| dbo:abstract |
أسيتات ميدروكسي بروجستيرون (بالإنجليزية: Medroxyprogesterone acetate) يباع تحت اسم العلامة التجارية ديبو بروفيراو هو هرمونطبي جنسي انثوي ينتمي لمجموعة البروجيستينات (بالإنجليزية: Progestins).يتشابه هذا الدواء مع الهرمون الطبيعي ويستخدم هذا الدواء كذلك في النشاط الجنسي غير الطبيعي في الذكورالبروجسترون. (ar) El 17-acetato de medroxiprogesterona (también conocido como acetato de medroxiprogesterona o MPA, del inglés: medroxyprogesterone acetate, disponible bajo la marca comercial Depo Provera) es una progestina, una variante sintética de la hormona humana progesterona. Se utiliza como un anticonceptivo, en terapia de sustitución hormonal y para el tratamiento de endometriosis como también varias otras indicaciones. También puede ser prescrita en terapias de sustitución hormonal en mujeres transgénero. El MPA es un derivado más potente de su progenitor alcohol medroxiprogesterona. Mientras que la medroxiprogesterona es algunas veces usada como un sinónimo de 17-acetato de medroxiprogesterona, lo que normalmente se administra es 17-acetato de medroxiprogesterona y no medroxiprogesterona. (es) L’acétate de médroxyprogestérone (en anglais Medroxyprogesterone acetate ou MPA), connu aussi sous le nom acétate de 17α-hydroxy-6α-méthylprogestérone, ou Depo-Provera est une forme synthétique de progestérone. Il est utilisé principalement comme contraceptif mais sert aussi pour le traitement de l'endométriose. Ses actions pharmacologiques sur le système endocrinien sont : * L'inhibition des gonadotrophines hypophysaires : hormone folliculostimulante (FSH) et hormone lutéinisante (LH). * La diminution des taux sanguins d'hormone corticotrope (ACTH) et d'hydrocortisone. * La diminution de la testostérone circulante. * La diminution des taux d’œstrogènes circulants : résultant à la fois de l'inhibition de la FSH et de l'induction enzymatique de la réductase hépatique, entraînant une augmentation de la clairance de la testostérone et par conséquent une diminution de la conversion des androgènes en œstrogènes. Son effet contraceptif est dû : * au blocage de l'ovulation, * à l'épaississement de la glaire cervicale, empêchant la progression des spermatozoïdes vers la cavité utérine, * à l'inhibition de la croissance endométriale, empêchant ainsi la nidation embryonnaire. (fr) Medroxyprogesterone acetate (MPA), also known as depot medroxyprogesterone acetate (DMPA) in injectable form and sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. It is used as a method of birth control and as a part of menopausal hormone therapy. It is also used to treat endometriosis, abnormal uterine bleeding, abnormal sexuality in males, and certain types of cancer. The medication is available both alone and in combination with an estrogen. It is taken by mouth, used under the tongue, or by injection into a muscle or fat. Common side effects include menstrual disturbances such as absence of periods, abdominal pain, and headaches. More serious side effects include bone loss, blood clots, allergic reactions, and liver problems. Use is not recommended during pregnancy as it may harm the baby. MPA is an artificial progestogen, and as such activates the progesterone receptor, the biological target of progesterone. It also has androgenic activity and weak glucocorticoid activity. Due to its progestogenic activity, MPA decreases the body's release of gonadotropins and can suppress sex hormone levels. It works as a form of birth control by preventing ovulation. MPA was discovered in 1956 and was introduced for medical use in the United States in 1959. It is on the World Health Organization's List of Essential Medicines. MPA is the most widely used progestin in menopausal hormone therapy and in progestogen-only birth control. DMPA is approved for