Anastassopoulou CG, Kostrikis LG: The impact of human allelic variation on HIV-1 disease. Curr HIV Res. 2003, 1 (2): 185-203. 10.2174/1570162033485311. CASPubMed Google Scholar
Telenti A, Ioannidis JP: Susceptibility to HIV infection--disentangling host genetics and host behavior. J Infect Dis. 2006, 193 (1): 4-6. 10.1086/498535. PubMed Google Scholar
Cunningham AL, Li S, Juarez J, Lynch G, Alali M, Naif H: The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes. J Leukoc Biol. 2000, 68 (3): 311-317. CASPubMed Google Scholar
Blaak H, Ran LJ, Rientsma R, Schuitemaker H: Susceptibility of in vitro stimulated PBMC to infection with NSI HIV-1 is associated with levels of CCR5 expression and beta-chemokine production. Virology. 2000, 267 (2): 237-246. 10.1006/viro.1999.0111. CASPubMed Google Scholar
Ciuffi A, Bleiber G, Munoz M, Martinez R, Loeuillet C, Rehr M, Fischer M, Gunthard HF, Oxenius A, Meylan P, Bonhoeffer S, Trono D, Telenti A: Entry and transcription as key determinants of differences in CD4 T-cell permissiveness to human immunodeficiency virus type 1 infection. J Virol. 2004, 78 (19): 10747-10754. 10.1128/JVI.78.19.10747-10754.2004. PubMed CentralCASPubMed Google Scholar
Naif HM, Li S, Alali M, Chang J, Mayne C, Sullivan J, Cunningham AL: Definition of the stage of host cell genetic restriction of replication of human immunodeficiency virus type 1 in monocytes and monocyte-derived macrophages by using twins. J Virol. 1999, 73 (6): 4866-4881. PubMed CentralCASPubMed Google Scholar
Chang J, Naif HM, Li S, Sullivan JS, Randle CM, Cunningham AL: Twin studies demonstrate a host cell genetic effect on productive human immunodeficiency virus infection of human monocytes and macrophages in vitro. J Virol. 1996, 70 (11): 7792-7803. PubMed CentralCASPubMed Google Scholar
Du Z, Lang SM, Sasseville VG, Lackner AA, Ilyinskii PO, Daniel MD, Jung JU, Desrosiers RC: Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell. 1995, 82 (4): 665-674. 10.1016/0092-8674(95)90038-1. CASPubMed Google Scholar
Petrucci A, Dorrucci M, Alliegro MB, Pezzotti P, Rezza G, Sinicco A, Lazzarin A, Angarano G: How many HIV-infected individuals may be defined as long-term nonprogressors? A report from the Italian Seroconversion Study. Italian Seroconversion Study Group (ISS). J Acquir Immune Defic Syndr Hum Retrovirol. 1997, 14 (3): 243-248. CASPubMed Google Scholar
Shacklett BL: Understanding the "lucky few": the conundrum of HIV-exposed, seronegative individuals. Curr HIV/AIDS Rep. 2006, 3 (1): 26-31. 10.1007/s11904-006-0005-2. PubMed Google Scholar
Bleiber G, May M, Martinez R, Meylan P, Ott J, Beckmann JS, Telenti A: Use of a combined ex vivo/in vivo population approach for screening of human genes involved in the human immunodeficiency virus type 1 life cycle for variants influencing disease progression. J Virol. 2005, 79 (20): 12674-12680. 10.1128/JVI.79.20.12674-12680.2005. PubMed CentralCASPubMed Google Scholar
Carrington M, O'Brien SJ: The influence of HLA genotype on AIDS. Annu Rev Med. 2003, 54: 535-551. 10.1146/annurev.med.54.101601.152346. CASPubMed Google Scholar
Kaslow RA, Dorak T, Tang JJ: Influence of host genetic variation on susceptibility to HIV type 1 infection. J Infect Dis. 2005, 191 Suppl 1: S68-77. 10.1086/425269. PubMed Google Scholar
O'Brien SJ, Nelson GW: Human genes that limit AIDS. Nat Genet. 2004, 36 (6): 565-574. 10.1038/ng1369. PubMed Google Scholar
Pierson TC, Doms RW: HIV-1 entry and its inhibition. Curr Top Microbiol Immunol. 2003, 281: 1-27. CASPubMed Google Scholar
Arenzana-Seisdedos F, Parmentier M: Genetics of resistance to HIV infection: Role of co-receptors and co-receptor ligands. Semin Immunol. 2006, 18 (6): 387-403. 10.1016/j.smim.2006.07.007. CASPubMed Google Scholar
Feng Y, Broder CC, Kennedy PE, Berger EA: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor [see comments]. Science. 1996, 272: 872-877. 10.1126/science.272.5263.872. CASPubMed Google Scholar
Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA: CC CKR5: a rantes, MIP-1alpha, MIP-1beta receptor as fusion cofactor for macrophage tropic HIV-1. Science. 1996, 272 (5270): 1955-1958. 10.1126/science.272.5270.1955. CASPubMed Google Scholar
Choe H, Farzan M, sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gierard N, Gerard C, Sodroski J: The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 1996, 85 (7): 1135-1148. 10.1016/S0092-8674(00)81313-6. CASPubMed Google Scholar
Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton R, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR: Identification of a major co-receptor for primary isolates of HIV-1. Nature. 1996, 381 (6584): 661-666. 10.1038/381661a0. CASPubMed Google Scholar
Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW: A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell. 1996, 85 (7): 1149-1158. 10.1016/S0092-8674(00)81314-8. CASPubMed Google Scholar
Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA: HIV-1 entry into CD4-positive cells is mediated by the chemokine receptor CC-CKR-5. Nature. 1996, 381 (6584): 667-673. 10.1038/381667a0. CASPubMed Google Scholar
Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, MacDonald ME, Stuhlmann H, Koup RA, Landau NR: Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996, 86 (3): 367-377. 10.1016/S0092-8674(00)80110-5. CASPubMed Google Scholar
Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SP, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, O'Brien SJ: Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science. 1996, 273 (5283): 1856-1862. 10.1126/science.273.5283.1856. CASPubMed Google Scholar
Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth RJ, Collman RG, Doms RW, Vassart G, Parmentier M: Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 1996, 382 (6593): 722-725. 10.1038/382722a0. CASPubMed Google Scholar
Benkirane M, Jin DY, Chun RF, Koup RA, Jeang KT: Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J Biol Chem. 1997, 272 (49): 30603-30606. 10.1074/jbc.272.49.30603. CASPubMed Google Scholar
Lederman MM, Penn-Nicholson A, Cho M, Mosier D: Biology of CCR5 and its role in HIV infection and treatment. Jama. 2006, 296 (7): 815-826. 10.1001/jama.296.7.815. CASPubMed Google Scholar
Stephens JC, Reich DE, Goldstein DB, Shin HD, Smith MW, Carrington M, Winkler C, Huttley GA, Allikmets R, Schriml L, Gerrard B, Malasky M, Ramos MD, Morlot S, Tzetis M, Oddoux C, di Giovine FS, Nasioulas G, Chandler D, Aseev M, Hanson M, Kalaydjieva L, Glavac D, Gasparini P, Kanavakis E, Claustres M, Kambouris M, Ostrer H, Duff G, Baranov V, Sibul H, Metspalu A, Goldman D, Martin N, Duffy D, Schmidtke J, Estivill X, O'Brien SJ, Dean M: Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet. 1998, 62 (6): 1507-1515. 10.1086/301867. PubMed CentralCASPubMed Google Scholar
Naif HM, Cunningham AL, Alali M, Li S, Nasr N, Buhler MM, Schols D, de Clercq E, Stewart G: A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4. J Virol. 2002, 76 (7): 3114-3124. 10.1128/JVI.76.7.3114-3124.2002. PubMed CentralCASPubMed Google Scholar
Gorry PR, Zhang C, Wu S, Kunstman K, Trachtenberg E, Phair J, Wolinsky S, Gabuzda D: Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele. Lancet. 2002, 359 (9320): 1832-1834. 10.1016/S0140-6736(02)08681-6. CASPubMed Google Scholar
Michael NL, Nelson JA, KewalRamani VN, Chang G, O'Brien SJ, Mascola JR, Volsky B, Louder M, White GC, Littman DR, Swanstrom R, O'Brien TR: Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32. J Virol. 1998, 72 (7): 6040-6047. PubMed CentralCASPubMed Google Scholar
Balotta C, Bagnarelli P, Violin M, Ridolfo AL, Zhou D, Berlusconi A, Corvasce S, Corbellino M, Clementi M, Clerici M, Moroni M, Galli M: Homozygous delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient. AIDS. 1997, 11 (10): F67-71. 10.1097/00002030-199710000-00001. CASPubMed Google Scholar
Kuipers H, Workman C, Dyer W, Geczy A, Sullivan J, Oelrichs R: An HIV-1-infected individual homozygous for the CCR-5 delta32 allele and the SDF-1 3'A. allele. AIDS. 1999, 13 (3): 433-434. 10.1097/00002030-199902250-00025. CASPubMed Google Scholar
O'Brien TR, Winkler C, Dean M, Nelson JA, Carrington M, Michael NL, White GC: HIV-1 infection in a man homozygous for CCR5 delta 32. Lancet. 1997, 349 (9060): 1219-10.1016/S0140-6736(97)24017-1. PubMed Google Scholar
Theodorou I, Meyer L, Magierowska M, Katlama C, Rouzioux C: HIV-1 infection in an individual homozygous for CCR5 delta 32. Seroco Study Group. Lancet. 1997, 349 (9060): 1219-1220. 10.1016/S0140-6736(05)62411-7. CASPubMed Google Scholar
Cohen OJ, Paolucci S, Bende SM, Daucher M, Moriuchi H, Moriuchi M, Cicala C, Davey RT, Baird B, Fauci AS: CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32. J Virol. 1998, 72 (7): 6215-6217. PubMed CentralCASPubMed Google Scholar
Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T, Kang S, Ceradini D, Jin Z, Yazdanbakhsh K, Kunstman K, Erickson D, Dragon E, Landau NR, Phair J, Ho DD, Koup RA: The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med. 1996, 2 (11): 1240-1243. 10.1038/nm1196-1240. CASPubMed Google Scholar
Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, Goedert JJ, O'Brien TR, Jacobson LP, Kaslow R, Buchbinder S, Vittinghoff E, Vlahov D, Hoots K, Hilgartner MW, O'Brien SJ: Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science. 1997, 277 (5328): 959-965. 10.1126/science.277.5328.959. CASPubMed Google Scholar
Stewart GJ, Ashton LJ, Biti RA, Ffrench RA, Bennetts BH, Newcombe NR, Benson EM, Carr A, Cooper DA, Kaldor JM: Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection. The Australian Long-Term Non-Progressor Study Group. AIDS. 1997, 11 (15): 1833-1838. 10.1097/00002030-199715000-00007. CASPubMed Google Scholar
