The cytoplasmic dynein transport machinery and its many cargoes (original) (raw)

• Gibbons, I. R. & Rowe, A. J. Dynein: a protein with adenosine triphosphatase activity from cilia. Science 149, 424–426 (1965). Describes the original discovery of dynein.
  Article PubMed CAS Google Scholar
• Paschal, B. M., Shpetner, H. S. & Vallee, R. B. MAP 1 C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like properties. J. Cell Biol. 105, 1273–1282 (1987). Describes the discovery of cytoplasmic dynein 1.
  Article PubMed CAS Google Scholar
• Paschal, B. M. & Vallee, R. B. Retrograde transport by the microtubule-associated protein MAP 1C. Nature 330, 181–183 (1987). Shows that cytoplasmic dynein 1 is a minus-end-directed motor.
  Article PubMed CAS Google Scholar
• Pazour, G. J., Dickert, B. L. & Witman, G. B. The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assembly. J. Cell Biol. 144, 473–481 (1999).
  Article PubMed PubMed Central CAS Google Scholar
• Porter, M. E., Bower, R., Knott, J. A., Byrd, P. & Dentler, W. Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas. Mol. Biol. Cell 10, 693–712 (1999).
  Article PubMed PubMed Central CAS Google Scholar
• Gepner, J. et al. Cytoplasmic dynein function is essential in Drosophila melanogaster. Genetics 142, 865–878 (1996).
  PubMed PubMed Central CAS Google Scholar
• Harada, A. et al. Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein. J. Cell Biol. 141, 51–59 (1998). Characterization of dynein knockout mice, which shows that dynein is essential during development.
  Article PubMed PubMed Central CAS Google Scholar
• Lipka, J., Kuijpers, M., Jaworski, J. & Hoogenraad, C. C. Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases. Biochem. Soc. Trans. 41, 1605–1612 (2013).
  Article PubMed CAS Google Scholar
• Raaijmakers, J. A. & Medema, R. H. Function and regulation of dynein in mitotic chromosome segregation. Chromosoma 123, 407–422 (2014).
  Article PubMed CAS Google Scholar
• Gill, S. R. et al. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J. Cell Biol. 115, 1639–1650 (1991).
  Article PubMed CAS Google Scholar
• Schroer, T. A. & Sheetz, M. P. Two activators of microtubule-based vesicle transport. J. Cell Biol. 115, 1309–1318 (1991). Along with reference 10, describes the discovery of dynactin.
  Article PubMed CAS Google Scholar
• Splinter, D. et al. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol. Biol. Cell 23, 4226–4241 (2012). Shows that the N-terminal domain of BICD2 strengthens the interaction between dynein and dynactin and activates motility in cells.
  Article PubMed PubMed Central CAS Google Scholar
• Mohler, J. & Wieschaus, E. F. Dominant maternal-effect mutations of Drosophila melanogaster causing the production of double-abdomen embryos. Genetics 112, 803–822 (1986).
  PubMed PubMed Central CAS Google Scholar
• McKenney, R. J., Huynh, W., Tanenbaum, M. E., Bhabha, G. & Vale, R. D. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science 345, 337–341 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Schlager, M. A., Hoang, H. T., Urnavicius, L., Bullock, S. L. & Carter, A. P. In vitro reconstitution of a highly processive recombinant human dynein complex. EMBO J. 33, 1855–1868 (2014). Along with reference 14, shows that coiled-coil containing activators like BICD2, along with dynactin, activate mammalian dynein to move processively.
  Article PubMed PubMed Central CAS Google Scholar
• Urnavicius, L. et al. Cryo-EM shows how dynactin recruits two dyneins for faster movement. Nature 554, 202–206 (2018).Describes the high-resolution structure of the dynein tail and shows that some activating adaptors preferentially recruit two dynein dimers.
  CAS Google Scholar
• Urnavicius, L. et al. The structure of the dynactin complex and its interaction with dynein. Science 347, 1441–1446 (2015). Reveals the structural basis for dynein activation by dynactin and the activating adaptor, BICD2.
  Article PubMed PubMed Central CAS Google Scholar
• Zhang, K. et al. Cryo-EM reveals how human cytoplasmic dynein is auto-inhibited and activated. Cell 169, 1303–1314.e18 (2017). Demonstrates how dynactin activates the ability of dynein to move long distances.
  Article PubMed PubMed Central CAS Google Scholar
• Kon, T. et al. The 2.8 A crystal structure of the dynein motor domain. Nature 484, 345–350 (2012).
  Article PubMed CAS Google Scholar
• Schmidt, H., Gleave, E. S. & Carter, A. P. Insights into dynein motor domain function from a 3.3-A crystal structure. Nat. Struct. Mol. Biol. 19, 492–7, S1 (2012).
  Article PubMed PubMed Central CAS Google Scholar
• Schmidt, H., Zalyte, R., Urnavicius, L. & Carter, A. P. Structure of human cytoplasmic dynein-2 primed for its power stroke. Nature 518, 435–438 (2015).
  Article PubMed CAS Google Scholar
• Lee, I. G. et al. A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity. Nat. Commun. 9, 986 (2018).
• Schroeder, C. M., Ostrem, J. M., Hertz, N. T. & Vale, R. D. A. Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. eLife 3, e03351 (2014). Identifies the C-terminus of the DLIC as a binding site for activating adaptors.
  Article PubMed PubMed Central CAS Google Scholar
• Schroeder, C. M. & Vale, R. D. Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3. J. Cell Biol. 214, 309–318 (2016).
  Article PubMed PubMed Central CAS Google Scholar
• Carter, A. P., Diamant, A. G. & Urnavicius, L. How dynein and dynactin transport cargos: a structural perspective. Curr. Opin. Struct. Biol. 37, 62–70 (2016).
  Article PubMed CAS Google Scholar
• Waterman-Storer, C. M., Karki, S. & Holzbaur, E. L. The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Proc. Natl Acad. Sci. USA 92, 1634–1638 (1995).
  Article PubMed PubMed Central CAS Google Scholar
• Gama, J. B. et al. Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly. J. Cell Biol. 216, 943–960 (2017). Identifies the CC1 box for DLIC binding in activating adaptors.
