| dbo:abstract |
Las lipoxinas son compuestos que se generan a partir de AA (ácido araquidónico) por la vía de las lipooxigenasas, pero a diferencia de los leucotrienos y prostaglandinas las lipoxinas son inhibidores de la inflamación. Las principales acciones de las lipoxinas son inhibir el reclutamiento de los leucocitos y componentes celulares de la inflamación, inhibe la quimiotaxis de los neutrofilos y la adherencia al endotelio, se sugiere que son reguladores negativos endógenos de los leucotrienos. A diferencia del resto de los derivados del AA, necesitan de dos tipos celulares para ser sintetizados: los neutrófilos producen intermediarios de la síntesis, que son convertidos en lipoxinas por plaquetas al interaccionar con los neutrófilos. (es) A lipoxin (LX or Lx), an acronym for lipoxygenase interaction product, is a bioactive autacoid metabolite of arachidonic acid made by various cell types. They are categorized as nonclassic eicosanoids and members of the specialized pro-resolving mediators (SPMs) family of polyunsaturated fatty acid (PUFA) metabolites. Like other SPMs, LXs form during, and then act to resolve, inflammatory responses. Initially, two lipoxins were identified, lipoxin A4 (LXA4) and LXB4, but more recent studies have identified epimers of these two LXs: the epi-lipoxins, 15-epi-LXA4 and 15-epi-LXB4 respectively. (en) Le lipossine sono molecole di natura lipidica derivanti dall'acido arachidonico con importanti funzioni biologiche. (it) |
| dbo:alternativeName |
LXB4 (en) |
| dbo:iupacName |
(5S,6E,8Z,10E,12E,14R,15S)-5,14,15-Trihydroxyicosa-6,8,10,12-tetraenoic acid (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Lipoxin_B4.svg?width=300 |
| dbo:wikiPageExternalLink |
https://clinicaltrials.gov/ct2/show/NCT02342691%3Fterm=Lipoxin&rank=3).%3Cref |
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Lipoxin B4.svg (en) |
| dbp:imagename |
Lipoxin B4 (en) |
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| dbp:name |
Lipoxin B4 (en) |
| dbp:othernames |
LXB4 (en) |
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dbc:Eicosanoids |
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owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound umbel-rc:ChemicalSubstanceType |
| rdfs:comment |
A lipoxin (LX or Lx), an acronym for lipoxygenase interaction product, is a bioactive autacoid metabolite of arachidonic acid made by various cell types. They are categorized as nonclassic eicosanoids and members of the specialized pro-resolving mediators (SPMs) family of polyunsaturated fatty acid (PUFA) metabolites. Like other SPMs, LXs form during, and then act to resolve, inflammatory responses. Initially, two lipoxins were identified, lipoxin A4 (LXA4) and LXB4, but more recent studies have identified epimers of these two LXs: the epi-lipoxins, 15-epi-LXA4 and 15-epi-LXB4 respectively. (en) Le lipossine sono molecole di natura lipidica derivanti dall'acido arachidonico con importanti funzioni biologiche. (it) Las lipoxinas son compuestos que se generan a partir de AA (ácido araquidónico) por la vía de las lipooxigenasas, pero a diferencia de los leucotrienos y prostaglandinas las lipoxinas son inhibidores de la inflamación. Las principales acciones de las lipoxinas son inhibir el reclutamiento de los leucocitos y componentes celulares de la inflamación, inhibe la quimiotaxis de los neutrofilos y la adherencia al endotelio, se sugiere que son reguladores negativos endógenos de los leucotrienos. (es) |
| rdfs:label |
Lipoxina (es) Lipossina (it) Lipoxin (en) |
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wikipedia-en:Lipoxin?oldid=1043024498&ns=0 |
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wikipedia-en:Lipoxin |
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Lipoxin B4 (en) |
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dbr:LX |
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dbr:LXB4 dbr:Lipoxins dbr:LXA4 dbr:Lipoxin_A4 dbr:Lipoxin_B4 dbr:Lipoxin_receptor dbr:Receptors,_lipoxin |
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