use as a form of long-acting birth control in more than 100 countries. In 2020, it was the 214th most commonly prescribed medication in the United States, with more than 2 million prescriptions. (en) Medroksiprogesteron asetat (MPA), juga disebut sebagai depot medroksiprogesteron asetat (DMPA) dan dijual dengan nama merek Depo-Provera dan lainnya, adalah dari tipe . Ini dipakai sebagai metode kontrol kelahiran dan sebagai bagian dari . (in) メドロキシプロゲステロン酢酸エステル（ｍedroxyprogesterone acetate、MPA）またはデポメドロキシプロゲステロンアセテート（depot medroxyprogesterone acetate、DMPA）は、商標名のプロベラ（Provera）などで売られているタイプのホルモン薬剤の1つである。用途は避妊や一部のに用いられる。加えて、子宮内膜症、、性的倒錯、 数種類のがんなどの治療にも用いられる。単体またはと混合されたものがある。投与法はまたは筋肉注射またはである。 よくある副作用には無月経、腹痛、頭痛などのがあげられる。重度の副作用には骨粗鬆症、血栓、アレルギー反応、があげられる。妊娠中のヒトへの投与はを及ぼすため勧められない。MPAはジェスタージェンの有機化合物であり、と結合し発動させる、プロゲステロンを生物学的標的とする薬剤である。MPAは若干の糖質コルチコイドとアンドロゲンの作用があるがその他の重要なホルモンの作用はない。黄体ホルモン物質の作用により、MPAは性腺刺激ホルモンの分泌を減らし性ホルモンレベルを抑えることできる。作用機序は排卵妨げることにより避妊薬としての効果がある。 MPAが発見されたのは1956年であり、米国で薬剤として使用され始めたのは1959年からである。MPAは 世界保健機構医薬品モデル・リストに掲載されており、最も効果的で安全な医療制度に必要とされる薬剤である。開発途上国での卸値はバイアル1本約$0.59～$1.57米ドルである。英国の国民保健サービスにかかる費用は1投与約￡6.01ポンドである。2015年の米国では1投与にかかる費用は$25米ドル以下である。MPAは閉経期のホルモン治療にもっと幅広く用いられるプロゲスチンであり、である。DMPAは長期間効果のある避妊薬として100カ国以上で使用が認可されている。 (ja) |
| dbo:alternativeName |
Provera, Depo-Provera, Depo-SubQ Provera 104, Curretab, Cycrin, Farlutal, Gestapuran, Perlutex, Veramix, others (en) |
| dbo:atcCode |
, |
| dbo:casNumber |
71-58-9 |
| dbo:chEBI |
6716 |
| dbo:chEMBL |
717 |
| dbo:class |
dbr:Progestin dbr:Progestogen_(medication) dbr:Progestogen_ester dbr:Antigonadotropin dbr:Steroidal_antiandrogen |
| dbo:drugbank |
DB00603 |
| dbo:fdaUniiCode |
C2QI4IOI2G |
| dbo:kegg |
C08150 |
| dbo:medlinePlus |
a604039 |
| dbo:pubchem |
6279 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Medroxyprogesterone_acetate.svg?width=300 |
| dbo:wikiPageExternalLink |
https://druginfo.nlm.nih.gov/drugportal/name/medroxyprogesterone%20acetate |
| dbo:wikiPageID |
23484633 (xsd:integer) |
| dbo:wikiPageLength |
182988 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1124727359 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Cancer dbr:Carcinogenicity dbr:Amenorrhea dbr:3α-androstanediol dbr:5α-dihydroprogesterone dbr:5α-reductase dbr:Benign_prostatic_hyperplasia dbr:Pregnancy dbr:Pregnane dbr:Pregnanolone dbr:Primary_biliary_cirrhosis dbr:Progesterone dbr:Progesterone_(medication) dbr:Progestin dbr:Progestogen_(medication) dbr:Progestogen_ester dbr:Promegestone dbr:Pulmonary_embolism dbr:Elimination_(pharmacology) dbc:Feminizing_hormone_therapy dbr:Endometrial_hyperplasia dbr:Endometrium dbr:Enzyme_induction_and_inhibition dbr:Enzyme_inhibitor dbr:Epilepsy dbr:Epithelium dbr:Mood_(psychology) dbr:MCF-7 dbr:HSD3B2 dbr:Menarche dbr:Menstrual_disorder dbr:Menstruation dbr:Meta-analysis dbr:Metabolite dbr:Methylation dbr:Transactivation dbr:Progestogen-only_injectable_contraceptive dbr:Stroma_(animal_tissue) dbr:Corticosteroid-binding_globulin dbr:Benzodiazepine dbr:Bipolar_disorder dbr:Blood_clot dbr:Breast_cancer dbr:Breastfeeding dbr:Dementia dbr:Depot_injection dbr:Developing_countries dbc:Hormonal_contraception dbr:Androgen dbr:Androgen-dependent_condition dbr:Androgen_deprivation_therapy dbr:Androgen_receptor dbr:Anterior_pituitary dbr:Anti-inflammatory dbr:Anticonvulsant dbr:Antiestrogen dbr:Antigonadotropin dbr:Antimineralocorticoid dbr:Appetite dbr:Appetite_stimulant dbr:Hypericum_perforatum dbr:Hypersexuality dbr:Hypertension dbr:Hypothalamus dbr:Cushing's_syndrome dbr:Cytokine dbr:Ulcerative_colitis dbr:United_Kingdom dbr:United_States dbr:University_of_Pennsylvania dbr:Upjohn dbr:Uterus dbr:Vagina dbr:Veterinary_medicine dbr:Viscosity dbr:Decidualization dbr:Deep_vein_thrombosis dbr:Depression_(mood) dbr:Downregulation_and_upregulation