  Article PubMed PubMed Central CAS Google Scholar
• Horgan, C. P., Hanscom, S. R., Jolly, R. S., Futter, C. E. & McCaffrey, M. W. Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment. J. Cell Sci. 123, 181–191 (2010).
  Article PubMed CAS Google Scholar
• Grotjahn, D. A. et al. Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. Nat. Struct. Mol. Biol. 25, 203–207 (2018). Along with reference 16, shows that dynactin can recruit two dynein dimers.
  Article CAS Google Scholar
• Siglin, A. E. et al. Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. PLoS ONE 8, e59453 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Kobayashi, T., Miyashita, T., Murayama, T. & Toyoshima, Y. Y. Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility. PLoS ONE 12, e0183672 (2017).
  Article PubMed PubMed Central CAS Google Scholar
• Torisawa, T. et al. Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein. Nat. Cell Biol. 16, 1118–1124 (2014).
  Article PubMed CAS Google Scholar
• Cavalli, V., Kujala, P., Klumperman, J. & Goldstein, L. S. Sunday Driver links axonal transport to damage signaling. J. Cell Biol. 168, 775–787 (2005).
  Article PubMed PubMed Central CAS Google Scholar
• Jordens, I. et al. The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors. Curr. Biol. 11, 1680–1685 (2001).
  Article PubMed CAS Google Scholar
• Scherer, J., Yi, J. & Vallee, R. B. PKA-dependent dynein switching from lysosomes to adenovirus: a novel form of host-virus competition. J. Cell Biol. 205, 163–177 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Cianfrocco, M. A., DeSantis, M. E., Leschziner, A. E. & Reck-Peterson, S. L. Mechanism and regulation of cytoplasmic dynein. Annu. Rev. Cell Dev. Biol. 31, 83–108 (2015).
  Article PubMed PubMed Central CAS Google Scholar
• DeSantis, M. E. et al. Lis1 has two opposing modes of regulating cytoplasmic dynein. Cell 170, 1197–1208.e12 (2017).Shows that LIS1 has two functionally distinct binding sites on the dynein motor domain.
  Article PubMed CAS PubMed Central Google Scholar
• Huang, J., Roberts, A. J., Leschziner, A. E. & Reck-Peterson, S. L. Lis1 acts as a “clutch” between the ATPase and microtubule-binding domains of the dynein motor. Cell 150, 975–986 (2012).
  Article PubMed PubMed Central CAS Google Scholar
• McKenney, R. J., Weil, S. J., Scherer, J. & Vallee, R. B. Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. J. Biol. Chem. 286, 39615–39622 (2011).
  Article PubMed PubMed Central CAS Google Scholar
• Wang, S. & Zheng, Y. Identification of a novel dynein binding domain in nudel essential for spindle pole organization in Xenopus egg extract. J. Biol. Chem. 286, 587–593 (2011).
  Article PubMed CAS Google Scholar
• Zylkiewicz, E. et al. The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein. J. Cell Biol. 192, 433–445 (2011).
  Article PubMed PubMed Central CAS Google Scholar
• Torisawa, T. et al. Functional dissection of LIS1 and NDEL1 towards understanding the molecular mechanisms of cytoplasmic dynein regulation. J. Biol. Chem. 286, 1959–1965 (2011).
  Article PubMed CAS Google Scholar
• Yamada, M. et al. LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein. EMBO J. 27, 2471–2483 (2008).
  Article PubMed PubMed Central CAS Google Scholar
• Baumbach, J. et al. Lissencephaly-1 is a context-dependent regulator of the human dynein complex. eLife 6, e21768 (2017).
  Article PubMed PubMed Central Google Scholar
• Gutierrez, P. A., Ackermann, B. E., Vershinin, M. & McKenney, R. J. Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility. J. Biol. Chem. 292, 12245–12255 (2017).
  Article PubMed CAS PubMed Central Google Scholar
• Wang, S. et al. Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis. Mol. Biol. Cell 24, 3522–3533 (2013).
  Article PubMed PubMed Central Google Scholar
• Seksek, O., Biwersi, J. & Verkman, A. S. Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus. J. Cell Biol. 138, 131–142 (1997).
  Article PubMed PubMed Central CAS Google Scholar
• Hutagalung, A. H. & Novick, P. J. Role of Rab GTPases in membrane traffic and cell physiology. Physiol. Rev. 91, 119–149 (2011).
  Article PubMed PubMed Central CAS Google Scholar
• Wozniak, M. J. et al. Role of kinesin-1 and cytoplasmic dynein in endoplasmic reticulum movement in VERO cells. J. Cell Sci. 122, 1979–1989 (2009).
  Article PubMed PubMed Central CAS Google Scholar
• Valenzuela, J. I. et al. Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors. J. Cell Sci. 127, 3382–3395 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Presley, J. F. et al. ER-to-Golgi transport visualized in living cells. Nature 389, 81–85 (1997). Elegantly demonstrates the role of dynein in transporting proteins from the ER to the Golgi apparatus.
  Article PubMed CAS Google Scholar
• Roghi, C. & Allan, V. J. Dynamic association of cytoplasmic dynein heavy chain 1a with the Golgi apparatus and intermediate compartment. J. Cell Sci. 112, 4673–4685 (1999).
  PubMed CAS Google Scholar
• Salogiannis, J. & Reck-Peterson, S. L. Hitchhiking: a non-canonical mode of microtubule-based transport. Trends Cell Biol. 27, 141–150 (2017).
  Article PubMed CAS Google Scholar
• Guimaraes, S. C. et al. Peroxisomes, lipid droplets, and endoplasmic reticulum “hitchhike” on motile early endosomes. J. Cell Biol. 211, 945–954 (2015).
  Article PubMed PubMed Central CAS Google Scholar
• Wedlich-Soldner, R., Straube, A., Friedrich, M. W. & Steinberg, G. A balance of KIF1A-like kinesin and dynein organizes early endosomes in the fungus Ustilago maydis. EMBO J 21, 2946–2957 (2002).