Eskild A, Jonassen TO, Heger B, Samuelsen SO, Grinde B: The estimated impact of the CCR-5 delta32 gene deletion on HIV disease progression varies with study design. Oslo HIV Cohort Study Group. AIDS. 1998, 12 (17): 2271-2274. 10.1097/00002030-199817000-00007. CASPubMed Google Scholar
Schinkel J, Langendam MW, Coutinho RA, Krol A, Brouwer M, Schuitemaker H: No evidence for an effect of the CCR5 delta32/+ and CCR2b 64I/+ mutations on human immunodeficiency virus (HIV)-1 disease progression among HIV-1-infected injecting drug users. J Infect Dis. 1999, 179 (4): 825-831. 10.1086/314658. CASPubMed Google Scholar
Wilkinson DA, Operskalski EA, Busch MP, Mosley JW, Koup RA: A 32-bp deletion within the CCR5 locus protects against transmission of parenterally acquired human immunodeficiency virus but does not affect progression to AIDS-defining illness. J Infect Dis. 1998, 178 (4): 1163-1166. CASPubMed Google Scholar
Morawetz RA, Rizzardi GP, Glauser D, Rutschmann O, Hirschel B, Perrin L, Opravil M, Flepp M, von Overbeck J, Glauser MP, Ghezzi S, Vicenzi E, Poli G, Lazzarin A, Pantaleo G: Genetic polymorphism of CCR5 gene and HIV disease: the heterozygous (CCR5/delta ccr5) genotype is neither essential nor sufficient for protection against disease progression. Swiss HIV Cohort. Eur J Immunol. 1997, 27 (12): 3223-3227. 10.1002/eji.1830271220. CASPubMed Google Scholar
Reynes J, Portales P, Segondy M, Baillat V, Andre P, Avinens O, Picot MC, Clot J, Eliaou JF, Corbeau P: CD4 T cell surface CCR5 density as a host factor in HIV-1 disease progression. AIDS. 2001, 15 (13): 1627-1634. 10.1097/00002030-200109070-00004. CASPubMed Google Scholar
Reynes J, Portales P, Segondy M, Baillat V, Andre P, Reant B, Avinens O, Couderc G, Benkirane M, Clot J, Eliaou JF, Corbeau P: CD4 T cell surface CCR5 density as a determining factor of virus load in persons infected with human immunodeficiency virus type 1. J Inf Dis. 2000, 181: 927-932. 10.1086/315315. CAS Google Scholar
Wu L, Paxton WA, Kassam N, Ruffing N, Rottman JB, Sullivan N, Choe H, Sodroski J, Newman W, Koup RA, Mackay CR: CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J Exp Med. 1997, 185 (9): 1681-1691. 10.1084/jem.185.9.1681. PubMed CentralCASPubMed Google Scholar
Blanpain C, Lee B, Tackoen M, Puffer B, Boom A, Libert F, Sharron M, Wittamer V, Vassart G, Doms RW, Parmentier M: Multiple nonfunctional alleles of CCR5 are frequent in various human populations. Blood. 2000, 96 (5): 1638-1645. CASPubMed Google Scholar
Capoulade-Metay C, Trong LX, Dudoit Y, Versmisse P, Nguyen NV, Nguyen M, Scott-Algara D, Barre-Sinoussi F, Debre P, Bismuth G, Pancino G, Theodorou I: New CCR5 variants associated with reduced HIV coreceptor function in southeast Asia. AIDS. 2004, 18 (17): 2243-2252. 10.1097/00002030-200411190-00004. CASPubMed Google Scholar
Carrington M, Kissner T, Gerrard B, Ivanov S, O'Brien SJ, Dean M: Novel alleles of the chemokine-receptor gene CCR5. Am J Hum Genet. 1997, 61 (6): 1261-1267. 10.1086/301645. PubMed CentralCASPubMed Google Scholar
Quillent C, Oberlin E, Braun J, Rousset D, Gonzalez-Canali G, Metais P, Montagnier L, Virelizier JL, Arenzana-Seisdedos F, Beretta A: HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene. Lancet. 1998, 351 (9095): 14-18. 10.1016/S0140-6736(97)09185-X. CASPubMed Google Scholar
Martin MP, Dean M, Smith MW, Winkler C, Gerrard B, Michael NL, Lee B, Doms RW, Margolick J, Buchbinder S, Goedert JJ, O'Brien TR, Hilgartner MW, Vlahov D, O'Brien SJ, Carrington M: Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science. 1998, 282 (5395): 1907-1911. 10.1126/science.282.5395.1907. CASPubMed Google Scholar
Clegg AO, Ashton LJ, Biti RA, Badhwar P, Williamson P, Kaldor JM, Stewart GJ: CCR5 promoter polymorphisms, CCR5 59029A and CCR5 59353C, are under represented in HIV-1-infected long-term non-progressors. The Australian Long-Term Non-Progressor Study Group. AIDS. 2000, 14 (2): 103-108. 10.1097/00002030-200001280-00004. CASPubMed Google Scholar
Hladik F, Liu H, Speelmon E, Livingston-Rosanoff D, Wilson S, Sakchalathorn P, Hwangbo Y, Greene B, Zhu T, McElrath MJ: Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. J Virol. 2005, 79 (18): 11677-11684. 10.1128/JVI.79.18.11677-11684.2005. PubMed CentralCASPubMed Google Scholar
Pastori C, Weiser B, Barassi C, Uberti-Foppa C, Ghezzi S, Longhi R, Calori G, Burger H, Kemal K, Poli G, Lazzarin A, Lopalco L: Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression. Blood. 2006, 107 (12): 4825-4233. 10.1182/blood-2005-06-2463. PubMed CentralCASPubMed Google Scholar
Bouhlal H, Latry V, Requena M, Aubry S, Kaveri SV, Kazatchkine MD, Belec L, Hocini H: Natural antibodies to CCR5 from breast milk block infection of macrophages and dendritic cells with primary R5-tropic HIV-1. J Immunol. 2005, 174 (11): 7202-7209. CASPubMed Google Scholar
Barassi C, Soprana E, Pastori C, Longhi R, Buratti E, Lillo F, Marenzi C, Lazzarin A, Siccardi AG, Lopalco L: Induction of murine mucosal CCR5-reactive antibodies as an anti-human immunodeficiency virus strategy. J Virol. 2005, 79 (11): 6848-6458. 10.1128/JVI.79.11.6848-6858.2005. PubMed CentralCASPubMed Google Scholar
Ray N, Doms RW: HIV-1 coreceptors and their inhibitors. Curr Top Microbiol Immunol. 2006, 303: 97-120. CASPubMed Google Scholar
Kilby JM, Eron JJ: Novel therapies based on mechanisms of HIV-1 cell entry. N Engl J Med. 2003, 348 (22): 2228-2238. 10.1056/NEJMra022812. CASPubMed Google Scholar
Fatkenheuer G, Pozniak AL, Johnson MA, Plettenberg A, Staszewski S, Hoepelman AI, Saag MS, Goebel FD, Rockstroh JK, Dezube BJ, Jenkins TM, Medhurst C, Sullivan JF, Ridgway C, Abel S, James IT, Youle M, van der Ryst E: Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat Med. 2005, 11 (11): 1170-1172. 10.1038/nm1319. PubMed Google Scholar
Smith MW, Carrington M, Winkler C, Lomb D, Dean M, Huttley G, O'Brien SJ: CCR2 chemokine receptor and AIDS progression. Nat Med. 1997, 3 (10): 1052-1053. 10.1038/nm1097-1052c. CASPubMed Google Scholar
Michael NL, Louie LG, Rohrbaugh AL, Schultz KA, Dayhoff DE, Wang CE, Sheppard HW: The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression. Nat Med. 1997, 3 (10): 1160-1162. 10.1038/nm1097-1160. CASPubMed Google Scholar
Lee B, Doranz BJ, Rana S, Yi Y, Mellado M, Frade JM, Martinez AC, O'Brien SJ, Dean M, Collman RG, Doms RW: Influence of the CCR2-V64I polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4. J Virol. 1998, 72 (9): 7450-7458. PubMed CentralCASPubMed Google Scholar
Mariani R, Wong S, Mulder LC, Wilkinson DA, Reinhart AL, LaRosa G, Nibbs R, O'Brien TR, Michael NL, Connor RI, Macdonald M, Busch M, Koup RA, Landau NR: CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function. J Virol. 1999, 73 (3): 2450-2459. PubMed CentralCASPubMed Google Scholar
Nakayama EE, Tanaka Y, Nagai Y, Iwamoto A, Shioda T: A CCR2-V64I polymorphism affects stability of CCR2A isoform. AIDS. 2004, 18 (5): 729-738. 10.1097/00002030-200403260-00003. CASPubMed Google Scholar
Mellado M, Rodriguez-Frade JM, Vila-Coro AJ, de Ana AM, Martinez AC: Chemokine control of HIV-1 infection. Nature. 1999, 400 (6746): 723-724. 10.1038/23382. CASPubMed Google Scholar
Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall TJ, Yoshie O: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell. 1997, 91 (4): 521-530. 10.1016/S0092-8674(00)80438-9. CASPubMed Google Scholar
Faure S, Meyer L, Costagliola D, Vaneensberghe C, Genin E, Autran B, Delfraissy JF, McDermott DH, Murphy PM, Debre P, Theodorou I, Combadiere C: Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1. Science. 2000, 287 (5461): 2274-2277. 10.1126/science.287.5461.2274. CASPubMed Google Scholar
Singh KK, Hughes MD, Chen J, Spector SA: Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4+ lymphocyte count and HIV-1 RNA load. J Infect Dis. 2005, 191 (11): 1971-1980. 10.1086/430091. CASPubMed Google Scholar
Brumme ZL, Dong WW, Chan KJ, Hogg RS, Montaner JS, O'Shaughnessy MV, Harrigan PR: Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response. AIDS. 2003, 17 (2): 201-208. 10.1097/00002030-200301240-00010. CASPubMed Google Scholar
Vidal F, Vilades C, Domingo P, Broch M, Pedrol E, Dalmau D, Knobel H, Peraire J, Gutierrez C, Sambeat MA, Fontanet A, Deig E, Cairo M, Montero M, Richart C, Mallal S: Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele. J Acquir Immune Defic Syndr. 2005, 40 (5): 527-531. 10.1097/01.qai.0000186362.50457.e0. CASPubMed Google Scholar
Kwa D, Boeser-Nunnink B, Schuitemaker H: Lack of evidence for an association between a polymorphism in CX3CR1 and the clinical course of HIV infection or virus phenotype evolution. AIDS. 2003, 17 (5): 759-761. 10.1097/00002030-200303280-00017. PubMed Google Scholar
Puissant B, Roubinet F, Massip P, Sandres-Saune K, Apoil PA, Abbal M, Pasquier C, Izopet J, Blancher A: Analysis of CCR5, CCR2, CX3CR1, and SDF1 polymorphisms in HIV-positive treated patients: impact on response to HAART and on peripheral T lymphocyte counts. AIDS Res Hum Retroviruses. 2006, 22 (2): 153-162. 10.1089/aid.2006.22.153. CASPubMed Google Scholar
McDermott DH, Colla JS, Kleeberger CA, Plankey M, Rosenberg PS, Smith ED, Zimmerman PA, Combadiere C, Leitman SF, Kaslow RA, Goedert JJ, Berger EA, O'Brien TR, Murphy PM: Genetic polymorphism in CX3CR1 and risk of HIV disease. Science. 2000, 290 (5499): 2031-10.1126/science.290.5499.2031a. CASPubMed Google Scholar
Faure S, Meyer L, Genin E, Pellet P, Debre P, Theodorou I, Combadiere C: Deleterious genetic influence of CX3CR1 genotypes on HIV-1 disease progression. J Acquir Immune Defic Syndr. 2003, 32 (3): 335-337. 10.1097/00126334-200303010-00014. CASPubMed Google Scholar
Koot M, Keet IP, Vos AH, de Goede RE, Roos MT, Coutinho RA, Miedema F, Schellekens PT, Tersmette M: Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med. 1993, 118 (9): 681-688. CASPubMed Google Scholar
