- Aiken C, Konner J, Landau N R, Lenburg M E and Trono D 1994 Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain;Cell 76 853–864
Article CAS PubMed Google Scholar
- Arold S, Franken P, Strub M P, Hoh F, Benichou S, Benarous R and Dumas C 1997 The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling;Structure 5 1361–1372
Article CAS PubMed Google Scholar
- Arora V K, Molina R P, Foster J L, Blakemore J L, Chernoff J, Fredericksen B L and Garcia J V 2000 Lentivirus Nef specifically activates Pak2;J. Virol. 74 11081–11087
Article CAS PubMed PubMed Central Google Scholar
- Bandres J C and Ratner L 1994 Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T-cells in vitro after T-cell receptor stimulation;J. Virol. 68 3243–3249
CAS PubMed PubMed Central Google Scholar
- Baur A S, Sass G, Laffert B, Willbold D, Cheng-Mayer C and Peterlin B M 1997 The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase;Immunity 6 283–291
Article CAS PubMed Google Scholar
- Baur A S, Sawai E T, Dazin P, Fantl W J, Cheng-Mayer C and Peterlin B M 1994 HIV-1 Nef leads to inhibition or activation of T-cells depending on its intracellular localization;Immunity 1 373–384
Article CAS PubMed Google Scholar
- Beaty C D, Franklin T L, Uehara Y and Wilson C B 1994 Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction;Eur. J. Immunol. 24 1278–1284
Article CAS PubMed Google Scholar
- Bell I, Schaefer T M, Trible R P, Amedee A and Reinhart T A 2001 Down-modulation of the costimulatory molecule, CD28, is a conserved activity of multiple SIV Nefs and is dependent on histidine 196 of Nef;Virology 283 148–158
Article CAS PubMed Google Scholar
- Benichou S, Liu L X, Erdtmann L, Selig L and Benarous R 1997 Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein;Res. Virol. 148 71–73
Article CAS PubMed Google Scholar
- Benson R E, Sanfridson A, Ottinger J S, Doyle C and Cullen B R 1993 Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection;J. Exp. Med. 177 1561–1566
Article CAS PubMed Google Scholar
- Bodeus M, Marie-Cardine A, Bougeret C, Ramos-Morales F and Benarous R 1995 In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase;J. Gen. Virol. 76 1337–1344
Article CAS PubMed Google Scholar
- Bolen J B, Rowley R B, Spana C and Tsygankov A Y 1992 The Src family of tyrosine protein kinases in hemopoietic signal transduction;Faseb J. 6 3403–3409
Article CAS PubMed Google Scholar
- Brady H J, Pennington D J, Miles C G and Dzierzak E A 1993 CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration;EMBO J. 12 4923–4932
Article CAS PubMed PubMed Central Google Scholar
- Briggs S D, Scholtz B, Jacque J M, Swingler S, Stevenson M and Smithgall T E 2001 HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway;J. Biol. Chem. 276 25605–25611
Article CAS PubMed Google Scholar
- Briggs S D, Sharkey M, Stevenson M and Smithgall TE 1997 SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1;J. Biol. Chem. 272 17899–17902
Article CAS PubMed Google Scholar
- Brown A, Wang X, Sawai E and Cheng-Mayer C 1999 Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex;J. Virol. 73 9899–9907
CAS PubMed PubMed Central Google Scholar
- Campbell S M, Crowe S M and Mak J 2001 Lipid rafts and HIV-1: from viral entry to assembly of progeny virions;J. Clin. Virol. 22 217–227
Article CAS PubMed Google Scholar
- Chang A H, O’Shaughnessy M V and Jirik F R 2001 Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation;Eur. J. Immunol. 31 2382–2387
Article CAS PubMed Google Scholar
- Chen B K, Gandhi R T and Baltimore D 1996 CD4 downmodulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef;J. Virol. 70 6044–6053
CAS PubMed PubMed Central Google Scholar
- Cheng H, Hoxie J P and Parks W P 1999 The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes;Virology 264 5–15