  Article PubMed PubMed Central CAS Google Scholar
• Burkhardt, J. K., Echeverri, C. J., Nilsson, T. & Vallee, R. B. Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J. Cell Biol. 139, 469–484 (1997).
  Article PubMed PubMed Central CAS Google Scholar
• Hoogenraad, C. C. et al. Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J 20, 4041–4054 (2001). Demonstrates a link between BICD2 and dynein–dynactin.
  Article PubMed PubMed Central CAS Google Scholar
• Matanis, T. et al. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat. Cell Biol. 4, 986–992 (2002).Shows that BICD proteins recruit dynein to RAB6-labelled Golgi vesicles.
  Article PubMed CAS Google Scholar
• Yadav, S., Puthenveedu, M. A. & Linstedt, A. D. Golgin160 recruits the dynein motor to position the Golgi apparatus. Dev. Cell 23, 153–165 (2012).
  Article PubMed PubMed Central CAS Google Scholar
• Schlager, M. A. et al. Bicaudal d family adaptor proteins control the velocity of Dynein-based movements. Cell Rep. 8, 1248–1256 (2014).
  Article PubMed CAS Google Scholar
• Schlager, M. A. et al. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. EMBO J. 29, 1637–1651 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Nokes, R. L., Fields, I. C., Collins, R. N. & Folsch, H. Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells. J. Cell Biol. 182, 845–853 (2008).
  Article PubMed PubMed Central CAS Google Scholar
• Bachmann-Gagescu, R. et al. The ciliopathy protein CC2D2A associates with NINL and functions in RAB8-MICAL3-regulated vesicle trafficking. PLoS Genet. 11, e1005575 (2015).
  Article PubMed PubMed Central CAS Google Scholar
• Baron Gaillard, C. L. et al. Hook2 is involved in the morphogenesis of the primary cilium. Mol. Biol. Cell 22, 4549–4562 (2011).
  Article PubMed PubMed Central Google Scholar
• Driskell, O. J., Mironov, A., Allan, V. J. & Woodman, P. G. Dynein is required for receptor sorting and the morphogenesis of early endosomes. Nat. Cell Biol. 9, 113–120 (2007).
  Article PubMed CAS Google Scholar
• Heerssen, H. M., Pazyra, M. F. & Segal, R. A. Dynein motors transport activated Trks to promote survival of target-dependent neurons. Nat. Neurosci. 7, 596–604 (2004).
  Article PubMed CAS Google Scholar
• Kramer, H. & Phistry, M. Mutations in the Drosophila hook gene inhibit endocytosis of the boss transmembrane ligand into multivesicular bodies. J. Cell Biol. 133, 1205–1215 (1996).
  Article PubMed CAS Google Scholar
• Bielska, E. et al. Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes. J. Cell Biol. 204, 989–1007 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Zhang, J. et al. HookA is a novel dynein-early endosome linker critical for cargo movement in vivo. J. Cell Biol. 204, 1009–1026 (2014). Along with reference 68, identifies a role for Hook proteins in dynein-based endosome motility.
  Article PubMed PubMed Central CAS Google Scholar
• Guo, X., Farias, G. G., Mattera, R. & Bonifacino, J. S. Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon. Proc. Natl Acad. Sci. USA 113, E5318–E5327 (2016).
  Article PubMed PubMed Central CAS Google Scholar
• Xu, L. et al. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Mol. Biol. Cell 19, 5059–5071 (2008).
  Article PubMed PubMed Central CAS Google Scholar
• Yao, X., Wang, X. & Xiang, X. FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus. Mol. Biol. Cell 25, 2181–2189 (2014).
  Article PubMed PubMed Central Google Scholar
• Gillingham, A. K., Sinka, R., Torres, I. L., Lilley, K. S. & Munro, S. Toward a comprehensive map of the effectors of rab GTPases. Dev. Cell 31, 358–373 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Gauthier, L. R. et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118, 127–138 (2004).
  Article PubMed CAS Google Scholar
• Caviston, J. P., Ross, J. L., Antony, S. M., Tokito, M. & Holzbaur, E. L. Huntingtin facilitates dynein/dynactin-mediated vesicle transport. Proc. Natl Acad. Sci. USA 104, 10045–10050 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Engelender, S. et al. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum. Mol. Genet. 6, 2205–2212 (1997).
  Article PubMed CAS Google Scholar
• Johansson, M. et al. Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin. J. Cell Biol. 176, 459–471 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Wu, M., Wang, T., Loh, E., Hong, W. & Song, H. Structural basis for recruitment of RILP by small GTPase Rab7. EMBO J. 24, 1491–1501 (2005).
  Article PubMed PubMed Central CAS Google Scholar
• Spang, A. Membrane tethering complexes in the endosomal system. Front. Cell Dev. Biol. 4, 35 (2016).
  Article PubMed PubMed Central Google Scholar
• Lin, X. et al. RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking. Sci. Rep. 4, 7282 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• van der Kant, R. et al. Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L. J. Cell Sci. 126, 3462–3474 (2013).
  Article PubMed CAS Google Scholar
• Szatmari, Z. et al. Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization. Mol. Biol. Cell 25, 522–531 (2014).
  Article PubMed PubMed Central Google Scholar
• Pu, J., Guardia, C. M., Keren-Kaplan, T. & Bonifacino, J. S. Mechanisms and functions of lysosome positioning. J. Cell Sci. 129, 4329–4339 (2016).
  Article PubMed PubMed Central CAS Google Scholar
• Drerup, C. M. & Nechiporuk, A. V. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. PLoS Genet. 9, e1003303 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Lorenzo, D. N. et al. A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport. J. Cell Biol. 207, 735–752 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Cai, Q. et al. Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons. Neuron 68, 73–86 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Holleran, E. A., Tokito, M. K., Karki, S. & Holzbaur, E. L. Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles. J. Cell Biol. 135, 1815–1829 (1996).
  Article PubMed CAS Google Scholar
• Schmieg, N., Menendez, G., Schiavo, G. & Terenzio, M. Signalling endosomes in axonal transport: travel updates on the molecular highway. Semin. Cell Dev. Biol. 27, 32–43 (2014).
