BMP Research Papers - Academia.edu (original) (raw)

Top Papers
Most Cited Papers
Most Downloaded Papers
Newest Papers
People
- by
- •
- Molecular Biology, Tissue Engineering, Drug delivery, Stem Cell
- by Junseok Hwang
- •
- Computer Science, Routing, Next Generation Internet Research, Digital Communication
- by Neal Pellis and +1
- •
- Tissue Engineering, Multidisciplinary, Cellular mechanotransduction, Humans
- by Neil Alles and +1
- •
- Stability, Protein Stability, Humans, Animals
- by Warren Thomas
- •
- Gene expression, Signal Transduction, Biological Sciences, NO
- by Salar Haghighatafshar
- •
- Climate Change, BMP, Storm Water
- by George Nakhla
- •
- Food, Multidisciplinary, Methane, BMP

Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural-(e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic-(e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first s...

- by Eben Alsberg
- •
- Engineering, Bioinformatics, Life Sciences, Polymerization
- by Ricardo Tejero
- •
- Engineering, Osseointegration, NHS, CS
- by Jorge Rodríguez
- •
- Linear Programming, Biogas, Multidisciplinary, BMP
- by Zeeshan Sheikh
- •
- Engineering, Biomaterials, Materials, Bone Regeneration
- by Jessica Appler
- •
- Cognitive Science, Neurogenesis, Molecular Genetics, Molecular Mechanics
- by Dante Emmanuel Patiño Perez
- •
- TGA, GIF, BMP, Png
- by Remegio Confesor
- •
- Eutrophication, Multidisciplinary, Algal Bloom, BMP
- by rahmat mulia
- •
- Chronic myeloid leukemia, BMP
- by Uzma Siddiqui
- •
- Information Systems, Data Compression, Software, Humans
- by Maurizio Ballico
- •
- Environmental Engineering, Waste Management, Sewage sludge, Solid waste
- by Editor IJRET
- •
- Environmental Engineering, Hydrology, Modeling, Stormwater

SMOC2 is a member of the BM-40 (SPARC) family of matricellular proteins, reported to influence signaling in the extracellular compartment. In mice, Smoc2 is expressed in many different tissues and was shown to enhance the response to angiogenic growth factors, mediate cell adhesion, keratinocyte migration, and metastasis. Additionally, SMOC2 is associated with vitiligo and craniofacial and dental defects. The function of Smoc2 during early zebrafish development has not been determined to date. In pregastrula zebrafish embryos, smoc2 is expressed ubiquitously. As development progresses, the expression pattern becomes more anteriorly restricted. At the onset of blood cell circulation, smoc2 morphants presented a mild ventralization of posterior structures. Molecular analysis of the smoc2 morphants indicated myelopoietic defects in the rostral blood islands during segmentation stages. Hemangioblast development and further specification of the myeloid progenitor cells were shown to be i...

- by Camila Esguerra
- •
- Hematopoiesis, Biological Sciences, Animals, BMP
- by Zhuojun Ma
- •
- Structural Biology, Crystal Growth, Immunohistochemistry, Crystallization
- by Cem Yetimoglu
- •
- Bone Healing, BMP
- by Christina Timmerman
- •
- Cognitive Science, Electrophysiology, Animal Behavior, Drosophila melanogaster
- by Mamoni Dash and +2
- •
- Engineering, Tissue Engineering, Gene Therapy, Life Sciences
- by Gerhard Schlosser
- •
- Developmental Biology, Transcription Factors, Signal Transduction, Biological Sciences
- by Edgar Pera
- •
- Collagen, Key words, BMP, TGFβ
- by Marc Fellous
- •
- Genetics, Obstetrics, Humans, Mutation
- by Sally Moody
- •
- Stem Cells, Transcription Factors, Bone Morphogenetic Proteins, Signal Transduction
- by Mingli Liu
- •
- Stem Cell, Signal Transduction, Biological Sciences, miRNA
- by Massimiliano Agostini
- •
- Membrane Proteins, Humans, Animals, Alternative splicing
- by Wendy Graham
- •
- Civil Engineering, Environmental Science, Irrigation, Agricultural Water Management
- by Jun Nakabayashi
- •
- Western blotting, Bone Morphogenetic Proteins, Signal Transduction, Xenopus
- by Donatella Barisani
- •
- Membrane Proteins, Gene expression, Hepatology, Biopsy
- by Eugene Olivier
- •
- Engineering, Biological Sciences, Animals, ALP
- by Corinne Sonnet
- •
- Genetics, Inflammation, Sensory, Bone Morphogenetic Proteins
- by Jessica Carmen
- •
- Cognitive Science, Stem Cells, Cell Cycle, Stem Cell
- by José-Frédéric Deroubaix
- •
- Engineering, Civil Engineering, Human Geography, Rainwater Harvesting
- by J. Makarewicz
- •
- Environmental Engineering, Great Lakes, Nonpoint Source Pollution, Soil moisture
- by Yoshitomo Honda
- •
- Calcium, Macrophages, Bone Morphogenetic Proteins, Cell line
- by Rui L Reis
- •
- Biomedical Engineering, Water, Tissue Engineering, Kinetics

