jeremy M Silverman - West Berkshire National Health Service (NHS) Trust, Reading, UK
Srinivasa Thirumalai - Mental Health Center Frederiksberg, Copenhagen University Hospital, Copenhagen, Denmark
Sally Timm - Department of Medical Genetics, University Hospital Maichin Dom, Sofia, Bulgaria
Draga Toncheva - Department of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, USA
Edwin van den Oord - Department of Neurology, Rudolf Magnus Institute of Neuroscience, Universitair Medisch Centrum (UMC) Utrecht, Utrecht, The Netherlands
Jan Veldink - The Health Research Board, Dublin, Ireland
Dermot Walsh - Mental Health Center Amager, Copenhagen University Hospital, Copenhagen, Denmark
August G Wang - Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, Mt Claremont, Western Australia, Australia
Dieter B Wildenauer - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Patrick F Sullivan - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Patrick F Sullivan
Consortia
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
- Stephan Ripke
- , Alan R Sanders
- , Kenneth S Kendler
- , Douglas F Levinson
- , Pamela Sklar
- , Peter A Holmans
- , Dan-Yu Lin
- , Jubao Duan
- , Roel A Ophoff
- , Ole A Andreassen
- , Edward Scolnick
- , Sven Cichon
- , David St. Clair
- , Aiden Corvin
- , Hugh Gurling
- , Thomas Werge
- , Dan Rujescu
- , Douglas H R Blackwood
- , Carlos N Pato
- , Anil K Malhotra
- , Shaun Purcell
- , Frank Dudbridge
- , Benjamin M Neale
- , Lizzy Rossin
- , Peter M Visscher
- , Danielle Posthuma
- , Douglas M Ruderfer
- , Ayman Fanous
- , Hreinn Stefansson
- , Stacy Steinberg
- , Bryan J Mowry
- , Vera Golimbet
- , Marc De Hert
- , Erik G Jönsson
- , István Bitter
- , Olli P H Pietiläinen
- , David A Collier
- , Sarah Tosato
- , Ingrid Agartz
- , Margot Albus
- , Madeline Alexander
- , Richard L Amdur
- , Farooq Amin
- , Nicholas Bass
- , Sarah E Bergen
- , Donald W Black
- , Anders D Børglum
- , Matthew A Brown
- , Richard Bruggeman
- , Nancy G Buccola
- , William F Byerley
- , Wiepke Cahn
- , Rita M Cantor
- , Vaughan J Carr
- , Stanley V Catts
- , Khalid Choudhury
- , C Robert Cloninger
- , Paul Cormican
- , Nicholas Craddock
- , Patrick A Danoy
- , Susmita Datta
- , Lieuwe de Haan
- , Ditte Demontis
- , Dimitris Dikeos
- , Srdjan Djurovic
- , Peter Donnelly
- , Gary Donohoe
- , Linh Duong
- , Sarah Dwyer
- , Anders Fink-Jensen
- , Robert Freedman
- , Nelson B Freimer
- , Marion Friedl
- , Lyudmila Georgieva
- , Ina Giegling
- , Michael Gill
- , Birte Glenthøj
- , Stephanie Godard
- , Marian Hamshere
- , Mark Hansen
- , Thomas Hansen
- , Annette M Hartmann
- , Frans A Henskens
- , David M Hougaard
- , Christina M Hultman
- , Andrés Ingason
- , Assen V Jablensky
- , Klaus D Jakobsen
- , Maurice Jay
- , Gesche Jürgens
- , René S Kahn
- , Matthew C Keller
- , Gunter Kenis
- , Elaine Kenny
- , Yunjung Kim
- , George K Kirov
- , Heike Konnerth
- , Bettina Konte
- , Lydia Krabbendam
- , Robert Krasucki
- , Virginia K Lasseter
- , Claudine Laurent
- , Jacob Lawrence
- , Todd Lencz
- , F Bernard Lerer
- , Kung-Yee Liang
- , Paul Lichtenstein
- , Jeffrey A Lieberman
- , Don H Linszen
- , Jouko Lönnqvist
- , Carmel M Loughland