  Article PubMed CAS Google Scholar
• Delcroix, J. D. et al. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 39, 69–84 (2003).
  Article PubMed CAS Google Scholar
• Saxena, S., Bucci, C., Weis, J. & Kruttgen, A. The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA. J. Neurosci. 25, 10930–10940 (2005).
  Article PubMed CAS Google Scholar
• Welz, T., Wellbourne-Wood, J. & Kerkhoff, E. Orchestration of cell surface proteins by Rab11. Trends Cell Biol. 24, 407–415 (2014).
  Article PubMed CAS Google Scholar
• Horgan, C. P. et al. Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment. Traffic 8, 414–430 (2007).
  Article PubMed CAS Google Scholar
• Wang, J. & Deretic, D. The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting. J. Cell Sci. 128, 1375–1385 (2015).
  Article PubMed PubMed Central CAS Google Scholar
• Wilson, G. M. et al. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol. Biol. Cell 16, 849–860 (2005).
  Article PubMed PubMed Central CAS Google Scholar
• Montagnac, G. et al. ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis. Curr. Biol. 19, 184–195 (2009).
  Article PubMed CAS Google Scholar
• Reilein, A. R. et al. Differential regulation of dynein-driven melanosome movement. Biochem. Biophys. Res. Commun. 309, 652–658 (2003).
  Article PubMed CAS Google Scholar
• Dona, M. et al. NINL and DZANK1 co-function in vesicle transport and are essential for photoreceptor development in zebrafish. PLoS Genet. 11, e1005574 (2015).
  Article PubMed PubMed Central CAS Google Scholar
• Redwine, W. B. et al. The human cytoplasmic dynein interactome reveals novel activators of motility. eLife 6, e28257 (2017). A proteomics resource of the cytoplasmic dynein interactome.
  Article PubMed PubMed Central Google Scholar
• Kimura, S., Noda, T. & Yoshimori, T. Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes. Cell Struct. Funct. 33, 109–122 (2008).
  Article PubMed CAS Google Scholar
• Maday, S., Wallace, K. E. & Holzbaur, E. L. Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J. Cell Biol. 196, 407–417 (2012).
  Article PubMed PubMed Central CAS Google Scholar
• Cheng, X. T., Zhou, B., Lin, M. Y., Cai, Q. & Sheng, Z. H. Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes. J. Cell Biol. 209, 377–386 (2015).
  Article PubMed PubMed Central CAS Google Scholar
• Lee, S., Sato, Y. & Nixon, R. A. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer’s-like axonal dystrophy. J. Neurosci. 31, 7817–7830 (2011).
  Article PubMed PubMed Central CAS Google Scholar
• Maday, S. & Holzbaur, E. L. Compartment-specific regulation of autophagy in primary neurons. J. Neurosci. 36, 5933–5945 (2016).
  Article PubMed PubMed Central CAS Google Scholar
• Ravikumar, B. et al. Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat. Genet. 37, 771–776 (2005).
  Article PubMed CAS Google Scholar
• Wong, Y. C. & Holzbaur, E. L. The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation. J. Neurosci. 34, 1293–1305 (2014). Demonstrates the roles of HTT and HAP1 in autophagy.
  Article PubMed PubMed Central CAS Google Scholar
• Fu, M. M., Nirschl, J. J. & Holzbaur, E. L. LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes. Dev. Cell 29, 577–590 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Klinman, E. & Holzbaur, E. L. Comparative analysis of axonal transport markers in primary mammalian neurons. Methods Cell Biol. 131, 409–424 (2016). Shows different types of retrograde transport of many key cargoes in axons.
  Article PubMed Google Scholar
• Hollenbeck, P. J. & Saxton, W. M. The axonal transport of mitochondria. J. Cell Sci. 118, 5411–5419 (2005).
  Article PubMed PubMed Central CAS Google Scholar
• Pilling, A. D., Horiuchi, D., Lively, C. M. & Saxton, W. M. Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol. Biol. Cell 17, 2057–2068 (2006).
  Article PubMed PubMed Central CAS Google Scholar
• Schwarz, T. L. Mitochondrial trafficking in neurons. Cold Spring Harb. Perspect. Biol. 5, a011304 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• van Spronsen, M. et al. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron 77, 485–502 (2013).
  Article PubMed CAS Google Scholar
• Neuhaus, A., Eggeling, C., Erdmann, R. & Schliebs, W. Why do peroxisomes associate with the cytoskeleton? Biochim. Biophys. Acta 1863, 1019–1026 (2016).
  Article PubMed CAS Google Scholar
• Schrader, M., King, S. J., Stroh, T. A. & Schroer, T. A. Real time imaging reveals a peroxisomal reticulum in living cells. J. Cell Sci. 113, 3663–3671 (2000).
  PubMed CAS Google Scholar
• Okumoto, K. et al.New splicing variants of mitochondrial Rho GTPase-1 (Miro) transport peroxisomes. J. Cell Biol. 217, 619–633 (2017).
  Google Scholar
• Egan, M. J., Tan, K. & Reck-Peterson, S. L. Lis1 is an initiation factor for dynein-driven organelle transport. J. Cell Biol. 197, 971–982 (2012).
  Article PubMed PubMed Central CAS Google Scholar
• Salogiannis, J., Egan, M. J. & Reck-Peterson, S. L. Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA. J. Cell Biol. 212, 289–296 (2016).
  Article PubMed PubMed Central CAS Google Scholar
• Thiam, A. R., Farese, R. V. Jr & Walther, T. C. The biophysics and cell biology of lipid droplets. Nat. Rev. Mol. Cell Biol. 14, 775–786 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Targett-Adams, P. et al. Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein. J. Biol. Chem. 278, 15998–16007 (2003).
  Article PubMed CAS Google Scholar
• Gross, S. P., Welte, M. A., Block, S. M. & Wieschaus, E. F. Dynein-mediated cargo transport in vivo. A switch controls travel distance. J. Cell Biol. 148, 945–956 (2000).
  Article PubMed PubMed Central CAS Google Scholar
• Shubeita, G. T. et al. Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets. Cell 135, 1098–1107 (2008).
