Toll-like receptor control of the adaptive immune responses (original) (raw)

• Janeway, C.A. Jr. & Medzhitov, R. Introduction: the role of innate immunity in the adaptive immune response. Semin. Immunol. 10, 349–350 (1998).
  Article PubMed Google Scholar
• Dangl, J.L. & Jones, J.D. Plant pathogens and integrated defence responses to infection. Nature 411, 826–833 (2001).
  Article CAS PubMed Google Scholar
• Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol. 21, 335–376 (2003).
  Article CAS PubMed Google Scholar
• Heil, F. et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303, 1526–1529 (2004).
  Article CAS PubMed Google Scholar
• Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S. & Reis, E.S.C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529–1531 (2004).
  Article CAS PubMed Google Scholar
• Lund, J.M. et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. USA 101, 5598–5603 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Heil, F. et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur. J. Immunol. 33, 2987–2997 (2003).
  Article CAS PubMed Google Scholar
• Lee, J. et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. USA 100, 6646–6651 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Matsumoto, M. et al. Subcellular localization of toll-like receptor 3 in human dendritic cells. J. Immunol. 171, 3154–3162 (2003).
  Article CAS PubMed Google Scholar
• Lund, J., Sato, A., Akira, S., Medzhitov, R. & Iwasaki, A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198, 513–520 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Leadbetter, E.A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603–607 (2002).
  Article CAS PubMed Google Scholar
• Laudanna, C., Kim, J.Y., Constantin, G. & Butcher, E. Rapid leukocyte integrin activation by chemokines. Immunol. Rev. 186, 37–46 (2002).
  Article CAS PubMed Google Scholar
• Huang, Q. et al. The plasticity of dendritic cell responses to pathogens and their components. Science 294, 870–875 (2001).
  Article CAS PubMed Google Scholar
• Mantovani, A. The chemokine system: redundancy for robust outputs. Immunol. Today 20, 254–257 (1999).
  Article CAS PubMed Google Scholar
• Hayashi, F., Means, T.K. & Luster, A.D. Toll-like receptors stimulate human neutrophil function. Blood 102, 2660–2669 (2003).
  Article CAS PubMed Google Scholar
• Neufert, C. et al. Mycobacterium tuberculosis 19-kDa lipoprotein promotes neutrophil activation. J. Immunol. 167, 1542–1549 (2001).
  Article CAS PubMed Google Scholar
• Hornung, V. et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168, 4531–4537 (2002).
  Article CAS PubMed Google Scholar
• Nagase, H. et al. Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand. J. Immunol. 171, 3977–3982 (2003).
  Article CAS PubMed Google Scholar
• McCurdy, J.D., Olynych, T.J., Maher, L.H. & Marshall, J.S. Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells. J. Immunol. 170, 1625–1629 (2003).
  Article CAS PubMed Google Scholar
• Supajatura, V. et al. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J. Clin. Invest. 109, 1351–1359 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Supajatura, V. et al. Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J. Immunol. 167, 2250–2256 (2001).
  Article CAS PubMed Google Scholar
• Fan, J. & Malik, A.B. Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors. Nat. Med. 9, 315–321 (2003).
  Article CAS PubMed Google Scholar
• Ashkar, A.A., Bauer, S., Mitchell, W.J., Vieira, J. & Rosenthal, K.L. Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. J. Virol. 77, 8948–8956 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Zhang, D. et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303, 1522–1526 (2004).
  Article CAS PubMed Google Scholar
• Kagnoff, M.F. & Eckmann, L. Epithelial cells as sensors for microbial infection. J. Clin. Invest. 100, 6–10 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Hertz, C.J. et al. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J. Immunol. 171, 6820–6826 (2003).
  Article CAS PubMed Google Scholar
• Andonegui, G. et al. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J. Clin. Invest. 111, 1011–1020 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Schilling, J.D., Martin, S.M., Hung, C.S., Lorenz, R.G. & Hultgren, S.J. Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli. Proc. Natl. Acad. Sci. USA 100, 4203–4208 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245–252 (1998).
  Article CAS PubMed Google Scholar
• Schnare, M. et al. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2, 947–950 (2001).
  Article CAS PubMed Google Scholar
• Palliser, D., Ploegh, H. & Boes, M. Myeloid differentiation factor 88 is required for cross-priming in vivo. J. Immunol. 172, 3415–3421 (2004).