Cheng-Mayer C, Seto D, Tateno M, Levy JA: Biologic features of HIV-1 that correlate with virulence in the host. Science. 1988, 240 (4848): 80-82. 10.1126/science.2832945. CASPubMed Google Scholar
Schuitemaker H, Koot M, Kootstra NA, Dercksen MW, de Goede RE, van Steenwijk RP, Lange JM, Schattenkerk JK, Miedema F, Tersmette M: Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J Virol. 1992, 66 (3): 1354-1360. PubMed CentralCASPubMed Google Scholar
Ho SH, Shek L, Gettie A, Blanchard J, Cheng-Mayer C: V3 loop-determined coreceptor preference dictates the dynamics of CD4+-T-cell loss in simian-human immunodeficiency virus-infected macaques. J Virol. 2005, 79 (19): 12296-12303. 10.1128/JVI.79.19.12296-12303.2005. PubMed CentralCASPubMed Google Scholar
Karlsson I, Antonsson L, Shi Y, Karlsson A, Albert J, Leitner T, Olde B, Owman C, Fenyo EM: HIV biological variability unveiled: frequent isolations and chimeric receptors reveal unprecedented variation of coreceptor use. AIDS. 2003, 17 (18): 2561-2569. 10.1097/00002030-200312050-00003. PubMed Google Scholar
Agace WW, Amara A, Roberts AI, Pablos JL, Thelen S, Uguccioni M, Li XY, Marsal J, Arenzana-Seisdedos F, Delaunay T, Ebert EC, Moser B, Parker CM: Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation. Curr Biol. 2000, 10 (6): 325-328. 10.1016/S0960-9822(00)00380-8. CASPubMed Google Scholar
Bunnik EM, Quakkelaar ED, van Nuenen AC, Boeser-Nunnink B, Schuitemaker H: Increased neutralization sensitivity of recently emerged CXCR4-using human immunodeficiency virus type 1 strains compared to coexisting CCR5-using variants from the same patient. J Virol. 2007, 81 (2): 525-531. 10.1128/JVI.01983-06. PubMed CentralCASPubMed Google Scholar
Marodon G, Warren D, Filomio MC, Posnett DN: Productive infection of double-negative T cells with HIV in vivo. Proc Natl Acad Sci USA. 1999, 96 (21): 11958-11963. 10.1073/pnas.96.21.11958. PubMed CentralCASPubMed Google Scholar
Menten P, Wuyts A, Van Damme J: Macrophage inflammatory protein-1. Cytokine Growth Factor Rev. 2002, 13 (6): 455-481. 10.1016/S1359-6101(02)00045-X. CASPubMed Google Scholar
Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 1995, 270 (5243): 1811-1815. 10.1126/science.270.5243.1811. CASPubMed Google Scholar
Ullum H, Cozzi Lepri A, Victor J, Aladdin H, Phillips AN, Gerstoft J, Skinhoj P, Pedersen BK: Production of beta-chemokines in human immunodeficiency virus (HIV) infection: evidence that high levels of macrophage inflammatory protein-1beta are associated with a decreased risk of HIV disease progression. J Infect Dis. 1998, 177 (2): 331-336. CASPubMed Google Scholar
Saha K, Bentsman G, Chess L, Volsky DJ: Endogenous production of beta-chemokines by CD4+, but not CD8+, T-cell clones correlates with the clinical state of human immunodeficiency virus type 1 (HIV-1)-infected individuals and may be responsible for blocking infection with non-syncytium-inducing HIV-1 in vitro. J Virol. 1998, 72 (1): 876-881. PubMed CentralCASPubMed Google Scholar
Koning FA, Jansen CA, Dekker J, Kaslow RA, Dukers N, van Baarle D, Prins M, Schuitemaker H: Correlates of resistance to HIV-1 infection in homosexual men with high-risk sexual behaviour. AIDS. 2004, 18 (8): 1117-1126. 10.1097/00002030-200405210-00005. PubMed Google Scholar
Saez-Cirion A, Versmisse P, Truong LX, Chakrabarti LA, Carpentier W, Barre-Sinoussi F, Scott-Algara D, Pancino G: Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks. Retrovirology. 2006, 3: 81-10.1186/1742-4690-3-81. PubMed CentralPubMed Google Scholar
Amara A, Gall SL, Schwartz O, Salamero J, Montes M, Loetscher P, Baggiolini M, Virelizier JL, Arenzana-Seisdedos F: HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med. 1997, 186 (1): 139-146. 10.1084/jem.186.1.139. PubMed CentralCASPubMed Google Scholar
Modi WS, Lautenberger J, An P, Scott K, Goedert JJ, Kirk GD, Buchbinder S, Phair J, Donfield S, O'Brien SJ, Winkler C: Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progression. Am J Hum Genet. 2006, 79 (1): 120-128. 10.1086/505331. PubMed CentralCASPubMed Google Scholar
Vidal F, Peraire J, Domingo P, Broch M, Cairo M, Pedrol E, Montero M, Vilades C, Gutierrez C, Sambeat MA, Fontanet A, Dalmau D, Deig E, Knobel H, Sirvent JJ, Richart C, Veloso S, Saumoy M, Lopez-Dupla M, Olona M, Cadafalch J, Fuster M, Ochoa A, Soler A, Guelar A, Gonzalez J: Polymorphism of RANTES chemokine gene promoter is not associated with long-term nonprogressive HIV-1 infection of more than 16 years. J Acq ImM Def Syndr. 2006, 41 (1): 17-22. 10.1097/01.qai.0000188335.86466.ea. CAS Google Scholar
Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K: Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q. Nucleic Acids Res. 1990, 18 (11): 3261-3270. 10.1093/nar/18.11.3261. PubMed CentralCASPubMed Google Scholar
Gonzalez E, Kulkarni H, Bolivar H, Mangano A, Sanchez R, Catano G, Nibbs RJ, Freedman BI, Quinones MP, Bamshad MJ, Murthy KK, Rovin BH, Bradley W, Clark RA, Anderson SA, O'Connell R J, Agan BK, Ahuja SS, Bologna R, Sen L, Dolan MJ, Ahuja SK: The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science. 2005, 307 (5714): 1434-1440. 10.1126/science.1101160. CASPubMed Google Scholar
Colobran R, Adreani P, Ashhab Y, Llano A, Este JA, Dominguez O, Pujol-Borrell R, Juan M: Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. J Immunol. 2005, 174 (9): 5655-5664. CASPubMed Google Scholar
Gallo RC, Garzino-Demo A, DeVico AL: HIV infection and pathogenesis: what about chemokines?. J Clin Immunol. 1999, 19 (5): 293-299. 10.1023/A:1020539524373. CASPubMed Google Scholar
Zagury D, Lachgar A, Chams V, Fall LS, Bernard J, Zagury JF, Bizzini B, Gringeri A, Santagostino E, Rappaport J, Feldman M, O'Brien SJ, Burny A, Gallo RC: C-C chemokines, pivotal in protection against HIV type 1 infection. Proc Natl Acad Sci U S A. 1998, 95 (7): 3857-3861. 10.1073/pnas.95.7.3857. PubMed CentralCASPubMed Google Scholar
Liu H, Chao D, Nakayama EE, Taguchi H, Goto M, Xin X, Takamatsu JK, Saito H, Ishikawa Y, Akaza T, Juji T, Takebe Y, Ohishi T, Fukutake K, Maruyama Y, Yashiki S, Sonoda S, Nakamura T, Nagai Y, Iwamoto A, Shioda T: Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression. Proc Natl Acad Sci U S A. 1999, 96 (8): 4581-4585. 10.1073/pnas.96.8.4581. PubMed CentralCASPubMed Google Scholar
Wichukchinda N, Nakayama EE, Rojanawiwat A, Pathipvanich P, Auwanit W, Vongsheree S, Ariyoshi K, Sawanpanyalert P, Shioda T: Protective effects of IL4-589T and RANTES-28G on HIV-1 disease progression in infected Thai females. AIDS. 2006, 20 (2): 189-196. 10.1097/01.aids.0000199830.64735.6f. CASPubMed Google Scholar
Zhao XY, Lee SS, Wong KH, Chan KC, Ma S, Yam WC, Yuen KY, Ng MH, Zheng BJ: Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese. Eur J Immunogenet. 2004, 31 (4): 179-183. 10.1111/j.1365-2370.2004.00466.x. CASPubMed Google Scholar
McDermott DH, Beecroft MJ, Kleeberger CA, Al-Sharif FM, Ollier WE, Zimmerman PA, Boatin BA, Leitman SF, Detels R, Hajeer AH, Murphy PM: Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study. Aids. 2000, 14 (17): 2671-2678. 10.1097/00002030-200012010-00006. CASPubMed Google Scholar
Fernandez RM, Borrego S, Marcos I, Rubio A, Lissen E, Antinolo G: Fluorescence resonance energy transfer analysis of the RANTES polymorphisms -403G --> A and -28G --> C: evaluation of both variants as susceptibility factors to HIV type 1 infection in the Spanish population. AIDS Res Hum Retroviruses. 2003, 19 (5): 349-352. 10.1089/088922203765551692. CASPubMed Google Scholar
Winkler C, An P, O'Brien SJ: Patterns of ethnic diversity among the genes that influence AIDS. Hum Mol Genet. 2004, 13 Spec No 1: R9-19. 10.1093/hmg/ddh075. PubMed Google Scholar
An P, Nelson GW, Donfield S, Goederrt JJ, Phair J, Vlahov D, Buchbinder S, Farrar WL, Modi W, O'Brien S J, Winkler CA: Modulating influence on HIV/AIDS by interacting RANTES gene variants. Proc Natl Acad Sci USA. 2002, 99 (15): 10002-10007. 10.1073/pnas.142313799. PubMed CentralCASPubMed Google Scholar
Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA: The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 1996, 382 (6594): 829-833. 10.1038/382829a0. CASPubMed Google Scholar
Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B: The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature. 1996, 382 (6594): 833-835. 10.1038/382833a0. CASPubMed Google Scholar
Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, Rosenkilde MM, Schwartz TW, Holmes W, Dallas W, Luther MA, Wells TN, Hoxie JA, Marsh M: Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J Cell Biol. 1997, 139 (3): 651-664. 10.1083/jcb.139.3.651. PubMed CentralCASPubMed Google Scholar
Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA. 1998, 95 (16): 9448-9453. 10.1073/pnas.95.16.9448. PubMed CentralCASPubMed Google Scholar
Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T: Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996, 382 (6592): 635-638. 10.1038/382635a0. CASPubMed Google Scholar
Arya SK, Ginsberg CC, Davis-Warren A, D'Costa J: In vitro phenotype of SDF1 gene mutant that delays the onset of human immunodeficiency virus disease in vivo. J Hum Virol. 1999, 2 (3): 133-138. CASPubMed Google Scholar
Winkler C, Modi W, Smith MW, Nelson GW, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert JJ, O'Brien TR, Jacobson LP, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, O'Brien SJ: Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC). Science. 1998, 279 (5349): 389-393. 10.1126/science.279.5349.389. CASPubMed Google Scholar
Hendel H, Henon N, Lebuanec H, Lachgar A, Poncelet H, Caillat-Zucman S, Winkler CA, Smith MW, Kenefic L, O'Brien S, Lu W, Andrieu JM, Zagury D, Schachter F, Rappaport J, Zagury JF: Distinctive effects of CCR5, CCR2, and SDF1 genetic polymorphisms in AIDS progression. J Acquir Immune Defic Syndr Hum Retrovirol. 1998, 19 (4): 381-386. CASPubMed Google Scholar