dbr:Dysmenorrhea dbr:Dysuria dbr:EC50 dbr:In_vitro dbr:Interleukin_6 dbr:Intramuscular_injection dbr:Intrauterine_device dbr:Intrinsic_activity dbr:Menopause dbr:Binding_affinity dbr:Libido dbr:Ligand_(biochemistry) dbr:Vitamin_B12_deficiency dbc:Acetate_esters dbc:Androgens_and_anabolic_steroids dbc:Diketones dbc:GABAA_receptor_negative_allosteric_modulators dbc:Glucocorticoids dbc:Pregnanes dbc:Progestogens dbr:Colorectal_cancer dbr:Combined_oral_contraceptive_pill dbr:Competitive_inhibition dbr:Conjugated_estrogens dbr:Conjugated_estrogens/medroxyprogesterone_acetate dbr:Corticosteroid dbr:Cortisol dbr:Crohn's_disease dbc:Appetite_stimulants dbr:Medrogestone dbr:Medroxyprogesterone dbr:Megestrol_acetate dbr:Chemical_castration dbr:Ester dbr:Estradiol/medroxyprogesterone_acetate dbr:Estrogen dbr:Estrogen-dependent_condition dbr:Estrogen_(medication) dbr:Nausea dbr:Neutering dbr:Oral_administration dbr:Oral_contraceptive dbr:Vaginal_bleeding dbr:Vascular_disease dbr:Virilization dbr:Cirrhosis dbr:Elimination_half-life dbr:Endometrial_cancer dbr:Endometriosis dbr:Enzyme dbr:Epileptic_seizure dbr:Full_agonist dbr:Germany dbr:Boxed_warning dbr:Myocardial_infarction dbc:Antigonadotropins dbc:Progestogen_esters dbr:Anesthesia dbr:Antiandrogen dbr:Anxiety dbr:Liver dbr:Louisiana dbr:Calcium_channel dbr:Cholesterol_side-chain_cleavage_enzyme dbr:Steroid dbr:Stroke dbr:Subcutaneous_injection dbr:Clinical_trial dbr:Deoxycorticosterone dbr:Zimbabwe dbr:Feces dbr:Functional_group dbr:Coagulation_factor dbr:Hot_flash dbr:Bone_mineral_density dbr:Iron_deficiency_anemia dbr:Receptor_antagonist dbr:Metabolic_pathway dbr:Particle_size dbr:Pelvic_inflammatory_disease dbr:Pharmacodynamics dbr:Positive_allosteric_modulator dbr:Prodrug dbr:Progesterone_receptor dbr:Prostate_cancer dbr:Surgery dbr:Triglyceride dbr:Microcrystalline dbr:Micronization dbr:Proinflammatory_cytokine dbc:Hormonal_antineoplastic_drugs dbr:CYP17A1 dbr:Cell_(biology) dbr:Aggression dbr:Transcription_(genetics) dbr:Transgender_women dbr:Tumor_necrosis_factor-alpha dbr:Tumor_necrosis_factor_alpha dbr:Dissociation_constant dbr:Drug_interaction dbr:GABAA_receptor dbr:Irregular_menstruation dbr:Fatigue_(medical) dbr:Mineralocorticoid dbr:Steroid_diabetes dbr:Ovulation dbr:Acetate dbr:Adrenocorticotropic_hormone dbr:Agonist dbr:Aldosterone dbr:Allopregnanolone dbr:Altered_state_of_consciousness dbr:Aminoglutethimide dbr:Anabolic dbr:Anabolic_steroid dbc:Wikipedia_medicine_articles_ready_to_translate dbc:World_Health_Organization_essential_medicines dbr:Cyproterone_acetate dbr:Drug_safety dbr:Dydrogesterone dbr:Ectopic_pregnancy dbr:Edema dbr:Estradiol dbr:Estradiol_(medication) dbr:Estradiol_cypionate dbr:Estradiol_cypionate/medroxyprogesterone_acetate dbr:Estradiol_valerate dbr:Estrogen_receptor dbr:Ethinylestradiol dbr:Feminizing_hormone_therapy dbr:Fertility dbr:Fertilization dbr:Flunitrazepam dbr:Follicle-stimulating_hormone dbr:Food_and_Drug_Administration dbr:France dbr:Angiogenesis_inhibitor dbr:American_Congress_of_Obstetricians_and_Gynecologists dbr:Nomegestrol_acetate dbr:Norethisterone dbr:Norethisterone_acetate dbr:Osteoporosis dbr:Ovarian_cyst dbr:Cardiovascular_disease dbr:Cell_proliferation dbr:Diabetic_nephropathy dbr:Diabetic_neuropathy dbr:Follicular_phase dbr:Glucocorticoid dbr:Glucocorticoid_receptor dbr:Gonadotropin dbr:Gonadotropin-releasing_hormone dbr:Hip_fracture dbr:Vomiting dbr:Conjugation_(biochemistry) dbr:Generic_term dbr:Lost_to_follow-up dbr:Positive_feedback dbr:Hormonal_birth_control dbr:Precocious_puberty dbr:Quality_and_Outcomes_Framework dbr:Radioimmunoassay dbr:Redox dbr:HDL_cholesterol dbr:Headache dbr:Hepatocellular_carcinoma dbr:Hirsutism dbr:Atherosclerosis dbr:Atrophy dbr:Israel dbc:3α-Hydroxysteroid_dehydrogenase_inhibitors