Next Generation Research Papers - Academia.edu (original) (raw)

Top Papers
Most Cited Papers
Most Downloaded Papers
Newest Papers
People
- by
- •
- Mass production, Next Generation, Total Cost of Ownership, Extreme Ultraviolet

... This configuration eliminates the extra processing step and cost of printing a dielectric layer over the ... widespread adoption against the backdrop of a hitherto constrained global demand for RFID labels, and ... ogy is based on... more

- by Leigh Turner and +1
- •
- Next Generation, Rfid Tag

Schizophrenia is a chronic, severe, and disabling brain disease. About one-third of all patients with schizophrenia do not respond adequately to drug treatment. Advances in neuroscience and clinical research have led to the introduction of a novel generation of compounds with neuroprotective properties. Despite numerous animal studies with promising neuroprotective agents, no successful strategy for neuroprotection from functional psychoses has been successfully demonstrated. There are two main targets for neuroprotective therapy: (1) neurodegenerative processes in schizophrenia (e.g. apoptosis, excitotoxicity, oxidative stress, stress sensitization, and alteration of neurosteroids); and (2) phenotypic presentations of illness including psychopathological symptoms, significant decline in cognition, psychosocial functioning and in health related quality of life (HRQL). In this chapter substantial information about clinical trials with neurosteroids, vitamins, and some herbal supplements with neuroprotective properties in schizophrenia is presented. Neurosteroids such as pregnenolone (PREG), dehydroepiandrosterone (DHEA) and their sulfates (PREGS and DHEAS) are reported to have a modulatory effect on neuronal excitability and synaptic plasticity. In addition, vitamins and herbal supplements are important for regular cell function, growth and development. As a rule, vitamins promote the activity of enzymes to improve their efficiency and in this role they are called coenzymes. The herbal supplements are active antioxidants with neuroptective properties. The authors hope that neuroprotective strategies will pave the way to the next generation of antipsychotic, sedative and mood stabilizer medications. The clinical effects of neuroprotective agents clearly merit further clinical trials for the treatment of mental disorders.

Passive optical network (PON) is one of the most successful broadband access architectures being deployed worldwide. PONs provide high capacity, increased reach, and low-power consumption at a very reasonable cost, on par with the cost of DSL deployments today. This paper provides an overview of present and emerging PON technologies, and discusses PON's important role in the evolution of optical access from the architectural perspective. While describing the evolution of optical access architecture, we present two important integration options: optical+wireless access integration and metro+access integration. Potential PON capacity upgrades are discussed with special emphasis on achieving a seamless upgrade. We evaluate different PON evolution strategies in the context of next-generation PON, where gradual, demand-based migration demonstrates a number of significant benefits.

- by Pulak Chowdhury
- •
- Biomedical Engineering, Migration, Evolution, Broadband Networks
- by Roberto Tinarelli
- •
- Power Quality, International organizations, IEEE, Next Generation

This paper describes the summary of a three-year development program for the first-stage stationary vane and rotating blade for the next generation, 1500°C class, high-efficiency gas turbine. In such a high-temperature gas turbine, the first turbine vane and blade are the most important hot parts. Full-coverage film cooling (FCFC) is adopted for the cooling scheme, and directionally solidified (DS) nickel base superalloy and thermal barrier coating (TBC) will be used to prolong the creep and thermal fatigue life. The concept of the cooling configuration, fundamental cascade test results, and material test results will be presented.

- by Kenichiro Takeishi
- •
- Engineering, Mechanical Engineering, Aerospace Engineering, Fluid Dynamics
- by Kostadin Ivanov
- •
- Kinetics, Parallel Processing, Level Of Detail (LOD), Nuclear power
- by Franco Davoli
- •
- Distributed Computing, Next Generation Networks, Future Internet, Carbon Footprint
- by Hartwig Steckel
- •
- Chemical Engineering, Light Scattering, Quality Control, Pharmaceutical industry
- by Erik Rozemuller
- •
- Immunology, Biology, DNA sequence design, High Resolution
- by Roberto Acosta
- •
- Antennas, Microstrip Antennas, Antenna arrays, Satellite Communication
- by Helen McDonald
- •
- Algorithms, Biological Sciences, Humans, Genome
- by Luísa Schmidt and +2
- •
- Human Geography, Environmental Education, Urban And Regional Planning, Young People

The main goal of our research was to examine the importance of transferring tacit and experiential knowledge as well as social capital of founders for innovativeness of the next family generation, i.e. successors in smaller family firms. Data were collected through in-depth case studies, including face-to-face structured interviews with 20 founders of smaller family firms and their successors. The research was carried out in Slovenia, which in our opinion still belongs to transition economies. Namely, transition from an economic-developmental aspect means transition from routine to innovative economy and society, which Slovenia has not achieved yet. Therefore, we find the innovativeness of next family generation owners and/or managers as crucial for transition of Slovenia to innovative economy and society. We assume that findings of our research may also have implications for other transition economies.