Ioannidis JP, Rosenberg PS, Goedert JJ, Ashton LJ, Benfield TL, Buchbinder SP, Coutinho RA, Eugen-Olsen J, Gallart T, Katzenstein TL, Kostrikis LG, Kuipers H, Louie LG, Mallal SA, Margolick JB, Martinez OP, Meyer L, Michael NL, Operskalski E, Pantaleo G, Rizzardi GP, Schuitemaker H, Sheppard HW, Stewart GJ, Theodorou ID, Ullum H, Vicenzi E, Vlahov D, Wilkinson D, Workman C, Zagury JF, O'Brien TR: Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. Ann Intern Med. 2001, 135 (9): 782-795. CASPubMed Google Scholar
Magierowska M, Lepage V, Lien TX, Lan NT, Guillotel M, Issafras H, Reynes JM, Fleury HJ, Chi NH, Follezou JY, Debre P, Theodorou I, Barre-Sinoussi F: Novel variant of the CCR5 gene in a Vietnamese population. Microbes Infect. 1999, 1 (2): 123-124. 10.1016/S1286-4579(99)80002-1. CASPubMed Google Scholar
Petersen DC, Glashoff RH, Shrestha S, Bergeron J, Laten A, Gold B, van Rensburg EJ, Dean M, Hayes VM: Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population. J Acquir Immune Defic Syndr. 2005, 40 (5): 521-526. 10.1097/01.qai.0000186360.42834.28. PubMed CentralCASPubMed Google Scholar
Ji X, Gewurz H, Spear GT: Mannose binding lectin (MBL) and HIV. Mol Immunol. 2005, 42 (2): 145-152. 10.1016/j.molimm.2004.06.015. CASPubMed Google Scholar
Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL: The role of dendritic cell C-type lectin receptors in HIV pathogenesis. J Leukoc Biol. 2003, 74 (5): 710-718. 10.1189/jlb.0503208. CASPubMed Google Scholar
Kwon DS, Gregorio G, Bitton N, Hendrickson WA, Littman DR: DC-SIGN-mediated internalization of HIV is required for trans- enhancement of T cell infection. Immunity. 2002, 16 (1): 135-144. 10.1016/S1074-7613(02)00259-5. CASPubMed Google Scholar
Burleigh L, Lozach PY, Schiffer C, Staropoli I, Pezo V, Porrot F, Canque B, Virelizier JL, Arenzana-Seisdedos F, Amara A: Infection of dendritic cells (DCs), not DC-SIGN-mediated internalization of human immunodeficiency virus, is required for long-term transfer of virus to T cells. J Virol. 2006, 80 (6): 2949-2957. 10.1128/JVI.80.6.2949-2957.2006. PubMed CentralCASPubMed Google Scholar
Martin MP, Lederman MM, Hutcheson HB, Goedert JJ, Nelson GW, van Kooyk Y, Detels R, Buchbinder S, Hoots K, Vlahov D, O'Brien SJ, Carrington M: Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection. J Virol. 2004, 78 (24): 14053-14056. 10.1128/JVI.78.24.14053-14056.2004. PubMed CentralCASPubMed Google Scholar
Gramberg T, Zhu T, Chaipan C, Marzi A, Liu H, Wegele A, Andrus T, Hofmann H, Pohlmann S: Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogens. Virology. 2006, 347 (2): 354-363. 10.1016/j.virol.2005.11.033. CASPubMed Google Scholar
Liu H, Hwangbo Y, Holte S, Lee J, Wang C, Kaupp N, Zhu H, Celum C, Corey L, McElrath MJ, Zhu T: Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1. J Infect Dis. 2004, 190 (6): 1055-1058. 10.1086/423209. CASPubMed Google Scholar
Santos PR, Michel-Salzat A, Butor C: Chimpanzee DC-SIGN alleles predict the existence of A and B isoforms, but do not support a role for resistance to HIV infection. AIDS Res Hum Retroviruses. 2005, 21 (9): 820-829. 10.1089/aid.2005.21.820. CASPubMed Google Scholar
Fahrbach KM, Barry SM, Ayehunie S, Lamore S, Klausner M, Hope TJ: Activated CD34-Derived Langerhans Cells Mediate Transinfection with Human Immunodeficiency Virus. J Virol. 2007, 81 (13): 6858-6868. 10.1128/JVI.02472-06. PubMed CentralCASPubMed Google Scholar
de Witte L, Nabatov A, Pion M, Fluitsma D, de Jong MA, de Gruijl T, Piguet V, van Kooyk Y, Geijtenbeek TB: Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. Nat Med. 2007, 13 (3): 367-371. 10.1038/nm1541. CASPubMed Google Scholar
Schwartz O: Langerhans cells lap up HIV-1. Nat Med. 2007, 13 (3): 245-246. 10.1038/nm0307-245. CASPubMed Google Scholar
Verdijk P, Dijkman R, Plasmeijer EI, Mulder AA, Zoutman WH, Mieke Mommaas A, Tensen CP: A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene. J Invest Dermatol. 2005, 124 (4): 714-717. 10.1111/j.0022-202X.2005.23645.x. CASPubMed Google Scholar
Daher KA, Selsted ME, Lehrer RI: Direct inactivation of viruses by human granulocyte defensins. J Virol. 1986, 60 (3): 1068-1074. PubMed CentralCASPubMed Google Scholar
Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI: Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest. 1985, 76 (4): 1427-1435. PubMed CentralCASPubMed Google Scholar
Cole AM, Ganz T: Human antimicrobial peptides: analysis and application. Biotechniques. 2000, 29 (4): 822-6, 828, 830-1. CASPubMed Google Scholar
Klotman ME, Chang TL: Defensins in innate antiviral immunity. Nat Rev Immunol. 2006, 6 (6): 447-456. 10.1038/nri1860. CASPubMed Google Scholar
Nakashima H, Yamamoto N, Masuda M, Fujii N: Defensins inhibit HIV replication in vitro. AIDS. 1993, 7 (8): 1129-10.1097/00002030-199308000-00019. CASPubMed Google Scholar
Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME: A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science. 1999, 286 (5439): 498-502. 10.1126/science.286.5439.498. CASPubMed Google Scholar
Cole AM, Lehrer RI: Minidefensins: antimicrobial peptides with activity against HIV-1. Curr Pharm Des. 2003, 9 (18): 1463-1473. 10.2174/1381612033454667. CASPubMed Google Scholar
Cole AM, Hong T, Boo LM, Nguyen T, Zhao C, Bristol G, Zack JA, Waring AJ, Yang OO, Lehrer RI: Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci USA. 2002, 99 (4): 1813-1818. 10.1073/pnas.052706399. PubMed CentralCASPubMed Google Scholar
Gallo SA, Wang W, Rawat SS, Jung G, Waring AJ, Cole AM, Lu H, Yan X, Daly NL, Craik DJ, Jiang S, Lehrer RI, Blumenthal R: Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation. J Biol Chem. 2006, 281 (27): 18787-18792. 10.1074/jbc.M602422200. CASPubMed Google Scholar
Furci L, Sironi F, Tolazzi M, Vassena L, Lusso P: Alpha-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4. Blood. 2007, 109 (7): 2928-2935. CASPubMed Google Scholar
Chang TL, Vargas J, DelPortillo A, Klotman ME: Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. J Clin Invest. 2005, 115 (3): 765-773. 10.1172/JCI200521948. PubMed CentralCASPubMed Google Scholar
Zhang L, Yu W, He T, Yu J, Caffrey RE, Dalmasso EA, Fu S, Pham T, Mei J, Ho JJ, Zhang W, Lopez P, Ho DD: Contribution of Human alpha -Defensin 1, 2, and 3 to the Anti-HIV-1 Activity of CD8 Antiviral Factor. Science. 2002, 298 (5595): 995-1000. 10.1126/science.1076185. CASPubMed Google Scholar
Walker CM, Moody DJ, Stites DP, Levy JA: CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science. 1986, 234 (4783): 1563-1566. 10.1126/science.2431484. CASPubMed Google Scholar
Levy JA: The search for the CD8+ cell anti-HIV factor (CAF). Trends Immunol. 2003, 24 (12): 628-632. 10.1016/j.it.2003.10.005. CASPubMed Google Scholar
Mackewicz CE, Yuan J, Tran P, Diaz L, Mack E, Selsted ME, Levy JA: alpha-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors. AIDS. 2003, 17 (14): F23-32. 10.1097/00002030-200309260-00001. CASPubMed Google Scholar
Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB: Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA. 2002, 99 (4): 2129-2133. 10.1073/pnas.042692699. PubMed CentralCASPubMed Google Scholar
Weinberg A, Quinones-Mateu ME, Lederman MM: Role of human beta-defensins in HIV infection. Adv Dent Res. 2006, 19 (1): 42-48. CASPubMed Google Scholar
Sun L, Finnegan CM, Kish-Catalone T, Blumenthal R, Garzino-Demo P, La Terra Maggiore GM, Berrone S, Kleinman C, Wu Z, Abdelwahab S, Lu W, Garzino-Demo A: Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. J Virol. 2005, 79 (22): 14318-14329. 10.1128/JVI.79.22.14318-14329.2005. PubMed CentralCASPubMed Google Scholar
Feng Z, Dubyak GR, Lederman MM, Weinberg A: Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4. J Immunol. 2006, 177 (2): 782-786. CASPubMed Google Scholar
Quinones-Mateu ME, Lederman MM, Feng Z, Chakraborty B, Weber J, Rangel HR, Marotta ML, Mirza M, Jiang B, Kiser P, Medvik K, Sieg SF, Weinberg A: Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication. AIDS. 2003, 17 (16): F39-48. 10.1097/00002030-200311070-00001. CASPubMed Google Scholar
Sun L, Demasi L, Lafferty M, Goicochea M, Lu W, Garzino-Demo A: CCR6 mediates the intracellular HIV inhibitory activity of human beta-defensin 2. Retrovirology. 2006, 3 Suppl 1: S77-10.1186/1742-4690-3-S1-S77. Google Scholar
Armogida SA, Yannaras NM, Melton AL, Srivastava MD: Identification and quantification of innate immune system mediators in human breast milk. Allergy Asthma Proc. 2004, 25 (5): 297-304. CASPubMed Google Scholar
Jia HP, Starner T, Ackermann M, Kirby P, Tack BF, McCray PB: Abundant human beta-defensin-1 expression in milk and mammary gland epithelium. J Pediatr. 2001, 138 (1): 109-112. 10.1067/mpd.2001.109375. CASPubMed Google Scholar
Kuhn L, Trabattoni D, Kankasa C, Semrau K, Kasonde P, Lissoni F, Sinkala M, Ghosh M, Vwalika C, Aldrovandi GM, Thea DM, Clerici M: Alpha-defensins in the prevention of HIV transmission among breastfed infants. J Acquir Immune Defic Syndr. 2005, 39 (2): 138-142. PubMed CentralCASPubMed Google Scholar
Braida L, Boniotto M, Pontillo A, Tovo PA, Amoroso A, Crovella S: A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children. AIDS. 2004, 18 (11): 1598-1600. 10.1097/01.aids.0000131363.82951.fb. PubMed Google Scholar
Segat L, Milanese M, Boniotto M, Crovella S, Bernardon M, Costantini M, Alberico S: DEFB-1 genetic polymorphism screening in HIV-1 positive pregnant women and their children. J Matern Fetal Neonatal Med. 2006, 19 (1): 13-16. 10.1080/14767050500381123. CASPubMed Google Scholar
Milanese M, Segat L, Pontillo A, Arraes LC, de Lima Filho JL, Crovella S: DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children. AIDS. 2006, 20 (12): 1673-1675. 10.1097/01.aids.0000238417.05819.40. CASPubMed Google Scholar