  Article PubMed PubMed Central CAS Google Scholar
• Larsen, K. S., Xu, J., Cermelli, S., Shu, Z. & Gross, S. P. BicaudalD actively regulates microtubule motor activity in lipid droplet transport. PLoS ONE 3, e3763 (2008).
  Article PubMed PubMed Central CAS Google Scholar
• McNally, F. J. Mechanisms of spindle positioning. J. Cell Biol. 200, 131–140 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Moore, J. K., Stuchell-Brereton, M. D. & Cooper, J. A. Function of dynein in budding yeast: mitotic spindle positioning in a polarized cell. Cell. Motil. Cytoskeleton 66, 546–555 (2009).
  Article PubMed PubMed Central CAS Google Scholar
• Plamann, M., Minke, P. F., Tinsley, J. H. & Bruno, K. S. Cytoplasmic dynein and actin-related protein Arp1 are required for normal nuclear distribution in filamentous fungi. J. Cell Biol. 127, 139–149 (1994).
  Article PubMed CAS Google Scholar
• Xiang, X., Beckwith, S. M. & Morris, N. R. Cytoplasmic dynein is involved in nuclear migration in Aspergillus nidulans. Proc. Natl Acad. Sci. USA 91, 2100–2104 (1994).
  Article PubMed PubMed Central CAS Google Scholar
• Gonczy, P., Pichler, S., Kirkham, M. & Hyman, A. A. Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo. J. Cell Biol. 147, 135–150 (1999).
  Article PubMed PubMed Central CAS Google Scholar
• Dujardin, D. L. et al. A role for cytoplasmic dynein and LIS1 in directed cell movement. J. Cell Biol. 163, 1205–1211 (2003).
  Article PubMed PubMed Central CAS Google Scholar
• Tsai, J. W., Bremner, K. H. & Vallee, R. B. Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue. Nat. Neurosci. 10, 970–979 (2007).
  Article PubMed CAS Google Scholar
• Tsai, J. W., Lian, W. N., Kemal, S., Kriegstein, A. R. & Vallee, R. B. Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Nat. Neurosci. 13, 1463–1471 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Cadot, B., Gache, V. & Gomes, E. R. Moving and positioning the nucleus in skeletal muscle — one step at a time. Nucleus 6, 373–381 (2015).
  Article PubMed PubMed Central Google Scholar
• Folker, E. S., Schulman, V. K. & Baylies, M. K. Translocating myonuclei have distinct leading and lagging edges that require kinesin and dynein. Development 141, 355–366 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Radulescu, A. E. & Cleveland, D. W. NuMA after 30 years: the matrix revisited. Trends Cell Biol. 20, 214–222 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Hu, D. J. et al. Dynein recruitment to nuclear pores activates apical nuclear migration and mitotic entry in brain progenitor cells. Cell 154, 1300–1313 (2013).
  Article PubMed CAS Google Scholar
• Splinter, D. et al. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol. 8, e1000350 (2010). Demonstrates a role for BICD2 in dynein recruitment to nuclear pores.
  Article PubMed PubMed Central CAS Google Scholar
• Bolhy, S. et al. A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase. J. Cell Biol. 192, 855–871 (2011).
  Article PubMed PubMed Central CAS Google Scholar
• Malone, C. J. et al. The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus. Cell 115, 825–836 (2003).
  Article PubMed CAS Google Scholar
• Bullock, S. L. Messengers, motors and mysteries: sorting of eukaryotic mRNAs by cytoskeletal transport. Biochem. Soc. Trans. 39, 1161–1165 (2011).
  Article PubMed CAS Google Scholar
• Bullock, S. L. & Ish-Horowicz, D. Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis. Nature 414, 611–616 (2001). Demonstrates a role for BicD in RNA localization.
  Article PubMed CAS Google Scholar
• Wilkie, G. S. & Davis, I. Drosophila wingless and pair-rule transcripts localize apically by dynein-mediated transport of RNA particles. Cell 105, 209–219 (2001).
  Article PubMed CAS Google Scholar
• Gershoni-Emek, N. et al. Proteomic analysis of dynein-interacting proteins in amyotrophic lateral sclerosis synaptosomes reveals alterations in the RNA-binding protein Staufen1. Mol. Cell Proteom. 15, 506–522 (2016).
  Article CAS Google Scholar
• van Niekerk, E. A. et al. Sumoylation in axons triggers retrograde transport of the RNA-binding protein La. Proc. Natl Acad. Sci. USA 104, 12913–12918 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Dienstbier, M., Boehl, F., Li, X. & Bullock, S. L. Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor. Genes Dev. 23, 1546–1558 (2009).
  Article PubMed PubMed Central CAS Google Scholar
• Weil, T. T. mRNA localization in the Drosophila germline. RNA Biol. 11, 1010–1018 (2014).
  Article PubMed PubMed Central Google Scholar
• Clark, A., Meignin, C. & Davis, I. A. Dynein-dependent shortcut rapidly delivers axis determination transcripts into the Drosophila oocyte. Development 134, 1955–1965 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Mische, S., Li, M., Serr, M. & Hays, T. S. Direct observation of regulated ribonucleoprotein transport across the nurse cell/oocyte boundary. Mol. Biol. Cell 18, 2254–2263 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Weil, T. T., Forrest, K. M. & Gavis, E. R. Localization of bicoid mRNA in late oocytes is maintained by continual active transport. Dev. Cell 11, 251–262 (2006).
  Article PubMed CAS Google Scholar
• Bianco, A., Dienstbier, M., Salter, H. K., Gatto, G. & Bullock, S. L. Bicaudal-D regulates fragile X mental retardation protein levels, motility, and function during neuronal morphogenesis. Curr. Biol. 20, 1487–1492 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Haag, C., Steuten, B. & Feldbrugge, M. Membrane-coupled mRNA trafficking in fungi. Annu. Rev. Microbiol. 69, 265–281 (2015).
  Article PubMed CAS Google Scholar
• Baumann, S., Konig, J., Koepke, J. & Feldbrugge, M. Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation. EMBO Rep. 15, 94–102 (2014).
