Tetracycline antibiotics (original) (raw)
تتراسيكلينات (بالإنجليزية: Tetracyclines) هي مضادات حيوية واسعة الطيف تشمل فعاليتها فعالية البنسلين والستربتومايسين والكلورامفينيكول.
| Property | Value |
|---|---|
| dbo:abstract | تتراسيكلينات (بالإنجليزية: Tetracyclines) هي مضادات حيوية واسعة الطيف تشمل فعاليتها فعالية البنسلين والستربتومايسين والكلورامفينيكول. (ar) Tetracykliny, též tetracyklinová antibiotika jsou velkou skupinou širokospektrálních antibiotik. Působí primárně bakteriostaticky především proti intracelulárním gramnegativním bakteriím a též proti mnoha druhům grampozitivních bakterií, i když v současnosti je již problémem velké rozšíření rezistence. Tetracykliny první generace jsou metabolickými produkty , další jsou již semisyntetické látky od nich odvozené. Jejich účinek na bakterie spočívá ve vazbě na ribozomy a inhibici syntézy proteinů v bakteriální buňce. (cs) Tetracycline oder Tetrazykline sind antibiotisch wirksame Substanzen, die als Arzneimittel zur Behandlung von Infektionskrankheiten eingesetzt werden. Es gibt natürlich vorkommende Vertreter, die von Bakterien der Gattung Streptomyces produziert werden, und halbsynthetisch hergestellte Varianten, die durch chemische Veränderunge der biogenen Ausgangsstoffe erzeugt werden. Tetracycline wirken bakteriostatisch durch Hemmung der bakteriellen Proteinbiosynthese an den Ribosomen. Somit wird das Wachstum von grampositiven, gramnegativen und zahlreichen zellwandlosen Bakterien unterdrückt. (de) Les cyclines ou tétracyclines constituent une famille d'antibiotiques dérivés de la tétracycline. Ces molécules ont pour caractéristique de posséder quatre cycles accolés, d'où leur nom. Elles sont capables de pénétrer les cellules eucaryotes. On les utilise donc en particulier pour cibler les bactéries parasites intra-cellulaires (exemple : Chlamydia pneumoniae). Ces molécules sont bactériostatiques ; il y a donc un risque de récidive. (fr) Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of Streptomyces bacteria or produced semi-synthetically from those isolated compounds. Tetracycline molecules comprise a linear fused tetracyclic nucleus (rings designated A, B, C and D) to which a variety of functional groups are attached. Tetracyclines are named for their four ("tetra-") hydrocarbon rings ("-cycl-") derivation ("-ine"). They are defined as a subclass of polyketides, having an octahydrotetracene-2-carboxamide skeleton and are known as derivatives of polycyclic naphthacene carboxamide.While all tetracyclines have a common structure, they differ from each other by the presence of chloride, methyl, and hydroxyl groups. These modifications do not change their broad antibacterial activity, but do affect pharmacological properties such as half-life and binding to proteins in serum. Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiota, mycoplasmatota, rickettsiae, and protozoan parasites. Tetracycline itself was discovered later than chlortetracycline and oxytetracycline but is still considered as the parent compound for nomenclature purposes.Tetracyclines are among the cheapest classes of antibiotics available and have been used extensively in prophylaxis and in treatment of human and animal infections, as well as at subtherapeutic levels in animal feed as growth promoters. Tetracyclines are growth inhibitors (bacteriostatic) rather than killers of the infectious agent (bacteriocidal) and are only effective against multiplying microorganisms. They are short-acting and passively diffuse through porin channels in the bacterial membrane. They inhibit protein synthesis by binding reversibly to the bacterial 30S ribosomal subunit and preventing the aminoacyl tRNA from binding to the A site of the ribosome. They also bind to some extent the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells. Tetracyclines all have the same antibacterial spectrum, although there are differences in species' sensitivity to types of tetracyclines. Tetracyclines inhibit protein synthesis in both bacterial and human cells. Bacteria have a system that allows tetracyclines to be transported into the cell, whereas human cells do not. Human cells therefore are spared the effects of tetracycline on protein synthesis. Tetracyclines retain an important role in medicine, although their usefulness has been reduced with the onset of antibiotic resistance. Tetracyclines remain the treatment of choice for some specific indications.Because not all of the tetracycline administered orally is absorbed from the gastrointestinal tract, the bacterial population of the intestine can become resistant to tetracyclines, resulting in overgrowth of resistant organisms. The widespread use of tetracyclines is thought to have contributed to an increase in the number of tetracycline-resistant organisms, in turn rendering certain infections more resilient to treatment.Tetracycline resistance is often due to the acquisition of new genes, which code for energy-dependent efflux of tetracyclines or for a protein that protects bacterial ribosomes from the action of tetracyclines. Furthermore, a limited number of bacteria acquire resistance to tetracyclines by mutations. (en) テトラサイクリン系抗生物質（英: Tetracycline antibiotics, Tetracycline class, Tetracyclines、略: TC系, TC類, TCs, TETs）は、一群のの総称である。テトラサイクリンという名称は、四つの(tetra-)炭化水素からなる(cycl-)の誘導体(-ine)という意味である。TC系の抗菌スペクトラムは、全ての抗生物質で最も広い部類に属している。抗菌作用のない化学修飾されたCMTs(Chemically Modified Tetracyclines)の研究も進んでいる。 (ja) Le tetracicline sono un vasto gruppo di farmaci antibatterici inibitori della sintesi proteica. Efficaci contro i batteri Gram-positivi, Gram-negativi aerobi e anaerobi, contro brucelle e diarree causate da Escherichia coli. Inoltre, esse sono attive nei confronti di alcuni microorganismi resistenti agli antibiotici che agiscono sulla parete cellulare batterica, quali le rickettsie, le clamidie, i micoplasmi e i fitoplasmi. (it) Tetracyclines zijn een groep antibiotica gebaseerd op tetracycline. De tetracyclines inhiberen de binding van het aminoacyl-tRNA met mRNA (codon) ter hoogte van het 30S-ribosoom. Ze werken bacteriostatisch. Hun werking is omkeerbaar en afhankelijk van de bereikte concentratie binnen in de bacteriële cel. De belangrijkste tetracyclines zijn tetracycline, , , doxycycline en . De tetracyclines zijn zowel actief tegen gram-positieve als tegen gram-negatieve bacteriën. Ze zijn actief tegen mycoplasma, chlamydia, rickettsia en anaerobe bacteriën maar niet tegen Pseudomonas. Hun activiteit is echter matig. Wegens hun goede zijn het de eerste keuze producten in de behandeling van chlamydia en rickettsia. Voor tetracyclines is er een plasmide dat verantwoordelijk is voor