Trabattoni D, Caputo SL, Maffeis G, Vichi F, Biasin M, Pierotti P, Fasano F, Saresella M, Franchini M, Ferrante P, Mazzotta F, Clerici M: Human alpha defensin in HIV-exposed but uninfected individuals. J Acquir Immune Defic Syndr. 2004, 35 (5): 455-463. 10.1097/00126334-200404150-00003. CASPubMed Google Scholar
Aldred PM, Hollox EJ, Armour JA: Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3. Hum Mol Genet. 2005, 14 (14): 2045-2052. 10.1093/hmg/ddi209. CASPubMed Google Scholar
Hollox EJ, Armour JA, Barber JC: Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. Am J Hum Genet. 2003, 73 (3): 591-600. 10.1086/378157. PubMed CentralCASPubMed Google Scholar
Mars WM, Patmasiriwat P, Maity T, Huff V, Weil MM, Saunders GF: Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3. J Biol Chem. 1995, 270 (51): 30371-30376. 10.1074/jbc.270.51.30371. CASPubMed Google Scholar
Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW: Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984, 226 (4674): 544-547. 10.1126/science.6238408. CASPubMed Google Scholar
Sandstrom EG, Kaplan JC: Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date. Drugs. 1987, 34 (3): 372-390. CASPubMed Google Scholar
Klatzmann D, Laporte JP, Achour A, Brisson E, Gruest J, Montagnier L, Gluckman JC: Functional inhibition by cyclosporin A of the lymphocyte receptor for the AIDS virus (HIV). C R Acad Sci III. 1986, 303 (9): 343-348. CASPubMed Google Scholar
Luban J, Bossolt KL, Franke EK, Kalpana GV, Goff SP: Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell. 1993, 73 (6): 1067-1078. 10.1016/0092-8674(93)90637-6. CASPubMed Google Scholar
Franke EK, Yuan HE, Luban J: Specific incorporation of cyclophilin A into HIV-1 virions. Nature. 1994, 372 (6504): 359-362. 10.1038/372359a0. CASPubMed Google Scholar
Ott DE, Coren LV, Johnson DG, Sowder RC, Arthur LO, Henderson LE: Analysis and localization of cyclophilin A found in the virions of human immunodeficiency virus type 1 MN strain. AIDS Res Hum Retroviruses. 1995, 11 (9): 1003-1006. CASPubMed Google Scholar
Thali M, Bukovsky A, Kondo E, Rosenwirth B, Walsh CT, Sodroski J, Gottlinger HG: Functional association of cyclophilin A with HIV-1 virions. Nature. 1994, 372 (6504): 363-365. 10.1038/372363a0. CASPubMed Google Scholar
Besnier C, Takeuchi Y, Towers G: Restriction of lentivirus in monkeys. Proc Natl Acad Sci USA. 2002, 99 (18): 11920-11925. 10.1073/pnas.172384599. PubMed CentralCASPubMed Google Scholar
Cowan S, Hatziioannou T, Cunningham T, Muesing MA, Gottlinger HG, Bieniasz PD: Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism. Proc Natl Acad Sci USA. 2002, 99 (18): 11914-11919. 10.1073/pnas.162299499. PubMed CentralCASPubMed Google Scholar
Munk C, Brandt SM, Lucero G, Landau NR: A dominant block to HIV-1 replication at reverse transcription in simian cells. Proc Natl Acad Sci USA. 2002, 99 (21): 13843-13848. 10.1073/pnas.212400099. PubMed CentralCASPubMed Google Scholar
Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD: Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. J Virol. 2005, 79 (1): 176-183. 10.1128/JVI.79.1.176-183.2005. PubMed CentralCASPubMed Google Scholar
Sokolskaja E, Sayah DM, Luban J: Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity. J Virol. 2004, 78 (23): 12800-12808. 10.1128/JVI.78.23.12800-12808.2004. PubMed CentralCASPubMed Google Scholar
Luban J: Cyclophilin A, TRIM5, and Resistance to HIV-1 Infection. J Virol. 2006, 81 (3): 1054-1061. 10.1128/JVI.01519-06. PubMed CentralPubMed Google Scholar
Fischer G, Tradler T, Zarnt T: The mode of action of peptidyl prolyl cis/trans isomerases in vivo: binding vs. catalysis. FEBS Lett. 1998, 426 (1): 17-20. 10.1016/S0014-5793(98)00242-7. CASPubMed Google Scholar
Coaker G, Falick A, Staskawicz B: Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilin. Science. 2005, 308 (5721): 548-550. 10.1126/science.1108633. CASPubMed Google Scholar
Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J: The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature. 2004, 427 (6977): 848-853. 10.1038/nature02343. CASPubMed Google Scholar
Keckesova Z, Ylinen LM, Towers GJ: Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity. J Virol. 2006, 80 (10): 4683-4690. 10.1128/JVI.80.10.4683-4690.2006. PubMed CentralCASPubMed Google Scholar
Sokolskaja E, Berthoux L, Luban J: Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. J Virol. 2006, 80 (6): 2855-2862. 10.1128/JVI.80.6.2855-2862.2006. PubMed CentralCASPubMed Google Scholar
Stremlau M, Song B, Javanbakht H, Perron M, Sodroski J: Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1. Virology. 2006, 351 (1): 112-120. CASPubMed Google Scholar
Speelmon EC, Livingston-Rosanoff D, Li SS, Vu Q, Bui J, Geraghty DE, Zhao LP, McElrath MJ: Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection. J Virol. 2006, 80 (5): 2463-2471. 10.1128/JVI.80.5.2463-2471.2006. PubMed CentralCASPubMed Google Scholar
Javanbakht H, An P, Gold B, Petersen DC, O'Huigin C, Nelson GW, O'Brien SJ, Kirk GD, Detels R, Buchbinder S, Donfield S, Shulenin S, Song B, Perron MJ, Stremlau M, Sodroski J, Dean M, Winkler C: Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology. 2006, 354 (1): 15-27. 10.1016/j.virol.2006.06.031. CASPubMed Google Scholar
Goldschmidt V, Bleiber G, May M, Martinez R, Ortiz M, Telenti A: Role of common human TRIM5alpha variants in HIV-1 disease progression. Retrovirology. 2006, 3: 54-10.1186/1742-4690-3-54. PubMed CentralPubMed Google Scholar
Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS, Malim MH: DNA deamination mediates innate immunity to retroviral infection. Cell. 2003, 113 (6): 803-809. 10.1016/S0092-8674(03)00423-9. CASPubMed Google Scholar
Mangeat B, Turelli P, Caron G, Friedli M, Perrin L, Trono D: Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature. 2003, 424 (6944): 99-103. 10.1038/nature01709. CASPubMed Google Scholar
Zhang H, Yang B, Pomerantz RJ, Zhang C, Arunachalam SC, Gao L: The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. Nature. 2003, 424 (6944): 94-98. 10.1038/nature01707. PubMed CentralCASPubMed Google Scholar
Lecossier D, Bouchonnet F, Clavel F, Hance AJ: Hypermutation of HIV-1 DNA in the absence of the Vif protein. Science. 2003, 300 (5622): 1112-10.1126/science.1083338. CASPubMed Google Scholar
Mariani R, Chen D, Schrofelbauer B, Navarro F, Konig R, Bollman B, Munk C, Nymark-McMahon H, Landau NR: Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. Cell. 2003, 114 (1): 21-31. 10.1016/S0092-8674(03)00515-4. CASPubMed Google Scholar
Yu Q, Konig R, Pillai S, Chiles K, Kearney M, Palmer S, Richman D, Coffin JM, Landau NR: Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome. Nat Struct Mol Biol. 2004, 11 (5): 435-442. 10.1038/nsmb758. CASPubMed Google Scholar
Turelli P, Mangeat B, Jost S, Vianin S, Trono D: Inhibition of hepatitis B virus replication by APOBEC3G. Science. 2004, 303 (5665): 1829-10.1126/science.1092066. PubMed Google Scholar
Newman EN, Holmes RK, Craig HM, Klein KC, Lingappa JR, Malim MH, Sheehy AM: Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity. Curr Biol. 2005, 15 (2): 166-170. 10.1016/j.cub.2004.12.068. CASPubMed Google Scholar
Chiu YL, Witkowska HE, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC: High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition. Proc Natl Acad Sci USA. 2006, 103 (42): 15588-15593. 10.1073/pnas.0604524103. PubMed CentralCASPubMed Google Scholar
Schumacher AJ, Nissley DV, Harris RS: APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast. Proc Natl Acad Sci USA. 2005, 102 (28): 9854-9859. 10.1073/pnas.0501694102. PubMed CentralCASPubMed Google Scholar
Esnault C, Heidmann O, Delebecque F, Dewannieux M, Ribet D, Hance AJ, Heidmann T, Schwartz O: APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses. Nature. 2005, 433 (7024): 430-433. 10.1038/nature03238. CASPubMed Google Scholar
Gu Y, Kodama H, Watanabe S, Kikuchi N, Ishitsuka I, Ozawa H, Fujisawa C, Shiga K: The first reported case of Menkes disease caused by an Alu insertion mutation. Brain Dev. 2007, 29 (2): 105-108. 10.1016/j.braindev.2006.05.012. PubMed Google Scholar
Deininger PL, Batzer MA: Alu repeats and human disease. Mol Genet Metab. 1999, 67 (3): 183-193. 10.1006/mgme.1999.2864. CASPubMed Google Scholar
Apoil PA, Kuhlein E, Robert A, Rubie H, Blancher A: HIGM syndrome caused by insertion of an AluYb8 element in exon 1 of the CD40LG gene. Immunogenetics. 2007, 59 (1): 17-23. 10.1007/s00251-006-0175-5. CASPubMed Google Scholar
Marin M, Rose KM, Kozak SL, Kabat D: HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. Nat Med. 2003, 9 (11): 1398-1403. 10.1038/nm946. CASPubMed Google Scholar
Yu X, Yu Y, Liu B, Luo K, Kong W, Mao P, Yu XF: Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science. 2003, 302 (5647): 1056-1060. 10.1126/science.1089591. CASPubMed Google Scholar
Mehle A, Strack B, Ancuta P, Zhang C, McPike M, Gabuzda D: Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway. J Biol Chem. 2004, 279 (9): 7792-7798. 10.1074/jbc.M313093200. CASPubMed Google Scholar
Mehle A, Goncalves J, Santa-Marta M, McPike M, Gabuzda D: Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. Genes Dev. 2004, 18 (23): 2861-2866. 10.1101/gad.1249904. PubMed CentralCASPubMed Google Scholar
Hassaine G, Agostini I, Candotti D, Bessou G, Caballero M, Agut H, Autran B, Barthalay Y, Vigne R: Characterization of human immunodeficiency virus type 1 vif gene in long-term asymptomatic individuals. Virology. 2000, 276 (1): 169-180. 10.1006/viro.2000.0543. CASPubMed Google Scholar
Alexander L, Aquino-DeJesus M, Chan M, Andiman WA: Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by two-amino-acid insertion in HIV-1 vif from nonprogressing mother and child. J Virol. 2002, 76 (20): 10533-10539. 10.1128/JVI.76.20.10533-10539.2002. PubMed CentralCASPubMed Google Scholar