- by Marina Letonja and +1
- •
- Business, Tacit Knowledge, Family Business, Social Capital

We have developed a super compact optical fluorescence spectrometer. Our innovative design combines advantages of guided wave planar optics and free-space microoptics. This innovation allows for miniaturization that is not achievable with pure planar or pure free-space optics. A prototype device has volume of its optical part below 1cm3. The spectrometer covers 450nm-650nm spectral range, and provides spectral resolution of

- by G. Auner
- •
- Optics, Image Processing, Lab On A Chip, Free Space Optics
- by Hilding Elmqvist
- •
- Modeling Language, Next Generation, Physical Model, Object Oriented
- by Sascha Disch
- •
- Spatial Audio, Next Generation
- by Victor Malka
- •
- Science, Multidisciplinary, Oscillations, Next Generation
- by Paal E Engelstad and +2
- •
- Distributed Computing, Mobility Management, Wireless, Network Mobility
- by Sylvia Hurtado
- •
- Sociology, Psychology, Intergroup Relations, Social Issues

... Eddy SW Ng, Management and Human Resources Department, College of Business Administration, California State Polytechnic University, Pomona ... an abundant of literature that focused on applicant attraction strategies and... more

- by Eddy Ng
- •
- Education, Strategic Planning, Career Development, Field Survey
- by Enrico Del Re
- •
- Computer Science, Distributed Computing, Mobile Communication, Cellular Network
- by Yvon Renotte
- •
- X Ray Astronomy, Dark Matter, X ray absorption spectroscopy, Adaptive Optics
- by Aurobi Das
- •
- Climate Change, Sustainable Development, Pervasive Computing, Solar Energy
- by T. Nasuno
- •
- Engineering, Computational Physics, Atmospheric Science, Atmospheric Modeling
- by Masood Habib
- •
- Computer Science, Network Security, Computer Network, Wireless Network
- by Hari Kumar
- •
- Materials Engineering, Thermodynamics, Pergamon, Phase equilibria

Page 1. Advanced pixel design for infrared 3D LADAR imaging Fabrice Guellec, Michaël Tchagaspanian Eric de Borniol, Pierre Castelein, André Perez, Johan Rothman CEA Leti – MINATEC, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France... more

- by André Perez
- •
- Engineering, LiDAR, Stereoscopy, Optical Imaging

The present paper will give an introduction to the work within the Cluster of Excellence (CoE) "Tailor-Made Fuels from Biomass (TMFB)", funded by the German research foundation to research on fuels from biomass for the next generation. The fluid properties of these new fuels differ a lot from conventional fuels. The paper will show the approach for finding technical solutions to deal with these challenges. The critical aspects in the injection systems for combustion engines will be presented. Furthermore the investigations to characterise the new fuels will be explained. One of the focuses is set on the fluid properties under high pressure conditions. The test rigs that had to be designed for measuring viscosity and bulk modulus will be presented. The design of a tribometer will also be presented to study the interaction between fuels and surfaces for mixed lubrication condition. The investigations on the properties of the new fuels are needed to parameterise simulation models of the injection system which will be set up parallel to the experiments.

- by Arshia Fatemi
- •
- High Pressure, Bulk Modulus, Next Generation, Point of View
- by Thomas Parker
- •
- Evidence Based Medicine, Kinetics, Mass Spectrometry, Chronic kidney disease

AbstractIntroduction: To ensure that nursing education stay abreast with modern technology advances has the Schoolof Nursing (SoN) of The University of the Western Cape integrated e-learning into the curriculum. This methodarticulates well with the case-based approach adopted by the SoN. The Learning Management System,Knowledge Environment for Web-Based Learning (Kewl), Next Generation (KNG), was used to facilitate onlineteaching and learning.Objectives: The primary aim was to gather baseline data on e-learning by exploring the perceptions andexperiences of the first pilot group of undergraduate nursing students who were exposed to this strategy.Methods: A descriptive cross-sectional quantitative design was used to determine the students' understandingand valuing of e-learning, the benefits and skills gained and challenges experienced, by means of a structured,close-ended questionnaire with space for comments. Convenience sampling was used and the questionnairewas distributed to...

- by Hester Julie
- •
- Primary Health Care, Community Health, Medicine, Web Based Learning
- by zahra shahrokh
- •
- Chemistry, Mass Spectrometry, Drug Discovery, Pharmacokinetics
- by Martin Lundborg
- •
- Telecommunications Policy, Telecommunications, Regulation, Multidisciplinary
- by Munirathna Padmanaban
- •
- Next Generation
- by Art Jung
- •
- Mechanical Engineering, Applied Mathematics, Two Phase Flow, Heat Transfer
- by anis ouni
- •
- Linear Programming, Routing, Wireless Mesh Networks, Energy Consumption
- by Lorraine Duffy and +3
- •
- Communication, Web Engineering, Gesture, Linguistics

The National Institute of Standards ,and ,Technology’s (NIST) Intelligent Systems Division (ISD) is working,with the material handling industry, specifically on automated guided vehicles, to develop next generation vehicles. ISD isalso,a participant ,in the ,Defense Advanced ,Research Project Agency ,(DARPA) Learning Applied to Ground Robots (LAGR) Project embedding ,learning algorithms into the modules,that make,up the,Four Dimensional/Real- Time Control System (4D/RCS).