de synthese van een proteïne dat zich in de celmembraan afzet, de efflux van teracycline bevordert en aldus resistentie opwekt. Deze efflux-geassocieerde resistentiesystemen zijn onder andere SMR, RND, MFS, MDR en MRP. (nl) Tetracykliny, antybiotyki tetracyklinowe − grupa antybiotyków o szerokim spektrum działania, pierwotnie otrzymywana ze szczepów promieniowca . Ich mechanizm działania polega na hamowaniu biosyntezy białka (zapobiegają wiązaniu się aminoacylo-tRNA z miejscem A rybosomu, blokując tym samym podjednostki 30S rybosomów bakteryjnych) i zaburzaniu procesów energetycznych w komórkach bakteryjnych. Są podawane drogą doustną, niektóre dożylnie; dobrze penetrują do narządów i tkanek (tkanka płucna, płyn otrzewnowy), mają dobrą penetrację do ośrodkowego układu nerwowego po podaniu drogą doustną, co ma istotne znaczenie w leczeniu zakażeń Borrelia burgdorferi (borelioza). (pl) Тетрациклины (англ. tetracyclines)— группа антибиотиков, относящихся к классу поликетидов, близких по химическому строению и биологическим свойствам. Представители данного семейства характеризуются общим спектром и механизмом антимикробного действия, полной перекрёстной устойчивостью, близкими фармакологическими характеристиками. Различия касаются некоторых физико-химических свойств, степени антибактериального эффекта, особенностей всасывания, распределения, метаболизма в макроорганизме и переносимости. (ru) 四环素类抗生素，一個（Broad-spectrum antibiotic）藥物家族的泛稱，因其氢化并四苯母核而得名。本类药物抗菌谱广，对革兰氏阴性菌、革兰氏阳性菌、螺旋体、衣原体、立克次氏体、支原体、放线菌和阿米巴原虫都有较强的作用。但近年来，其应用受到耐药的影响。 (zh) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Tetracycline_numbering.svg?width=300 |
| dbo:wikiPageID | 3917234 (xsd:integer) |
| dbo:wikiPageLength | 44513 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1105579598 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Calcium dbr:Aminoacyl-tRNA dbr:Benjamin_Minge_Duggar dbr:Rocky_Mountain_spotted_fever dbr:Rolitetracycline dbr:Rosacea dbr:Sarecycline dbr:Neoplasm dbr:Tooth_(human) dbr:Demeclocycline dbr:Antibiotic dbr:Beta-lactam dbr:Pfizer dbr:Rhodamine_B dbr:Vaccine dbr:Veterinary_medicine dbr:Derivative_(chemistry) dbr:Incyclinide dbr:International_nonproprietary_name dbr:Steatosis dbr:Meclocycline dbr:Chemical_modification dbr:Gastrointestinal_tract dbr:Emory_University dbr:Enzyme dbr:Functional_groups dbr:Gene dbr:George_J._Armelagos dbr:Minocycline dbr:Mitochondria dbr:Myasthenia_gravis dbr:Phototoxicity dbr:Psittacosis dbr:Urethritis dbr:Pharmacological dbr:Protein_synthesis dbc:Hepatotoxins dbr:Animal_Drug_Availability_Act_1996 dbr:Antacids dbr:Anthrax dbr:Anthropology dbr:Lyme_disease dbr:Lymecycline dbr:Lymphogranuloma_venereum dbr:Magnesium dbr:Malaria dbc:Tetracycline_antibiotics dbr:Streptomyces dbr:Streptomyces_aureofaciens dbr:Community-acquired_pneumonia dbr:Horizontal_gene_transfer dbr:Hormonal_contraception dbr:Porin_(protein) dbr:Macrolide dbr:Bacteria dbr:Tigecycline dbr:Gram-positive dbr:Acne_vulgaris dbr:Aluminium dbr:Doxycycline dbr:Eravacycline dbr:FDA dbr:Fluorescent dbr:Nubia dbr:Oxytetracycline dbr:Parasite dbr:Fanconi_syndrome dbr:Glycylcycline dbr:Gram-negative_bacteria dbr:History_of_beer dbr:Kidney_failure dbr:Yersinia_pestis dbr:Protein dbr:Half-life dbr:Intracellular dbr:Iron dbr:Bacillus_anthracis dbr:Teratogenesis dbr:Tetracycline dbr:Trachoma