Alcantara AA, Chen V, Herring BE, Mendenhall JM, Berlanga ML (2003). Localization of dopamine D2 receptors on cholinergic interneurons of the dorsal striatum and nucleus accumbens of the rat. Brain Res986: 22–29. ArticleCASPubMed Google Scholar
Alexander GE, Crutcher MD, DeLong MR (1990). Basal ganglia–thalamocortical circuits: parallel substrates for motor, oculomotor, ‘prefrontal’ and ‘limbic’ functions. Prog Brain Res85: 119–146. ArticleCASPubMed Google Scholar
Alheid GF, Heimer L (1988). New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience27: 1–39. CASPubMed Google Scholar
Amaral DG, Dolorfo C, Alvarez-Royo P (1991). Organization of CA1 projections to the subiculum: a PHA-L analysis in the rat. Hippocampus1: 415–435. ArticleCASPubMed Google Scholar
Ambroggi F, Ishikawa A, Fields HL, Nicola SM (2008). Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons. Neuron59: 648–661. ArticleCASPubMedPubMed Central Google Scholar
Araki M, McGeer PL, Kimura H (1988). The efferent projections of the rat lateral habenular nucleus revealed by the PHA-L anterograde tracing method. Brain Res441: 319–330. ArticleCASPubMed Google Scholar
Arencibia-Albite F, Paladini C, Williams JT, Jiménez-Rivera CA (2007). Noradrenergic modulation of the hyperpolarization-activated cation current (Ih) in dopamine neurons of the ventral tegmental area. Neuroscience149: 303–314. ArticleCASPubMed Google Scholar
Bacon SJ, Headlam AJN, Gabbott PLA, Smith AD (1996). Amygdala input to medial prefrontal cortex (mPFC) in the rat: a light and electron microscopic study. Brain Res720: 211–219. ArticleCASPubMed Google Scholar
Badiani A, Oates MM, Fraioli S, Browman KE, Ostrander MM, Xue CJ et al (2000). Environmental modulation of the response to amphetamine: dissociation between changes in behavior and changes in dopamine and glutamate overflow in the rat striatal complex. Psychopharmacology151: 166–174. ArticleCASPubMed Google Scholar
Balcita-Pedicino JJ, Sesack SR (2007). Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and gamma-aminobutyric acid neurons. J Comp Neurol503: 668–684. ArticlePubMed Google Scholar
Beckstead RM (1979). An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal-projection (prefrontal) cortex in the rat. J Comp Neurol184: 43–62. ArticleCASPubMed Google Scholar
Beckstead RM, Domesick VB, Nauta WJH (1979). Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Res175: 191–217. ArticleCASPubMed Google Scholar
Bell RL, Omelchenko N, Sesack SR (2007). Lateral habenula projections to the ventral tegmental area in the rat synapse onto dopamine and GABA neurons. Soc Neurosc Abstr33: 780.9. Google Scholar
Bellone C, Luscher C (2006). Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression. Nat Neurosci9: 636–641. ArticleCASPubMed Google Scholar
Belujon P, Grace AA (2008). Critical role of the prefrontal cortex in the regulation of hippocampus–accumbens information flow. J Neurosci28: 9797–9805. This paper demonstrated that the PFC is required to facilitate ventral hippocampal excitation of the NAc, which has relevance to both models of plasticity and cortical modulation of subcortical circuits. ArticleCASPubMedPubMed Central Google Scholar
Bennett BD, Bolam JP (1994). Synaptic input and output of parvalbumin-immunoreactive neurons in the neostriatum of the rat. Neuroscience62: 707–719. ArticleCASPubMed Google Scholar
Berendse HW, Galis-de Graaf Y, Groenewegen HJ (1992). Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J Comp Neurol316: 314–347. ArticleCASPubMed Google Scholar
Berendse HW, Groenewegen HJ (1990). Organization of the thalamostriatal projections in the rat, with special emphasis on the ventral striatum. J Comp Neurol299: 187–228. ArticleCASPubMed Google Scholar
Berke JD (2003). Learning and memory mechanisms involved in compulsive drug use and relapse. Methods Mol Med79: 75–101. This paper provided important new insights into habit formation, and the transition from rewards to habits during drug-reinforced behavior. CASPubMed Google Scholar
Berke JD (2008). Uncoordinated firing rate changes of striatal fast-spiking interneurons during behavioral task performance. J Neurosci28: 10075–10080. ArticleCASPubMedPubMed Central Google Scholar
Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL et al (1992). The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol319: 218–245. ArticleCASPubMed Google Scholar
Björklund A, Dunnett SB (2007). Dopamine neuron systems in the brain: an update. Trends Neurosci30: 194–202. PubMed Google Scholar
Blaha CD, Allen LF, Das S, Inglis WL, Latimer MP, Vincent SR et al (1996). Modulation of dopamine efflux in the nucleus accumbens after cholinergic stimulation of the ventral tegmental area in intact, pedunculopontine tegmental nucleus-lesioned, and laterodorsal tegmental nucleus-lesioned rats. J Neurosci16: 714–722. ArticleCASPubMedPubMed Central Google Scholar
Blomeley CP, Kehoe LA, Bracci E (2009). Substance P mediates excitatory interactions between striatal projection neurons. J Neurosci29: 4953–4963. ArticleCASPubMedPubMed Central Google Scholar
Bonson KR, Grant SJ, Contoreggi CS, Links JM, Metcalfe J, Weyl HL et al (2002). Neural systems and cue-induced cocaine craving. Neuropsychopharmacology26: 376–386. ArticleCASPubMed Google Scholar
Borgland SL, Malenka RC, Bonci A (2004). Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats. J Neurosci24: 7482–7490. ArticleCASPubMedPubMed Central Google Scholar
Borgland SL, Taha SA, Sarti F, Fields HL, Bonci A (2006). Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron49: 589–601. Orexin is gaining increasing recognition as a modulator of attentional and reward states, and this paper detailed how this peptide can affect DA systems. ArticleCASPubMed Google Scholar
Bouton ME, Bolles RC (1979). Role of conditioned contextual stimuli in reinstatement of extinguished fear. J Exp Psychol Anim Behav Process5: 368–378. ArticleCASPubMed Google Scholar
Bouton ME, King DA (1983). Contextual control of the extinction of conditioned fear: tests for the associative value of the context. J Exp Psychol Anim Behav Process9: 248–265. ArticleCASPubMed Google Scholar
Bouyer JJ, Park DH, Joh TH, Pickel VM (1984). Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum. Brain Res302: 267–275. ArticleCASPubMed Google Scholar
Brady AM, O'Donnell P (2004). Dopaminergic modulation of prefrontal cortical input to nucleus accumbens neurons in vivo. J Neurosci24: 1040–1049. ArticleCASPubMedPubMed Central Google Scholar
Brinley-Reed M, Mascagni F, McDonald AJ (1995). Synaptology of prefrontal cortical projections to the basolateral amygdala: an electron microscopic study in the rat. Neurosci Lett202: 45–48. ArticleCASPubMed Google Scholar
Brog JS, Salyapongse A, Deutch AY, Zahm DS (1993). The patterns of afferent innervation of the core and shell in the ‘accumbens’ part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold. J Comp Neurol338: 255–278. This paper detailed the major cortical and subcortical inputs to the core and shell subterritories of the NAc. ArticleCASPubMed Google Scholar
Brown P, Molliver ME (2000). Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. J Neurosci20: 1952–1963. ArticleCASPubMedPubMed Central Google Scholar
Bunney BS, Grace AA (1978). Acute and chronic haloperidol treatment: comparison of effects on nigral dopaminergic cell activity. Life Sci23: 1715–1727. ArticleCASPubMed Google Scholar
Cardinal RN, Winstanley CA, Robbins TW, Everitt BJ (2004). Limbic corticostriatal systems and delayed reinforcement. Ann NY Acad Sci1021: 33–50. ArticlePubMed Google Scholar
Carlezon Jr WA, Devine DP, Wise RA (1995). Habit-forming actions of nomifensine in nucleus accumbens. Psychopharmacology122: 194–197. ArticleCASPubMed Google Scholar
Carlezon Jr WA, Thomas MJ (2009). Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis. Neuropharmacology56 (Suppl 1): 122–132. ArticleCASPubMed Google Scholar
Carr DB, Sesack SR (2000a). GABA-containing neurons in the rat ventral tegmental area project to the prefrontal cortex. Synapse38: 114–123. This paper established that most of the VTA projection to the PFC derives from GABA as opposed to DA cells. ArticleCASPubMed Google Scholar
Carr DB, Sesack SR (2000b). Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons. J Neurosci20: 3864–3873. This publication was the first to provide evidence consistent with different populations of VTA DA neurons having distinct sources of afferent drive. ArticleCASPubMedPubMed Central Google Scholar
Celada P, Paladini CA, Tepper JM (1999). GABAergic control of rat substantia nigra dopaminergic neurons: role of globus pallidus and substantia nigra pars reticulata. Neuroscience89: 813–825. ArticleCASPubMed Google Scholar
Cepeda C, Buchwald NA, Levine MS (1993). Neuromodulatory actions of dopamine in the neostriatum are dependent on the excitatory amino acid receptor subtypes activated. Proc Natl Acad Sci90: 9576–9580. ArticleCASPubMedPubMed Central Google Scholar
Cepeda C, Colwell CS, Itri JN, Chandler SH, Levine MS (1998). Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: contribution of calcium conductances. J Neurophysiol79: 82–94. ArticleCASPubMed Google Scholar
Charara A, Grace AA (2003). Dopamine receptor subtypes selectively modulate excitatory afferents from the hippocampus and amygdala to rat nucleus accumbens neurons. Neuropsychopharmacology28: 1412–1421. ArticleCASPubMed Google Scholar
Charara A, Smith Y, Parent A (1996). Glutamatergic inputs from the pedunculopontine nucleus to midbrain dopaminergic neurons in primates: _Phaseolus vulgaris_-leucoagglutinin anterograde labeling combined with postembedding glutamate and GABA immunohistochemistry. J Comp Neurol364: 254–266. This paper provided the first anatomical evidence for an ascending subcortical excitatory projection that synapses onto VTA DA neurons. ArticleCASPubMed Google Scholar