  Article CAS PubMed Google Scholar
• Jarrossay, D., Napolitani, G., Colonna, M., Sallusto, F. & Lanzavecchia, A. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur. J. Immunol. 31, 3388–3393 (2001).
  Article CAS PubMed Google Scholar
• Kadowaki, N. et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194, 863–869 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Krug, A. et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31, 3026–3037 (2001).
  Article CAS PubMed Google Scholar
• Ito, T. et al. Interferon-α and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 195, 1507–1512 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Visintin, A. et al. Regulation of Toll-like receptors in human monocytes and dendritic cells. J. Immunol. 166, 249–255 (2001).
  Article CAS PubMed Google Scholar
• Muzio, M. et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol. 164, 5998–6004 (2000).
  Article CAS PubMed Google Scholar
• Edwards, A.D. et al. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 α+ DC correlates with unresponsiveness to imidazoquinolines. Eur. J. Immunol. 33, 827–833 (2003).
  Article CAS PubMed Google Scholar
• Doxsee, C.L. et al. The immune response modifier and Toll-like receptor 7 agonist S-27609 selectively induces IL-12 and TNF-α production in CD11c+CD11b+CD8− dendritic cells. J. Immunol. 171, 1156–1163 (2003).
  Article CAS PubMed Google Scholar
• Boonstra, A. et al. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J. Exp. Med. 197, 101–109 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Underhill, D.M. et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401, 811–815 (1999).
  Article CAS PubMed Google Scholar
• Ahmad-Nejad, P. et al. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32, 1958–1968 (2002).
  Article CAS PubMed Google Scholar
• Krug, A. et al. Herpes simplex virus type 1 (HSV-1) activates murine natural interferon-producing cells (IPC) through Toll-like receptor 9. Blood 103, 1433–1437 (2003).
  Article PubMed CAS Google Scholar
• Sallusto, F. et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 28, 2760–2769 (1998).
  Article CAS PubMed Google Scholar
• Dieu, M.C. et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 188, 373–386 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Forster, R. et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99, 23–33 (1999).
  Article CAS PubMed Google Scholar
• Gunn, M.D. et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451–460 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Constant, S.L. & Bottomly, K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 15, 297–322 (1997).
  Article CAS PubMed Google Scholar
• Janssen, E.M. et al. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 421, 852–856 (2003).
  Article CAS PubMed Google Scholar
• Shedlock, D.J. & Shen, H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300, 337–339 (2003).
  Article CAS PubMed Google Scholar
• Sun, J.C. & Bevan, M.J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300, 339–342 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Bourgeois, C., Veiga-Fernandes, H., Joret, A.M., Rocha, B. & Tanchot, C. CD8 lethargy in the absence of CD4 help. Eur. J. Immunol. 32, 2199–2207 (2002).
  Article CAS PubMed Google Scholar
• Medzhitov, R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1, 135–145 (2001).
  Article CAS PubMed Google Scholar
• Hemmi, H., Kaisho, T., Takeda, K. & Akira, S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 170, 3059–3064 (2003).
  Article CAS PubMed Google Scholar
• Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057–1061 (2003).
  Article CAS PubMed Google Scholar
• Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330–336 (2003).
  Article CAS PubMed Google Scholar
• Khattri, R., Cox, T., Yasayko, S.A. & Ramsdell, F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4, 337–342 (2003).
  Article CAS PubMed Google Scholar
• Pasare, C. & Medzhitov, R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 1033–1036 (2003).
  Article CAS PubMed Google Scholar
• Yang, Y., Huang, C.T., Huang, X. & Pardoll, D.M. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat. Immunol. 5, 508–515 (2004).
  Article CAS PubMed Google Scholar
• Trinchieri, G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3, 133–146 (2003).
  Article CAS PubMed Google Scholar
• Kaisho, T. et al. Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int. Immunol. 14, 695–700 (2002).
  Article CAS PubMed Google Scholar
• Redecke, V. et al. Cutting edge: Activation of toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J. Immunol. 172, 2739–2743 (2004).
  Article CAS PubMed Google Scholar
• Pulendran, B. et al. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J. Immunol. 167, 5067–5076 (2001).