dbr:Testicle dbr:Testosterone_(medication) dbr:Thailand dbr:Hydroxylation dbr:Hydroxyprogesterone_acetate dbr:Hypnotic dbr:Hypothalamic–pituitary–adrenal_axis dbr:Hypothalamic–pituitary–gonadal_axis dbr:Metrorrhagia dbr:Thrombus dbr:Abdominal_pain dbr:Abnormal_uterine_bleeding dbr:Acne dbc:3β-Hydroxysteroid_dehydrogenase_inhibitors dbc:Drugs_with_unknown_mechanisms_of_action dbr:Adrenal_gland dbr:Adrenal_insufficiency dbr:Adverse_effect dbr:Chlormadinone_acetate dbr:Affinity_(pharmacology) dbr:Bioavailability dbr:Bioidentical_hormone_replacement_therapy dbr:Biological_target dbr:Biosynthesis dbr:Biotransformation dbr:Birth_control dbr:Birth_defect dbr:Blood_vessel dbr:Sweden dbr:Tablet_(pharmacy) dbr:Coagulation dbr:Ejaculation dbr:Hepatitis dbr:High-dose_estrogen dbr:Drowsiness dbr:Mittelschmerz dbr:Idiopathic_thrombocytopenic_purpura dbr:Syntex dbr:Rectal_administration dbr:Viral_hepatitis dbr:Uterine_fibroids dbr:Dexamethasone dbr:Diabetes dbr:Diabetes_mellitus dbr:Diabetic_retinopathy dbr:Diethylstilbestrol dbr:Dihydrotestosterone dbr:Dizziness dbr:Aura_(symptom) dbr:Autoimmune_hemolytic_anemia |
| dbp:atcPrefix |
G03 (en) |
| dbp:atcSuffix |
AC06 (en) |
| dbp:atcSupplemental |
, (en) |
| dbp:bcType |
Hormonal (en) |
| dbp:benefits |
Especially good if poor pill compliance. (en) Reduced endometrial cancer risk. (en) |
| dbp:bioavailability |
By mouth: ~100% (en) |
| dbp:c |
24 (xsd:integer) |
| dbp:casNumber |
71 (xsd:integer) |
| dbp:chebi |
6716 (xsd:integer) |
| dbp:chembl |
717 (xsd:integer) |
| dbp:chemspiderid |
6043 (xsd:integer) |
| dbp:class |
dbr:Progestin dbr:Progestogen_(medication) dbr:Progestogen_ester dbr:Antigonadotropin dbr:Steroidal_antiandrogen |
| dbp:clinicInterval |
12 (xsd:integer) |
| dbp:dateFirstUse |
1969 (xsd:integer) |
| dbp:drugbank |
DB00603 (en) |
| dbp:durationEffect |
(en) 7889400.0 |
| dbp:eliminationHalfLife |
4320000.0 3456000.0 -118800.0 |
| dbp:excretion |
Urine (en) |
| dbp:h |
34 (xsd:integer) |
| dbp:image |
Medroxyprogesterone acetate molecule ball.png (en) |
| dbp:iupacName |
[-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate (en) |
| dbp:iupharLigand |
2879 (xsd:integer) |
| dbp:kegg |
8150.0 |
| dbp:legalAu |
S4 (en) |
| dbp:legalStatus |
Rx-only (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:medicalNotes |
1.57788E7 |
| dbp:medlineplus |
a604039 (en) |
| dbp:meltingHigh |
209 (xsd:integer) |
| dbp:meltingPoint |
207 (xsd:integer) |
| dbp:metabolism |
Liver (en) |
| dbp:name |
Depot medroxyprogesterone acetate (en) |
| dbp:o |
4 (xsd:integer) |
| dbp:perfectFailure%_ |
0.200000 (xsd:double) |
| dbp:periodsAdvantage |
Usually no periods from 2nd injection (en) |
| dbp:periodsDisadvantage |
Especially in first injection may be frequent spotting (en) |
| dbp:proteinBound |
88.0 |
| dbp:pubchem |
6279 (xsd:integer) |
| dbp:rateType |
Failure (en) |
| dbp:reversibility |
-4.73364E7 |
| dbp:risks |
Reduced bone density, which may reverse after discontinuation (en) |
| dbp:routesOfAdministration |
dbr:Intramuscular_injection dbr:Oral_administration dbr:Subcutaneous_injection dbr:Sublingual_administration |
| dbp:smiles |
C[C@H]1C[C@@H]2[C@H][C@@]4C (en) |
| dbp:stdProtectionYesno |
No (en) |
| dbp:stdinchi |
InChI=1S/C24H34O4/c1-14-12-18-197-10-23208-11-2428-1626/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1 (en) |
| dbp:stdinchikey |
PSGAAPLEWMOORI-PEINSRQWSA-N (en) |
| dbp:synonyms |
MPA; DMPA; Methylhydroxyprogesterone acetate; Methylacetoxyprogesterone; MAP; Methypregnone; Metipregnone; 6α-Methyl-17α-hydroxyprogesterone acetate; 6α-Methyl-17α-acetoxyprogesterone; 6α-Methyl-17α-hydroxypregn-4-ene-3,20-dione acetate; NSC-26386 (en) |
| dbp:title |
dbr:Pharmacodynamics |
| dbp:titlestyle |
background:#ccccff (en) |
| dbp:tradename |