Farrow MA, Somasundaran M, Zhang C, Gabuzda D, Sullivan JL, Greenough TC: Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation. AIDS Res Hum Retroviruses. 2005, 21 (6): 565-574. 10.1089/aid.2005.21.565. CASPubMed Google Scholar
An P, Bleiber G, Duggal P, Nelson G, May M, Mangeat B, Alobwede I, Trono D, Vlahov D, Donfield S, Goedert JJ, Phair J, Buchbinder S, O'Brien SJ, Telenti A, Winkler CA: APOBEC3G genetic variants and their influence on the progression to AIDS. J Virol. 2004, 78 (20): 11070-11076. 10.1128/JVI.78.20.11070-11076.2004. PubMed CentralCASPubMed Google Scholar
Do H, Vasilescu A, Diop G, Hirtzig T, Heath SC, Coulonges C, Rappaport J, Therwath A, Lathrop M, Matsuda F, Zagury JF: Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort. J Infect Dis. 2005, 191 (2): 159-163. 10.1086/426826. CASPubMed Google Scholar
Valcke HS, Bernard NF, Bruneau J, Alary M, Tsoukas CM, Roger M: APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians. AIDS. 2006, 20 (15): 1984-1986. 10.1097/01.aids.0000247124.35129.e1. CASPubMed Google Scholar
Jin X, Brooks A, Chen H, Bennett R, Reichman R, Smith H: APOBEC3G/CEM15 (hA3G) mRNA levels associate inversely with human immunodeficiency virus viremia. J Virol. 2005, 79 (17): 11513-11516. 10.1128/JVI.79.17.11513-11516.2005. PubMed CentralCASPubMed Google Scholar
An P, Duggal P, Wang LH, O'Brien SJ, Donfield S, Goedert JJ, Phair J, Buchbinder S, Kirk GD, Winkler CA: Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals. PLoS Genet. 2007, 3 (1): e19-10.1371/journal.pgen.0030019. PubMed CentralPubMed Google Scholar
Varthakavi V, Smith RM, Bour SP, Strebel K, Spearman P: Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production. Proc Natl Acad Sci USA. 2003, 100 (25): 15154-15159. 10.1073/pnas.2433165100. PubMed CentralCASPubMed Google Scholar
Neil SJ, Eastman SW, Jouvenet N, Bieniasz PD: HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane. PLoS Pathog. 2006, 2 (5): e39-10.1371/journal.ppat.0020039. PubMed CentralPubMed Google Scholar
Hsu K, Seharaseyon J, Dong P, Bour S, Marban E: Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel. Mol Cell. 2004, 14 (2): 259-267. 10.1016/S1097-2765(04)00183-2. CASPubMed Google Scholar
Strebel K: HIV-1 Vpu: putting a channel to the TASK. Mol Cell. 2004, 14 (2): 150-152. 10.1016/S1097-2765(04)00205-9. CASPubMed Google Scholar
Akari H, Bour S, Kao S, Adachi A, Strebel K: The Human Immunodeficiency Virus Type 1 Accessory Protein Vpu Induces Apoptosis by Suppressing the Nuclear Factor kappaB-dependent Expression of Antiapoptotic Factors. J Exp Med. 2001, 194 (9): 1299-1312. 10.1084/jem.194.9.1299. PubMed CentralCASPubMed Google Scholar
Margottin F, Bour SP, Durand H, Selig L, Benichou S, Richard V, Thomas D, Strebel K, Benarous R: A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to ER degradation pathway through an F-box motif. Mol Cell. 1998, 4: 565-574. 10.1016/S1097-2765(00)80056-8. Google Scholar
Garrus JE, von Schwedler UK, Pornillos OW, Morham SG, Zavitz KH, Wang HE, Wettstein DA, Stray KM, Cote M, Rich RL, Myszka DG, Sundquist WI: Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell. 2001, 107 (1): 55-65. 10.1016/S0092-8674(01)00506-2. CASPubMed Google Scholar
VerPlank L, Bouamr F, LaGrassa TJ, Agresta B, Kikonyogo A, Leis J, Carter CA: Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag). Proc Natl Acad Sci USA. 2001, 98 (14): 7724-7729. 10.1073/pnas.131059198. PubMed CentralCASPubMed Google Scholar
Martin-Serrano J, Zang T, Bieniasz PD: HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress. Nat Med. 2001, 7 (12): 1313-1319. 10.1038/nm1201-1313. CASPubMed Google Scholar
Welsch S, Keppler OT, Habermann A, Allespach I, Krijnse-Locker J, Krausslich HG: HIV-1 buds predominantly at the plasma membrane of primary human macrophages. PLoS Pathog. 2007, 3 (3): e36-10.1371/journal.ppat.0030036. PubMed CentralPubMed Google Scholar
Jouvenet N, Neil SJ, Bess C, Johnson MC, Virgen CA, Simon SM, Bieniasz PD: Plasma membrane is the site of productive HIV-1 particle assembly. PLoS Biol. 2006, 4 (12): e435-10.1371/journal.pbio.0040435. PubMed CentralPubMed Google Scholar
Deneka M, Pelchen-Matthews A, Byland R, Ruiz-Mateos E, Marsh M: In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53. J Cell Biol. 2007, 177 (2): 329-341. 10.1083/jcb.200609050. PubMed CentralCASPubMed Google Scholar
Morita E, Sundquist WI: Retrovirus budding. Annu Rev Cell Dev Biol. 2004, 20: 395-425. 10.1146/annurev.cellbio.20.010403.102350. CASPubMed Google Scholar
von Schwedler UK, Stuchell M, Muller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Krausslich HG, Kaplan J, Morham SG, Sundquist WI: The protein network of HIV budding. Cell. 2003, 114 (6): 701-713. 10.1016/S0092-8674(03)00714-1. CASPubMed Google Scholar
Amit I, Yakir L, Katz M, Zwang Y, Marmor MD, Citri A, Shtiegman K, Alroy I, Tuvia S, Reiss Y, Roubini E, Cohen M, Wides R, Bacharach E, Schubert U, Yarden Y: Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding. Genes Dev. 2004, 18 (14): 1737-1752. 10.1101/gad.294904. PubMed CentralCASPubMed Google Scholar
Eastman SW, Martin-Serrano J, Chung W, Zang T, Bieniasz PD: Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. J Biol Chem. 2005, 280 (1): 628-636. 10.1074/jbc.M413556200. CASPubMed Google Scholar
Strack B, Calistri A, Craig S, Popova E, Gottlinger HG: AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell. 2003, 114 (6): 689-699. 10.1016/S0092-8674(03)00653-6. CASPubMed Google Scholar
Stuchell MD, Garrus JE, Muller B, Stray KM, Ghaffarian S, McKinnon R, Krausslich HG, Morham SG, Sundquist WI: The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. J Biol Chem. 2004, 279 (34): 36059-360571. 10.1074/jbc.M405226200. CASPubMed Google Scholar
Bashirova AA, Bleiber G, Qi Y, Hutcheson H, Yamashita T, Johnson RC, Cheng J, Alter G, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, May M, Maldarelli F, Jacobson L, O'Brien S J, Telenti A, Carrington M: Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1. J Virol. 2006, 80 (14): 6757-6763. 10.1128/JVI.00094-06. PubMed CentralCASPubMed Google Scholar
Smith MS, Thresher RJ, Pagano JS: Inhibition of human immunodeficiency virus type 1 morphogenesis in T cells by alpha interferon. Antimicrob Agents Chemother. 1991, 35 (1): 62-67. PubMed CentralCASPubMed Google Scholar
Yasuda Y, Miyake S, Kato S, Kita M, Kishida T, Kimura T, Ikuta K: Interferon-alpha treatment leads to accumulation of virus particles on the surface of cells persistently infected with the human immunodeficiency virus type 1. J Acquir Immune Defic Syndr. 1990, 3 (11): 1046-1051. CASPubMed Google Scholar
Okumura A, Lu G, Pitha-Rowe I, Pitha PM: Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15. Proc Natl Acad Sci USA. 2006, 103 (5): 1440-1445. 10.1073/pnas.0510518103. PubMed CentralCASPubMed Google Scholar
Dooher JE, Schneider BL, Reed JC, Lingappa JR: Host ABCE1 is at Plasma Membrane HIV Assembly Sites and Its Dissociation from Gag is Linked to Subsequent Events of Virus Production. Traffic. 2007, 8 (3): 195-211. 10.1111/j.1600-0854.2006.00524.x. PubMed CentralCASPubMed Google Scholar
Lingappa JR, Dooher JE, Newman MA, Kiser PK, Klein KC: Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly. J Biol Chem. 2006, 281 (7): 3773-3784. 10.1074/jbc.M507255200. CASPubMed Google Scholar
Zimmerman C, Klein KC, Kiser PK, Singh AR, Firestein BL, Riba SC, Lingappa JR: Identification of a host protein essential for assembly of immature HIV- 1 capsids. Nature. 2002, 415 (6867): 88-92. 10.1038/415088a. CASPubMed Google Scholar
Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P: AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell. 2005, 120 (5): 663-674. 10.1016/j.cell.2004.12.023. CASPubMed Google Scholar
Huizing M, Gahl WA: Disorders of vesicles of lysosomal lineage: the Hermansky-Pudlak syndromes. Curr Mol Med. 2002, 2 (5): 451-467. 10.2174/1566524023362357. CASPubMed Google Scholar
Hammarstedt M, Garoff H: Passive and active inclusion of host proteins in human immunodeficiency virus type 1 gag particles during budding at the plasma membrane. J Virol. 2004, 78 (11): 5686-5697. 10.1128/JVI.78.11.5686-5697.2004. PubMed CentralCASPubMed Google Scholar
Tremblay MJ, Fortin JF, Cantin R: The acquisition of host-encoded proteins by nascent HIV-1. Immunol Today. 1998, 19 (8): 346-351. 10.1016/S0167-5699(98)01286-9. CASPubMed Google Scholar
Fortin JF, Cantin R, Lamontagne G, Tremblay M: Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity. J Virol. 1997, 71 (5): 3588-3596. PubMed CentralCASPubMed Google Scholar
Bounou S, Leclerc JE, Tremblay MJ: Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T- cell depletion in human lymphoid tissue, a major site of replication in vivo. J Virol. 2002, 76 (3): 1004-1014. PubMed CentralCASPubMed Google Scholar
Fortin JF, Cantin R, Bergeron MG, Tremblay MJ: Interaction between virion-bound host intercellular adhesion molecule-1 and the high-affinity state of lymphocyte function-associated antigen-1 on target cells renders R5 and X4 isolates of human immunodeficiency virus type 1 more refractory to neutralization. Virology. 2000, 268 (2): 493-503. 10.1006/viro.2000.0190. CASPubMed Google Scholar
Fortin JF, Cantin R, Tremblay MJ: T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1. J Virol. 1998, 72 (3): 2105-2112. PubMed CentralCASPubMed Google Scholar
Losier M, Fortin JF, Cantin R, Bergeron MG, Tremblay MJ: Virion-bound ICAM-1 and activated LFA-1: a combination of factors conferring resistance to neutralization by sera from human immunodeficiency virus type 1-infected individuals independently of the disease status and phase. Clin Immunol. 2003, 108 (2): 111-118. 10.1016/S1521-6616(03)00093-7. CASPubMed Google Scholar