  Article CAS PubMed Google Scholar
• Agrawal, S. et al. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J. Immunol. 171, 4984–4989 (2003).
  Article CAS PubMed Google Scholar
• Eisenbarth, S.C. et al. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196, 1645–1651 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Katze, M.G., He, Y. & Gale, M. Jr. Viruses and interferon: a fight for supremacy. Nat. Rev. Immunol. 2, 675–687 (2002).
  Article CAS PubMed Google Scholar
• Taniguchi, T. & Takaoka, A. The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr. Opin. Immunol. 14, 111–116 (2002).
  Article CAS PubMed Google Scholar
• Tough, D.F., Sun, S., Zhang, X. & Sprent, J. Stimulation of naive and memory T cells by cytokines. Immunol. Rev. 170, 39–47 (1999).
  Article CAS PubMed Google Scholar
• Nguyen, K.B. et al. Critical role for STAT4 activation by type 1 interferons in the interferon-γ response to viral infection. Science 297, 2063–2066 (2002).
  Article CAS PubMed Google Scholar
• Sareneva, T., Matikainen, S., Kurimoto, M. & Julkunen, I. Influenza A virus-induced IFN-α/β and IL-18 synergistically enhance IFN-γ gene expression in human T cells. J. Immunol. 160, 6032–6038 (1998).
  CAS PubMed Google Scholar
• Rogge, L. et al. The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J. Immunol. 161, 6567–6574 (1998).
  CAS PubMed Google Scholar
• Le Bon, A. et al. Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat. Immunol. 4, 1009–1015 (2003).
  Article CAS PubMed Google Scholar
• Le Bon, A. et al. Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 14, 461–470 (2001).
  Article CAS PubMed Google Scholar
• Biron, C.A., Nguyen, K.B., Pien, G.C., Cousens, L.P. & Salazar-Mather, T.P. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17, 189–220 (1999).
  Article CAS PubMed Google Scholar
• Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O. & Akira, S. Differential involvement of IFN-β in Toll-like receptor-stimulated dendritic cell activation. Int. Immunol. 14, 1225–1231 (2002).
  Article CAS PubMed Google Scholar
• Honda, K. et al. Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc. Natl. Acad. Sci. USA 100, 10872–10877 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Hoebe, K. et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol. 4, 1223–1229 (2003).
  Article CAS PubMed Google Scholar
• Itano, A.A. et al. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19, 47–57 (2003).
  Article CAS PubMed Google Scholar
• Steinman, R.M., Hawiger, D. & Nussenzweig, M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685–711 (2003).
  Article CAS PubMed Google Scholar
• Smith, C.M. et al. Cutting Edge: Conventional CD8α+ Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-1. J. Immunol. 170, 4437–4440 (2003).
  Article CAS PubMed Google Scholar
• Belz, G.T. et al. Cutting edge: conventional CD8α+ dendritic cells are generally involved in priming CTL immunity to viruses. J. Immunol. 172, 1996–2000 (2004).
  Article CAS PubMed Google Scholar
• Pulendran, B. et al. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc. Natl. Acad. Sci. USA 96, 1036–1041 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Maldonado, L.R. et al. CD8α+ and CD8α- Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In vivo. J. Exp. Med. 189, 587–592 (1999).
  Article Google Scholar
• Iwasaki, A. & Kelsall, B.L. Unique functions of CD11b+, CD8 α+, and double-negative Peyer's patch dendritic cells. J. Immunol. 166, 4884–4890 (2001).
  Article CAS PubMed Google Scholar
• Moser, M. & Murphy, K.M. Dendritic cell regulation of TH1-TH2 development. Nat. Immunol. 1, 199–205 (2000).
  Article CAS PubMed Google Scholar
• Akbari, O., DeKruyff, R.H. & Umetsu, D.T. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2, 725–731 (2001).
  Article CAS PubMed Google Scholar
• Alpan, O. Oral tolerance and gut-oriented immune response to dietary proteins. Curr. Allergy Asthma Rep. 1, 572–577 (2001).
  Article CAS PubMed Google Scholar
• Zhao, X. et al. Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J. Exp. Med. 197, 153–162 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Allan, R.S. et al. Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells. Science 301, 1925–1928 (2003).