Depo-Provera, Depo-SubQ Provera 104, others (en) Provera, Depo-Provera, Depo-SubQ Provera 104, Curretab, Cycrin, Farlutal, Gestapuran, Perlutex, Veramix, others (en) |
| dbp:typicalFailure%_ |
6 (xsd:integer) |
| dbp:unii |
C2QI4IOI2G (en) |
| dbp:userReminders |
7889400.0 |
| dbp:verifiedfields |
verified (en) |
| dbp:verifiedrevid |
307255781 (xsd:integer) |
| dbp:watchedfields |
verified (en) |
| dbp:width |
235 (xsd:integer) 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Abbr dbt:Androgen_receptor_modulators dbt:As_of dbt:Center dbt:Citation_needed dbt:Cite_web dbt:Distinguish dbt:Drugbox dbt:Gallery dbt:Glucocorticoid_receptor_modulators dbt:IPAc-en dbt:Navboxes dbt:Nbsp dbt:Notefoot dbt:Notelist dbt:Portal_bar dbt:Progesterone_receptor_modulators dbt:Reflist dbt:Respell dbt:See_also dbt:Short_description dbt:TOC_limit dbt:Use_dmy_dates dbt:Abbrlink dbt:Ebicite dbt:Keggcite dbt:Progestogens_and_antiprogestogens dbt:Appetite_stimulants dbt:Glucocorticoid_activity_of_selected_steroids_in_vitro dbt:Health_risks_in_the_conjugated_estroge...tudy_of_the_Women's_Health_Initiative dbt:ATC dbt:Drugs.com dbt:Infobox_birth_control dbt:Parenteral_potencies_and_durations_of_progestogens |
| dcterms:subject |
dbc:Feminizing_hormone_therapy dbc:Hormonal_contraception dbc:Acetate_esters dbc:Androgens_and_anabolic_steroids dbc:Diketones dbc:GABAA_receptor_negative_allosteric_modulators dbc:Glucocorticoids dbc:Pregnanes dbc:Progestogens dbc:Appetite_stimulants dbc:Antigonadotropins dbc:Progestogen_esters dbc:Hormonal_antineoplastic_drugs dbc:Wikipedia_medicine_articles_ready_to_translate dbc:World_Health_Organization_essential_medicines dbc:3α-Hydroxysteroid_dehydrogenase_inhibitors dbc:3β-Hydroxysteroid_dehydrogenase_inhibitors dbc:Drugs_with_unknown_mechanisms_of_action |
| gold:hypernym |
dbr:Progestin |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatSteroids yago:Abstraction100002137 yago:BodySubstance105263850 yago:Chemical114806838 yago:Compound114818238 yago:Ester114850483 yago:Hormone105407119 yago:LiquidBodySubstance105397468 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Progestin114747338 yago:Relation100031921 dbo:Drug yago:Secretion105404728 yago:Steroid115057744 yago:SteroidHormone114745635 yago:Substance100019613 yago:WikicatAcetateEsters yago:WikicatProgestogens umbel-rc:ChemicalSubstanceType |
| rdfs:comment |
أسيتات ميدروكسي بروجستيرون (بالإنجليزية: Medroxyprogesterone acetate) يباع تحت اسم العلامة التجارية ديبو بروفيراو هو هرمونطبي جنسي انثوي ينتمي لمجموعة البروجيستينات (بالإنجليزية: Progestins).يتشابه هذا الدواء مع الهرمون الطبيعي ويستخدم هذا الدواء كذلك في النشاط الجنسي غير الطبيعي في الذكورالبروجسترون. (ar) Medroksiprogesteron asetat (MPA), juga disebut sebagai depot medroksiprogesteron asetat (DMPA) dan dijual dengan nama merek Depo-Provera dan lainnya, adalah dari tipe . Ini dipakai sebagai metode kontrol kelahiran dan sebagai bagian dari . (in) El 17-acetato de medroxiprogesterona (también conocido como acetato de medroxiprogesterona o MPA, del inglés: medroxyprogesterone acetate, disponible bajo la marca comercial Depo Provera) es una progestina, una variante sintética de la hormona humana progesterona. Se utiliza como un anticonceptivo, en terapia de sustitución hormonal y para el tratamiento de endometriosis como también varias otras indicaciones. También puede ser prescrita en terapias de sustitución hormonal en mujeres transgénero. (es) Medroxyprogesterone acetate (MPA), also known as depot medroxyprogesterone acetate (DMPA) in injectable form and sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. It is used as a method of birth control and as a part of menopausal hormone therapy. It is also used to treat endometriosis, abnormal uterine bleeding, abnormal sexuality in males, and certain