Chen BT, Bowers MS, Martin M, Hopf FW, Guillory AM, Carelli RM et al (2008). Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA. Neuron59: 288–297. ArticleCASPubMedPubMed Central Google Scholar
Chergui K, Charlety PJ, Akaoka H, Saunier CF, Brunet J-L, Svensson TH et al (1993). Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. Eur J Neurosci5: 137–144. ArticleCASPubMed Google Scholar
Chergui K, Lacey MG (1999). Modulation by dopamine D1-like receptors of synaptic transmission and NMDA receptors in rat nucleus accumbens is attenuated by the protein kinase C inhibitor Ro 32-0432. Neuropharmacology38: 223–231. ArticleCASPubMed Google Scholar
Chuhma N, Zhang H, Masson J, Zhuang X, Sulzer D, Hen R et al (2004). Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses. J Neurosci24: 972–981. ArticleCASPubMedPubMed Central Google Scholar
Churchill L, Kalivas PW (1994). A topographically organized gamma-aminobutyric acid projection from the ventral pallidum to the nucleus accumbens in the rat. J Comp Neurol345: 579–595. ArticleCASPubMed Google Scholar
Coizet V, Comoli E, Westby GW, Redgrave P (2003). Phasic activation of substantia nigra and the ventral tegmental area by chemical stimulation of the superior colliculus: an electrophysiological investigation in the rat. Eur J Neurosci17: 28–40. ArticlePubMed Google Scholar
Colussi-Mas J, Geisler S, Zimmer L, Zahm DS, Berod A (2007). Activation of afferents to the ventral tegmental area in response to acute amphetamine: a double-labelling study. Eur J Neurosci26: 1011–1025. ArticlePubMedPubMed Central Google Scholar
Comoli E, Coizet V, Boyes J, Bolam JP, Canteras NS, Quirk RH et al (2003). A direct projection from superior colliculus to substantia nigra for detecting salient visual events. Nat Neurosci6: 974–980. ArticleCASPubMed Google Scholar
Crombag HS, Badiani A, Maren S, Robinson TE (2000). The role of contextual vs discrete drug-associated cues in promoting the induction of psychomotor sensitization to intravenous amphetamine. Behav Brain Res116: 1–22. This paper provided an important link between environment and behavioral sensitization by demonstrating how context can modify behavioral expression. ArticleCASPubMed Google Scholar
Dallvechia-Adams S, Kuhar MJ, Smith Y (2002). Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with g-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons. J Comp Neurol448: 360–372. ArticleCASPubMed Google Scholar
Dallvechia-Adams S, Smith Y, Kuhar MJ (2001). CART peptide-immunoreactive projection from the nucleus accumbens targets substantia nigra pars reticulata neurons in the rat. J Comp Neurol434: 29–39. ArticleCASPubMed Google Scholar
Day M, Wang Z, Ding J, An X, Ingham CA, Shering AF et al (2006). Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models. Nat Neurosci9: 251–259. ArticleCASPubMed Google Scholar
Del-Fava F, Hasue RH, Ferreira JG, Shammah-Lagnado SJ (2007). Efferent connections of the rostral linear nucleus of the ventral tegmental area in the rat. Neuroscience145: 1059–1076. ArticleCASPubMed Google Scholar
Delfs JM, Zhu Y, Druhan JP, Aston-Jones GS (1998). Origin of noradrenergic afferents to the shell subregion of the nucleus accumbens: anterograde and retrograde tract-tracing studies in the rat. Brain Res806: 127–140. ArticleCASPubMed Google Scholar
Deng YP, Lei WL, Reiner A (2006). Differential perikaryal localization in rats of D1 and D2 dopamine receptors on striatal projection neuron types identified by retrograde labeling. J Chem Neuroanat32: 101–116. ArticleCASPubMed Google Scholar
Descarries L, Berube-Carriere N, Riad M, Bo GD, Mendez JA, Trudeau LE (2008). Glutamate in dopamine neurons: synaptic vs diffuse transmission. Brain Res Rev58: 290–302. ArticleCASPubMed Google Scholar
Descarries L, Watkins KC, Garcia S, Bosler O, Doucet G (1996). Dual character, asynaptic and synaptic, of the dopamine innervation in adult rat neostriatum: a quantitative autoradiographic and immunocytochemical analysis. J Comp Neurol375: 167–186. ArticleCASPubMed Google Scholar
Deutch AY, Goldstein M, Baldino Jr F, Roth RH (1988). Telencephalic projections of the A8 dopamine cell group. Ann NY Acad Sci537: 27–50. ArticleCASPubMed Google Scholar
Dobi A, Morales M (2007). Dopaminergic neurons in the rat ventral tegmental area (VTA) receive glutamatergic inputs from local glutamatergic neurons. Soc Neurosci Abstr916: 8. Google Scholar
Dommett E, Coizet V, Blaha CD, Martindale J, Lefebvre V, Walton N et al (2005). How visual stimuli activate dopaminergic neurons at short latency. Science307: 1476–1479. This publication, along with the Coizet and Comoli papers, provides an essential link between sensory processes and DA neuron activation and has important implications for understanding phasic activation of DA neurons in reward-related processes. ArticleCASPubMed Google Scholar
Dubé L, Smith AD, Bolam JP (1988). Identification of synaptic terminals of thalamic or cortical origin in contact with distinct medium-size spiny neurons in the rat neostriatum. J Comp Neurol267: 455–471. ArticlePubMed Google Scholar
Dumartin B, Caillé I, Gonon F, Bloch B (1998). Internalization of D1 dopamine receptor in striatal neurons in vivo as evidence of activation by dopamine agonists. J Neurosci18: 1650–1661. ArticleCASPubMedPubMed Central Google Scholar
Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW (2008). Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc London Ser B363: 3125–3135. Article Google Scholar
Everitt BJ, Robbins TW (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci8: 1481–1489. ArticleCASPubMed Google Scholar
Fadel J, Zahm DS, Deutch AY (2002). Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience111: 379–387. ArticleCASPubMed Google Scholar
Faleiro LJ, Jones S, Kauer JA (2003). Rapid AMPAR/NMDAR response to amphetamine: a detectable increase in AMPAR/NMDAR ratios in the ventral tegmental area is detectable after amphetamine injection. Ann NY Acad Sci1003: 391–394. ArticleCASPubMed Google Scholar
Faleiro LJ, Jones S, Kauer JA (2004). Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection. Neuropsychopharmacology29: 2115–2125. ArticleCASPubMed Google Scholar
Fallon JH, Moore RY (1978). Catecholamine innervation of the basal forebrain: IV. Topography of the dopamine projection to the basal forebrain and neostriatum. J Comp Neurol180: 545–580. ArticleCASPubMed Google Scholar
Fanselow MS (2000). Contextual fear, gestalt memories, and the hippocampus. Behav Brain Res110: 73–81. ArticleCASPubMed Google Scholar
Ferreira JG, Del-Fava F, Hasue RH, Shammah-Lagnado SJ (2008). Organization of ventral tegmental area projections to the ventral tegmental area—nigral complex in the rat. Neuroscience153: 196–213. This publication demonstrated that different subdivisions of the nigral–VTA complex are interconnected, most likely via non-DA cells. ArticleCASPubMed Google Scholar
Fields HL, Hjelmstad GO, Margolis EB, Nicola SM (2007). Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. Annu Rev Neurosci30: 289–316. ArticleCASPubMed Google Scholar
Finch DM (1996). Neurophysiology of converging synaptic inputs from the rat prefrontal cortex, amygdala, midline thalamus, and hippocampal formation onto single neurons of the caudate/putamen and nucleus accumbens. Hippocampus6: 495–512. ArticleCASPubMed Google Scholar
Flores G, Alquicer G, Silva-Gomez AB, Zaldivar G, Stewart J, Quirion R et al (2005). Alterations in dendritic morphology of prefrontal cortical and nucleus accumbens neurons in post-pubertal rats after neonatal excitotoxic lesions of the ventral hippocampus. Neuroscience133: 463–470. ArticleCASPubMed Google Scholar
Floresco SB, Grace AA (2003). Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area. J Neurosci23: 3930–3943. ArticleCASPubMedPubMed Central Google Scholar
Floresco SB, Todd CL, Grace AA (2001). Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of the ventral tegmental area dopamine neurons. J Neurosci21: 4915–4922. ArticleCASPubMedPubMed Central Google Scholar
Floresco SB, West AR, Ash B, Moore H, Grace AA (2003). Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nat Neurosci6: 968–973. This paper provided a physiological explanation for tonic and phasic DA transmission and how it is modulated by different afferent systems. ArticleCASPubMed Google Scholar
Ford CP, Mark GP, Williams JT (2006). Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. J Neurosci26: 2788–2797. ArticleCASPubMedPubMed Central Google Scholar
Forster GL, Blaha CD (2000). Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area. Eur J Neurosci12: 3596–3604. ArticleCASPubMed Google Scholar
Frankle WG, Laruelle M, Haber SN (2006). Prefrontal cortical projections to the midbrain in primates: evidence for a sparse connection. Neuropsychopharmacology31: 1627–1636. ArticleCASPubMed Google Scholar
Freeman AS, Meltzer LT, Bunney BS (1985). Firing properties of substantia nigra dopaminergic neurons in freely moving rats. Life Sci36: 1983–1994. ArticleCASPubMed Google Scholar
French SJ, Hailstone JC, Totterdell S (2003). Basolateral amygdala efferents to the ventral subiculum preferentially innervate pyramidal cell dendritic spines. Brain Res981: 160–167. ArticleCASPubMed Google Scholar
French SJ, Ritson GP, Hidaka S, Totterdell S (2005). Nucleus accumbens nitric oxide immunoreactive interneurons receive nitric oxide and ventral subicular afferents in rats. Neuroscience135: 121–131. ArticleCASPubMed Google Scholar