Hioe CE, Chien PC, Lu C, Springer TA, Wang XH, Bandres J, Tuen M: LFA-1 expression on target cells promotes human immunodeficiency virus type 1 infection and transmission. J Virol. 2001, 75 (2): 1077-1082. 10.1128/JVI.75.2.1077-1082.2001. PubMed CentralCASPubMed Google Scholar
Tardif MR, Tremblay MJ: LFA-1 is a key determinant for preferential infection of memory CD4+ T cells by human immunodeficiency virus type 1. J Virol. 2005, 79 (21): 13714-13724. 10.1128/JVI.79.21.13714-13724.2005. PubMed CentralCASPubMed Google Scholar
Papa A, Danese S, Urgesi R, Grillo A, Guglielmo S, Roberto I, Semeraro S, Scaldaferri F, Pola R, Flex A, Fedeli G, Gasbarrini G, Pola P, Gasbarrini A: Intercellular adhesion molecule 1 gene polymorphisms in inflammatory bowel disease. Eur Rev Med Pharmacol Sci. 2004, 8 (5): 187-191. CASPubMed Google Scholar
Hoxie JA, Fitzharris TP, Youngbar PR, Matthews DM, Rackowski JL, Radka SF: Nonrandom association of cellular antigens with HTLV-III virions. Hum Immunol. 1987, 18 (1): 39-52. 10.1016/0198-8859(87)90111-X. CASPubMed Google Scholar
Orentas RJ, Hildreth JE: Association of host cell surface adhesion receptors and other membrane proteins with HIV and SIV. AIDS Res Hum Retroviruses. 1993, 9 (11): 1157-1165. CASPubMed Google Scholar
Chan WL, Rodgers A, Grief C, Almond N, Ellis S, Flanagan B, Silvera P, Bootman J, Stott J, Kent K, et al: Immunization with class I human histocompatibility leukocyte antigen can protect macaques against challenge infection with SIVmac-32H. AIDS. 1995, 9 (3): 223-228. CASPubMed Google Scholar
Arthur LO, Bess JW, Urban RG, Strominger JL, Morton WR, Mann DL, Henderson LE, Benveniste RE: Macaques immunized with HLA-DR are protected from challenge with simian immunodeficiency virus. J Virol. 1995, 69 (5): 3117-3124. PubMed CentralCASPubMed Google Scholar
Rossio JL, Bess J, Henderson LE, Cresswell P, Arthur LO: HLA class II on HIV particles is functional in superantigen presentation to human T cells: implications for HIV pathogenesis. AIDS Res Hum Retroviruses. 1995, 11 (12): 1433-1439. CASPubMed Google Scholar
Gurer C, Cimarelli A, Luban J: Specific incorporation of heat shock protein 70 family members into primate lentiviral virions. J Virol. 2002, 76 (9): 4666-4670. 10.1128/JVI.76.9.4666-4670.2002. PubMed CentralCASPubMed Google Scholar
Yung E, Sorin M, Pal A, Craig E, Morozov A, Delattre O, Kappes J, Ott D, Kalpana GV: Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1. Nat Med. 2001, 7 (8): 920-926. 10.1038/90959. CASPubMed Google Scholar
Halwani R, Cen S, Javanbakht H, Saadatmand J, Kim S, Shiba K, Kleiman L: Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly. J Virol. 2004, 78 (14): 7553-7564. 10.1128/JVI.78.14.7553-7564.2004. PubMed CentralCASPubMed Google Scholar
Javanbakht H, Halwani R, Cen S, Saadatmand J, Musier-Forsyth K, Gottlinger H, Kleiman L: The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly. J Biol Chem. 2003, 278 (30): 27644-27651. 10.1074/jbc.M301840200. CASPubMed Google Scholar
Kleiman L, Halwani R, Javanbakht H: The selective packaging and annealing of primer tRNALys3 in HIV-1. Curr HIV Res. 2004, 2 (2): 163-175. 10.2174/1570162043484988. CASPubMed Google Scholar
Chertova E, Bess Jr JW, Crise BJ, Sowder IR, Schaden TM, Hilburn JM, Hoxie JA, Benveniste RE, Lifson JD, Henderson LE, Arthur LO: Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus. J Virol. 2002, 76 (11): 5315-5325. 10.1128/JVI.76.11.5315-5325.2002. PubMed CentralCASPubMed Google Scholar
Freed EO, Martin MA: Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix. J Virol. 1995, 69: 1984-1989. PubMed CentralCASPubMed Google Scholar
Freed EO, Martin MA: Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions. J Virol. 1996, 70: 341-351. PubMed CentralCASPubMed Google Scholar
Freed EO, Orenstein JM, Buckler White AJ, Martin MA: Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production. J Virol. 1994, 68: 5311-5320. PubMed CentralCASPubMed Google Scholar
West JT, Weldon SK, Wyss S, Lin X, Yu Q, Thali M, Hunter E: Mutation of the dominant endocytosis motif in human immunodeficiency virus type 1 gp41 can complement matrix mutations without increasing Env incorporation. J Virol. 2002, 76 (7): 3338-3349. 10.1128/JVI.76.7.3338-3349.2002. PubMed CentralCASPubMed Google Scholar
Blot G, Janvier K, Le Panse S, Benarous R, Berlioz-Torrent C: Targeting of the human immunodeficiency virus type 1 envelope to the trans-Golgi network through binding to TIP47 is required for env incorporation into virions and infectivity. J Virol. 2003, 77 (12): 6931-6945. 10.1128/JVI.77.12.6931-6945.2003. PubMed CentralCASPubMed Google Scholar
Lopez-Verges S, Camus G, Blot G, Beauvoir R, Benarous R, Berlioz-Torrent C: Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions. Proc Natl Acad Sci USA. 2006, 103 (40): 14947-14952. 10.1073/pnas.0602941103. PubMed CentralCASPubMed Google Scholar
Lama J: The physiological relevance of CD4 receptor down-modulation during HIV infection. Curr HIV Res. 2003, 1: 167-184. 10.2174/1570162033485276. CASPubMed Google Scholar
Cortes MJ, Wong-Staal F, Lama J: Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells. J Biol Chem. 2002, 277 (3): 1770-1779. 10.1074/jbc.M109807200. CASPubMed Google Scholar
Lama J, Mangasarian A, Trono D: Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner. Curr Biol. 1999, 9: 622-631. 10.1016/S0960-9822(99)80284-X. CASPubMed Google Scholar
Chen BK, Gandhi RT, Baltimore D: CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef. J Virol. 1996, 70: 6044-6053. PubMed CentralCASPubMed Google Scholar
Wildum S, Schindler M, Munch J, Kirchhoff F: Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection. J Virol. 2006, 80 (16): 8047-8059. 10.1128/JVI.00252-06. PubMed CentralCASPubMed Google Scholar
Glushakova S, Munch J, Carl S, Greenough TC, Sullivan JL, Margolis L, Kirchhoff F: CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T- cell depletion in human lymphoid tissue ex vivo. J Virol. 2001, 75 (21): 10113-10117. 10.1128/JVI.75.21.10113-10117.2001. PubMed CentralCASPubMed Google Scholar
Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C: Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol. 2002, 76 (9): 4625-4633. 10.1128/JVI.76.9.4625-4633.2002. PubMed CentralCASPubMed Google Scholar
Stoddart CA, Geleziunas R, Ferrell S, Linquist-Stepps V, Moreno ME, Bare C, Xu W, Yonemoto W, Bresnahan PA, McCune JM, Greene WC: Human immunodeficienty virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J Virol. 2003, 77 (3): 2124-2133. 10.1128/JVI.77.3.2124-2133.2003. PubMed CentralCASPubMed Google Scholar
Arganaraz ER, Schindler M, Kirchhoff F, Cortes MJ, Lama J: Enhanced CD4 down-modulation by late-stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication. J Biol Chem. 2003, 36: 33912-33919. 10.1074/jbc.M303679200. Google Scholar
Carl S, Greenough TC, Krumbiegel M, Greenberg M, Skowronski J, Sullivan JL, Kirchhoff F: Modulation of different human immunodeficiency virus type 1 nef functions during progression to AIDS. J Virol. 2001, 75 (8): 3657-3665. 10.1128/JVI.75.8.3657-3665.2001. PubMed CentralCASPubMed Google Scholar
Brambilla A, Turchetto L, Gatti A, Bovolenta C, Veglia F, Santagostino E, Gringeri A, Clementi M, Poli G, Bagnarelli P, Vicenzi E: Defective nef alleles in a cohort of hemophiliacs with progressing and nonprogressing HIV-1 infection. Virology. 1999, 259 (2): 349-368. 10.1006/viro.1999.9783. CASPubMed Google Scholar
Geffin R, Wolf D, Muller R, Hill MD, Stellwag E, Freitag M, Sass G, Scott GB, Baur AS: Functional and structural defects in HIV type 1 nef genes derived from pediatric long-term survivors. AIDS Res Hum Retroviruses. 2000, 16 (17): 1855-1868. 10.1089/08892220050195810. CASPubMed Google Scholar
Rhodes DI, Ashton L, Solomon A, Carr A, Cooper D, Kaldor J, Deacon N: Characterization of three nef-defective human immunodeficiency virus type 1 strains associated with long-term nonprogression. Australian Long-Term Nonprogressor Study Group. J Virol. 2000, 74 (22): 10581-10588. 10.1128/JVI.74.22.10581-10588.2000. PubMed CentralCASPubMed Google Scholar
Tobiume M, Takahoko M, Yamada T, Tatsumi M, Iwamoto A, Matsuda M: Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors. J Virol. 2002, 76 (12): 5959-5965. 10.1128/JVI.76.12.5959-5965.2002. PubMed CentralCASPubMed Google Scholar
Coleman SH, Day JR, Guatelli J: The HIV-1 Nef protein as a target for antiretroviral therapy. Emerg Ther Targets. 2001, 5 (1): 1-22. 10.1517/14728222.5.1.1. CAS Google Scholar
Kedzierska K, Crowe SM: Cytokines and HIV-1: interactions and clinical implications. Antivir Chem Chemother. 2001, 12 (3): 133-150. CASPubMed Google Scholar
Jacques C, Gosset M, Berenbaum F, Gabay C: The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation. Vitam Horm. 2006, 74: 371-403. CASPubMed Google Scholar
Do H, Vasilescu A, Carpentier W, Meyer L, Diop G, Hirtzig T, Coulonges C, Labib T, Spadoni JL, Therwath A, Lathrop M, Matsuda F, Zagury JF: Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort. J Infect Dis. 2006, 194 (11): 1492-1504. 10.1086/508545. CASPubMed Google Scholar
Kinter A, Fauci AS: Interleukin-2 and human immunodeficiency virus infection: pathogenic mechanisms and potential for immunologic enhancement. Immunol Res. 1996, 15 (1): 1-15. CASPubMed Google Scholar
Shrestha S, Strathdee SA, Galai N, Oleksyk T, Fallin MD, Mehta S, Schaid D, Vlahov D, O'Brien SJ, Smith MW: Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. J Infect Dis. 2006, 193 (1): 16-26. 10.1086/498532. CASPubMed Google Scholar
Modi WS, O'Brien TR, Vlahov D, Buchbinder S, Gomperts E, Phair J, O'Brien SJ, Winkler C: Haplotype diversity in the interleukin-4 gene is not associated with HIV-1 transmission and AIDS progression. Immunogenetics. 2003, 55 (3): 157-164. 10.1007/s00251-003-0541-5. CASPubMed Google Scholar