types of cancer. The medication is available both alone and in combination with an estrogen. It is taken by mouth, used under the tongue, or by injection into a muscle or fat. (en) L’acétate de médroxyprogestérone (en anglais Medroxyprogesterone acetate ou MPA), connu aussi sous le nom acétate de 17α-hydroxy-6α-méthylprogestérone, ou Depo-Provera est une forme synthétique de progestérone. Il est utilisé principalement comme contraceptif mais sert aussi pour le traitement de l'endométriose. Ses actions pharmacologiques sur le système endocrinien sont : Son effet contraceptif est dû : (fr) メドロキシプロゲステロン酢酸エステル（ｍedroxyprogesterone acetate、MPA）またはデポメドロキシプロゲステロンアセテート（depot medroxyprogesterone acetate、DMPA）は、商標名のプロベラ（Provera）などで売られているタイプのホルモン薬剤の1つである。用途は避妊や一部のに用いられる。加えて、子宮内膜症、、性的倒錯、 数種類のがんなどの治療にも用いられる。単体またはと混合されたものがある。投与法はまたは筋肉注射またはである。 よくある副作用には無月経、腹痛、頭痛などのがあげられる。重度の副作用には骨粗鬆症、血栓、アレルギー反応、があげられる。妊娠中のヒトへの投与はを及ぼすため勧められない。MPAはジェスタージェンの有機化合物であり、と結合し発動させる、プロゲステロンを生物学的標的とする薬剤である。MPAは若干の糖質コルチコイドとアンドロゲンの作用があるがその他の重要なホルモンの作用はない。黄体ホルモン物質の作用により、MPAは性腺刺激ホルモンの分泌を減らし性ホルモンレベルを抑えることできる。作用機序は排卵妨げることにより避妊薬としての効果がある。 (ja) |
| rdfs:label |
Medroxyprogesterone acetate (en) أسيتات ميدروكسي بروجستيرون (ar) 17-acetato de medroxiprogesterona (es) Medroksiprogesteron asetat (in) Acétate de médroxyprogestérone (fr) メドロキシプロゲステロン (ja) |
| rdfs:seeAlso |
dbr:List_of_progestogens dbr:Conjugated_estrogens dbr:Medroxyprogesterone_acetate dbr:The_United_States dbr:Steroidogenesis_inhibitor dbr:List_of_progestogens_available |
| owl:sameAs |
freebase:Medroxyprogesterone acetate yago-res:Medroxyprogesterone acetate http://www4.wiwiss.fu-berlin.de/sider/resource/drugs/10631 wikidata:Medroxyprogesterone acetate dbpedia-ar:Medroxyprogesterone acetate http://ckb.dbpedia.org/resource/مێدرۆکسی_پرۆجێسترۆن_ئاستەیت dbpedia-es:Medroxyprogesterone acetate dbpedia-fi:Medroxyprogesterone acetate dbpedia-fr:Medroxyprogesterone acetate dbpedia-gl:Medroxyprogesterone acetate dbpedia-id:Medroxyprogesterone acetate dbpedia-ja:Medroxyprogesterone acetate http://or.dbpedia.org/resource/ମେଡ୍ରକ୍ସିପ୍ରୋଜେସ୍ଟେରନ_ଆସେଟେଟ dbpedia-sh:Medroxyprogesterone acetate dbpedia-sr:Medroxyprogesterone acetate dbpedia-th:Medroxyprogesterone acetate dbpedia-tr:Medroxyprogesterone acetate https://global.dbpedia.org/id/2cqW9 |
| prov:wasDerivedFrom |
wikipedia-en:Medroxyprogesterone_acetate?oldid=1124727359&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Levels_of_medroxyprog...e_acetate_in_postmenopausal_women.png wiki-commons:Special:FilePath/Medroxyprogesterone_acetate.svg wiki-commons:Special:FilePath/Medroxyprogesterone_a...roxyprogesterone_acetate_in_women.png wiki-commons:Special:FilePath/Medroxyprogesterone_a...roxyprogesterone_acetate_in_women.png wiki-commons:Special:FilePath/Medroxyprogesterone_a...roxyprogesterone_acetate_in_women.png wiki-commons:Special:FilePath/Medroxyprogesterone_acetate_molecule_ball.png wiki-commons:Special:FilePath/Prikpil.jpg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Medroxyprogesterone_acetate |
| is dbo:wikiPageRedirects of |
dbr:MPA_Gyn_5 dbr:Novo-Medrone dbr:Perlutex dbr:Perlutex_Leo dbr:Prodasone dbr:Progestalfa dbr:Progevera dbr:Proverone dbr:Asconale dbr:Clinofem dbr:Clinovir dbr:Depo-Clinovir dbr:Depo-Prodasone dbr:Depo-Progestin dbr:Depo-Promone dbr:Depo-Provera dbr:Depo-provera dbr:Depo_Provera dbr:G-Farlutal dbr:Gestapuran dbr:Colirest dbr:Curretab dbr:Cycrin dbr:Farlutal dbr:Farlutin dbr:Amen_(drug) dbr:ATC_code_G03AC06 dbr:ATC_code_G03DA02 dbr:ATC_code_L02AB02 dbr:ATCvet_code_QG03AC06 dbr:ATCvet_code_QG03DA02 dbr:ATCvet_code_QL02AB02 dbr:Sodelut_G dbr:Hematrol dbr:Aragest dbr:Aragest_5 dbr:Controlestril dbr:Hysron dbr:Nadigest dbr:Methylacetoxyprogesterone dbr:Methylhydroxyprogesterone_acetate dbr:Methylpregnone dbr:Methypregnone