French SJ, Totterdell S (2002). Hippocampal and prefrontal cortical inputs monosynaptically converge with individual projection neurons of the nucleus accumbens. J Comp Neurol446: 151–165. This publication and the 2003 paper below provide the first definitive anatomical evidence for synaptic convergence of multiple cortical inputs onto the same NAc medium spiny neurons, supporting a complex integrative function of this system. ArticlePubMed Google Scholar
French SJ, Totterdell S (2003). Individual nucleus accumbens-projection neurons receive both basolateral amygdala and ventral subicular afferents in rats. Neuroscience119: 19–31. ArticleCASPubMed Google Scholar
French SJ, Totterdell S (2004). Quantification of morphological differences in boutons from different afferent populations to the nucleus accumbens. Brain Res1007: 167–177. ArticleCASPubMed Google Scholar
Fudge JL, Haber SN (2000). The central nucleus of the amygdala projection to dopamine subpopulations in primates. Neuroscience97: 479–494. ArticleCASPubMed Google Scholar
Futami T, Takakusaki K, Kitai S (1995). Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta. Neurosci Res Suppl21: 331–342. ArticleCAS Google Scholar
Garzón M, Vaughan RA, Uhl GR, Kuhar MJ, Pickel VM (1999). Cholinergic axon terminals in the ventral tegmental area target a subpopulation of neurons expressing low levels of the dopamine transporter. J Comp Neurol410: 197–210. ArticlePubMed Google Scholar
Gaykema RP, Záborszky L (1996). Direct catecholaminergic–cholinergic interactions in the basal forebrain. II. Substantia nigra–ventral tegmental area projections to cholinergic neurons. J Comp Neurol374: 555–577. ArticleCASPubMed Google Scholar
Geisler S, Derst C, Veh RW, Zahm DS (2007). Glutamatergic afferents of the ventral tegmental area in the rat. J Neurosci27: 5730–5743. This seminal paper revealed that a substantial number of glutamate neurons, most previously uncharacterized, send excitatory projections to the VTA from many levels of the neural axis. ArticleCASPubMedPubMed Central Google Scholar
Geisler S, Marinelli M, Degarmo B, Becker ML, Freiman AJ, Beales M et al (2008). Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine. Neuropsychopharmacology33: 2688–2700. ArticleCASPubMed Google Scholar
Geisler S, Zahm DS (2005). Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions. J Comp Neurol490: 270–294. This paper revealed that the VTA integrates convergent information from an interconnected network of cells comprising the reticular (isodendritic) core of the brain. ArticlePubMed Google Scholar
Geisler S, Zahm DS (2006). Neurotensin afferents of the ventral tegmental area in the rat: [1] re-examination of their origins and [2] responses to acute psychostimulant and antipsychotic drug administration. Eur J Neurosci24: 116–134. ArticlePubMed Google Scholar
Georges F, Aston-Jones G (2002). Activation of ventral tegmental area cells by the bed nucleus of the stria terminalis: a novel excitatory amino acid input to midbrain dopamine neurons. J Neurosci22: 5173–5187. ArticleCASPubMedPubMed Central Google Scholar
Gerfen CR (1992). The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu Rev Neurosci15: 285–320. ArticleCASPubMed Google Scholar
Gerfen CR, Engber TM, Mahan LC, Susel Z, Chase TN, Monsma FJ et al (1990). D1 and D2 dopamine receptor regulated gene expression of striatonigral and striatopallidal neurons. Science250: 1429–1432. ArticleCASPubMed Google Scholar
Gervais J, Rouillard C (2000). Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. Synapse35: 281–291. ArticleCASPubMed Google Scholar
Gonzales C, Chesselet MF (1990). Amygdalonigral pathway: an anterograde study in the rat with Phaseolus vulgaris leucoagglutinin (PHA-L). J Comp Neurol297: 182–200. ArticleCASPubMed Google Scholar
Goto Y, Grace AA (2005a). Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization. Neuron47: 255–266. This paper used in vivo recordings and drug administration to demonstrate how changes in synaptic plasticity induced by cocaine can translate into behavioral alterations, providing an important insight into how drug-induced alterations in circuitry can lead to pathological responses. ArticleCASPubMed Google Scholar
Goto Y, Grace AA (2005b). Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior. Nat Neurosci8: 805–812. ArticleCASPubMed Google Scholar
Goto Y, O'Donnell P (2002). Timing-dependent limbic–motor synaptic integration in the nucleus accumbens. Proce Natl Acad Sci99: 13189–13193. ArticleCAS Google Scholar
Grace AA (1991). Phasic vs tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience41: 1–24. This paper provided the first accounting of phasic vs tonic modes of DA transmission and how they can differentially signal postsynaptic structures. ArticleCASPubMed Google Scholar
Grace AA, Bunney BS (1979). Paradoxical GABA excitation of nigral dopaminergic cells: indirect mediation through reticulata inhibitory neurons. Eur J Pharmacol59: 211–218. ArticleCASPubMed Google Scholar
Grace AA, Bunney BS (1983). Intracellular and extracellular electrophysiology of nigral dopaminergic neurons. 1. Identification and characterization. Neuroscience10: 301–315. ArticleCASPubMed Google Scholar
Grace AA, Bunney BS (1985). Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Res333: 271–284. ArticleCASPubMed Google Scholar
Grace AA, Floresco SB, Goto Y, Lodge DJ (2007). Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends Neurosci30: 220–227. ArticleCASPubMed Google Scholar
Grace AA, Onn S (1989). Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. J Neurosci9: 3463–3481. ArticleCASPubMedPubMed Central Google Scholar
Grenhoff J, North RA, Johnson SW (1995). Alpha 1-adrenergic effects on dopamine neurons recorded intracellularly in the rat midbrain slice. Eur J Neurosci7: 1707–1713. ArticleCASPubMed Google Scholar
Groenewegen HJ (1988). Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography. Neuroscience24: 379–431. ArticleCASPubMed Google Scholar
Groenewegen HJ, Berendse HW, Haber SN (1993). Organization of the output of the ventral striatopallidal system in the rat: ventral pallidal efferents. Neuroscience57: 113–142. ArticleCASPubMed Google Scholar
Groenewegen HJ, Russchen FT (1984). Organization of the efferent projections of the nucleus accumbens to pallidal, hypothalamic, and mesencephalic structures: a tracing and immunohistochemical study in the cat. J Comp Neurol223: 347–367. ArticleCASPubMed Google Scholar
Groenewegen HJ, Vermeulen-Van der Zee E, te Kortschot A, Witter MP (1987). Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgais leucoagglutinin. Neuroscience23: 103–120. ArticleCASPubMed Google Scholar
Groenewegen HJ, Wright CI, Beijer AV (1996). The nucleus accumbens: gateway for limbic structures to reach the motor system? Prog Brain Res107: 485–511. ArticleCASPubMed Google Scholar
Groenewegen HJ, Wright CI, Beijer AV, Voorn P (1999). Convergence and segregation of ventral striatal inputs and outputs. Ann NY Acad Sci877: 49–63. ArticleCASPubMed Google Scholar
Gruber AJ, Hussain RJ, O'Donnell P (2009a). The nucleus accumbens: a switchboard for goal-directed behaviors. PLoS ONE4: e5062. This paper used in vivo recordings in PFC, hippocampus, and NAc to show that alterations in synchrony of rhythmic activity occur in concert with changes in behavioral contingencies. ArticlePubMedPubMed CentralCAS Google Scholar
Gruber AJ, Powell EM, O'Donnell P (2009b). Cortically activated interneurons shape spatial aspects of cortico-accumbens processing. J Neurophysiol101: 1876–1882. ArticleCASPubMedPubMed Central Google Scholar
Guiard BP, El Mansari M, Blier P (2008). Cross-talk between dopaminergic and noradrenergic systems in the rat ventral tegmental area, locus ceruleus, and dorsal hippocampus. Mol Pharmacol74: 1463–1475. ArticleCASPubMed Google Scholar
Haber SN, Fudge JL, McFarland NR (2000). Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J Neurosci20: 2369–2382. This paper reconceptualized the model of ‘parallel loops’ running through basal ganglia circuitry to one of an ascending medial to lateral spiral that ultimately communicates limbic information to motor control and cognitive function. ArticleCASPubMedPubMed Central Google Scholar
Haber SN, Lynd E, Klein C, Groenewegen HJ (1990). Topographic organization of the ventral striatal efferent projections in the rhesus monkey: an anterograde tracing study. J Comp Neurol293: 282–298. ArticleCASPubMed Google Scholar
Haber SN, Ryoo H, Cox C, Lu W (1995). Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity. J Comp Neurol362: 400–410. ArticleCASPubMed Google Scholar
Hariri AR, Mattay VS, Tessitore A, Fera F, Weinberger DR (2003). Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry53: 494–501. ArticlePubMed Google Scholar
Harris GC, Wimmer M, Aston-Jones G (2005). A role for lateral hypothalamic orexin neurons in reward seeking. Nature437: 556–559. ArticleCASPubMed Google Scholar
Hasue RH, Shammah-Lagnado SJ (2002). Origin of the dopaminergic innervation of the central extended amygdala and accumbens shell: a combined retrograde tracing and immunohistochemical study in the rat. J Comp Neurol454: 15–33. ArticleCASPubMed Google Scholar
Heimer L, Zahm DS, Churchill L, Kalivas PW, Wohltmann C (1991). Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience41: 89–125. This important paper detailing the projections from the NAc core and shell to relatively segregated regions within the VP, basal forebrain, hypothalamus and midbrain, established the striatal character of both the core and shell subdivisions and highlighted the additional alignment of the shell with the extended amygdala. ArticleCASPubMed Google Scholar