Article CAS PubMed Google Scholar
- Coates K, Cooke S J, Mann D A and Harris M P G 1997 Protein kinase C-mediated phosphorylation of HIV-I nef in human cell lines;J. Biol. Chem. 272 12289–12294
Article CAS PubMed Google Scholar
- Collette Y, Arold S, Picard C, Janvier K, Benichou S, Benarous R, Olive D and Dumas C 2000 HIV-2 and SIV nef proteins target different Src family SH3 domains than does HIV-1 Nef because of a triple amino acid substitution;J. Biol. Chem. 275 4171–4176
Article CAS PubMed Google Scholar
- Collette Y, Dutartre H, Benziane A, Ramos M, Benarous R, Harris M and Olive D 1996 Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects;J. Biol. Chem. 271 6333–6341
Article CAS PubMed Google Scholar
- Collette Y and Olive D 1999 The primate lentivirus-encoded Nef protein can regulate several steps of the viral replication cycle;Virology 265 173–177
Article CAS PubMed Google Scholar
- Collins K L, Chen B K, Kalams S A, Walker B D and Baltimore D 1998 HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes;Nature (London) 391 397–401
Article CAS Google Scholar
- Craig H M, Pandori M W and Guatelli J C 1998 Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity;Proc. Natl. Acad. Sci. USA 95 11229–11234
Article CAS PubMed Google Scholar
- Crise B and Rose J K 1992 Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum;J. Virol. 66 2296–2301
CAS PubMed PubMed Central Google Scholar
- De S K and Marsh J W 1994 HIV-1 Nef inhibits a common activation pathway in NIH-3T3 cells;J. Biol. Chem. 269 6656–6660
CAS PubMed Google Scholar
- De S K, Venkateshan C N, Seth P, Gajdusek D C and Gibbs C J 1998 Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines;Blood 91 2108–2117
CAS PubMed Google Scholar
- Deacon N J, Tsykin A, Solomon A, Smith K, Ludford-Menting M, Hooker D J, McPhee D A, Greenway A L, Ellett A, Chatfield C, Larison V A, Crowe S, Maerz A, Sonza S, Learmont J, Sullivan J S, Cunningham A, Dwyer D, Dowton D and Mills J 1995 Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients [see comments];Science 270 988–991
Article CAS PubMed Google Scholar
- Dutartre H, Harris M, Olive D and Collette Y 1998 The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism;Virology 247 200–211
Article CAS PubMed Google Scholar
- Ernst C A, Zhang Y J, Hancock P R, Rutledge B J, Corless C L and Rollins B J 1994 Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains;J. Immunol. 152 3541–3549
CAS PubMed Google Scholar
- Fackler O T, Luo W, Geyer M, Alberts A S and Peterlin B M 1999 Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions;Mol. Cell 3 729–739
Article CAS PubMed Google Scholar
- Fauci A S 1988 The human immunodeficiency virus: infectivity and mechanisms of pathogenesis;Science 239 617–622
Article CAS PubMed Google Scholar
- Flaherty M T, Barber S A and Clements J E 1998 Neurovirulent simian immunodeficiency virus incorporates a Nef-associated kinase activity into virions;AIDS Res. Hum. Retroviruses 14 163–170
Article CAS PubMed Google Scholar
- Frank S J, Samelson L E and Klausner R D 1990 The structure and signalling functions of the invariant T cell receptor components;Semin. Immunol. 2 89–97
CAS PubMed Google Scholar
- Garcia J V, Alfano J and Miller A D 1993 The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4;J. Virol. 67 1511–1516
CAS PubMed PubMed Central Google Scholar
- Garcia J V and Miller A D 1991 Serine phosphorylation-independent downregulation of cell-surface CD4 by nef;Nature (London) 350 508–511
Article CAS Google Scholar
- Geleziunas R, Xu W, Takeda K, Ichijo H and Greene W C 2001 HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell;Nature (London) 410 834–838
Article CAS Google Scholar
- Gratton S, Yao X J, Venkatesan S, Cohen E A and Sekaly R P 1996 Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef;J. Immunol. 157 3305–3311