- , Alan W Maclean
- , Brion S Maher
- , Wolfgang Maier
- , Jacques Mallet
- , Pat Malloy
- , Manuel Mattheisen
- , Morten Mattingsdal
- , Kevin A McGhee
- , John J McGrath
- , Andrew McIntosh
- , Duncan E McLean
- , Andrew McQuillin
- , Ingrid Melle
- , Patricia T Michie
- , Vihra Milanova
- , Derek W Morris
- , Ole Mors
- , Preben B Mortensen
- , Valentina Moskvina
- , Pierandrea Muglia
- , Inez Myin-Germeys
- , Deborah A Nertney
- , Gerald Nestadt
- , Jimmi Nielsen
- , Ivan Nikolov
- , Merete Nordentoft
- , Nadine Norton
- , Markus M Nöthen
- , Colm T O'Dushlaine
- , Ann Olincy
- , Line Olsen
- , F Anthony O'Neill
- , Torben F Ørntoft
- , Michael J Owen
- , Christos Pantelis
- , George Papadimitriou
- , Michele T Pato
- , Leena Peltonen
- , Hannes Petursson
- , Ben Pickard
- , Jonathan Pimm
- , Ann E Pulver
- , Vinay Puri
- , Digby Quested
- , Emma M Quinn
- , Henrik B Rasmussen
- , János M Réthelyi
- , Robert Ribble
- , Marcella Rietschel
- , Brien P Riley
- , Mirella Ruggeri
- , Ulrich Schall
- , Thomas G Schulze
- , Sibylle G Schwab
- , Rodney J Scott
- , Jianxin Shi
- , Engilbert Sigurdsson
- , Jeremy M Silverman
- , Chris C A Spencer
- , Kari Stefansson
- , Amy Strange
- , Eric Strengman
- , T Scott Stroup
- , Jaana Suvisaari
- , Lars Terenius
- , Srinivasa Thirumalai
- , Johan H Thygesen
- , Sally Timm
- , Draga Toncheva
- , Edwin van den Oord
- , Jim van Os
- , Ruud van Winkel
- , Jan Veldink
- , Dermot Walsh
- , August G Wang
- , Durk Wiersma
- , Dieter B Wildenauer
- , Hywel J Williams
- , Nigel M Williams
- , Brandon Wormley
- , Stan Zammit
- , Patrick F Sullivan
- , Michael C O'Donovan
- , Mark J Daly
- & Pablo V Gejman
Contributions
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC): overall coordination: P.V.G. Coordination of statistical analyses: M.J.D. Coordination of phenotypic analyses: K.S.K. Statistical analyses: S.R., M.J.D., P.A.H., D.-Y.L., S.P., F.D., B.M.N., L.R., P.M.V., D.P., D.M.R. Manuscript preparation: P.V.G. (primary), M.J.D. (primary), A.R.S. (primary), S.R. (primary), M.C.O. (primary), K.S.K., D.F.L., P.S., P.A.H., P.F.S. (primary), D.-Y.L., J.D., R.A.O., O.A.A., E. Scolnick. Phenotypic analyses: K.S.K., A.F., A.C., R.L.A. Stage 1 GWAS sample 1–Cardiff, UK: M.C.O., N.C., P.A.H., M. Hamshere, H.J.W., V. Moskvina, S. Dwyer, L.G., S.Z., M.J.O. Stage 1 GWAS sample 2–Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): P.F.S., D.-Y.L., E.v.d.O., Y.K., T.S.S., J.A.L. Stage 1 GWAS sample 3–International Schizophrenia Consortium (ISC)–Aberdeen: D.St.C. Stage 1 GWAS sample 4–ISC–Cardiff: G.K.K., M.C.O., P.A.H., L.G., I.N., H.J.W., D.T., V. Milanova, M.J.O. Stage 1 GWAS sample 5–ISC–Dublin: D.W.M., C.T.O., E.K., E.M.Q., M.G., A.C. Stage 1 GWAS sample 6–ISC–Edinburgh: D.H.R.B., K.A.M., B.P., P. Malloy, A.W.M., A. McIntosh. Stage 1 GWAS sample 7–ISC–London: A. McQuillin, K.C., S. Datta, J.P., S. Thirumalai, V.P., R.K., J. Lawrence, D.Q., N.B., H.G. Stage 1 GWAS sample 8–ISC–Portugal: M.T.P., C.N.P., A.F. Stage 1 GWAS sample 9–ISC–SW1–Sweden, stage 1 GWAS sample 10–ISC–SW2–Sweden, stage 2 replication follow-up sample 16–SW3–Sweden, stage 2 replication follow-up sample 17–SW4–Sweden: C.M.H., P.L., S.E.B., S.P., E. Scolnick, P.S., P.F.S. Stage 1 GWAS sample 11–Molecular Genetics of Schizophrenia (MGS): J. Shi, D.F.L., J.D., A.R.S., M.C.K., B.J.M., A.O., F.A., C.R.C., J.M.S., N.G.B., W.FB., D.W.B., K.S.K., R.F., P.V.G. Stage 1 GWAS sample 12–Schizophrenia Genetics Consortium (SGENE)–Bonn: S.C., M. Rietschel, M.M.N., W.M., T.G.S., M. Mattheisen. Stage 1 GWAS sample 13–SGENE–Copenhagen, stage 2 replication follow-up sample 5–SGENE–Copenhagen: T.H., A.I., K.D.J., L.D., G.J., H.B.R., B.G., J.N., S. Timm, L.O., A.G.W., A.F.-J., J.H.T., T.W. Stage 1 GWAS sample 14–SGENE–Munich, stage 2 replication follow-up sample 12–SGENE–Munich, stage 2 replication follow-up sample 13–SGENE–Munich: I.G., A.M.H., H.K., M.F., B.K., P. Muglia, D.R. Stage 1 GWAS sample 15–SGENE–Thematic Organized Psychoses Research 3 (TOP3): S. Djurovic, M. Mattingsdal, I.A., I.M., O.A.A. Stage 1 GWAS sample 16–SGENE–UCLA: R.A.O., R.M.C., N.B.F., R.S.K., D.H.L., J.v.O., D. Wiersma, R.B., W.C., L.d.H., L.K., I.M.-G., E. Strengman. Stage 1 GWAS sample 1–Zucker Hillside A.K.M., T.L.Stage 2 replication follow-up sample –multicenter pedigree P.A.H., B.P.R., A.E.P., M.J.O., D.B.W., P.V.G., B.J.M., C.L., K.S.K., G.N., N.M.W., S.G.S., A.R.S., M. Hansen, D.A.N., J.M., B.W., V.K.L., M.C.O., J.D., M. Albus, M. Alexander, S.G., R.R., K.-Y.L., N.N., W.M., G.P., D. Walsh, M.J., F.A.O., F.B.L., D. Dikeos, J.M.S., D.F.L.Stage 2 replication follow-up sample –SGEN–Aarhus A.D.B., D. Demontis, P.B.M., D.M.H., T.FØ., O.M.Stage 2 replication follow-up sample –SGEN–Aarhus O.M., M.N., A.D.B.Stage 2 replication follow-up sample –SGEN–Belgium R.v.W., G.K., M.D.H., J.V.Stage 2 replication follow-up sample –SGEN–Iceland H.S., S.S., E. Sigurdsson, H.P., K.S.Stage 2 replication follow-up sample –SGEN–England D.A.C.Stage 2 replication follow-up sample –SGEN–Helsinki, stage 2 replication follow-up sample 1–SGEN–Kuusamo L.P., O.P.H.P., J. Suvisaari, J. önnqvist.Stage 2 replication follow-up sample –SGEN–Hungary I.B., J.M.R.Stage 2 replication follow-up sample 1–SGEN–Italy M. Ruggeri, S. Tosato.Stage 2 replication follow-up sample 1–SGEN–Russia V.G.Stage 2 replication follow-up sample 1–SGEN–Sweden E.G.J., I.A., L.T.Stage 2 replication follow-up sample 1–University of Queensland B.J.M., M.A.B., P.A.D., J.J.M., D.E.M.Stage 2 replication follow-up sample 1–Australian Schizophrenia Research Bank B.J.M., V.J.C., R.J.S., S.V.C., F.A.H., A.V.J., C.M.L., P.T.M., C.P., U.S.Stage 2 replication follow-up sample 1–Irish Schizophrenia Genomics Consortium (ISGC) A.C., D.W.M., P.C., B.S.M., C.T.O., G.D., F.A.O., M.G., K.S.K., B.P.R., ISGC (see the Acknowledgments in theSupplementary Not for additional contributors not listed above).Stage 2 replication follow-up sample 1–Wellcome Trust Case Control Consortium 2 (WTCCC2) P.D. (Chair of Management Committee; Data and Analysis Group), C.C.A.S. (Data and Analysis Group; Publications Committee), A.S. (Data and Analysis Group), WTCCC2 (see Acknowledgments in theSupplementary Not for additional contributors not listed above). All authors contributed to the current version of the paper
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Correspondence toPablo V Gejman.