Herkenham M, Nauta WJ (1979). Efferent connections of the habenular nuclei in the rat. J Comp Neurol187: 19–47. ArticleCASPubMed Google Scholar
Herman JP, Mueller NK (2006). Role of the ventral subiculum in stress integration. Behav Brain Res174: 215–224. This paper brought to the forefront research demonstrating that the ventral subiculum has a central and important role in the regulation of the stress response. ArticleCASPubMed Google Scholar
Hersch SM, Ciliax BJ, Gutekunst CA, Rees HD, Heilman CJ, Yung KKL et al (1995). Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents. J Neurosci15: 5222–5237. ArticleCASPubMedPubMed Central Google Scholar
Hervé D, Pickel VM, Joh TH, Beaudet A (1987). Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons. Brain Res435: 71–83. ArticlePubMed Google Scholar
Herzog E, Bellenchi GC, Gras C, Bernard V, Ravassard P, Bedet C et al (2001). The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci21: RC181. ArticleCASPubMedPubMed Central Google Scholar
Hidaka S, Totterdell S (2001). Ultrastructural features of the nitric oxide synthase-containing interneurons in the nucleus accumbens and their relationship with tyrosine hydroxylase-containing terminals. J Comp Neurol431: 139–154. ArticleCASPubMed Google Scholar
Hikosaka O, Sesack SR, Lecourtier L, Shepard PD (2008). Habenula: crossroad between the basal ganglia and the limbic system. J Neurosci28: 11825–11829. ArticleCASPubMedPubMed Central Google Scholar
Hollerman JR, Schultz W (1998). Dopamine neurons report an error in the temporal prediction of reward during learning. Nat Neurosci1: 304–309. This paper, which formed the basis of many computational models of DA system function, was the first manuscript to demonstrate that DA neuron activity shows attenuation when animals are presented with the absence of a reward, or an error in reward prediction. ArticleCASPubMed Google Scholar
Horvitz JC (2000). Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience96: 651–656. ArticleCASPubMed Google Scholar
Huey ED, Zahn R, Krueger F, Moll J, Kapogiannis D, Wassermann EM et al (2008). A psychological and neuroanatomical model of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci20: 390–408. ArticlePubMedPubMed Central Google Scholar
Hur EE, Zaborszky L (2005). Vglut2 afferents to the medial prefrontal and primary somatosensory cortices: a combined retrograde tracing in situ hybridization. J Comp Neurol483: 351–373. ArticlePubMed Google Scholar
Hussain Z, Johnson LR, Totterdell S (1996). A light and electron microscopic study of NADPH-diaphorase-, calretinin- and parvalbumin-containing neurons in the rat nucleus accumbens. J Chem Neuroanat10: 19–39. ArticleCASPubMed Google Scholar
Hyman SE, Malenka RC, Nestler EJ (2006). Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci29: 565–598. ArticleCASPubMed Google Scholar
Ikemoto S (2007). Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex. Brain Res Rev56: 27–78. ArticleCASPubMedPubMed Central Google Scholar
Ishikawa A, Ambroggi F, Nicola SM, Fields HL (2008). Contributions of the amygdala and medial prefrontal cortex to incentive cue responding. Neuroscience155: 573–584. ArticleCASPubMed Google Scholar
Ito R, Dalley JW, Robbins TW, Everitt BJ (2002). Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue. J Neurosci22: 6247–6253. ArticleCASPubMedPubMed Central Google Scholar
Ito R, Robbins TW, Pennartz CM, Everitt BJ (2008). Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning. J Neurosci28: 6950–6959. This paper provided an important link between understanding brain circuitry and appetitive conditioning. ArticleCASPubMedPubMed Central Google Scholar
Izzo PN, Bolam JP (1988). Cholinergic synaptic input to different parts of spiny striatonigral neurons in the rat. J Comp Neurol269: 219–234. ArticleCASPubMed Google Scholar
Jay TM, Thierry AM, Wiklund L, Glowinski J (1992). Excitatory amino acid pathway from the hippocampus to the prefrontal cortex. Contribution of AMPA receptors in hippocampo–prefrontal cortex transmission. Eur J Neurosci4: 1285–1295. ArticlePubMed Google Scholar
Jhou TC, Fields HL, Baxter MG, Saper CB, Holland PC (2009a). The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron61: 786–800. ArticleCASPubMedPubMed Central Google Scholar
Jhou TC, Gallagher M (2007). Paramedian raphe neurons that project to midbrain dopamine neurons are activated by aversive stimuli. Soc Neurosci Abstr425: 5. Google Scholar
Jhou TC, Geisler S, Marinelli M, Degarmo BA, Zahm DS (2009b). The mesopontine rostromedial tegmental nucleus: a structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta. J Comp Neurol513: 566–596. This noteworthy paper presented extensive evidence that a previously unappreciated area of the brainstem serves as an essential inhibitory gateway to midbrain DA neurons. ArticlePubMedPubMed Central Google Scholar
Ji H, Shepard PD (2007). Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism. J Neurosci27: 6923–6930. ArticleCASPubMedPubMed Central Google Scholar
Johnson LR, Aylward RLM, Hussain Z, Totterdell S (1994). Input from the amygdala to the rat nucleus accumbens: its relationship with tyrosine hydroxylase immunoreactivity and identified neurons. Neuroscience61: 851–865. ArticleCASPubMed Google Scholar
Jongen-Rêlo AL, Groenewegen HJ, Voorn P (1993). Evidence for a multi-compartmental histochemical organization of the nucleus accumbens in the rat. J Comp Neurol337: 267–276. ArticlePubMed Google Scholar
Jongen-Rêlo AL, Voorn P, Groenewegen HJ (1994). Immunohistochemical characterization of the shell and core territories of the nucleus accumbens in the rat. Eur J Neurosci6: 1255–1264. ArticlePubMed Google Scholar
Kalivas PW (1995). Interactions between dopamine and excitatory amino acids in behavioral sensitization to psychostimulants. Drug Alcohol Depend37: 95–100. ArticleCASPubMed Google Scholar
Kalivas PW, McFarland K (2003). Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology168: 44–56. ArticleCASPubMed Google Scholar
Kalivas PW, Stewart J (1991). Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Rev16: 223–244. ArticleCASPubMed Google Scholar
Kalivas PW, Volkow N, Seamans J (2005). Unmanageable motivation in addiction: a pathology in prefrontal–accumbens glutamate transmission. Neuron45: 647–650. This paper provided a synthesis of data regarding how PFC glutamate projections to the NAc may underlie the behavioral deficits associated with addictive behavior. ArticleCASPubMed Google Scholar
Kaufling J, Veinante P, Pawlowski SA, Freund-Mercier M-J, Barrot M (2009). Afferents to the GABAergic tail of the ventral tegmental area in the rat. J Comp Neurol513: 597–621. ArticlePubMed Google Scholar
Kawaguchi Y, Wilson CJ, Augood SJ, Emson PC (1995). Striatal interneurones: chemical, physiological and morphological characterization. Trends Neurosci18: 527–535. ArticleCASPubMed Google Scholar
Kawano M, Kawasaki A, Sakata-Haga H, Fukui Y, Kawano H, Nogami H et al (2006). Particular subpopulations of midbrain and hypothalamic dopamine neurons express vesicular glutamate transporter 2 in the rat brain. J Comp Neurol498: 581–592. ArticleCASPubMed Google Scholar
Kelley AE, Domesick VB (1982). The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: an anterograde- and retrograde-horseradish peroxidase study. Neuroscience7: 2321–2335. ArticleCASPubMed Google Scholar
Kelley AE, Domesick VB, Nauta WJH (1982). The amygdalostriatal projection in the rat—an anatomical study by anterograde and retrograde tracing methods. Neuroscience7: 615–630. ArticleCASPubMed Google Scholar
Kelley AE, Stinus L (1984). The distribution of the projection from the parataenial nucleus of the thalamus to the nucleus accumbens in the rat: an autoradiographic study. Exp Brain Res54: 499–512. ArticleCASPubMed Google Scholar
Ketter TA (2008). Monotherapy vs combined treatment with second-generation antipsychotics in bipolar disorder. J Clin Psychiatry69 (Suppl 5): 9–15. CASPubMed Google Scholar
Kita H, Kitai ST (1990). Amygdaloid projections to the frontal cortex and the striatum in the rat. J Comp Neurol298: 40–49. ArticleCASPubMed Google Scholar
Klitenick MA, Deutch AY, Churchill L, Kalivas PW (1992). Topography and functional role of dopaminergic projections from the ventral mesencephalic tegmentum to the ventral pallidum. Neuroscience50: 371–386. ArticleCASPubMed Google Scholar
Koob GF (1992). Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci13: 177–184. ArticleCASPubMed Google Scholar
Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE (2003). Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. J Neurosci23: 7–11. ArticleCASPubMedPubMed Central Google Scholar
Lammel S, Hetzel A, Hackel O, Jones I, Liss B, Roeper J (2008). Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron57: 760–773. This is the first paper providing evidence for functionally defined subclasses of midbrain dopamine neurons in the mouse brain. ArticleCASPubMed Google Scholar
Lapper SR, Bolam JP (1992). Input from the frontal cortex and the parafascicular nucleus to cholinergic interneurons in the dorsal striatum of the rat. Neuroscience51: 533–545. ArticleCASPubMed Google Scholar
Lapper SR, Smith Y, Sadikot AF, Parent A, Bolam JP (1992). Cortical input to parvalbumin-immunoreactive neurones in the putamen of the squirrel monkey. Brain Res580: 215–224. ArticleCASPubMed Google Scholar
Lavin A, Grace AA (1994). Modulation of dorsal thalamic cell activity by the ventral pallidum: its role in the regulation of thalamocortical activity by the basal ganglia. Synapse18: 104–127. ArticleCASPubMed Google Scholar
Lavin A, Nogueira L, Lapish CC, Wightman RM, Phillips PE, Seamans JK (2005). Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling. J Neurosci25: 5013–5023. ArticleCASPubMedPubMed Central Google Scholar