CAS PubMed Google Scholar
- Greenberg M, DeTulleo L, Rapoport I, Skowronski J and Kirchhausen T 1998 A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4;Curr. Biol. 8 1239–1242
Article CAS PubMed Google Scholar
- Greenberg M E, Bronson S, Lock M, Neumann M, Pavlakis G N and Skowronski J 1997 Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nefinduced CD4 down-regulation;EMBO J. 16 6964–6976
Article CAS PubMed PubMed Central Google Scholar
- Greenway A, Azad A and McPhee D 1995 Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines;J. Virol. 69 1842–1850
CAS PubMed PubMed Central Google Scholar
- Greenway A, Azad A, Mills J and McPhee D 1996 Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity;J. Virol. 70 6701–6708
CAS PubMed PubMed Central Google Scholar
- Greenway A L, Dutartre H, Allen K, McPhee D A, Olive D and Collette Y 1999 Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation;J. Virol. 73 6152–6158
CAS PubMed PubMed Central Google Scholar
- Greenway A L, McPhee D A, Allen K, Johnstone R, Holloway G, Mills J, Azad A, Sankovich S and Lambert P 2002 Human immunodeficiency virus type 1 Nef binds to tumour suppressor p53 and protects cells against p53-mediated apoptosis;J. Virol. 76 2692–2702
Article CAS PubMed PubMed Central Google Scholar
- Greenway A L, McPhee D A, Grgacic E, Hewish D, Lucantoni A, Macreadie I and Azad A 1994 Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4.3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells;Virology 198 245–256
Article CAS PubMed Google Scholar
- Grzesiek S, Stahl S J, Wingfield P T and Bax A 1996 The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR;Biochemistry 35 10256–10261
Article CAS PubMed Google Scholar
- Gupta D, Jin Y P and Dziarski R 1995 Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages;J. Immunol. 155 2620–2630
CAS PubMed Google Scholar
- Hanna Z, Kay D G, Rebai N, Guimond A, Jothy S and Jolicoeur P 1998 Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice;Cell 95 163–175
Article CAS PubMed Google Scholar
- Hanna Z, Weng X, Kay D G, Poudrier J, Lowell C and Jolicoeur P 2001 The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck;J. Virol. 75 9378–9392
Article CAS PubMed PubMed Central Google Scholar
- Harris M P and Neil J C 1994 Myristoylation-dependent binding of HIV-1 Nef to CD4;J. Mol. Biol. 241 136–142
Article CAS PubMed Google Scholar
- Holly S P and Blumer K J 1999 PAK-family kinases regulate cell and actin polarization throughout the cell cycle of_Saccharomyces cerevisiae_;J. Cell. Biol. 147 845–856
Article CAS PubMed PubMed Central Google Scholar
- Holstein S E, Drucker M and Robinson D G 1994 Identification of a beta-type adaptin in plant clathrin-coated vesicles;J. Cell. Sci. 107 945–953
CAS PubMed Google Scholar
- Horak I D, Gress R E, Lucas P J, Horak E M, Waldmann T A and Bolen J B 1991 T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck;Proc. Natl. Acad. Sci. USA 88 1996–2000
Article CAS PubMed Google Scholar
- Iafrate A J, Bronson S and Skowronski J 1997 Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling;EMBO J. 16 673–684
Article CAS PubMed PubMed Central Google Scholar
- Jacque J M, Mann A, Enslen H, Sharova N, Brichacek B, Davis R J and Stevenson M 1998 Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase;EMBO J. 17 2607–2618
Article CAS PubMed PubMed Central Google Scholar
- Jakobi R, Moertl E and Koeppel M A 2001 p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts;J. Biol. Chem. 276 16624–16634
Article CAS PubMed Google Scholar
- Kamp W, Berk M B, Visser C J and Nottet H S 2000 Mechanisms of HIV-1 to escape from the host immune surveillance;Eur. J. Clin. Invest. 30 740–746
Article CAS PubMed Google Scholar