dbr:Absorption_(pharmacology) dbr:Acne dbr:Children dbr:Chlamydia_infection dbr:Chlamydiota dbr:Chloride dbr:Chlortetracycline dbr:Cholera dbr:Biological_activity dbr:Biomarker dbr:Syphilis dbr:Systemic_lupus_erythematosus dbr:Efflux_(microbiology) dbr:Hepatotoxicity dbr:Diabetes dbr:Filariasis dbr:Cytoplasmic_membrane dbr:Methacycline dbr:Methyl dbr:Idiopathic_intracranial_hypertension dbr:Inguinal_hernia dbr:Antibiotic_resistance dbr:Meroë dbr:Microorganisms dbr:Brucellosis dbr:Bubonic_plague dbr:Omadacycline dbr:Rabies_vaccine dbr:Raccoon dbr:Reagent dbr:Yellapragada_Subbarow dbr:Hydroxyl dbr:Medicine dbr:Skin_and_skin_structure_infection dbr:Serum_(blood) dbr:Typhus dbr:Ultraviolet dbr:Tetracycline-controlled_transcriptional_activation dbr:Protein_synthesis_inhibitor dbr:Mycoplasmatota dbr:Narrow-spectrum_antibiotic dbr:Salpingitis dbr:Intestine dbr:Oxidoreductase dbr:Polyketides dbr:Rickettsia dbr:50S_ribosomal_subunit dbr:Bacteriocidal dbr:Bacteriostatic dbr:Matrix_metalloproteinases dbr:Borreliosis dbr:Prophylactic dbr:Rickettsiae dbr:Tetracycline_controlled_transcriptional_activation dbr:Aminoacyl_tRNA dbr:Water-soluble dbr:Chlamydia_(bacterium) dbr:30S_ribosomal_subunit dbr:Confound dbr:Kaposi_Sarcoma dbr:MRNA_translation dbr:Spirochete dbr:File:Tetracycline_numbering.svg |
| dbp:wikiPageUsesTemplate | dbt:About dbt:Authority_control dbt:Commons_category-inline dbt:Reflist dbt:Short_description dbt:TetracyclineAntiBiotics |
| dcterms:subject | dbc:Hepatotoxins dbc:Tetracycline_antibiotics |
| gold:hypernym | dbr:Group |
| rdf:type | owl:Thing yago:Abstraction100002137 yago:Act100030358 yago:Activity100407535 yago:Care100654885 yago:Chemical114806838 yago:Compound114818238 yago:Enol114605590 yago:Event100029378 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:PsychologicalFeature100023100 yago:Relation100031921 yago:Work100575741 yago:YagoPermanentlyLocatedEntity dbo:Band yago:Substance100019613 yago:Treatment100658082 yago:WikicatAcneTreatments yago:WikicatEnols yago:WikicatPhenols |
| rdfs:comment | تتراسيكلينات (بالإنجليزية: Tetracyclines) هي مضادات حيوية واسعة الطيف تشمل فعاليتها فعالية البنسلين والستربتومايسين والكلورامفينيكول. (ar) Tetracykliny, též tetracyklinová antibiotika jsou velkou skupinou širokospektrálních antibiotik. Působí primárně bakteriostaticky především proti intracelulárním gramnegativním bakteriím a též proti mnoha druhům grampozitivních bakterií, i když v současnosti je již problémem velké rozšíření rezistence. Tetracykliny první generace jsou metabolickými produkty , další jsou již semisyntetické látky od nich odvozené. Jejich účinek na bakterie spočívá ve vazbě na ribozomy a inhibici syntézy proteinů v bakteriální buňce. (cs) Tetracycline oder Tetrazykline sind antibiotisch wirksame Substanzen, die als Arzneimittel zur Behandlung von Infektionskrankheiten eingesetzt werden. Es gibt natürlich vorkommende Vertreter, die von Bakterien der Gattung Streptomyces produziert werden, und halbsynthetisch hergestellte Varianten, die durch chemische Veränderunge der biogenen Ausgangsstoffe erzeugt werden. Tetracycline wirken bakteriostatisch durch Hemmung der bakteriellen Proteinbiosynthese an den Ribosomen. Somit wird das Wachstum von grampositiven, gramnegativen und zahlreichen zellwandlosen Bakterien unterdrückt. (de) Les cyclines ou tétracyclines