Laviolette SR, Grace AA (2006). The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction. Cell Mol Life Sci63: 1597–1613. ArticleCASPubMed Google Scholar
Laviolette SR, Lipski WJ, Grace AA (2005). A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala input. J Neurosci25: 6066–6075. This manuscript was the first to demonstrate the importance of the PFC (vs the amygdala) in the expression of behavioral learning, and refocused attention on the role of D4 receptors on interneurons in controlling this behavioral output. ArticleCASPubMedPubMed Central Google Scholar
Lavoie B, Parent A (1994). Pedunculopontine nucleus in the squirrel monkey: cholinergic and glutamatergic projections to the substantia nigra. J Comp Neurol344: 232–241. ArticleCASPubMed Google Scholar
Le Moine C, Bloch B (1995). D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum. J Comp Neurol355: 418–426. ArticleCASPubMed Google Scholar
Le Moine C, Bloch B (1996). Expression of the D3 dopamine receptor in peptidergic neurons of the nucleus accumbens: comparison with the D1 and D2 dopamine receptors. Neuroscience73: 131–143. ArticleCASPubMed Google Scholar
Lee KW, Kim Y, Kim AM, Helmin K, Nairn AC, Greengard P (2006). Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. Proc Natl Acad Sci103: 3399–3404. ArticleCASPubMedPubMed Central Google Scholar
Lewis DA, Sesack SR (1997). Dopamine systems in the primate brain. In: Bloom FE, Björklund A, Hökfelt T (eds). Handbook of Chemical Neuroanatomy, The Primate Nervous System, Part I. Elsevier: Amsterdam. pp 261–373. Google Scholar
Lin YJ, Greif GJ, Freedman JE (1996). Permeation and block of dopamine-modulated potassium channels on rat striatal neurons by cesium and barium ions. J Neurophysiol76: 1413–1422. ArticleCASPubMed Google Scholar
Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR (2004). Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area. Synapse52: 233–244. ArticleCASPubMed Google Scholar
Lipski WJ, Grace AA (2008). Neurons in the ventral subiculum are activated by noxious stimuli and are modulated by noradrenergic afferents. Soc Neurosci Abstr195: 1. Google Scholar
Lisman JE, Grace AA (2005). The hippocampal–VTA loop: controlling the entry of information into long-term memory. Neuron46: 703–713. ArticleCASPubMed Google Scholar
Lodge DJ, Grace AA (2006a). The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activation. Neuropsychopharmacology31: 1356–1361. The data in this paper demonstrated independent pathways regulating DA neuron populations: one supplying the ‘signal’ that drives phasic firing and one that provides the ‘gain’ of the signal based on the environmental context. ArticleCASPubMed Google Scholar
Lodge DJ, Grace AA (2006b). The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons. Proc Natl Acad Sci103: 5167–5172. ArticleCASPubMedPubMed Central Google Scholar
Lodge DJ, Grace AA (2008). Amphetamine activation of hippocampal drive of mesolimbic dopamine neurons: a mechanism of behavioral sensitization. J Neurosc28: 7876–7882. This paper showed that alteration in the DA ‘gain,’ i.e. the number of DA neurons firing, is disrupted by amphetamine sensitization, thus providing an electrophysiological link between context-dependent sensitization and DA neuron activity. ArticleCAS Google Scholar
Lokwan SJ, Overton PG, Berry MS, Clark D (1999). Stimulation of the pedunculopontine tegmental nucleus in the rat produces burst firing in A9 dopaminergic neurons. Neuroscience92: 245–254. ArticleCASPubMed Google Scholar
Loughlin SE, Fallon JH (1983). Dopaminergic and non-dopaminergic projections to amygdala from substantia nigra and ventral tegmental area. Brain Res262: 334–338. ArticleCASPubMed Google Scholar
Lu X-Y, Churchill L, Kalivas PW (1997). Expression of D1 receptor mRNA in projections from the forebrain to the ventral tegmental area. Synapse25: 205–214. ArticleCASPubMed Google Scholar
Lu X-Y, Ghasemzadeh MB, Kalivas PW (1998). Expression of D1 receptor, D2 receptor, substance P and enkephalin messenger RNAs in the neurons projecting from the nucleus accumbens. Neuroscience82: 767–780. ArticleCASPubMed Google Scholar
Mallet N, Le Moine C, Charpier S, Gonon F (2005). Feedforward inhibition of projection neurons by fast-spiking GABA interneurons in the rat striatum in vivo. J Neurosci25: 3857–3869. ArticleCASPubMedPubMed Central Google Scholar
Maren S (1999). Neurotoxic or electrolytic lesions of the ventral subiculum produce deficits in the acquisition and expression of Pavlovian fear conditioning in rats. Behav Neurosci113: 283–290. ArticleCASPubMed Google Scholar
Martin G, Fabre V, Siggins GR, de Lecea L (2002). Interaction of the hypocretins with neurotransmitters in the nucleus accumbens. Regul Pept104: 111–117. ArticleCASPubMed Google Scholar
Martin LJ, Hadfield MG, Dellovade TL, Price DL (1991). The striatal mosaic in primates: patterns of neuropeptide immunoreactivity differentiate the ventral striatum from the dorsal striatum. Neuroscience43: 397–417. ArticleCASPubMed Google Scholar
Martone ME, Armstrong DM, Young SJ, Groves PM (1992). Ultrastructural examination of enkephalin and substance P input to cholinergic neurons within the rat neostriatum. Brain Res594: 253–262. ArticleCASPubMed Google Scholar
Matsumoto M, Hikosaka O (2007). Lateral habenula as a source of negative reward signals in dopamine neurons. Nature447: 1111–1115. In this manuscript, the authors provided evidence suggesting that the habenula mediates an important inhibitory regulation of DA neurons that may signal errors in reward expectancy. ArticleCASPubMed Google Scholar
McDonald AJ (1991). Topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens, and related striatal-like areas of the rat brain. Neuroscience44: 15–33. ArticleCASPubMed Google Scholar
McGinty VB, Grace AA (2008). Selective activation of medial prefrontal-to-accumbens projection neurons by amygdala stimulation and Pavlovian conditioned stimuli. Cereb Cortex18: 1961–1972. ArticlePubMed Google Scholar
McGinty VB, Grace AA (2009). Timing-dependent regulation of evoked spiking in nucleus accumbens neurons by integration of limbic and prefrontal cortical inputs. J Neurophysiol101: 1823–1835. ArticlePubMedPubMed Central Google Scholar
Mejías-Aponte CA, Drouin C, Aston-Jones G (2009). Adrenergic and noradrenergic innervation of the midbrain ventral tegmental area and retrorubral field: prominent inputs from medullary homeostatic centers. J Neurosci29: 3613–3626. ArticlePubMedPubMed CentralCAS Google Scholar
Melchitzky DS, Erickson SL, Lewis DA (2006). Dopamine innervation of the monkey mediodorsal thalamus: location of projection neurons and ultrastructural characteristics of axon terminals. Neuroscience143: 1021–1030. ArticleCASPubMed Google Scholar
Mena-Segovia J, Winn P, Bolam JP (2008). Cholinergic modulation of midbrain dopaminergic systems. Brain Res Rev58: 265–271. ArticleCASPubMed Google Scholar
Meredith GE (1999). The synaptic framework for chemical signaling in nucleus accumbens. Ann NY Acad Sci877: 140–156. ArticleCASPubMed Google Scholar
Meredith GE, Agolia R, Arts MP, Groenewegen HJ, Zahm DS (1992). Morphological differences between projection neurons of the core and shell in the nucleus accumbens of the rat. Neuroscience50: 149–162. ArticleCASPubMed Google Scholar
Meredith GE, Pattiselanno A, Groenewegen HJ, Haber SN (1996). Shell and core in monkey and human nucleus accumbens identified with antibodies to calbindin-D28k . J Comp Neurol365: 628–639. ArticleCASPubMed Google Scholar
Meredith GE, Wouterlood FG (1990). Hippocampal and midline thalamic fibers and terminals in relation to the choline acetyltransferase-immunoreactive neurons in nucleus accumbens of the rat: a light and electron microscopic study. J Comp Neurol296: 204–221. ArticleCASPubMed Google Scholar
Meredith GE, Wouterlood FG, Pattiselanno A (1990). Hippocampal fibers make synaptic contacts with glutamate decarboxylase-immunoreactive neurons in the rat nucleus accumbens. Brain Res513: 329–334. ArticleCASPubMed Google Scholar
Mink JW (1996). The basal ganglia: focused selection and inhibition of competing motor programs. Prog Neurobiol50: 381–425. ArticleCASPubMed Google Scholar
Mogenson GJ, Jones DL, Yim CY (1980). From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol14: 69–97. This landmark paper defined the essential role of the NAc. ArticleCASPubMed Google Scholar
Montague PR, Hyman SE, Cohen JD (2004). Computational roles for dopamine in behavioural control. Nature431: 760–767. ArticleCASPubMed Google Scholar
Montaron MF, Deniau JM, Menetrey A, Glowinski J, Thierry AM (1996). Prefrontal cortex inputs of the nucleus accumbens–nigro–thalamic circuit. Neuroscience71: 371–382. ArticleCASPubMed Google Scholar
Moore H, West AR, Grace AA (1999). The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia. Biol Psychiatry46: 40–55. ArticleCASPubMed Google Scholar
Moss J, Bolam JP (2008). A dopaminergic axon lattice in the striatum and its relationship with cortical and thalamic terminals. J Neurosci28: 11221–11230. ArticleCASPubMedPubMed Central Google Scholar
Mugnaini E, Oertel WH (1985). An atlas of the distribution of GABAergic neurons and terminals in the rat CNS as revealed by GAD immunocytochemistry. In: Björklund A, Hökfelt T (eds). Handbook of Chemical Neuroanatomy. Vol 4: GABA and Neuropeptides in the CNS, Part I. Elsevier BV: Amsterdam. pp 436–608. Google Scholar
Nair-Roberts RG, Chatelain-Badie SD, Benson E, White-Cooper H, Bolam JP, Ungless MA (2008). Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. Neuroscience152: 1024–1031. ArticleCASPubMed Google Scholar