  Article PubMed CAS Google Scholar
• Higuchi, Y., Ashwin, P., Roger, Y. & Steinberg, G. Early endosome motility spatially organizes polysome distribution. J. Cell Biol. 204, 343–357 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Garcia-Mata, R., Gao, Y. S. & Sztul, E. Hassles with taking out the garbage: aggravating aggresomes. Traffic 3, 388–396 (2002).
  Article PubMed CAS Google Scholar
• Garcia-Mata, R., Bebok, Z., Sorscher, E. J. & Sztul, E. S. Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. J. Cell Biol. 146, 1239–1254 (1999).
  Article PubMed PubMed Central CAS Google Scholar
• Johnston, J. A., Illing, M. E. & Kopito, R. R. Cytoplasmic dynein/dynactin mediates the assembly of aggresomes. Cell. Motil. Cytoskeleton 53, 26–38 (2002).
  Article PubMed CAS Google Scholar
• Kawaguchi, Y. et al. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115, 727–738 (2003).
  Article PubMed CAS Google Scholar
• Yan, J. et al. SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity. PLoS ONE 8, e76016 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Calderilla-Barbosa, L. et al. Interaction of SQSTM1 with the motor protein dynein — SQSTM1 is required for normal dynein function and trafficking. J. Cell Sci. 127, 4052–4063 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Gamerdinger, M., Kaya, A. M., Wolfrum, U., Clement, A. M. & Behl, C. BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins. EMBO Rep. 12, 149–156 (2011).
  Article PubMed PubMed Central CAS Google Scholar
• Xu, Z. et al. 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes. J. Cell Sci. 126, 4173–4186 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Perry, R. B. & Fainzilber, M. Local translation in neuronal processes — in vivo tests of a “heretical hypothesis”. Dev. Neurobiol. 74, 210–217 (2014).
  Article PubMed CAS Google Scholar
• Ben-Yaakov, K. et al. Axonal transcription factors signal retrogradely in lesioned peripheral nerve. EMBO J. 31, 1350–1363 (2012).
  Article PubMed PubMed Central CAS Google Scholar
• Hanz, S. et al. Axoplasmic importins enable retrograde injury signaling in lesioned nerve. Neuron 40, 1095–1104 (2003).
  Article PubMed CAS Google Scholar
• Lowery, J., Kuczmarski, E. R., Herrmann, H. & Goldman, R. D. Intermediate filaments play a pivotal role in regulating cell architecture and function. J. Biol. Chem. 290, 17145–17153 (2015).
  Article PubMed PubMed Central CAS Google Scholar
• Hookway, C. et al. Microtubule-dependent transport and dynamics of vimentin intermediate filaments. Mol. Biol. Cell 26, 1675–1686 (2015).
  Article PubMed PubMed Central CAS Google Scholar
• Helfand, B. T., Mikami, A., Vallee, R. B. & Goldman, R. D. A requirement for cytoplasmic dynein and dynactin in intermediate filament network assembly and organization. J. Cell Biol. 157, 795–806 (2002).
  Article PubMed PubMed Central CAS Google Scholar
• Payne, C., Rawe, V., Ramalho-Santos, J., Simerly, C. & Schatten, G. Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate genomic union during mammalian fertilization. J. Cell Sci. 116, 4727–4738 (2003).
  Article PubMed CAS Google Scholar
• He, Y. et al. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. J. Cell Biol. 168, 697–703 (2005).
  Article PubMed PubMed Central CAS Google Scholar
• Wagner, O. I. et al. The interaction of neurofilaments with the microtubule motor cytoplasmic dynein. Mol. Biol. Cell 15, 5092–5100 (2004).
  Article PubMed PubMed Central CAS Google Scholar
• Ahmad, F. J., Echeverri, C. J., Vallee, R. B. & Baas, P. W. Cytoplasmic dynein and dynactin are required for the transport of microtubules into the axon. J. Cell Biol. 140, 391–401 (1998).
  Article PubMed PubMed Central CAS Google Scholar
• del Castillo, U., Winding, M., Lu, W. & Gelfand, V. I. Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons. eLife 4, e10140 (2015).
  Article PubMed PubMed Central Google Scholar
• Tang, N. & Marshall, W. F. Centrosome positioning in vertebrate development. J. Cell Sci. 125, 4951–4961 (2012).
  Article PubMed PubMed Central CAS Google Scholar
• Jia, Y., Fong, K. W., Choi, Y. K., See, S. S. & Qi, R. Z. Dynamic recruitment of CDK5RAP2 to centrosomes requires its association with dynein. PLoS ONE 8, e68523 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Fong, K. W., Choi, Y. K., Rattner, J. B. & Qi, R. Z. CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. Mol. Biol. Cell 19, 115–125 (2008).
  Article PubMed PubMed Central CAS Google Scholar
• Casenghi, M. et al. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev. Cell 5, 113–125 (2003).
  Article PubMed CAS Google Scholar
• Mogensen, M. M., Malik, A., Piel, M., Bouckson-Castaing, V. & Bornens, M. Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: the role of ninein. J. Cell Sci. 113, 3013–3023 (2000).
  PubMed CAS Google Scholar
• Szebenyi, G., Hall, B., Yu, R., Hashim, A. I. & Kramer, H. Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. Traffic 8, 32–46 (2007).
  Article PubMed CAS Google Scholar
• Hori, A. & Toda, T. Regulation of centriolar satellite integrity and its physiology. Cell. Mol. Life Sci. 74, 213–229 (2017).
  Article PubMed CAS Google Scholar
• Kim, J. C. et al. The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat. Genet. 36, 462–470 (2004).
  Article PubMed CAS Google Scholar
• Dammermann, A. & Merdes, A. Assembly of centrosomal proteins and microtubule organization depends on PCM-1. J. Cell Biol. 159, 255–266 (2002).
  Article PubMed PubMed Central CAS Google Scholar
• Ge, X., Frank, C. L., Calderon de Anda, F. & Tsai, L. H. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron 65, 191–203 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Cao, J. et al. Circovirus transport proceeds via direct interaction of the cytoplasmic dynein IC1 subunit with the viral capsid protein. J. Virol. 89, 2777–2791 (2015).