- Kestler H W D, Ringler D J, Mori K, Panicali D L, Sehgal P K, Daniel M D and Desrosiers R C 1991 Importance of the nef gene for maintenance of high virus loads and for development of AIDS;Cell 65 651–662
Article CAS PubMed Google Scholar
- Kirchhoff F, Greenough T C, Brettler D B, Sullivan J L and Desrosiers R C 1995 Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection [see comments];N. Engl. J. Med. 332 228–232
Article CAS PubMed Google Scholar
- Le Gall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu L, Benarous R, Heard J M and Schwartz O 1998 Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules;Immunity 8 483–495
Article Google Scholar
- Le Gall S, Heard J M and Schwartz O 1997 Analysis of Nefinduced MHC-I endocytosis;Res. Virol. 148 43–47
Article Google Scholar
- Lee C H, Leung B, Lemmon M A, Zheng J, Cowburn D, Kuriyan J and Saksela K 1995 A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein;EMBO J. 14 5006–5015
Article CAS PubMed PubMed Central Google Scholar
- Lee C H, Saksela K, Mirza U A, Chait B T and Kuriyan J 1996 Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain;Cell 85 931–942
Article CAS PubMed Google Scholar
- Letourneur F and Klausner R D 1992 A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains;Cell 69 1143–1157
Article CAS PubMed Google Scholar
- Lock M, Greenberg M E, Iafrate A J, Swigut T, Muench J, Kirchhoff F, Shohdy N and Skowronski J 1999 Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis;EMBO J. 18 2722–2733
Article CAS PubMed PubMed Central Google Scholar
- Luria S, Chambers I and Berg P 1991 Expression of the type 1 human immunodeficiency virus Nef protein in T-cells prevents antigen receptor-mediated induction of interleukin 2 mRNA;Proc. Natl. Acad. Sci. USA 88 5326–5330
Article CAS PubMed Google Scholar
- Mangasarian A, Foti M, Aiken C, Chin D, Carpentier J L and Trono D 1997 The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane;Immunity 6 67–77
Article CAS PubMed Google Scholar
- Mangasarian A, Piguet V, Wang J K, Chen Y L and Trono D 1999 Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking;J. Virol. 73 1964–1973
CAS PubMed PubMed Central Google Scholar
- Manninen A, Hiipakka M, Vihinen M, Lu W, Mayer B J and Saksela K 1998 SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase;Virology 250 273–282
Article CAS PubMed Google Scholar
- Manninen A, Renkema G H and Saksela K 2000 Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway;J. Biol. Chem. 275 16513–16517
Article CAS PubMed Google Scholar
- Mariani R and Skowronski J 1993 CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals;Proc. Natl. Acad. Sci. USA 90 5549–5553
Article CAS PubMed Google Scholar
- Miller M D, Warmerdam M T, Gaston I, Greene W C and Feinberg M B 1994 The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages;J. Exp. Med. 179 101–113
Article CAS PubMed Google Scholar
- Minami Y, Kono T, Yamada K, Kobayashi N, Kawahara A, Perlmutter R M and Taniguchi T 1993 Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck;EMBO J. 12 759–768
Article CAS PubMed PubMed Central Google Scholar
- Moarefi I, LaFevre-Bernt M, Sicheri F, Huse M, Lee C H, Kuriyan J and Miller W T 1997 Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement [see comments];Nature (London) 385 650–653
Article CAS Google Scholar
- Mountz J D, Zhou T, Wu J, Wang W, Su X and Cheng J 1995 Regulation of apoptosis in immune cells;J. Clin. Immunol. 15 1–16
Article CAS PubMed Google Scholar
- Niederman T M, Hastings W R, Luria S, Bandres J C and Ratner L 1993 HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells;Virology 194 338–344
Article CAS PubMed Google Scholar
- Nunn M F and Marsh J W 1996 Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family;J. Virol. 70 6157–6161