- by Roger Bostelman and +1
- •
- Intelligent System, Reference model, Autonomous Vehicle, Next Generation
- by George Xylomenos
- •
- Future Internet, Performance Evaluation, Internet Architecture, Next Generation
- by Young-Soo Kim
- •
- Mechanical Engineering, Aerospace Engineering, Sensitivity Analysis, Space

Prostate cancer chemoprevention represents a relatively new and promising strategy for reducing the immense public health burden of this devastating cancer of men in the United States and Western societies. Chemoprevention is defined as the administration of agents (drugs, biologics, and natural products) that modulate (inhibit) one or more steps in the multistage carcinogenesis process culminating in invasive adenocarcinoma of the prostate. In 2000, there were an estimated 170,000 new cases of prostate cancer and 31,000 deaths in the United States. During the past decade, the National Cancer Institute (NCI) organized the chemoprevention research program and began testing the first generation of promising agents (eg, 4-(hydroxy)-fenretinide [4-HPR], difluoromethylornithine [DFMO], antiandrogens) in high-risk cohorts and launched the first-large scale US phase 3 primary prevention trial, known as Prostate Cancer Prevention Trial (PCPT-1), in 18,000 average-risk men (age more than 55 years and prostate-specific antigen [PSA] less than 3 ng/mL) treated for 7 years with finasteride or placebo. In the summer of 1998, the NCI Prostate Cancer Progress Review Group (PRG) Report to the director of NCI was published in response to the leadership of the prostate cancer advocacy community in conjunction with Congress. To further elucidate and address critical issues identified in this report and to develop a research agenda for the newly created Prostate and Urologic Cancer Research Group in the Division of Cancer Prevention at NCI, the NCI organized the workshop "New Clinical Trial Strategies for Prostate Cancer Chemoprevention." The major objectives were to promote understanding and cooperation among the NCI, US Food and Drug Administration (FDA), academia, pharmaceutical industry, and the public regarding new opportunities for clinical prevention trials for prostate cancer. The workshop was divided into three concurrent breakout panels and a fourth joint integrative panel. The workshop addressed multiple key areas identified in the PRG report in the following panels: (1) Molecular Targets and Promising Agents in Clinical Development; (2) Intermediate Endpoint Biomarkers for Prevention Trials; (3) High-Risk Study Populations for Prevention Trials, and (4) Preventive Clinical Trial Designs and Regulatory Issues. Expert panelists were drawn from leading academic, pharmaceutical, and government scientists in basic research and clinical investigation. Key pharmaceutical, biotechnology, academic, and National Institutes of Health scientists presented overviews of their new agents and products in clinical development (representing the next generation of promising agents). Senior FDA physicians from the Center for Drugs and Center for Biologics presented on current standards for new drug and biologic approval for chemoprevention efficacy. Some of the key topics included recent advances in the state of knowledge of promising agents in the clinic based on molecular targets as well as bottlenecks in drug development for pharmaceutical sponsors; strategic modulable biomarkers that can serve as primary endpoints in phase 1/2 trials to assess preventive efficacy; high-risk cohorts with precancer (high-grade prostatic intraepithelial neoplasia) and representative clinical trial designs that are ready for immediate translation into efficient prevention trials, such as Bayesian sequential monitoring for early assessment of biologic activity and factorial designs for assessment of multiagent combinations. Finally, each expert panel generated recommendations for areas of future research emphasizing opportunities and infrastructure needs.

- by Frank Meyskens
- •
- Urology, Government, Clinical Trial, Prostate Cancer
- by Dejan Mumovic
- •
- Architecture, Energy Conservation, Energy Consumption, New Technology

The paper reports on a qualitative analysis of 15 personal interviews with holocaust survivors in Israel concerning their perceptions of similarities and differences between socially-assisted dying and the holocaust policies. The design of the study was exploratory/descriptive and asked the following questions: "Some discussions have expressed similarities between Nazi Germany and euthanasia. Do you believe the comparison is justified? In what ways are euthanasia and the holocaust similar? In what ways are they different?" Participants concluded that profound differences existed between Nazi Germany and socially assisted dying. These differences were established from four different perspectives in 10 different themes, and demonstrated by 24 different examples of the themes. Informants further cautioned philosophers about comparisons between the holocaust and other human behaviors. The survivors perceived that such a comparison has negative consequences for their own well-b...

- by Ronit Leichtentritt
- •
- Sociology, Anthropology, Euthanasia, Social Perception

Since the STS-114 mission in August of 2005, the FAA has partnered with NASA to protect aircraft flying in the National Airspace System from the potential hazards associated with a catastrophic failure of a reentering Space Shuttle... more

- by Daniel Murray
- •
- Engineering, Situation awareness, Air Traffic Management, Traffic Safety