  Article CAS PubMed Google Scholar
• Randolph, G.J. Is maturation required for Langerhans cell migration? J. Exp. Med. 196, 413–416 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Geissmann, F. et al. Accumulation of immature Langerhans cells in human lymph nodes draining chronically inflamed skin. J. Exp. Med. 196, 417–430 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Valladeau, J. et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12, 71–81 (2000).
  Article CAS PubMed Google Scholar
• Valladeau, J. et al. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J. Immunol. 168, 782–792 (2002).
  Article CAS PubMed Google Scholar
• Henri, S. et al. The dendritic cell populations of mouse lymph nodes. J. Immunol. 167, 741–748 (2001).
  Article CAS PubMed Google Scholar
• Anjuere, F. et al. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse. Blood 93, 590–598 (1999).
  CAS PubMed Google Scholar
• Itano, A.A. et al. Distinct dendritic cell populations sequentially present a subcutaneous antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity (in the press).
• Filippi, C. et al. CD4+ T cell polarization in mice is modulated by strain-specific MHC-independent differences within dendritic cells. J. Exp. Med. 198, 201–209 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Rescigno, M. et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2, 361–367 (2001).
  Article CAS PubMed Google Scholar
• Macpherson, A.J. & Uhr, T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662–1665 (2004).
  Article CAS PubMed Google Scholar
• Lambrecht, B.N. & Hammad, H. Taking our breath away: dendritic cells in the pathogenesis of asthma. Nat. Rev. Immunol. 3, 994–1003 (2003).
  Article CAS PubMed Google Scholar
• Akbari, O., Stock, P., DeKruyff, R.H. & Umetsu, D.T. Mucosal tolerance and immunity: regulating the development of allergic disease and asthma. Int. Arch. Allergy Immunol. 130, 108–118 (2003).
  Article PubMed Google Scholar
• Legge, K.L. & Braciale, T.J. Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection. Immunity 18, 265–277 (2003).
  Article CAS PubMed Google Scholar
• Dahl, M.E., Dabbagh, K., Liggitt, D., Kim, S. & Lewis, D.B. Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells. Nat. Immunol. 5, 337–343 (2004).
  Article CAS PubMed Google Scholar
• Randolph, G.J., Beaulieu, S., Lebecque, S., Steinman, R.M. & Muller, W.A. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 282, 480–483 (1998).
  Article CAS PubMed Google Scholar
• Cella, M. et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5, 919–923 (1999).
  Article CAS PubMed Google Scholar
• Asselin-Paturel, C. et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2, 1144–1150 (2001).
  Article CAS PubMed Google Scholar
• Rissoan, M.C. et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 283, 1183–1186 (1999).
  Article CAS PubMed Google Scholar
• Gilliet, M. et al. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 195, 953–958 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Brawand, P. et al. Murine plasmacytoid pre-dendritic cells generated from flt3 ligand-supplemented bone marrow cultures are immature APCs. J. Immunol. 169, 6711–6719 (2002).
  Article CAS PubMed Google Scholar
• Grouard, G. et al. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J. Exp. Med. 185, 1101–1111 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Cella, M., Facchetti, F., Lanzavecchia, A. & Colonna, M. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent Th1 polarization. Nat. Immunol. 4, 305–310 (2000).
  Article CAS Google Scholar
• Martin, P. et al. Characterization of a new subpopulation of mouse CD8α+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood 100, 383–390 (2002).
  Article CAS PubMed Google Scholar
• Gilliet, M. & Liu, Y.J. Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum. Immunol. 63, 1149–1155 (2002).
  Article CAS PubMed Google Scholar
• Filippi, C. et al. CD4+ T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells. J. Exp. Med. 198, 201–209 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Jego, G. et al. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 19, 225–234 (2003).
  Article CAS PubMed Google Scholar
• Martin, F. & Kearney, J.F. Marginal-zone B cells. Nat. Rev. Immunol. 2, 323–335 (2002).
  Article CAS PubMed Google Scholar
• Rui, L., Vinuesa, C.G., Blasioli, J. & Goodnow, C.C. Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat. Immunol. 4, 594–600 (2003).
  Article PubMed CAS Google Scholar
• Bernasconi, N.L., Traggiai, E. & Lanzavecchia, A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298, 2199–2202 (2002).
  Article CAS PubMed Google Scholar