dbr:Metigesterona dbr:Metipregnone dbr:The_jag dbr:Depot_medroxyprogesterone_acetate dbr:Lutopolar dbr:Lutoral dbr:Medroxyhexal dbr:Med-Pro dbr:Megestron dbr:Meprate dbr:Metigestrona dbr:Nidaxin dbr:6α-Methyl-17α-acetoxyprogesterone dbr:6α-Methyl-17α-hydroxyprogesterone_acetate dbr:6α-Methyl-3,20-dioxopregn-4-en-17α-yl_acetate dbr:6α-methyl-17α-acetoxyprogesterone dbr:6α-methyl-17α-hydroxyprogesterone_acetate dbr:6α-methyl-3,20-dioxopregn-4-en-17α-yl_acetate dbr:Oragest dbr:Ralovera dbr:Repromap dbr:Repromix dbr:Veramix dbr:Sirprogen dbr:Oral_medroxyprogesterone dbr:Oral_medroxyprogesterone_acetate dbr:17α-Hydroxy-6α-methylpregn-4-ene-3,20-dione_acetate dbr:17α-hydroxy-6α-methylpregn-4-ene-3,20-dione_acetate dbr:Acetato_de_medroxiprogesterona dbr:Médroxyprogestérone,_acétate_de dbr:Médroxyprogestérone_(acétate_de) dbr:Médroxyprogestérone_acétate_de dbr:OMPA dbr:Birth_control_shot dbr:Depo_Injection dbr:Depo_provera dbr:Depo_shot dbr:Depomedroxy-progesterone_acetate dbr:Depot_medroxyprogesterone dbr:Deprovera dbr:Medroksiprogesteron_Asetat dbr:Medroksiprogesteron_asetat dbr:Medroksiprogesteroniasetaatti dbr:Medroksiprogesterono_acetatas dbr:Medroksyprogesteronu_octan dbr:Medroxiprogesteronacetat dbr:Medroxiprogeszteron-acetát dbr:Medroxiprogeszteron_acetát dbr:Medroxyprogesteron-acetát dbr:Medroxyprogesteron_acetát dbr:Medroxyprogesteronacetat dbr:Medroxyprogesterone_17-acetate dbr:Medroxyprogesterone_Acetate dbr:Medroxyprogesteroni_acetas |
| is dbo:wikiPageWikiLink of |
dbr:Progesterone dbr:Progesterone_(medication) dbr:Progestogen_(medication) dbr:Progestogen_ester dbr:Quingestrone dbr:Endometrioma dbr:Endometriosis_and_infertility dbr:List_of_antiandrogens dbr:List_of_corticosteroids dbr:List_of_estrogens_available_in_the_United_States dbr:Progestin-induced_virilization dbr:Progestogen dbr:Progestogen-only_contraception dbr:Progestogen-only_injectable_contraceptive dbr:Delmadinone_acetate dbr:Depot_injection dbr:Androgen-dependent_condition dbr:Anticorticotropin dbr:Antigonadotropin dbr:Appetite_stimulant dbr:Hydroxyprogesterone_caproate dbr:Pharmacodynamics_of_progesterone dbr:Pharmacokinetics_of_progesterone dbr:Pharmacology_of_cyproterone_acetate dbr:Cushing's_syndrome dbr:Uyghur_genocide dbr:List_of_progestogen_esters dbr:List_of_progestogens dbr:List_of_progestogens_available_in_the_United_States dbr:List_of_sex-hormonal_aqueous_suspensions dbr:MPA_Gyn_5 dbr:Novo-Medrone dbr:Perlutex dbr:Perlutex_Leo dbr:16-Dehydropregnenolone_acetate dbr:17α-Allyl-19-nortestosterone dbr:17α-Hydroxyprogesterone dbr:17α-Methylprogesterone dbr:Combined_oral_contraceptive_pill dbr:Conjugated_estrogens dbr:Conjugated_estrogens/medroxyprogesterone_acetate dbr:Anagestone_acetate dbr:Anaphrodisiac dbr:Medrogestone dbr:Medroxyprogesterone dbr:Megestrol dbr:Megestrol_acetate dbr:Melengestrol_acetate dbr:Chemical_castration dbr:Estradiol/medroxyprogesterone_acetate dbr:Estradiol_valerate/gestonorone_caproate dbr:Estrogen-dependent_condition dbr:Estrogen_(medication) dbr:Vaginal_bleeding dbr:Elizabeth_Wilson_(doctor) dbr:Gary_Schaefer dbr:Concept_Foundation dbr:Prodasone dbr:Progestalfa dbr:Progevera dbr:Proverone dbr:Antiandrogen dbr:Asconale dbr:California_Proposition_65_list_of_chemicals dbr:Combined_injectable_birth_control dbr:Comparison_of_birth_control_methods dbr:Clinofem dbr:Clinovir dbr:Haloprogesterone dbr:Depo-Clinovir dbr:Depo-Prodasone dbr:Depo-Progestin dbr:Depo-Promone dbr:Depo-Provera dbr:Depo-provera dbr:Depo_Provera dbr:Hormonal_therapy_(oncology) dbr:Hormone_replacement_therapy dbr:G-Farlutal dbr:Gestapuran dbr:Pedophilia dbr:Progesterone_receptor dbr:Progestogen_challenge_test dbr:Medical_uses_of_bicalutamide dbr:Medroxyprogesterone_caproate dbr:Puberty_blocker dbr:6α-Methylprogesterone dbr:Galactagogue dbr:Colirest