Nauta WJ, Smith GP, Faull RL, Domesick VB (1978). Efferent connections and nigral afferents of the nucleus accumbens septi in the rat. Neuroscience3: 385–401. ArticleCASPubMed Google Scholar
Nicola SM, Surmeier J, Malenka RC (2000). Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. Annu Rev of Neurosci23: 185–215. ArticleCAS Google Scholar
Nugent FS, Kauer JA (2008). LTP of GABAergic synapses in the ventral tegmental area and beyond. J Physiol586: 1487–1493. ArticleCASPubMed Google Scholar
O'Donnell P (2003). Dopamine gating of forebrain neural ensembles. Eur J Neurosci17: 429–435. ArticlePubMed Google Scholar
O'Donnell P, Grace AA (1993). Physiological and morphological properties of accumbens core and shell neurons recorded in vitro. Synapse13: 135–160. ArticleCASPubMed Google Scholar
O'Donnell P, Grace AA (1994). Tonic D2-mediated attenuation of cortical excitation in nucleus accumbens neurons recorded in vitro. Brain Res634: 105–112. ArticleCASPubMed Google Scholar
O'Donnell P, Grace AA (1995). Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input. J Neurosci15: 3622–3639. This study provided electrophysiological evidence for convergence of cortical inputs onto NAc neurons and further demonstrated that the ventral hippocampus drives ‘up’ states in NAc cells, thus functionally gating information flow in this region. ArticleCASPubMedPubMed Central Google Scholar
O'Donnell P, Grace AA (1996). Dopaminergic reduction of excitability in nucleus accumbens neurons recorded in vitro. Neuropsychopharmacology15: 87–97. ArticleCASPubMed Google Scholar
O'Donnell P, Grace AA (1998). Phencyclidine interferes with the hippocampal gating of nucleus accumbens neuronal activity in vivo. Neuroscience87: 823–830. ArticleCASPubMed Google Scholar
O'Donnell P, Lavin A, Enquist LW, Grace AA, Card JP (1997). Interconnected parallel circuits between rat nucleus accumbens and thalamus revealed by retrograde transynaptic transport of pseudorabies virus. J Neurosci17: 2143–2167. ArticleCASPubMedPubMed Central Google Scholar
O'Mara S (2005). The subiculum: what it does, what it might do, and what neuroanatomy has yet to tell us. J Anat207: 271–282. ArticlePubMedPubMed Central Google Scholar
Oakman SC, Faris PL, Kerr PE, Cozzari C, Hartman BK (1995). Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. J Neurosci15: 5859–5869. ArticleCASPubMedPubMed Central Google Scholar
Oleskevich S, Descarries L, Lacaille JC (1989). Quantified distribution of the noradrenaline innervation in the hippocampus of adult rat. J Neurosci9: 3803–3815. ArticleCASPubMedPubMed Central Google Scholar
Olson VG, Nestler EJ (2007). Topographical organization of GABAergic neurons within the ventral tegmental area of the rat. Synapse61: 87–95. ArticleCASPubMed Google Scholar
Omelchenko N, Sesack SR (2005). Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area. J Comp Neurol483: 217–235. ArticlePubMed Google Scholar
Omelchenko N, Sesack SR (2006). Cholinergic axons in the rat ventral tegmental area synapse preferentially onto mesoaccumbens dopamine neurons. J Comp Neurol494: 863–875. ArticlePubMedPubMed Central Google Scholar
Omelchenko N, Sesack SR (2007). Glutamate synaptic inputs to ventral tegmental area neurons in the rat derive primarily from subcortical sources. Neuroscience146: 1259–1274. ArticleCASPubMed Google Scholar
Omelchenko N, Sesack SR (2009). Ultrastructural analysis of local collaterals of rat ventral tegmental area neurons: GABA phenotype and synapses onto dopamine and GABA cells. Synapse63: 895–906. ArticleCASPubMedPubMed Central Google Scholar
Onn SP, Grace AA (1994). Dye coupling between rat striatal neurons recorded in vivo: compartmental organization and modulation by dopamine. J Neurophysiol71: 1917–1934. This paper demonstrated that gap junction conductance in the striatum is functionally regulated, and may be implicated in DA-related disorders. ArticleCASPubMed Google Scholar
Onn SP, West AR, Grace AA (2000). Dopamine-mediated regulation of striatal neuronal and network interactions. Trends Neurosci23: S48–S56. ArticleCASPubMed Google Scholar
Otake K, Nakamura Y (1998). Single midline thalamic neurons projecting to both the ventral striatum and the prefrontal cortex in the rat. Neuroscience86: 635–649. ArticleCASPubMed Google Scholar
Pacchioni AM, Gioino G, Assis A, Cancela LM (2002). A single exposure to restraint stress induces behavioral and neurochemical sensitization to stimulating effects of amphetamine: involvement of NMDA receptors. Ann NY Acad Sci965: 233–246. ArticleCASPubMed Google Scholar
Pennartz CM, Groenewegen HJ, Lopes da Silva FH (1994). The nucleus accumbens as a complex of functionally distinct neuronal ensembles: an integration of behavioural, electrophysiological and anatomical data. Prog Neurobiol42: 719–761. ArticleCASPubMed Google Scholar
Perrotti LI, Bolanos CA, Choi KH, Russo SJ, Edwards S, Ulery PG et al (2005). DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. Eur J Neurosci21: 2817–2824. ArticlePubMed Google Scholar
Pessia M, Jiang ZG, North RA, Johnson SW (1994). Actions of 5-hydroxytryptamine on ventral tegmental area neurons of the rat in vitro. Brain Res654: 324–330. ArticleCASPubMed Google Scholar
Peyron C, Tighe DK, Van Den Pol AN, de Lecea L, Heller HC, Sutcliffe JG et al (1998). Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci18: 9996–10015. ArticleCASPubMedPubMed Central Google Scholar
Phillipson OT (1979a). Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: a horseradish peroxidase study in the rat. J Comp Neurol187: 117–144. ArticleCASPubMed Google Scholar
Phillipson OT (1979b). A Golgi study of the ventral tegmental area of Tsai and interfascicular nucleus in the rat. J Comp Neurol187: 99–116. ArticleCASPubMed Google Scholar
Pickel VM, Chan J (1990). Spiny neurons lacking choline acetyltransferase immunoreactivity are major targets of cholinergic and catecholaminergic terminals in rat striatum. J Neurosci Res25: 263–280. ArticleCASPubMed Google Scholar
Pickel VM, Chan J, Sesack SR (1993). Cellular substrates for interactions between dynorphin terminals and dopamine dendrites in rat ventral tegmental area and substantia nigra. Brain Res602: 275–289. ArticleCASPubMed Google Scholar
Pickel VM, Towle A, Joh TH, Chan J (1988). Gamma-aminobutyric acid in the medial rat nucleus accumbens: ultrastructural localization in neurons receiving monosynaptic input from catecholaminergic afferents. J Comp Neurol272: 1–14. ArticleCASPubMed Google Scholar
Pinto A, Jankowski M, Sesack SR (2003). Projections from the paraventricular nucleus of the thalamus to the rat prefrontal cortex and nucleus accumbens shell: ultrastructural characteristics and spatial relationships with dopamine afferents. J Comp Neurol459: 142–155. This paper provided the first evidence that thalamic as well as cortical axons exhibit synaptic convergence with DA afferents onto the same distal dendrites of medium spiny neurons in the NAc. ArticlePubMed Google Scholar
Pitkänen A, Pikkarainen M, Nurminen N, Ylinen A (2000). Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review. Ann NY Acad Sci911: 369–391. ArticlePubMed Google Scholar
Porrino LJ, Lyons D, Smith HR, Daunais JB, Nader MA (2004). Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains. J Neurosci24: 3554–3562. ArticleCASPubMedPubMed Central Google Scholar
Post RM, Rose H (1976). Increasing effects of repetitive cocaine administration in the rat. Nature260: 731–732. This paper demonstrated the phenomenon of cocaine sensitization, i.e. the increasing behavioral actions (reverse tolerance) observed with repeated cocaine administration. ArticleCASPubMed Google Scholar
Price JL, Amaral DG (1981). An autoradiographic study of the projections of the central nucleus of the monkey amygdala. J Neurosci1: 1242–1259. ArticleCASPubMedPubMed Central Google Scholar
Ramón-Moliner E, Nauta WJH (1966). The isodendritic core of the brain stem. J Comp Neurol126: 311–335. ArticlePubMed Google Scholar
Redgrave P, Gurney K, Reynolds J (2008). What is reinforced by phasic dopamine signals? Brain Res Rev58: 322–339. ArticleCASPubMed Google Scholar
Redgrave P, Prescott TJ, Gurney K (1999). The basal ganglia: a vertebrate solution to the selection problem? Neuroscience89: 1009–1023. ArticleCASPubMed Google Scholar
Reynolds SM, Geisler S, Berod A, Zahm DS (2006). Neurotensin antagonist acutely and robustly attenuates locomotion that accompanies stimulation of a neurotensin-containing pathway from rostrobasal forebrain to the ventral tegmental area. Eur J Neurosci24: 188–196. ArticlePubMed Google Scholar
Reynolds SM, Zahm DS (2005). Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and the extended amygdala. J Neurosci25: 11757–11767. ArticleCASPubMedPubMed Central Google Scholar
Robbins TW, Ersche KD, Everitt BJ (2008). Drug addiction and the memory systems of the brain. Ann NY Acad Sci1141: 1–21. ArticleCASPubMed Google Scholar
Robbins TW, Everitt BJ (2002). Limbic–striatal memory systems and drug addiction. Neurobiol Learn Mem78: 625–636. ArticleCASPubMed Google Scholar
Robertson GS, Jian M (1995). D1 and D2 dopamine receptors differentially increase Fos-like immunoreactivity in accumbal projections to the ventral pallidum and midbrain. Neuroscience64: 1019–1034. ArticleCASPubMed Google Scholar
Robinson TE, Kolb B (2004). Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology47 (Suppl 1): 33–46. ArticleCASPubMed Google Scholar
Rodaros D, Caruana DA, Amir S, Stewart J (2007). Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area. Neuroscience150: 8–13. ArticleCASPubMed Google Scholar
