| dbo:abstract |
أسيتات ميدروكسي بروجستيرون (بالإنجليزية: Medroxyprogesterone acetate) يباع تحت اسم العلامة التجارية ديبو بروفيراو هو هرمونطبي جنسي انثوي ينتمي لمجموعة البروجيستينات (بالإنجليزية: Progestins).يتشابه هذا الدواء مع الهرمون الطبيعي ويستخدم هذا الدواء كذلك في النشاط الجنسي غير الطبيعي في الذكورالبروجسترون. (ar) El 17-acetato de medroxiprogesterona (también conocido como acetato de medroxiprogesterona o MPA, del inglés: medroxyprogesterone acetate, disponible bajo la marca comercial Depo Provera) es una progestina, una variante sintética de la hormona humana progesterona. Se utiliza como un anticonceptivo, en terapia de sustitución hormonal y para el tratamiento de endometriosis como también varias otras indicaciones. También puede ser prescrita en terapias de sustitución hormonal en mujeres transgénero. El MPA es un derivado más potente de su progenitor alcohol medroxiprogesterona. Mientras que la medroxiprogesterona es algunas veces usada como un sinónimo de 17-acetato de medroxiprogesterona, lo que normalmente se administra es 17-acetato de medroxiprogesterona y no medroxiprogesterona. (es) L’acétate de médroxyprogestérone (en anglais Medroxyprogesterone acetate ou MPA), connu aussi sous le nom acétate de 17α-hydroxy-6α-méthylprogestérone, ou Depo-Provera est une forme synthétique de progestérone. Il est utilisé principalement comme contraceptif mais sert aussi pour le traitement de l'endométriose. Ses actions pharmacologiques sur le système endocrinien sont : * L'inhibition des gonadotrophines hypophysaires : hormone folliculostimulante (FSH) et hormone lutéinisante (LH). * La diminution des taux sanguins d'hormone corticotrope (ACTH) et d'hydrocortisone. * La diminution de la testostérone circulante. * La diminution des taux d’œstrogènes circulants : résultant à la fois de l'inhibition de la FSH et de l'induction enzymatique de la réductase hépatique, entraînant une augmentation de la clairance de la testostérone et par conséquent une diminution de la conversion des androgènes en œstrogènes. Son effet contraceptif est dû : * au blocage de l'ovulation, * à l'épaississement de la glaire cervicale, empêchant la progression des spermatozoïdes vers la cavité utérine, * à l'inhibition de la croissance endométriale, empêchant ainsi la nidation embryonnaire. (fr) Medroxyprogesterone acetate (MPA), also known as depot medroxyprogesterone acetate (DMPA) in injectable form and sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. It is used as a method of birth control and as a part of menopausal hormone therapy. It is also used to treat endometriosis, abnormal uterine bleeding, abnormal sexuality in males, and certain types of cancer. The medication is available both alone and in combination with an estrogen. It is taken by mouth, used under the tongue, or by injection into a muscle or fat. Common side effects include menstrual disturbances such as absence of periods, abdominal pain, and headaches. More serious side effects include bone loss, blood clots, allergic reactions, and liver problems. Use is not recommended during pregnancy as it may harm the baby. MPA is an artificial progestogen, and as such activates the progesterone receptor, the biological target of progesterone. It also has androgenic activity and weak glucocorticoid activity. Due to its progestogenic activity, MPA decreases the body's release of gonadotropins and can suppress sex hormone levels. It works as a form of birth control by preventing ovulation. MPA was discovered in 1956 and was introduced for medical use in the United States in 1959. It is on the World Health Organization's List of Essential Medicines. MPA is the most widely used progestin in menopausal hormone therapy and in progestogen-only birth control. DMPA is approved for use as a form of long-acting birth control in more than 100 countries. In 2020, it was the 214th most commonly prescribed medication in the United States, with more than 2 million prescriptions. (en) Medroksiprogesteron asetat (MPA), juga disebut sebagai depot medroksiprogesteron asetat (DMPA) dan dijual dengan nama merek Depo-Provera dan lainnya, adalah dari tipe . Ini dipakai sebagai metode kontrol kelahiran dan sebagai bagian dari . (in) メドロキシプロゲステロン酢酸エステル（ｍedroxyprogesterone acetate、MPA）またはデポメドロキシプロゲステロンアセテート（depot medroxyprogesterone acetate、DMPA）は、商標名のプロベラ（Provera）などで売られているタイプのホルモン薬剤の1つである。