CAS PubMed PubMed Central Google Scholar
- Ono A and Freed E O 2001 Plasma membrane rafts play a critical role in HIV-1 assembly and release;Proc. Natl. Acad. Sci. USA 98 13925–13930
Article CAS PubMed Google Scholar
- Oyaizu N, Than S, McCloskey T W and Pahwa S 1995 Requirement of p56lck in T-cell receptor/CD3-mediated apoptosis and Fas-ligand induction in Jurkat cells;Biochem. Biophys. Res. Commun. 213 994–1001
Article CAS PubMed Google Scholar
- Pandori M, Craig H, Moutouh L, Corbeil J and Guatelli J 1998 Virological importance of the protease-cleavage site in human immunodeficiency virus type 1: Nef is independent of both intravirion processing and CD4 down-regulation;Virology 251 302–316
Article CAS PubMed Google Scholar
- Pandori M W, Fitch N J, Craig H M, Richman D D, Spina C A and Guatelli J C 1996 Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein;J. Virol. 70 4283–4290
CAS PubMed PubMed Central Google Scholar
- Piguet V, Chen Y L, Mangasarian A, Foti M, Carpentier J L and Trono D 1998 Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes;EMBO J. 17 2472–2481
Article CAS PubMed PubMed Central Google Scholar
- Piguet V, Gu F, Foti M, Demaurex N, Gruenberg J, Carpentier J L and Trono D 1999a Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes;Cell 97 63–73
Article CAS PubMed Google Scholar
- Piguet V, Schwartz O, Le Gall S and Trono D 1999b The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors;Immunol. Rev. 168 51–63
Article CAS PubMed Google Scholar
- Piguet V and Trono D 1999 The Nef protein of primate lentiviruses;Rev. Med. Virol. 9 111–120
Article CAS PubMed Google Scholar
- Renkema G H, Manninen A and Saksela K 2001 Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX;J. Virol. 75 2154–2160
Article CAS PubMed PubMed Central Google Scholar
- Rhee S S and Marsh J W 1994 HIV-1 Nef activity in murine T-cells. CD4 modulation and positive enhancement;J. Immunol. 152 5128–5134
CAS PubMed Google Scholar
- Riggs N L, Craig H M, Pandori M W and Guatelli J C 1999 The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC;Virology 258 203–207
Article CAS PubMed Google Scholar
- Rousso I, Mixon M B, Chen B K and Kim P S 2000 Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity;Proc. Natl. Acad. Sci. USA 97 13523–13525
Article CAS PubMed Google Scholar
- Rudd C E, Trevillyan J M, Dasgupta J D, Wong L L and Schlossman S F 1988 The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp 58) from human T lymphocytes;Proc. Natl. Acad. Sci. USA 85 5190–5194
Article CAS PubMed Google Scholar
- Saksela K, Cheng G and Baltimore D 1995 Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4;EMBO J. 14 484–491
Article CAS PubMed PubMed Central Google Scholar
- Salghetti S, Mariani R and Skowronski J 1995 Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail;Proc. Natl. Acad. Sci. USA 92 349–353
Article CAS PubMed Google Scholar
- Sawai E T, Baur A S, Peterlin B M, Levy J A and Cheng-Mayer C 1995 A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity;J. Biol. Chem. 270 15307–15314
Article CAS PubMed Google Scholar
- Sawai E T, Baur A, Struble H, Peterlin B M, Levy J A and Cheng-Mayer C 1994 Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes;Proc. Natl. Acad. Sci. USA 91 1539–1543
Article CAS PubMed Google Scholar
- Sawai E T, Khan I H, Montbriand P M, Peterlin B M, Cheng-Mayer C and Luciw P A 1996 Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques;Curr. Biol. 6 1519–1527
Article CAS PubMed Google Scholar
- Schrager J A and Marsh J W 1999 HIV-1 Nef increases T-cell activation in a stimulus-dependent manner;Proc. Natl. Acad. Sci. USA 96 8167–8172
Article CAS PubMed Google Scholar
- Schwartz O, Marechal V, Danos O and Heard J M 1995 Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell;J. Virol. 69 4053–4059
