Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control (original) (raw)

• Schnitt, S. J. & Connolly, J. L. in Diseases of the Breast (eds. Harris, J., Lippman, M. E., Morrow, M. & Osborne, K.) 77–99 (Lippincott Williams & Wilkins, Philadelphia, 2004).
  Google Scholar
• Polosukhin, V. V. Ultrastructural of the bronchial epithelium in chronic inflammation. Ultrastruct. Pathol. 25, 119–128 (2001).
  Article CAS PubMed Google Scholar
• Dranoff, G. Cytokines in cancer pathogenesis and cancer therapy. Nature Rev. Cancer 4, 11–22 (2004).
  Article CAS Google Scholar
• Drubin, D. G. & Nelson, W. J. Origins of cell polarity. Cell 84, 335–344 (1996).
  Article CAS PubMed Google Scholar
• Schneeberger, E. E. & Lynch, R. D. The tight junction: a multifunctional complex. Am. J. Physiol. Cell Physiol. 286, C1213–C1228 (2004).
  Article CAS PubMed Google Scholar
• Rodriguez-Boulan, E., Kreitzer, G. & Musch, A. Organization of vesicular trafficking in epithelia. Nature Rev. Mol. Cell Biol. 6, 233–247 (2005).
  Article CAS Google Scholar
• Zegers, M. M., O'Brien, L. E., Yu, W., Datta, A. & Mostov, K. E. Epithelial polarity and tubulogenesis in vitro. Trends Cell Biol. 13, 169–176 (2003).
  Article CAS PubMed Google Scholar
• Muthuswamy, S. K., Li, D., Lelievre, S., Bissell, M. J. & Brugge, J. S. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nature Cell Biol. 3, 785–792 (2001).
  Article CAS PubMed Google Scholar
• Schoenenberger, C. A., Zuk, A., Kendall, D. & Matlin, K. S. Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras. J. Cell Biol. 112, 873–889 (1991).
  Article CAS PubMed Google Scholar
• Li, D. & Mrsny, R. J. Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. J. Cell Biol. 148, 791–800 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Reichmann, E. et al. Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. Cell 71, 1103–1116 (1992).
  Article CAS PubMed Google Scholar
• Fialka, I. et al. The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions. J. Cell Biol. 132, 1115–1132 (1996).
  Article CAS PubMed Google Scholar
• Jou, T. S., Schneeberger, E. E. & Nelson, W. J. Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol. 142, 101–115 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Rojas, R., Ruiz, W. G., Leung, S. M., Jou, T. S. & Apodaca, G. Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells. Mol. Biol. Cell 12, 2257–2274 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Behrens, J. et al. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J. Cell Biol. 120, 757–766 (1993).
  Article CAS PubMed Google Scholar
• Bilder, D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev. 18, 1909–1925 (2004).
  Article CAS PubMed Google Scholar
• Nelson, W. J. Adaptation of core mechanisms to generate cell polarity. Nature 422, 766–774 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Stoll, M. et al. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nature Genet. 36, 476–480 (2004).
  Article CAS PubMed Google Scholar
• Ragaz, J. in Diseases of the Breast (eds. Harris, J., Lippman, M. E., Morrow, M. & Osborne, K.) 619–652 (Lippincott Williams & Wilkins, Philadelphia, 2004).
  Google Scholar
• Hynes, N. E. & Lane, H. A. ERBB receptors and cancer: the complexity of targeted inhibitors. Nature Rev. Cancer 5, 341–354 (2005).
  Article CAS Google Scholar
• Debnath, J. et al. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111, 29–40 (2002).
  Article CAS PubMed Google Scholar
• Andrechek, E. R. et al. Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc. Natl Acad. Sci. USA 97, 3444–3449 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Muthuswamy, S. K., Gilman, M. & Brugge, J. S. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol. Cell Biol. 19, 6845–6857 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Amara, J. F. et al. A versatile synthetic dimerizer for the regulation of protein–protein interactions. Proc. Natl Acad. Sci. USA 94, 10618–10623 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Etienne-Manneville, S. & Hall, A. Cell polarity: Par6, aPKC and cytoskeletal crosstalk. Curr. Opin. Cell Biol. 15, 67–72 (2003).