  Article PubMed CAS Google Scholar
• Castle, M. J., Perlson, E., Holzbaur, E. L. & Wolfe, J. H. Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment. Mol. Ther. 22, 554–566 (2014).
  Article PubMed CAS Google Scholar
• Dodding, M. P. & Way, M. Coupling viruses to dynein and kinesin-1. EMBO J 30, 3527–3539 (2011).
  Article PubMed PubMed Central CAS Google Scholar
• Lakadamyali, M., Rust, M. J., Babcock, H. P. & Zhuang, X. Visualizing infection of individual influenza viruses. Proc. Natl Acad. Sci. USA 100, 9280–9285 (2003).
  Article PubMed PubMed Central CAS Google Scholar
• Petit, C. et al. Targeting of incoming retroviral Gag to the centrosome involves a direct interaction with the dynein light chain 8. J. Cell Sci. 116, 3433–3442 (2003).
  Article PubMed CAS Google Scholar
• Alonso, C. et al. African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein. J. Virol. 75, 9819–9827 (2001).
  Article PubMed PubMed Central CAS Google Scholar
• Mainou, B. A. et al. Reovirus cell entry requires functional microtubules. mBio 4, e00405–13 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Ploubidou, A. et al. Vaccinia virus infection disrupts microtubule organization and centrosome function. EMBO J. 19, 3932–3944 (2000).
  Article PubMed PubMed Central CAS Google Scholar
• Ramanathan, H. N. et al. Dynein-dependent transport of the hantaan virus nucleocapsid protein to the endoplasmic reticulum-Golgi intermediate compartment. J. Virol. 81, 8634–8647 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Shrivastava, N., Sripada, S., Kaur, J., Shah, P. S. & Cecilia, D. Insights into the internalization and retrograde trafficking of Dengue 2 virus in BHK-21 cells. PLoS ONE 6, e25229 (2011).
  Article PubMed PubMed Central CAS Google Scholar
• Klingen, Y., Conzelmann, K. K. & Finke, S. Double-labeled rabies virus: live tracking of enveloped virus transport. J. Virol. 82, 237–245 (2008).
  Article PubMed CAS Google Scholar
• Boulant, S. et al. Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner. Traffic 9, 1268–1282 (2008).
  Article PubMed CAS Google Scholar
• Kim, S. et al. Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners. J. Virol. 81, 1714–1726 (2007).
  Article PubMed CAS Google Scholar
• Banerjee, I. et al. Influenza A virus uses the aggresome processing machinery for host cell entry. Science 346, 473–477 (2014).
  Article PubMed CAS Google Scholar
• Lycke, E. et al. Herpes simplex virus infection of the human sensory neuron. An electron microscopy study. Arch. Virol. 101, 87–104 (1988).
  Article PubMed CAS Google Scholar
• Radtke, K. et al. Plus- and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures. PLoS Pathog. 6, e1000991 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Zaichick, S. V. et al. The herpesvirus VP1/2 protein is an effector of dynein-mediated capsid transport and neuroinvasion. Cell Host Microbe 13, 193–203 (2013). Provides evidence that a herpes virus contains a protein that can activate dynein–dynactin transport.
  Article PubMed CAS Google Scholar
• Suomalainen, M. et al. Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus. J. Cell Biol. 144, 657–672 (1999).
  Article PubMed PubMed Central CAS Google Scholar
• Bremner, K. H. et al. Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. Cell Host Microbe 6, 523–535 (2009).
  Article PubMed PubMed Central CAS Google Scholar
• Suikkanen, S. et al. Exploitation of microtubule cytoskeleton and dynein during parvoviral traffic toward the nucleus. J. Virol. 77, 10270–10279 (2003).
  Article PubMed PubMed Central CAS Google Scholar
• Mazarakis, N. D. et al. Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery. Hum. Mol. Genet. 10, 2109–2121 (2001).
  Article PubMed CAS Google Scholar
• Laan, L. et al. Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters. Cell 148, 502–514 (2012).
  Article PubMed PubMed Central CAS Google Scholar
• Ligon, L. A., Karki, S., Tokito, M. & Holzbaur, E. L. Dynein binds to beta-catenin and may tether microtubules at adherens junctions. Nat. Cell Biol. 3, 913–917 (2001).
  Article PubMed CAS Google Scholar
• Rosse, C. et al. Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration. J. Cell Sci. 125, 3733–3738 (2012).
  Article PubMed CAS Google Scholar
• Mallik, R., Rai, A. K., Barak, P., Rai, A. & Kunwar, A. Teamwork in microtubule motors. Trends Cell Biol. 23, 575–582 (2013).
  Article PubMed CAS Google Scholar
• Hancock, W. O. Bidirectional cargo transport: moving beyond tug of war. Nat. Rev. Mol. Cell Biol. 15, 615–628 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Grigoriev, I. et al. Rab6 regulates transport and targeting of exocytotic carriers. Dev. Cell 13, 305–314 (2007).
  Article PubMed CAS Google Scholar
• Block-Galarza, J. et al. Fast transport and retrograde movement of huntingtin and HAP 1 in axons. Neuroreport 8, 2247–2251 (1997).
  Article PubMed CAS Google Scholar
• Li, S. H., Gutekunst, C. A., Hersch, S. M. & Li, X. J. Interaction of huntingtin-associated protein with dynactin P150Glued. J. Neurosci. 18, 1261–1269 (1998).
  Article PubMed CAS Google Scholar
• Fu, M. M. & Holzbaur, E. L. JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. J. Cell Biol. 202, 495–508 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Hong, Z. et al. The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport. Cell Res. 19, 1334–1349 (2009).
  Article PubMed CAS Google Scholar
• Wassmer, T. et al. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the _trans_-Golgi network. Dev. Cell 17, 110–122 (2009).
  Article PubMed PubMed Central CAS Google Scholar
• Holleran, E. A. et al. βIII spectrin binds to the Arp1 subunit of dynactin. J. Biol. Chem. 276, 36598–36605 (2001).