Rodd-Henricks ZA, McKinzie DL, Li TK, Murphy JM, McBride WJ (2002). Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats. J Pharmacol Exp Ther303: 1216–1226. ArticleCASPubMed Google Scholar
Rodríguez A, González-Hernández T (1999). Electrophysiological and morphological evidence for a GABAergic nigrostriatal pathway. J Neurosci19: 4682–4694. ArticlePubMedPubMed Central Google Scholar
Rosenkranz JA, Grace AA (2001). Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats. J Neurosci21: 4090–4103. ArticleCASPubMedPubMed Central Google Scholar
Rosenkranz JA, Grace AA (2002). Cellular mechanisms of infralimbic and prelimbic prefrontal cortical inhibition and dopaminergic modulation of basolateral amygdala neurons in vivo. J Neurosci22: 324–327. ArticleCASPubMedPubMed Central Google Scholar
Saka E, Goodrich C, Harlan P, Madras BK, Graybiel AM (2004). Repetitive behaviors in monkeys are linked to specific striatal activation patterns. J Neurosci24: 7557–7565. ArticleCASPubMedPubMed Central Google Scholar
Sánchez-González MA, García-Cabezas MA, Rico B, Cavada C (2005). The primate thalamus is a key target for brain dopamine. J Neurosci25: 6076–6083. ArticlePubMedCASPubMed Central Google Scholar
Schilstrom B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT et al (2006). Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. J Neurosci26: 8549–8558. ArticleCASPubMedPubMed Central Google Scholar
Schroeter S, Apparsundaram S, Wiley RG, Miner LAH, Sesack SR, Blakely RD (2000). Immunolocalization of the cocaine- and antidepressant sensitive L-norepinephrine transporter. J Comp Neurol420: 211–232. ArticleCASPubMed Google Scholar
Schultz W (1998a). The phasic reward signal of primate dopamine neurons. Adv Pharmacol42: 686–690. ArticleCASPubMed Google Scholar
Schultz W, Dickinson A (2000). Neuronal coding of prediction errors. Annu Rev Neurosci23: 473–500. ArticleCASPubMed Google Scholar
Segal DS, Mandell AJ (1974). Long-term administration of D-amphetamine: progressive augmentation of motor activity and stereotypy. Pharmacol Biochem Behav2: 249–255. ArticleCASPubMed Google Scholar
Sellings LH, Clarke PB (2003). Segregation of amphetamine reward and locomotor stimulation between nucleus accumbens medial shell and core. J Neurosci23: 6295–6303. ArticleCASPubMedPubMed Central Google Scholar
Sesack SR (2009). Functional implications of dopamine D2 receptor localization in relation to glutamate neurons. In: Bjorklund A, Dunnett S, Iversen L, Iversen S (eds). Dopamine Handbook. Oxford University Press: New York. Google Scholar
Sesack SR, Carr DB (2002). Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia. Physiol Behav77: 513–517. ArticleCASPubMed Google Scholar
Sesack SR, Deutch AY, Roth RH, Bunney BS (1989). Topographic organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study using Phaseolus vulgaris leucoagglutinin. J Comp Neurol290: 213–242. ArticleCASPubMed Google Scholar
Sesack SR, Pickel VM (1990). In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other. Brain Res527: 266–279. ArticleCASPubMed Google Scholar
Sesack SR, Pickel VM (1992a). Dual ultrastructural localization of enkephalin and tyrosine hydroxylase immunoreactivity in the rat ventral tegmental area: multiple substrates for opiate–dopamine interactions. J Neurosci12: 1335–1350. ArticleCASPubMedPubMed Central Google Scholar
Sesack SR, Pickel VM (1992b). Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area. J Comp Neurol320: 145–160. This paper was the first to demonstrate the synaptic integration of the PFC and VTA DA neurons, both at the level of the VTA and in the NAc. ArticleCASPubMed Google Scholar
Sharp PE (1999). Complimentary roles for hippocampal vs subicular/entorhinal place cells in coding place, context, and events. Hippocampus9: 432–443. ArticleCASPubMed Google Scholar
Sidibé M, Smith Y (1999). Thalamic inputs to striatal interneurons in monkeys: synaptic organization and co-localization of calcium binding proteins. Neuroscience89: 1189–1208. ArticlePubMed Google Scholar
Simmons DA, Neill DB (2009). Functional interaction between the basolateral amygdala and the nucleus accumbens underlies incentive motivation for food reward on a fixed ratio schedule. Neuroscience159: 1264–1273. ArticleCASPubMed Google Scholar
Smith Y, Bennett BD, Bolam JP, Parent A, Sadikot AF (1994). Synaptic relationship between dopaminergic afferents and cortical or thalamic input in the sensorimotor territory of the striatum in monkey. J Comp Neurol344: 1–19. ArticleCASPubMed Google Scholar
Smith Y, Bolam JP (1990). The output neurones and the dopaminergic neurones of the substantia nigra receive a GABA-containing input from the globus pallidus in the rat. J Comp Neurol296: 47–64. ArticleCASPubMed Google Scholar
Smith Y, Charara A, Parent A (1996). Synaptic innervation of midbrain dopaminergic neurons by glutamate-enriched terminals in the squirrel monkey. J Comp Neurol364: 231–253. ArticleCASPubMed Google Scholar
Smith Y, Kieval J, Couceyro P, Kuhar MJ (1999). CART peptide-immunoreactive neurons in the nucleus accumbens in monkeys: ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferents. J Comp Neurol407: 491–511. ArticleCASPubMed Google Scholar
Smith Y, Raju DV, Pare JF, Sidibe M (2004). The thalamostriatal system: a highly specific network of the basal ganglia circuitry. Trends Neurosci27: 520–527. ArticleCASPubMed Google Scholar
Smith Y, Villalba R (2008). Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brains. Mov Disord23: S534–S547. ArticlePubMed Google Scholar
Somogyi P, Bolam JP, Totterdell S, Smith AD (1981). Monosynaptic input from the nucleus accumbens–ventral striatum region to retrogradely labeled nigrostriatal neurones. Brain Res217: 245–263. ArticleCASPubMed Google Scholar
Steffensen SC, Svingos AL, Pickel VM, Henriksen SJ (1998). Electrophysiological characterization of GABAergic neurons in the ventral tegmental area. J Neurosci18: 8003–8015. ArticleCASPubMedPubMed Central Google Scholar
Surmeier DJ, Ding J, Day M, Wang Z, Shen W (2007). D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. Trends Neurosci30: 228–235. ArticleCASPubMed Google Scholar
Surmeier DJ, Eberwine J, Wilson CJ, Cao Y, Stefani A, Kitai ST (1992). Dopamine receptor subtypes colocalize in rat striatonigral neurons. Proc Natl Acad Sci89: 10178–10182. ArticleCASPubMedPubMed Central Google Scholar
Surmeier DJ, Song W-J, Yan Z (1996). Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J Neurosci16: 6579–6591. ArticleCASPubMedPubMed Central Google Scholar
Suto N, Tanabe LM, Austin JD, Creekmore E, Vezina P (2003). Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in an NMDA, AMPA/kainate, and metabotropic glutamate receptor-dependent manner. Neuropsychopharmacology28: 629–639. ArticleCASPubMed Google Scholar
Swanson LW (1982). The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. Brain Res Bull9: 321–353. This comprehensive analysis detailed the forebrain projections, DA component, and extent of collateralization of VTA neurons. ArticleCASPubMed Google Scholar
Swanson LW, Hartman BK (1975). The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-B-hydroxylase as a marker. J Comp Neurol163: 467–487. ArticleCASPubMed Google Scholar
Swanson LW, Köhler C (1986). Anatomical evidence for direct projections from the entorhinal area to the entire cortical mantle in the rat. J Neurosci6: 3010–3023. ArticleCASPubMedPubMed Central Google Scholar
Tagliaferro P, Morales M (2008). Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. J Comp Neurol506: 616–626. ArticleCASPubMedPubMed Central Google Scholar
Taverna S, Canciani B, Pennartz CM (2007). Membrane properties and synaptic connectivity of fast-spiking interneurons in rat ventral striatum. Brain Res1152: 49–56. ArticleCASPubMed Google Scholar
Taverna S, van Dongen YC, Groenewegen HJ, Pennartz CM (2004). Direct physiological evidence for synaptic connectivity between medium-sized spiny neurons in rat nucleus accumbens in situ. J Neurophysiol91: 1111–1121. ArticlePubMed Google Scholar
Tepper JM, Wilson CJ, Koos T (2008). Feedforward and feedback inhibition in neostriatal GABAergic spiny neurons. Brain Res Rev58: 272–281. ArticleCASPubMed Google Scholar
Thomas TM, Smith Y, Levey AI, Hersch SM (2000). Cortical inputs to m2-immunoreactive striatal interneurons in rat and monkey. Synapse37: 252–261. ArticleCASPubMed Google Scholar
Totterdell S, Meredith GE (1997). Topographical organization of projections from the entorhinal cortex to the striatum of the rat. Neuroscience78: 715–729. ArticleCASPubMed Google Scholar
Totterdell S, Smith AD (1989). Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat. J Chem Neuroanat2: 285–298. This paper provided the first anatomical evidence for synaptic convergence of cortical and DA axons onto common medium spiny neurons in the NAc. CASPubMed Google Scholar
Uchimura N, Higashi H, Nishi S (1986). Hyperpolarizing and depolarizing actions of dopamine via D-1 and D-2 receptors on nucleus accumbens neurons. Brain Res375: 368–372. ArticleCASPubMed Google Scholar
Ungless MA, Magill PJ, Bolam JP (2004). Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. Science303: 2040–2042. ArticleCASPubMed Google Scholar
Ungless MA, Whistler JL, Malenka RC, Bonci A (2001). Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature411: 583–587. This paper showed that even single doses of cocaine can cause long-term alterations in responses of DA neurons. ArticleCASPubMed Google Scholar
Usuda I, Tanaka K, Chiba T (1998). Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study. Brain Res797: 73–93. ArticleCASPubMed Google Scholar
Valenti O, Grace AA (2008). Acute and repeated stress induce a pronounced and sustained activation of VTA DA neuron population activity. Soc Neurosc Abstr: 479.11.