  Article CAS PubMed Google Scholar
• Macara, I. G. Par proteins: partners in polarization. Curr. Biol. 14, R160–R162 (2004).
  Article CAS PubMed Google Scholar
• Margolis, B. & Borg, J. P. Apicobasal polarity complexes. J. Cell Sci. 118, 5157–5159 (2005).
  Article CAS PubMed Google Scholar
• Suzuki, A. & Ohno, S. The PAR–aPKC system: lessons in polarity. J. Cell Sci. 119, 979–987 (2006).
  Article CAS PubMed Google Scholar
• Yamanaka, T. et al. PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Genes Cells 6, 721–731 (2001).
  Article CAS PubMed Google Scholar
• Ozdamar, B. et al. Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity. Science 307, 1603–1609 (2005).
  Article CAS PubMed Google Scholar
• Noda, Y. et al. Molecular recognition in dimerization between PB1 domains. J. Biol. Chem. 278, 43516–43524 (2003).
  Article CAS PubMed Google Scholar
• Wilson, M. I., Gill, D. J., Perisic, O., Quinn, M. T. & Williams, R. L. PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. Mol. Cell 12, 39–50 (2003).
  Article CAS PubMed Google Scholar
• Loden, M., Perris, F., Nielsen, N. H., Emdin, S. O. & Landberg, G. C-erbB2, p27 and G1/S aberrations in human primary breast cancer. Anticancer Res. 23, 2053–2061 (2003).
  CAS PubMed Google Scholar
• Qin, Y., Capaldo, C., Gumbiner, B. M. & Macara, I. G. The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. J. Cell Biol. 171, 1061–1071 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Howley, P. M., Munger, K., Werness, B. A., Phelps, W. C. & Schlegel, R. Molecular mechanisms of transformation by the human papillomaviruses. Princess Takamatsu Symp. 20, 199–206 (1989).
  CAS PubMed Google Scholar
• Nakagawa, S. & Huibregtse, J. M. Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol. Cell Biol. 20, 8244–8253 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Kiyono, T. et al. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc. Natl Acad. Sci. USA 94, 11612–11616 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Liu, H., Radisky, D. C., Wang, F. & Bissell, M. J. Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J. Cell Biol. 164, 603–612 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Guo, W. et al. β4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126, 489–502 (2006).
  Article CAS PubMed Google Scholar
• Downward, J. Targeting RAS signalling pathways in cancer therapy. Nature Rev. Cancer 3, 11–22 (2003).
  Article CAS Google Scholar
• Yu, H. & Jove, R. The STATs of cancer — new molecular targets come of age. Nature Rev. Cancer 4, 97–105 (2004).
  Article CAS Google Scholar
• Citri, A. & Yarden, Y. EGF–ERBB signalling: towards the systems level. Nature Rev. Mol. Cell Biol. 7, 505–516 (2006).
  Article CAS Google Scholar
• Maurer, U., Charvet, C., Wagman, A. S., Dejardin, E. & Green, D. R. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21, 749–760 (2006).
  Article CAS PubMed Google Scholar
• Regala, R. P. et al. Atypical protein kinase C Q is an oncogene in human non-small cell lung cancer. Cancer Res. 65, 8905–8911 (2005).
  Article CAS PubMed Google Scholar
• Eder, A. M. et al. Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc. Natl Acad. Sci. USA 102, 12519–12524 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Lin, D. et al. A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nature Cell Biol. 2, 540–547 (2000).
  Article CAS PubMed Google Scholar
• Silva, J. M. et al. Second-generation shRNA libraries covering the mouse and human genomes. Nature Genet. 37, 1281–1288 (2005).
  Article CAS PubMed Google Scholar
• Dickins, R. A. et al. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nature Genet. 37, 1289–1295 (2005).
  Article CAS PubMed Google Scholar
• Debnath, J., Muthuswamy, S. K. & Brugge, J. S. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30, 256–268 (2003).
  Article CAS PubMed Google Scholar