  Article PubMed CAS Google Scholar
• Starcevic, M. & Dell’Angelica, E. C. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J. Biol. Chem. 279, 28393–28401 (2004).
  Article PubMed CAS Google Scholar
• Tynan, S. H., Purohit, A., Doxsey, S. J. & Vallee, R. B. Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. J. Biol. Chem. 275, 32763–32768 (2000).
  Article PubMed CAS Google Scholar
• Schmoranzer, J. et al. Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration. Curr. Biol. 19, 1065–1074 (2009).
  Article PubMed PubMed Central CAS Google Scholar
• Williams, J. C. et al. Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. Proc. Natl Acad. Sci. USA 104, 10028–10033 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Tai, A. W., Chuang, J. Z., Bode, C., Wolfrum, U. & Sung, C. H. Rhodopsin’s carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1. Cell 97, 877–887 (1999).
  Article PubMed CAS Google Scholar
• Tai, A. W., Chuang, J. Z. & Sung, C. H. Cytoplasmic dynein regulation by subunit heterogeneity and its role in apical transport. J. Cell Biol. 153, 1499–1509 (2001).
  Article PubMed PubMed Central CAS Google Scholar
• Meiri, D. et al. Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition. Mol. Cell 45, 642–655 (2012).
  Article PubMed CAS Google Scholar
• Wu, H., Maciejewski, M. W., Takebe, S. & King, S. M. Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions. Structure 13, 213–223 (2005).
  Article PubMed CAS Google Scholar
• Echeverri, C. J., Paschal, B. M., Vaughan, K. T. & Vallee, R. B. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J. Cell Biol. 132, 617–633 (1996). Presents the discovery that p50 overexpression inhibits dynein function.
  Article PubMed CAS Google Scholar
• Quintyne, N. J. et al. Dynactin is required for microtubule anchoring at centrosomes. J. Cell Biol. 147, 321–334 (1999). Presents the discovery that overexpression of the CC1 fragment of the p150 dynactin subunit inhibits dynein function.
  Article PubMed PubMed Central CAS Google Scholar
• Schroer, T. A. Dynactin. Annu. Rev. Cell Dev. Biol. 20, 759–779 (2004).
  Article PubMed CAS Google Scholar
• Steffen, W. et al. The involvement of the intermediate chain of cytoplasmic dynein in binding the motor complex to membranous organelles of Xenopus oocytes. Mol. Biol. Cell 8, 2077–2088 (1997).
  Article PubMed PubMed Central CAS Google Scholar
• Hoogenraad, C. C. et al. Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport. EMBO J. 22, 6004–6015 (2003). The first use of a relocation assay to monitor dynein recruitment and activation.
  Article PubMed PubMed Central CAS Google Scholar
• Kapitein, L. C. et al. Probing intracellular motor protein activity using an inducible cargo trafficking assay. Biophys. J. 99, 2143–2152 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Olenick, M. A., Tokito, M., Boczkowska, M., Dominguez, R. & Holzbaur, E. L. Hook adaptors induce unidirectional processive motility by enhancing the dynein-dynactin interaction. J. Biol. Chem. 291, 18239–18251 (2016).
  Article PubMed PubMed Central CAS Google Scholar
• Griffis, E. R., Stuurman, N. & Vale, R. D. Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J. Cell Biol. 177, 1005–1015 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Maldonado-Baez, L., Cole, N. B., Kramer, H. & Donaldson, J. G. Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1. J. Cell Biol. 201, 233–247 (2013).
  Article PubMed PubMed Central CAS Google Scholar
• Walenta, J. H., Didier, A. J., Liu, X. & Kramer, H. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. J. Cell Biol. 152, 923–934 (2001). Describes the discovery of the Hook family of proteins.
  Article PubMed PubMed Central CAS Google Scholar
• Fumoto, K., Hoogenraad, C. C. & Kikuchi, A. GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25, 5670–5682 (2006).
  Article PubMed PubMed Central CAS Google Scholar
• Okuda, H. et al. LRGUK1 is part of a multiprotein complex required for manchette function and male fertility. FASEB J. 31, 1141–1152 (2017).
  Article PubMed CAS Google Scholar
• Ham, H., Huynh, W., Schoon, R. A., Vale, R. D. & Billadeau, D. D. HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing. J. Immunol. 194, 3984–3996 (2015).
  Article PubMed PubMed Central CAS Google Scholar
• Merdes, A., Heald, R., Samejima, K., Earnshaw, W. C. & Cleveland, D. W. Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. J. Cell Biol. 149, 851–862 (2000).
  Article PubMed PubMed Central CAS Google Scholar
• Hueschen, C., Kenny, S. J., Xu, K. & Dumont, S. NuMA targets dynein to microtubule minus-ends at mitosis. bioRxiv https://doi.org/10.1101/148692 (2017).
• Dohner, K. et al. Function of dynein and dynactin in herpes simplex virus capsid transport. Mol. Biol. Cell 13, 2795–2809 (2002).
  Article PubMed PubMed Central CAS Google Scholar
• Smith, G. A., Pomeranz, L., Gross, S. P. & Enquist, L. W. Local modulation of plus-end transport targets herpesvirus entry and egress in sensory axons. Proc. Natl Acad. Sci. USA 101, 16034–16039 (2004).
  Article PubMed PubMed Central CAS Google Scholar
• Zila, V., Difato, F., Klimova, L., Huerfano, S. & Forstova, J. Involvement of microtubular network and its motors in productive endocytic trafficking of mouse polyomavirus. PLoS ONE 9, e96922 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Liu, W. J. et al. Association of bovine papillomavirus type 1 with microtubules. Virology 282, 237–244 (2001).
  Article PubMed CAS Google Scholar
• Eyre, N. S. et al. Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection. J. Virol. 88, 3636–3652 (2014).
  Article PubMed PubMed Central CAS Google Scholar
• Sfakianos, J. N., LaCasse, R. A. & Hunter, E. The M-PMV cytoplasmic targeting-retention signal directs nascent Gag polypeptides to a pericentriolar region of the cell. Traffic 4, 660–670 (2003).
  Article PubMed CAS Google Scholar