dbr:Curretab dbr:Cycrin dbr:Farlutal dbr:Farlutin dbr:Reproductive_coercion dbr:Algestone_acetophenide dbr:Allylestrenol dbr:Aminoglutethimide dbr:3β-Hydroxysteroid_dehydrogenase dbr:Cyproterone_acetate dbr:Drospirenone dbr:Dydrogesterone dbr:Estradiol_(medication) dbr:Estradiol_cypionate dbr:Estradiol_cypionate/medroxyprogesterone_acetate dbr:Ethynerone dbr:Feminizing_hormone_therapy dbr:Fluoromedroxyprogesterone_acetate dbr:Amen_(drug) dbr:Nomegestrol_acetate dbr:Norethisterone dbr:Norethisterone_enanthate dbr:Dimepregnen dbr:Dimethisterone dbr:Family_planning_in_India dbr:Flip–flop_kinetics dbr:Flumedroxone_acetate dbr:List_of_EORTC_trials dbr:Sexual_fetishism dbr:Provera dbr:RANKL dbr:ATC_code_G03AC06 dbr:ATC_code_G03DA02 dbr:ATC_code_L02AB02 dbr:ATCvet_code_QG03AC06 dbr:ATCvet_code_QG03DA02 dbr:ATCvet_code_QL02AB02 dbr:Hydroxyprogesterone_acetate dbr:Hypoestrogenism dbr:Sodelut_G dbr:ATC_code_G03 dbr:ATC_code_L02 dbr:Chlormadinone_acetate dbr:Chloroethynylnorgestrel dbr:Birth_control dbr:High-dose_estrogen dbr:Hematrol dbr:Aragest dbr:Aragest_5 dbr:C24H34O4 dbr:CYP2C9 dbr:Polyestradiol_phosphate dbr:Controlestril dbr:Hysron dbr:Nadigest dbr:Methylacetoxyprogesterone dbr:Methylhydroxyprogesterone_acetate dbr:Methylpregnone dbr:Methypregnone dbr:Metigesterona dbr:Metipregnone dbr:The_jag dbr:Injection_(medicine) dbr:Obesity_hypoventilation_syndrome dbr:Cervical_agenesis dbr:Sex-hormonal_agent dbr:MPA dbr:Map_(disambiguation) dbr:Masculinizing_hormone_therapy dbr:Saint_Luke_Institute dbr:Women's_Health_Initiative dbr:Neurosteroidogenesis_inhibitor dbr:IARC_group_2B dbr:Sex_hormone-binding_globulin dbr:Subcutaneous_administration dbr:Navicular_cell dbr:Depot_medroxyprogesterone_acetate dbr:WHO_Model_List_of_Essential_Medicines dbr:Polyestradiol_phosphate/medroxyprogesterone_acetate dbr:Senile_osteoporosis dbr:Lutopolar dbr:Lutoral dbr:Side_effects_of_cyproterone_acetate dbr:Non-surgical_fertility_control_for_dogs_and_cats dbr:Paraphilia dbr:Medroxyhexal dbr:Med-Pro dbr:Megestron dbr:Meprate dbr:Metigestrona dbr:Nidaxin dbr:Steroid_hormone dbr:Steroidal_antiandrogen dbr:Steroidogenesis_inhibitor dbr:6α-Methyl-17α-acetoxyprogesterone dbr:6α-Methyl-17α-hydroxyprogesterone_acetate dbr:6α-Methyl-3,20-dioxopregn-4-en-17α-yl_acetate dbr:6α-methyl-17α-acetoxyprogesterone dbr:6α-methyl-17α-hydroxyprogesterone_acetate dbr:6α-methyl-3,20-dioxopregn-4-en-17α-yl_acetate dbr:Oragest dbr:Ralovera dbr:Repromap dbr:Repromix dbr:Veramix dbr:Sirprogen dbr:Oral_medroxyprogesterone dbr:Oral_medroxyprogesterone_acetate dbr:17α-Hydroxy-6α-methylpregn-4-ene-3,20-dione_acetate dbr:17α-hydroxy-6α-methylpregn-4-ene-3,20-dione_acetate dbr:Acetato_de_medroxiprogesterona dbr:Médroxyprogestérone,_acétate_de dbr:Médroxyprogestérone_(acétate_de) dbr:Médroxyprogestérone_acétate_de dbr:OMPA dbr:Birth_control_shot dbr:Depo_Injection dbr:Depo_provera dbr:Depo_shot dbr:Depomedroxy-progesterone_acetate dbr:Depot_medroxyprogesterone dbr:Deprovera dbr:Medroksiprogesteron_Asetat dbr:Medroksiprogesteron_asetat dbr:Medroksiprogesteroniasetaatti dbr:Medroksiprogesterono_acetatas dbr:Medroksyprogesteronu_octan dbr:Medroxiprogesteronacetat dbr:Medroxiprogeszteron-acetát dbr:Medroxiprogeszteron_acetát dbr:Medroxyprogesteron-acetát dbr:Medroxyprogesteron_acetát dbr:Medroxyprogesteronacetat dbr:Medroxyprogesterone_17-acetate dbr:Medroxyprogesterone_Acetate dbr:Medroxyprogesteroni_acetas |
| is dbp:caption of |
dbr:Polyestradiol_phosphate/medroxyprogesterone_acetate |
| is rdfs:seeAlso of |
dbr:Conjugated_estrogens dbr:Medroxyprogesterone_acetate dbr:Estradiol_cypionate |
| is owl:differentFrom of |
dbr:Hydroxyprogesterone_caproate dbr:Medroxyprogesterone_caproate dbr:Hydroxyprogesterone_acetate |
| is foaf:primaryTopic of |
wikipedia-en:Medroxyprogesterone_acetate |