用途は避妊や一部のに用いられる。加えて、子宮内膜症、、性的倒錯、 数種類のがんなどの治療にも用いられる。単体またはと混合されたものがある。投与法はまたは筋肉注射またはである。 よくある副作用には無月経、腹痛、頭痛などのがあげられる。重度の副作用には骨粗鬆症、血栓、アレルギー反応、があげられる。妊娠中のヒトへの投与はを及ぼすため勧められない。MPAはジェスタージェンの有機化合物であり、と結合し発動させる、プロゲステロンを生物学的標的とする薬剤である。MPAは若干の糖質コルチコイドとアンドロゲンの作用があるがその他の重要なホルモンの作用はない。黄体ホルモン物質の作用により、MPAは性腺刺激ホルモンの分泌を減らし性ホルモンレベルを抑えることできる。作用機序は排卵妨げることにより避妊薬としての効果がある。 MPAが発見されたのは1956年であり、米国で薬剤として使用され始めたのは1959年からである。MPAは 世界保健機構医薬品モデル・リストに掲載されており、最も効果的で安全な医療制度に必要とされる薬剤である。開発途上国での卸値はバイアル1本約$0.59～$1.57米ドルである。英国の国民保健サービスにかかる費用は1投与約￡6.01ポンドである。2015年の米国では1投与にかかる費用は$25米ドル以下である。MPAは閉経期のホルモン治療にもっと幅広く用いられるプロゲスチンであり、である。DMPAは長期間効果のある避妊薬として100カ国以上で使用が認可されている。 (ja) |
| dbo:alternativeName |
Provera, Depo-Provera, Depo-SubQ Provera 104, Curretab, Cycrin, Farlutal, Gestapuran, Perlutex, Veramix, others (en) |
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, |
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71-58-9 |
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6716 |
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717 |
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dbr:Progestin dbr:Progestogen_(medication) dbr:Progestogen_ester dbr:Antigonadotropin dbr:Steroidal_antiandrogen |
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DB00603 |
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C2QI4IOI2G |
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C08150 |
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a604039 |
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6279 |
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wiki-commons:Special:FilePath/Medroxyprogesterone_acetate.svg?width=300 |
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https://druginfo.nlm.nih.gov/drugportal/name/medroxyprogesterone%20acetate |
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G03 (en) |
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AC06 (en) |
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, (en) |
| dbp:bcType |
Hormonal (en) |
| dbp:benefits |
Especially good if poor pill compliance. (en) Reduced endometrial cancer risk. (en) |
| dbp:bioavailability |
By mouth: ~100% (en) |
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Urine (en) |
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Medroxyprogesterone acetate molecule ball.png (en) |
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[-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate (en) |
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a604039 (en) |
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Liver (en) |
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Depot medroxyprogesterone acetate (en) |
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Usually no periods from 2nd injection (en) |
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Especially in first injection may be frequent spotting (en) |
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88.0 (dbd:perCent) |
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Failure (en) |
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-4.73364E7 (dbd:second) |
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Reduced bone density, which may reverse after discontinuation (en) |
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dbr:Intramuscular_injection dbr:Oral_administration dbr:Subcutaneous_injection dbr:Sublingual_administration |
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C[C@H]1C[C@@H]2[C@H][C@@]4C (en) |