One of the hypotheses regarding the calcification induction by mineral trioxide aggregate (MTA) is the involvement of transforming growth factor-Beta (TGF-β) super family. Calcium-enriched mixture (CEM) cement is one of the endodontic biomaterials with clinical applications similar to MTA. The aim of the present in vitro study was to compare the induction of bone morphogenic protein-2 (BMP-2) by a combination of disodium hydrogen phosphate (DSHP) and tooth colored ProRoot MTA (WMTA), to that of CEM cement and WMTA. Human gingival fibroblasts (HGFs) were obtained from the attached gingiva of human premolars. HGFs were cultured in Dulbecco's Modified Eagle's medium, supplemented with 10% fetal calf serum, penicillin, and streptomycin. Cells in groups 1, 2 and 3 were exposed to WMTA, CEM and WMTA+DSHP discs, respectively. The fourth group served as the control. After 72 h of exposure, HGF viability was determined by Mosmann's tetrazolium toxicity (MTT) assay. BMP-2 levels i...

- by Amin Milani
- •
- BMP, Transforming Growth Factor Beta
- by Dieter Scharnweber
- •
- Biomaterials, Immune response, Complement activation, Wound Healing
- by Maurice Elphick
- •
- Neuroscience, Psychology, Immunohistochemistry, Gene expression

Elastin-like polymers are a new type of protein-based polymers that display interesting properties in the biomaterial field. Bone morphogenetic proteins (BMPs) are cytokines with a strong ability to promote new bone formation. In this work, we explored the use of elastin-like nanoparticles (average size 237.5 ± 3.0 nm), created by thermoresponsive self-assembly, for the combined release of bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-14 (BMP-14). These BMPs could be encapsulated at high efficiency into the elastin-like particles and delivered in a sustained way for 14 days. The activity of the growth factors was retained, as shown by the induction of ALP activity and osteogenic mineralization in C2C12 cells. Increased bioactivity was observed with a combined release of BMP-2 and BMP-14. This approach shows a significant potential for future tissue engineering applications in bone.The release of BMP-2 and BMP-14 from elastin-like polymer nanoparticles was sustained over time (2 weeks) and induced osteogenic mineralization of C2C12 cells.

- by Raul Machado
- •
- Biomedical Engineering, Tissue Engineering, Nanoparticle, Self Assembly
- by Maria Guillen
- •
- MicroRNA, Cytokines, Osteoarthritis, Humans
- by Róza Zákány and +1
- •
- Gene Silencing, Cell Culture, Signal Transduction, Cell Differentiation

The use of embryonic stem (ES) cells for generating healthy tissues has the potential to revolutionize therapies for human disease or injury, for which there are currently no effective treatments. Strategies for manipulating stem cell differentiation should be based on knowledge of the mechanisms by which lineage decisions are made during early embryogenesis. Here, we review current research into the factors influencing lineage differentiation in the mouse embryo and the application of this knowledge to in vitro differentiation of ES cells. In the mouse embryo, specification of tissue lineages requires cell-cell interactions that are influenced by coordinated cell migration and cellular neighborhood mediated by the key WNT, FGF, and TGFbeta signaling pathways. Mimicking the cellular interactions of the embryo by providing appropriate signaling molecules in culture has enabled the differentiation of ES cells to be directed predominately toward particular lineages. Multistep strategie...

... catfish (Pangasianodon hypothalamus), commonly referred to as pangasius, account for approximately 50% of the total production of aquaculture in Vietnam, significantly contributing to the country&#x27;s top-10 ranking among... more

- by Phạm Anh
- •
- Business, Corporate Governance, Water quality, Vietnam
- by igor skrjanec
- •
- Chemistry, Biomass, BPR, Medicine

Current and contemporary regulation of development-related activities affecting receiving waters can require complex approaches to the management of stormwater and resource avoidance including an on-the-ground historical basis for practicable regulatory decision-making. Such experience indicates growth can be accommodated in a manner that avoids and minimizes stream and wetland impacts and remain compatible with effective stormwater management (SWM) strategies. The historically innovative example is the first of several development projects in a 405-hectare (1000 acre) watershed of the Potomac River in the greater Washington, DC area and is actually one of the first "Environmental Site Design (ESD)" or "Low Impact Development (LID)" approaches to nonpoint source water quality management before the strategy was formalized in the industry. Impacts were reduced and mitigated by innovative design revisions, creative approaches to wetland mitigation, and contemporary ...

- by Andrew T . Der, C.E.P.
- •
- Environmental Science, Wetlands, Hydrology, Regulation And Governance

Current and contemporary regulation of development-related activities affecting receiving waters can require complex approaches to the management of stormwater and resource avoidance including an on-the-ground historical basis for practicable regulatory decision-making. Such experience indicates growth can be accommodated in a manner that avoids and minimizes stream and wetland impacts and remain compatible with effective stormwater management (SWM) strategies. The historically innovative example is the first of several development projects in a 405-hectare (1000 acre) watershed of the Potomac River in the greater Washington, DC area and is actually one of the first “Environmental Site Design (ESD)” or “Low Impact Development (LID)” approaches to nonpoint source water quality management before the strategy was formalized in the industry. Impacts were reduced and mitigated by innovative design revisions, creative approaches to wetland mitigation, and contemporary SWM. These practices...

- by Andrew T . Der, C.E.P.
- •
- Environmental Science, Wetlands, Hydrology, Regulation And Governance