Van Bockstaele EJ, Cestari DM, Pickel VM (1994). Synaptic structure and connectivity of serotonin terminals in the ventral tegmental area: potential sites for modulation of mesolimbic dopamine neurons. Brain Res647: 307–322. ArticleCASPubMed Google Scholar
Van Bockstaele EJ, Pickel VM (1993). Ultrastructure of serotonin-immunoreactive terminals in the core and shell of the rat nucleus accumbens: cellular substrates for interactions with catecholamine afferents. J Comp Neurol334: 603–617. ArticleCASPubMed Google Scholar
Van Bockstaele EJ, Pickel VM (1995). GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain. Brain Res682: 215–221. ArticleCASPubMed Google Scholar
van Dongen YC, Mailly P, Thierry AM, Groenewegen HJ, Deniau JM (2008). Three-dimensional organization of dendrites and local axon collaterals of shell and core medium-sized spiny projection neurons of the rat nucleus accumbens. Brain Struct Funct213: 129–147. ArticlePubMedPubMed Central Google Scholar
Vezina P, Giovino AA, Wise RA, Stewart J (1989). Environment-specific cross-sensitization between the locomotor activating effects of morphine and amphetamine. Pharmacol Biochem Behav32: 581–584. ArticleCASPubMed Google Scholar
Vezina P, Queen AL (2000). Induction of locomotor sensitization by amphetamine requires the activation of NMDA receptors in the rat ventral tegmental area. Psychopharmacology151: 184–191. ArticleCASPubMed Google Scholar
Voorn P, Gerfen CR, Groenewegen HJ (1989). Compartmental organization of the ventral striatum of the rat: immunohistochemical distribution of enkephalin, substance P, dopamine, and calcium-binding protein. J Comp Neurol289: 189–201. ArticleCASPubMed Google Scholar
Voorn P, Jorritsma-Byham B, Van Dijk C, Buijs R (1986). The dopaminergic innervation of the ventral striatum in the rat: a light- and electron-microscopical study with antibodies against dopamine. J Comp Neurol251: 84–99. This was one of the first papers to characterize the light microscopic distribution and ultrastructural features of the DA input to the NAc in the rat. ArticleCASPubMed Google Scholar
Wanat MJ, Hopf FW, Stuber GD, Phillips PE, Bonci A (2008). Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih. J Physiol586: 2157–2170. ArticleCASPubMedPubMed Central Google Scholar
Wang HL, Morales M (2009). Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat. Eur J Neurosci29: 340–358. ArticlePubMed Google Scholar
Wang Z, Kai L, Day M, Ronesi J, Yin HH, Ding J et al (2006). Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron50: 443–452. ArticleCASPubMed Google Scholar
Waraczynski MA (2006). The central extended amygdala network as a proposed circuit underlying reward valuation. Neurosci Biobehav Rev30: 472–496. ArticlePubMed Google Scholar
West AR, Galloway MP, Grace AA (2002). Regulation of striatal dopamine neurotransmission by nitric oxide: effector pathways and signaling mechanisms. Synapse44: 227–245. ArticleCASPubMed Google Scholar
West AR, Grace AA (2002). Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: studies combining in vivo intracellular recordings and reverse microdialysis. J Neurosci22: 294–304. By using in vivo recordings, this paper showed how endogenous DA release affects the activity and excitability of striatal neurons via distinct receptor subclasses. ArticleCASPubMedPubMed Central Google Scholar
White FJ, Wang RY (1986). Electrophysiological evidence for the existence of both D-1 and D-2 dopamine receptors in the rat nucleus accumbens. J Neurosci6: 274–280. ArticleCASPubMedPubMed Central Google Scholar
Williams SM, Goldman-Rakic PS (1998). Widespread origin of the primate mesofrontal dopamine system. Cerebral Cortex8: 321–345. ArticleCASPubMed Google Scholar
Wilson CJ, Groves PM, Kitai ST, Linder JC (1983). Three-dimensional structure of dendritic spines in the rat neostriatum. J Neurosci3: 383–398. ArticleCASPubMedPubMed Central Google Scholar
Wolf ME (1998). The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol54: 679–720. ArticleCASPubMed Google Scholar
Wolf ME (2002). Addiction: making the connection between behavioral changes and neuronal plasticity in specific pathways. Mol Intervent2: 146–157. ArticleCAS Google Scholar
Wolf ME, Sun X, Mangiavacchi S, Chao SZ (2004). Psychomotor stimulants and neuronal plasticity. Neuropharmacology47 (Suppl 1): 61–79. ArticleCASPubMed Google Scholar
Wong DF, Kuwabara H, Schretlen DJ, Bonson KR, Zhou Y, Nandi A et al (2006). Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. Neuropsychopharmacology31: 2716–2727. ArticleCASPubMed Google Scholar
Wright CI, Beijer AV, Groenewegen HJ (1996). Basal amygdaloid complex afferents to the rat nucleus accumbens are compartmentally organized. J Neurosci16: 1877–1893. ArticleCASPubMedPubMed Central Google Scholar
Wu M, Hrycyshyn AW, Brudzynski SM (1996). Subpallidal outputs to the nucleus accumbens and ventral tegmental area: anatomical and electrophysiological studies. Brain Res740: 151–161. ArticleCASPubMed Google Scholar
Yamaguchi T, Sheen W, Morales M (2007). Glutamatergic neurons are present in the rat ventral tegmental area. Eur J Neurosci25: 106–118. This definitive paper demonstrated a newly identified population of glutamate neurons in the VTA and quantified the extent to which they are colocalized with DA cells. ArticlePubMedPubMed Central Google Scholar
Yang CR, Mogenson GJ (1984). Electrophysiological responses of neurones in the nucleus accumbens to hippocampal stimulation and the attenuation of the excitatory responses by the mesolimbic dopaminergic system. Brain Res324: 69–84. ArticleCASPubMed Google Scholar
Yin HH, Ostlund SB, Balleine BW (2008). Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. Eur J Neurosci28: 1437–1448. ArticlePubMedPubMed Central Google Scholar
Zahm DS (1989). The ventral striatopallidal parts of the basal ganglia in the rat—II. Compartmentation of ventral pallidal afferents. Neuroscience30: 33–50. ArticleCASPubMed Google Scholar
Zahm DS (1992). An electron microscopic morphometric comparison of tyrosine hydroxylase immunoreactive innervation in the neostriatum and the nucleus accumbens core and shell. Brain Res575: 341–346. ArticleCASPubMed Google Scholar
Zahm DS (2000). An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neurosci Biobehav Rev24: 85–105. ArticleCASPubMed Google Scholar
Zahm DS (2006). The evolving theory of basal forebrain functional-anatomical ‘macrosystems’. Neurosci Biobehav Rev30: 148–172. ArticlePubMed Google Scholar
Zahm DS, Brog JS (1992). On the significance of subterritories in the ‘accumbens’ part of the rat ventral striatum. Neuroscience50: 751–767. This decisive paper solidified years of work justifying the structural, functional, connectional, and neurochemical subdivision of the NAc into core, shell and rostral pole territories. ArticleCASPubMed Google Scholar
Zahm DS, Grosu S, Williams EA, Qin S, Bérod A (2001). Neurons of origin of the neurotensinergic plexus enmeshing the ventral tegmental area in rat: retrograde labeling and in situ hybridization combined. Neuroscience104: 841–851. ArticleCASPubMed Google Scholar
Zahm DS, Heimer L (1990). Two transpallidal pathways originating in the rat nucleus accumbens. J Comp Neurol302: 437–446. ArticleCASPubMed Google Scholar
Zahm DS, Heimer L (1993). Specificity in the efferent projections of the nucleus accumbens in the rat: comparison of the rostral pole projection patterns with those of core and shell. J Comp Neurol327: 220–232. ArticleCASPubMed Google Scholar
Zahm DS, Williams E, Wohltmann C (1996). Ventral striatopallidothalamic projection: IV. Relative involvements of neurochemically distinct subterritories in the ventral pallidum and adjacent parts of the rostroventral forebrain. J Comp Neurol364: 340–362. ArticleCASPubMed Google Scholar
Zhang XF, Hu XT, White FJ, Wolf ME (1997). Increased responsiveness of ventral tegmental area dopamine neurons to glutamate after repeated administration of cocaine or amphetamine is transient and selectively involves AMPA receptors. J Pharmacol Exp Ther281: 699–706. CASPubMed Google Scholar
Zweifel LS, Argilli E, Bonci A, Palmiter RD (2008). Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. Neuron59: 486–496. ArticleCASPubMedPubMed Central Google Scholar