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No (en) |
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InChI=1S/C24H34O4/c1-14-12-18-197-10-23208-11-2428-1626/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1 (en) |
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PSGAAPLEWMOORI-PEINSRQWSA-N (en) |
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MPA; DMPA; Methylhydroxyprogesterone acetate; Methylacetoxyprogesterone; MAP; Methypregnone; Metipregnone; 6α-Methyl-17α-hydroxyprogesterone acetate; 6α-Methyl-17α-acetoxyprogesterone; 6α-Methyl-17α-hydroxypregn-4-ene-3,20-dione acetate; NSC-26386 (en) |
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dbr:Pharmacodynamics |
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background:#ccccff (en) |
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Depo-Provera, Depo-SubQ Provera 104, others (en) Provera, Depo-Provera, Depo-SubQ Provera 104, Curretab, Cycrin, Farlutal, Gestapuran, Perlutex, Veramix, others (en) |
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dbr:Progestin |
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أسيتات ميدروكسي بروجستيرون (بالإنجليزية: Medroxyprogesterone acetate) يباع تحت اسم العلامة التجارية ديبو بروفيراو هو هرمونطبي جنسي انثوي ينتمي لمجموعة البروجيستينات (بالإنجليزية: Progestins).يتشابه هذا الدواء مع الهرمون الطبيعي ويستخدم هذا الدواء كذلك في النشاط الجنسي غير الطبيعي في الذكورالبروجسترون. (ar) Medroksiprogesteron asetat (MPA), juga disebut sebagai depot medroksiprogesteron asetat (DMPA) dan dijual dengan nama merek Depo-Provera dan lainnya, adalah dari tipe . Ini dipakai sebagai metode kontrol kelahiran dan sebagai bagian dari . (in) El 17-acetato de medroxiprogesterona (también conocido como acetato de medroxiprogesterona o MPA, del inglés: medroxyprogesterone acetate, disponible bajo la marca comercial Depo Provera) es una progestina, una variante sintética de la hormona humana progesterona. Se utiliza como un anticonceptivo, en terapia de sustitución hormonal y para el tratamiento de endometriosis como también varias otras indicaciones. También puede ser prescrita en terapias de sustitución hormonal en mujeres transgénero. (es) Medroxyprogesterone acetate (MPA), also known as depot medroxyprogesterone acetate (DMPA) in injectable form and sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. It is used as a method of birth control and as a part of menopausal hormone therapy. It is also used to treat endometriosis, abnormal uterine bleeding, abnormal sexuality in males, and certain types of cancer. The medication is available both alone and in combination with an estrogen. It is taken by mouth, used under the tongue, or by injection into a muscle or fat. (en) L’acétate de médroxyprogestérone (en anglais Medroxyprogesterone acetate ou MPA), connu aussi sous le nom acétate de 17α-hydroxy-6α-méthylprogestérone, ou Depo-Provera est une forme synthétique de progestérone. Il est utilisé principalement comme contraceptif mais sert aussi pour le traitement de l'endométriose. Ses actions pharmacologiques sur le système endocrinien sont : Son effet contraceptif est dû : (fr) メドロキシプロゲステロン酢酸エステル（ｍedroxyprogesterone acetate、MPA）またはデポメドロキシプロゲステロンアセテート（depot medroxyprogesterone acetate、DMPA）は、商標名のプロベラ（Provera）などで売られているタイプのホルモン薬剤の1つである。用途は避妊や一部のに用いられる。加えて、子宮内膜症、、性的倒錯、 数種類のがんなどの治療にも用いられる。単体またはと混合されたものがある。投与法はまたは筋肉注射またはである。 よくある副作用には無月経、腹痛、頭痛などのがあげられる。重度の副作用には骨粗鬆症、血栓、アレルギー反応、があげられる。妊娠中のヒトへの投与はを及ぼすため勧められない。MPAはジェスタージェンの有機化合物であり、と結合し発動させる、プロゲステロンを生物学的標的とする薬剤である。MPAは若干の糖質コルチコイドとアンドロゲンの作用があるがその他の重要なホルモンの作用はない。黄体ホルモン物質の作用により、MPAは性腺刺激ホルモンの分泌を減らし性ホルモンレベルを抑えることできる。作用機序は排卵妨げることにより避妊薬としての効果がある。 (ja) |
| rdfs:label |
Medroxyprogesterone acetate (en) أسيتات ميدروكسي بروجستيرون (ar) 17-acetato de medroxiprogesterona (es) Medroksiprogesteron asetat (in) Acétate de médroxyprogestérone (fr) メドロキシプロゲステロン (ja) |
| rdfs:seeAlso |
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