CAS PubMed PubMed Central Google Scholar
- Schwartz O, Marechal V, Le Gall S, Lemonnier F and Heard J M 1996 Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein;Nat. Med. 2 338–342
Article CAS PubMed Google Scholar
- Simard M C, Chrobak P, Kay D G, Hanna Z, Jothy S and Jolicoeur P 2002 Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease;J. Virol. 76 3981–3995
Article CAS PubMed PubMed Central Google Scholar
- Simmons A, Aluvihare V and McMichael A 2001 Nef triggers a transcriptional program in T-cells imitating singlesignal T cell activation and inducing HIV virulence mediators;Immunity 14 763–777
Article CAS PubMed Google Scholar
- Skowronski J, Parks D and Mariani R 1993 Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene;EMBO J. 12 703–713
Article CAS PubMed PubMed Central Google Scholar
- Smith B L, Krushelnycky B W, Mochly-Rosen D and Berg P 1996 The HIV nef protein associates with protein kinase C theta;J. Biol. Chem. 271 16753–16757
Article CAS PubMed Google Scholar
- Swigut T, Shohdy N and Skowronski J 2001 Mechanism for down-regulation of CD28 by Nef;EMBO J. 20 1593–1604
Article CAS PubMed PubMed Central Google Scholar
- Swingler S, Mann A, Jacque J, Brichacek B, Sasseville V G, Williams K, Lackner A A, Janoff E N, Wang R, Fisher D and Stevenson M 1999 HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages;Nat. Med. 5 997–1103
Article CAS PubMed Google Scholar
- Van Parijs L, Peterson D A and Abbas A K 1998 The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens;Immunity 8 265–274
Article PubMed Google Scholar
- Veillette A, Horak I D, Horak E M, Bookman M A and Bolen J B 1988 Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation;Mol. Cell. Biol. 8 4353–4361
Article CAS PubMed PubMed Central Google Scholar
- Weiss A 1993 T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases;Cell 73 209–212
Article CAS PubMed Google Scholar
- Weiss A and Littman D R 1994 Signal transduction by lymphocyte antigen receptors;Cell 76 263–274
Article CAS PubMed Google Scholar
- Weiss A, Wiskocil R L and Stobo J D 1984 The role of T3 surface molecules in the activation of human T cells: a twostimulus requirement for IL 2 production reflects events occurring at a pre-translational level;J. Immunol. 133 123–128
CAS PubMed Google Scholar
- Willey R L, Maldarelli F, Martin M A and Strebel K 1992 Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes;J. Virol. 66 226–234
CAS PubMed PubMed Central Google Scholar
- Wiskerchen M and Cheng-Mayer C 1996 HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis;Virology 224 292–301
Article CAS PubMed Google Scholar
- Wolf D, Witte V, Laffert B, Blume K, Stromer E, Trapp S, d’Aloja P, Schurmann A and Baur A S 2001 HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals;Nat. Med. 7 1217–1224
Article CAS PubMed Google Scholar
- Xu X N, Laffert B, Screaton G R, Kraft M, Wolf D, Kolanus W, Mongkolsapay J, McMichael A J and Baur A S 1999 Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain;J. Exp. Med. 189 1489–1496
Article CAS PubMed PubMed Central Google Scholar
- Yoon K, Jeong J G and Kim S 2001 Stable expression of human immunodeficiency virus type 1 Nef confers resistance against Fas-mediated apoptosis;AIDS Res. Hum. Retroviruses 17 99–104
Article CAS PubMed Google Scholar
- Zang M, Waelde C A, Xiang X, Rana A, Wen R and Luo Z 2001 Microtubule integrity regulates Pak leading to Rasindependent activation of Raf-1. Insights into mechanisms of Raf-1 activation;J. Biol. Chem. 276 25157–25165
Article CAS PubMed Google Scholar
- Zhou J and Aiken C 2001 Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: evidence supporting a role for Nef at the virion envelope;J. Virol. 75 5851–5859
Article CAS PubMed PubMed Central Google Scholar