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Competing interests
Eli Lilly funded portions of the genotyping for CATIE and TOP. P.F.S. received research funding from Eli Lilly in connection with CATIE. T.S.S. received research funding from Eli Lilly and consulting fees from Janssen Pharmaceutica, GlaxoSmithKline and Bristol-Myers Squibb. J.A.L. received research funding from AstraZeneca Pharmaceuticals, Bristol-Myers Squibb, GlaxoSmithKline, Janssen Pharmaceutica and Pfizer and consulting and educational fees from AstraZeneca Pharmaceuticals, Bristol-Myers Squibb, Eli Lilly, Forest Pharmaceuticals, GlaxoSmithKline, Janssen Pharmaceutica, Novartis, Pfizer and Solvay. D.St.C. received research funding from GlaxoSmithKline and Generation Scotland, Genetics Health Initiative. F.A. received funds from Pfizer, Organon and the Foundation for the National Institutes of Health. D.W.B. has received research support from Shire and Forest, has been on the speakers' bureau for Pfizer and has received consulting honoraria from Forest and Jazz. T.W. has received consulting and lecture fees from H. Lundbeck A/S. O.A.A. has received Speaker's honorarium from AstraZeneca, Janssen, Bristol-Myers Squibb and GlaxoSmithKline. I.M. has received a Speaker's honorarium from Janssen and AstraZeneca. A.K.M. has received consulting fees or honoraria from Eli Lilly & Company, Janssen Pharmaceutica, Merck, Bristol-Meyers Squibb, Pfizer, PGxHealth (a division of Clinical Data, Inc.), Roche Diagnostics and Vanda Pharmaceuticals and has received research support from Eli Lilly & Company. T.L. has received consulting fees or honoraria from Merck, Eli Lilly & Company, Golden Helix, Inc., InforMed Insights and PGxHealth (a division of Clinical Data, Inc.). I.B. has been an advisory board member, consultant and lecturer for AstraZeneca, Bristol-Myers Squibb, Eli Lilly, EGIS, Janssen, H. Lundbeck A/S, Novartis, Pfizer, Richter and Schering-Plough and received a grant for an investigator-initiated study from H. Lundbeck A/S. J.J.M. has received consulting and speaker's fees from Johnson & Johnson, Schering-Plough and Eli Lilly. C.P. has received grant support from Janssen-Cilag, Eli Lilly, Hospira (Mayne) and AstraZeneca, provided consultancy to Janssen-Cilag, Eli Lilly, Hospira (Mayne), AstraZeneca, Pfizer and Schering-Plough and has undertaken investigator-initiated studies supported by Eli Lilly, Hospira, Janssen Cilag and AstraZeneca. The Denmark-Aarhus group (The GEMS Stud with principal investigators A.D.B., O.M. and P.B.M.) received research funding from H. Lundbeck A/S. E.G.J. has served as an unpaid consultant for Eli Lilly.
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The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study identifies five new schizophrenia loci.Nat Genet 43, 969–976 (2011). https://doi.org/10.1038/ng.940
- Received: 16 February 2011
- Accepted: 19 August 2011
- Published: 18 September 2011
- Issue Date: October 2011
- DOI: https://doi.org/10.1038/ng.940