constituent une famille d'antibiotiques dérivés de la tétracycline. Ces molécules ont pour caractéristique de posséder quatre cycles accolés, d'où leur nom. Elles sont capables de pénétrer les cellules eucaryotes. On les utilise donc en particulier pour cibler les bactéries parasites intra-cellulaires (exemple : Chlamydia pneumoniae). Ces molécules sont bactériostatiques ; il y a donc un risque de récidive. (fr) テトラサイクリン系抗生物質（英: Tetracycline antibiotics, Tetracycline class, Tetracyclines、略: TC系, TC類, TCs, TETs）は、一群のの総称である。テトラサイクリンという名称は、四つの(tetra-)炭化水素からなる(cycl-)の誘導体(-ine)という意味である。TC系の抗菌スペクトラムは、全ての抗生物質で最も広い部類に属している。抗菌作用のない化学修飾されたCMTs(Chemically Modified Tetracyclines)の研究も進んでいる。 (ja) Le tetracicline sono un vasto gruppo di farmaci antibatterici inibitori della sintesi proteica. Efficaci contro i batteri Gram-positivi, Gram-negativi aerobi e anaerobi, contro brucelle e diarree causate da Escherichia coli. Inoltre, esse sono attive nei confronti di alcuni microorganismi resistenti agli antibiotici che agiscono sulla parete cellulare batterica, quali le rickettsie, le clamidie, i micoplasmi e i fitoplasmi. (it) Тетрациклины (англ. tetracyclines)— группа антибиотиков, относящихся к классу поликетидов, близких по химическому строению и биологическим свойствам. Представители данного семейства характеризуются общим спектром и механизмом антимикробного действия, полной перекрёстной устойчивостью, близкими фармакологическими характеристиками. Различия касаются некоторых физико-химических свойств, степени антибактериального эффекта, особенностей всасывания, распределения, метаболизма в макроорганизме и переносимости. (ru) 四环素类抗生素，一個（Broad-spectrum antibiotic）藥物家族的泛稱，因其氢化并四苯母核而得名。本类药物抗菌谱广，对革兰氏阴性菌、革兰氏阳性菌、螺旋体、衣原体、立克次氏体、支原体、放线菌和阿米巴原虫都有较强的作用。但近年来，其应用受到耐药的影响。 (zh) Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of Streptomyces bacteria or produced semi-synthetically from those isolated compounds. Tetracycline molecules comprise a linear fused tetracyclic nucleus (rings designated A, B, C and D) to which a variety of functional groups are attached. Tetracyclines are named for their four ("tetra-") hydrocarbon rings ("-cycl-") derivation ("-ine"). They are defined as a subclass of polyketides, having an octahydrotetracene-2-carboxamide skeleton and are known as derivatives of polycyclic naphthacene carboxamide.While all tetracyclines have a common structure, they differ from each other by the presence of chloride, methyl, and hydroxyl groups. Thes (en) Tetracyclines zijn een groep antibiotica gebaseerd op tetracycline. De tetracyclines inhiberen de binding van het aminoacyl-tRNA met mRNA (codon) ter hoogte van het 30S-ribosoom. Ze werken bacteriostatisch. Hun werking is omkeerbaar en afhankelijk van de bereikte concentratie binnen in de bacteriële cel. De belangrijkste tetracyclines zijn tetracycline, , , doxycycline en . (nl) Tetracykliny, antybiotyki tetracyklinowe − grupa antybiotyków o szerokim spektrum działania, pierwotnie otrzymywana ze szczepów promieniowca . Ich mechanizm działania polega na hamowaniu biosyntezy białka (zapobiegają wiązaniu się aminoacylo-tRNA z miejscem A rybosomu, blokując tym samym podjednostki 30S rybosomów bakteryjnych) i zaburzaniu procesów energetycznych w komórkach bakteryjnych. (pl) |