Vasilescu A, Heath SC, Ivanova R, Hendel H, Do H, Mazoyer A, Khadivpour E, Goutalier FX, Khalili K, Rappaport J, Lathrop GM, Matsuda F, Zagury JF: Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression. Genes Immun. 2003, 4 (6): 441-449. 10.1038/sj.gene.6363983. CASPubMed Google Scholar
Soriano A, Lozano F, Oliva H, Garcia F, Nomdedeu M, De Lazzari E, Rodriguez C, Barrasa A, Lorenzo JI, Del Romero J, Plana M, Miro JM, Gatell JM, Vives J, Gallart T: Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS. Immunogenetics. 2005, 57 (9): 644-654. 10.1007/s00251-005-0041-x. CASPubMed Google Scholar
Zhou P, Goldstein S, Devadas K, Tewari D, Notkins AL: Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nat Med. 1997, 3 (6): 659-664. 10.1038/nm0697-659. CASPubMed Google Scholar
Kornfeld H, Cruikshank WW: Prospects for IL-16 in the treatment of AIDS. Expert Opin Biol Ther. 2001, 1 (3): 425-432. 10.1517/14712598.1.3.425. CASPubMed Google Scholar
Scala E, D'Offizi G, Rosso R, Turriziani O, Ferrara R, Mazzone AM, Antonelli G, Aiuti F, Paganelli R: C-C chemokines, IL-16, and soluble antiviral factor activity are increased in cloned T cells from subjects with long-term nonprogressive HIV. infection. J Immunol. 1997, 158 (9): 4485-4492. CASPubMed Google Scholar
Amiel C, Darcissac E, Truong MJ, Dewulf J, Loyens M, Mouton Y, Capron A, Bahr GM: Interleukin-16 (IL-16) inhibits human immunodeficiency virus replication in cells from infected subjects, and serum IL-16 levels drop with disease progression. J Infect Dis. 1999, 179 (1): 83-91. 10.1086/314550. CASPubMed Google Scholar
Bader A, Brockmeyer N, Schnaitmann E, Mertins L, Otteken A, Kurth R, Werner A: Interleukin-16 serum levels during the course of HIV-1 infection. AIDS. 2001, 15 (4): 528-529. 10.1097/00002030-200103090-00014. CASPubMed Google Scholar
Nakayama EE, Wasi C, Ajisawa A, Iwamoto A, Shioda T: A new polymorphism in the promoter region of the human interleukin-16 (IL-16) gene. Genes Immun. 2000, 1 (4): 293-294. 10.1038/sj.gene.6363672. CASPubMed Google Scholar
Stylianou E, Bjerkeli V, Yndestad A, Heggelund L, Waehre T, Damas JK, Aukrust P, Froland SS: Raised serum levels of interleukin-18 is associated with disease progression and may contribute to virological treatment failure in HIV-1-infected patients. Clin Exp Immunol. 2003, 132 (3): 462-466. 10.1046/j.1365-2249.2003.02179.x. PubMed CentralCASPubMed Google Scholar
Wiercinska-Drapalo A, Jaroszewicz J, Flisiak R, Prokopowicz D: Plasma interleukin-18 is associated with viral load and disease progression in HIV-1-infected patients. Microbes Infect. 2004, 6 (14): 1273-1277. 10.1016/j.micinf.2004.07.009. CASPubMed Google Scholar
Torre D, Pugliese A: Interleukin-18: a proinflammatory cytokine in HIV-1 infection. Curr HIV Res. 2006, 4 (4): 423-430. 10.2174/157016206778559993. CASPubMed Google Scholar
Segat L, Bevilacqua D, Boniotto M, Arraes LC, de Souza PR, de Lima Filho JL, Crovella S: IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population. Immunogenetics. 2006, 58 (5-6): 471-473. 10.1007/s00251-006-0104-7. CASPubMed Google Scholar
Song W, Wilson CM, Allen S, Wang C, Li Y, Kaslow RA, Tang J: Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults. Clin Exp Immunol. 2006, 144 (1): 117-124. 10.1111/j.1365-2249.2006.03050.x. PubMed CentralCASPubMed Google Scholar
Biron CA: Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections. Semin Immunol. 1998, 10 (5): 383-390. 10.1006/smim.1998.0138. CASPubMed Google Scholar
Diop G, Hirtzig T, Do H, Coulonges C, Vasilescu A, Labib T, Spadoni JL, Therwath A, Lathrop M, Matsuda F, Zagury JF: Exhaustive genotyping of the interferon alpha receptor 1 (IFNAR1) gene and association of an IFNAR1 protein variant with AIDS progression or susceptibility to HIV-1 infection in a French AIDS cohort. Biomed Pharmacother. 2006, 60 (9): 569-577. 10.1016/j.biopha.2006.08.002. CASPubMed Google Scholar
Bafica A, Scanga CA, Schito M, Chaussabel D, Sher A: Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors. J Immunol. 2004, 172 (12): 7229-7234. CASPubMed Google Scholar
Finberg RW, Wang JP, Kurt-Jones EA: Toll like receptors and viruses. Rev Med Virol. 2007, 17 (1): 35-43. 10.1002/rmv.525. CASPubMed Google Scholar
Bentwich Z, Kalinkovich A, Weisman Z: Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today. 1995, 16 (4): 187-191. 10.1016/0167-5699(95)80119-7. CASPubMed Google Scholar
Quinn TC, Piot P, McCormick JB, Feinsod FM, Taelman H, Kapita B, Stevens W, Fauci AS: Serologic and immunologic studies in patients with AIDS in North America and Africa. The potential role of infectious agents as cofactors in human immunodeficiency virus infection. JAMA. 1987, 257 (19): 2617-2621. 10.1001/jama.257.19.2617. CASPubMed Google Scholar
Pomerantz RJ, Feinberg MB, Trono D, Baltimore D: Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. J Exp Med. 1990, 172 (1): 253-261. 10.1084/jem.172.1.253. CASPubMed Google Scholar
Schlaepfer E, Audige A, Joller H, Speck RF: TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection. J Immunol. 2006, 176 (5): 2888-2895. CASPubMed Google Scholar
Agrawal S, Martin RR: Was induction of HIV-1 through TLR9?. J Immunol. 2003, 171 (4): 1621- CASPubMed Google Scholar
Bafica A, Scanga CA, Schito ML, Hieny S, Sher A: Cutting edge: in vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2. J Immunol. 2003, 171 (3): 1123-1127. CASPubMed Google Scholar
Equils O, Faure E, Thomas L, Bulut Y, Trushin S, Arditi M: Bacterial lipopolysaccharide activates HIV long terminal repeat through Toll-like receptor 4. J Immunol. 2001, 166 (4): 2342-2347. CASPubMed Google Scholar
Equils O, Schito ML, Karahashi H, Madak Z, Yarali A, Michelsen KS, Sher A, Arditi M: Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication. J Immunol. 2003, 170 (10): 5159-5164. CASPubMed Google Scholar
Sundstrom JB, Little DM, Villinger F, Ellis JE, Ansari AA: Signaling through Toll-like receptors triggers HIV-1 replication in latently infected mast cells. J Immunol. 2004, 172 (7): 4391-4401. CASPubMed Google Scholar
Toossi Z: Virological and immunological impact of tuberculosis on human immunodeficiency virus type 1 disease. J Infect Dis. 2003, 188 (8): 1146-1155. 10.1086/378676. PubMed Google Scholar
Agrawal S: Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides. Biochim Biophys Acta. 1999, 1489 (1): 53-68. CASPubMed Google Scholar
Lisziewicz J, Sun D, Weichold FF, Thierry AR, Lusso P, Tang J, Gallo RC, Agrawal S: Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells. Proc Natl Acad Sci USA. 1994, 91 (17): 7942-7946. 10.1073/pnas.91.17.7942. PubMed CentralCASPubMed Google Scholar
Bochud PY, Hersberger M, Taffe P, Bochud M, Stein CM, Rodrigues SD, Calandra T, Francioli P, Telenti A, Speck RF, Aderem A: Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection. AIDS. 2007, 21 (4): 441-446. 10.1097/QAD.0b013e328012b8ac. CASPubMed Google Scholar
Abu-Raddad LJ, Patnaik P, Kublin JG: Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa. Science. 2006, 314 (5805): 1603-1606. 10.1126/science.1132338. CASPubMed Google Scholar
Kublin JG, Patnaik P, Jere CS, Miller WC, Hoffman IF, Chimbiya N, Pendame R, Taylor TE, Molyneux ME: Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study. Lancet. 2005, 365 (9455): 233-240. PubMed Google Scholar
Patnaik P, Jere CS, Miller WC, Hoffman IF, Wirima J, Pendame R, Meshnick SR, Taylor TE, Molyneux ME, Kublin JG: Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural Malawi. J Infect Dis. 2005, 192 (6): 984-991. 10.1086/432730. CASPubMed Google Scholar
Gallagher M, Malhotra I, Mungai PL, Wamachi AN, Kioko JM, Ouma JH, Muchiri E, King CL: The effects of maternal helminth and malaria infections on mother-to-child HIV transmission. AIDS. 2005, 19 (16): 1849-1855. 10.1097/01.aids.0000189846.90946.5d. PubMed Google Scholar
Kannangara S, DeSimone JA, Pomerantz RJ: Attenuation of HIV-1 infection by other microbial agents. J Infect Dis. 2005, 192 (6): 1003-1009. 10.1086/432767. PubMed Google Scholar
Grivel JC, Ito Y, Faga G, Santoro F, Shaheen F, Malnati MS, Fitzgerald W, Lusso P, Margolis L: Suppression of CCR5- but not CXCR4-tropic HIV-1 in lymphoid tissue by human herpesvirus 6. Nat Med. 2001, 7 (11): 1232-1235. 10.1038/nm1101-1232. CASPubMed Google Scholar
Lisco A, Grivel JC, Biancotto A, Vanpouille C, Origgi F, Malnati MS, Schols D, Lusso P, Margolis LB: Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation. J Virol. 2007, 81 (2): 708-717. 10.1128/JVI.01367-06. PubMed CentralCASPubMed Google Scholar
Wallace PK, Howell AL, Fanger MW: Role of Fc gamma receptors in cancer and infectious disease. J Leukoc Biol. 1994, 55 (6): 816-826. CASPubMed Google Scholar
Brouwer KC, Lal RB, Mirel LB, Yang C, van Eijk AM, Ayisi J, Otieno J, Nahlen BL, Steketee R, Lal AA, Shi YP: Polymorphism of Fc receptor IIa for IgG in infants is associated with susceptibility to perinatal HIV-1 infection. AIDS. 2004, 18 (8): 1187-1194. 10.1097/00002030-200405210-00012. CASPubMed Google Scholar
Shi YP, Nahlen BL, Kariuki S, Urdahl KB, McElroy PD, Roberts JM, Lal AA: Fcgamma receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection. VII. Asembo Bay Cohort Project. J Infect Dis. 2001, 184 (1): 107-111. 10.1086/320999. CASPubMed Google Scholar
Griffiths GM: Protein sorting and secretion during CTL killing. Semin Immunol. 1997, 9 (2): 109-115. 10.1006/smim.1997.0059. CASPubMed Google Scholar
Migueles SA, Laborico AC, Shupert WL, Sabbaghian MS, Rabin R, Hallahan CW, Van Baarle D, Kostense S, Miedema F, McLaughlin M, Ehler L, Metcalf J, Liu S, Connors M: HIV-specific CD8 T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nature. 2002, 3 (11): 1061-1068. CAS Google Scholar
McIlroy D, Meyer L, Dudoit Y, Samri A, Delfraissy JF, Autran B, Debre P, Theodorou I: Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection. Int J Immunogenet. 2006, 33 (2): 73-79. 10.1111/j.1744-313X.2006.00571.x. CASPubMed Google Scholar