| rdfs:label | Tetracycline antibiotics (en) تتراسيكلينات (ar) Tetracykliny (cs) Tetracycline (de) Cyclines (antibiotiques) (fr) Tetracicline (it) テトラサイクリン系抗生物質 (ja) Tetracykliny (pl) Tetracyclines (nl) Тетрациклины (ru) 四环素类抗生素 (zh) |
| owl:sameAs | freebase:Tetracycline antibiotics freebase:Tetracycline antibiotics yago-res:Tetracycline antibiotics http://d-nb.info/gnd/4078215-3 wikidata:Tetracycline antibiotics dbpedia-ar:Tetracycline antibiotics dbpedia-cs:Tetracycline antibiotics dbpedia-da:Tetracycline antibiotics dbpedia-de:Tetracycline antibiotics dbpedia-fa:Tetracycline antibiotics dbpedia-fi:Tetracycline antibiotics http://fo.dbpedia.org/resource/Tetracyklin dbpedia-fr:Tetracycline antibiotics dbpedia-gl:Tetracycline antibiotics dbpedia-hr:Tetracycline antibiotics http://hy.dbpedia.org/resource/Տետրացիկլիններ dbpedia-it:Tetracycline antibiotics dbpedia-ja:Tetracycline antibiotics dbpedia-nl:Tetracycline antibiotics dbpedia-pl:Tetracycline antibiotics dbpedia-ro:Tetracycline antibiotics dbpedia-ru:Tetracycline antibiotics dbpedia-sh:Tetracycline antibiotics dbpedia-sk:Tetracycline antibiotics dbpedia-sl:Tetracycline antibiotics dbpedia-sr:Tetracycline antibiotics dbpedia-vi:Tetracycline antibiotics dbpedia-zh:Tetracycline antibiotics https://global.dbpedia.org/id/3vZU2 |
| prov:wasDerivedFrom | wikipedia-en:Tetracycline_antibiotics?oldid=1105579598&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Tetracycline_numbering.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Tetracycline_antibiotics |
| is dbo:wikiPageRedirects of | dbr:E701 dbr:Biomycin dbr:Tetracyclines dbr:Aminomethylcycline dbr:Tetracycline_antibiotic |
| is dbo:wikiPageWikiLink of | dbr:Enamel_microabrasion dbr:List_of_antibiotics dbr:Methicillin-resistant_Staphylococcus_aureus dbr:Primary_polydipsia dbr:Bartonella dbr:Demeclocycline dbr:Antimicrobial dbr:Infantile_acne dbr:List_of_infectious_diseases dbr:Potomac_horse_fever dbr:Meclocycline dbr:Boutonneuse_fever dbr:Phototoxicity dbr:Animal_Drug_Availability_Act_1996 dbr:Anirban_Basu dbr:Apicomplexa dbr:Lyme_disease dbr:Lymecycline dbr:Chlamydia_felis dbr:Cholestasis dbr:Stuart_B._Levy dbr:Dentinogenesis_imperfecta dbr:Actinomyces_viscosus dbr:Aggressive_periodontitis dbr:Tigecycline dbr:Helicobacter_cinaedi dbr:Lipid dbr:Doxycycline dbr:E701 dbr:Broad-spectrum_antibiotic dbr:Oxytetracycline dbr:Chryseobacterium dbr:Biomycin dbr:Dirofilariasis dbr:Legionnaires'_disease dbr:Recurrent_corneal_erosion dbr:Rickettsialpox dbr:Bacillus_anthracis dbr:Tetracene dbr:Tetracycline dbr:ATC_code_J01 dbr:Chlortetracycline dbr:Biosynthesis_of_doxorubicin dbr:Tetracyclic dbr:Pig_farming dbr:Platensimycin dbr:Idiopathic_intracranial_hypertension dbr:Infection dbr:Omadacycline dbr:Scrub_typhus dbr:CMT dbr:X-ray_crystallography dbr:Yellapragada_Subbarow dbr:Kitasatospora_aureofaciens dbr:Listeriosis_in_animals dbr:Protein_synthesis_inhibitor dbr:Mycoplasma_bovis dbr:Taylorella_equigenitalis dbr:Molar_incisor_hypomineralisation dbr:Phlyctenular_keratoconjunctivitis dbr:Photodermatitis dbr:Photosensitivity dbr:Paeniclostridium_sordellii dbr:Physical_hazard dbr:Soil_microbiology dbr:PAPA_syndrome dbr:Treatment_of_equine_lameness dbr:Rickettsia dbr:Tetracyclines dbr:Aminomethylcycline dbr:Tetracycline_antibiotic |
| is rdfs:seeAlso of | dbr:Doxycycline |
| is foaf:primaryTopic of | wikipedia-en:Tetracycline_antibiotics |
